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Evidence of Interaction Between BCAR1 and PTK2

The interaction score between BCAR1 and PTK2 is 19.10.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismBCAR1 OrthologuePTK2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00031407 0.173 IPI00029702 0.259
  • InVivo

Get References From PubMed
fly Q7KVE5 1 Q9V8U8 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 1.07
Domains Domains present in BCAR1 and PTK2:
Domains in BCAR1Domains in PTK2
IPR001452 SH3
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR000299 Band 4.1
IPR009065 FERM
IPR005189 Focal adhesion targeting region

The Chi square scores for co-occurrence of domains that are present in BCAR1 and PTK2 are listed below.

Domain 1Domain 2Chi Square
IPR001452 SH3 IPR008266 Tyrosine protein kinase, active site 164.706
IPR001452 SH3 IPR001245 Tyrosine protein kinase 100.857
IPR001452 SH3 IPR000719 Protein kinase 27.1334
IPR001452 SH3 IPR005189 Focal adhesion targeting region 26.2372
IPR001452 SH3 IPR000299 Band 4.1 16.3215
IPR001452 SH3 IPR009065 FERM 2.91839

The background colour of the table refers to:

  • Blue Domain is only present in BCAR1
  • Yellow Domain is only present in PTK2
  • Green Domain is present in both BCAR1 and PTK2

 0.051
Post-translational Modifications

Protein: BCAR1

PTMResidueReference
Phosphorylation 115 PubMed, HPRD
Phosphorylation 128 PubMed, HPRD
Phosphorylation 165 PubMed, HPRD
Phosphorylation 179 PubMed, HPRD
Phosphorylation 192 PubMed, HPRD
Phosphorylation 222 PubMed, HPRD
Phosphorylation 224 PubMed, HPRD
Phosphorylation 234 PubMed, HPRD
Phosphorylation 249 PubMed, HPRD
Phosphorylation 267 PubMed, HPRD
Phosphorylation 287 PubMed, HPRD
Phosphorylation 306 PubMed, HPRD
Phosphorylation 327 PubMed, HPRD
Phosphorylation 362 PubMed, HPRD
Phosphorylation 387 PubMed, HPRD
Phosphorylation 410 PubMed, HPRD
Phosphorylation 653 PubMed, HPRD
Phosphorylation 664 PubMed, HPRD
Phosphorylation 666 PubMed, HPRD
Phosphotyrosine 327 HPRD
Proteolytic Cleavage 318 PubMed, HPRD
Proteolytic Cleavage 650 PubMed, HPRD

Protein: PTK2

PTMResidueReference
Phosphotyrosine 397 HPRD
Phosphotyrosine 407 HPRD
Phosphotyrosine 577 PubMed, HPRD
Phosphotyrosine 861 HPRD
Phosphotyrosine 925 HPRD
Localisation

Protein: BCAR1

LocalisationReference
ER HPRD
Plasma membrane HPRD
Cytoplasm HPRD

Protein: PTK2

LocalisationReference
Cytoplasm HPRD
Transitive Score

The common interactors between BCAR1 and PTK2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between BCAR1 andPTK2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , BCAR1 has 462 interactors and PTK2 has 1141 interactors of which there are 344 common interactors.

Common InteractorName of Common InteractorScore for BCAR1-Interactor (?)Score for PTK2-Interactor (?)
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 22.10 563.00
NCK2 NCK2: Cytoplasmic protein NCK2 22.10 0.874
CRKL CRKL: Crk-like protein 22.10 370.00
GRAP GRAP: GRB2-related adapter protein 1.29 76.00
BCAR3 BCAR3, NSP2, UNQ271/PRO308, SH2D3B: Breast cancer anti-estrogen resistance prote 1.07 0.592
GAB1 GAB1: GRB2-associated-binding protein 1 0.051 0.152
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.051 0.859
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.051 0.026
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.051 0.058
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.051 0.065
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.051 0.044
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.051 0.098
EPOR EPOR: Erythropoietin receptor precursor 0.051 0.072
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.051 0.202
LNK SH2B3, LNK: SH2B adapter protein 3 0.051 1.30
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.051 1.30
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.051 0.058
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.051 0.109
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.051 0.026
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.051 0.065
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.051 0.096
C6orf21 LY6G6F, C6orf21, G6F, LY6G6D, NG32: Lymphocyte antigen 6 complex locus protein G 0.051 0.051
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.051 0.872
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.051 0.100
GRB10 N/A 0.051 0.617
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.051 0.123
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.051 0.081
FN1 N/A 0.051 0.109
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.051 0.044
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.051 0.165
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.051 0.109
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.051 0.0688
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.051 0.109
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.051 0.056
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.051 0.065
ITGB4 N/A 0.051 0.0407
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.051 0.081
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.051 0.251
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.051 0.029
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.051 0.109
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.051 0.902
SCML2 SCML2: Sex comb on midleg-like protein 2 0.051 0.037
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.051 0.029
UBAP2L N/A 0.051 0.051
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.051 0.859
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.051 1.30
PTPNS1 SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP: Tyrosine-protein phosphatase non-rec 0.051 0.051
LAT LAT: Linker for activation of T-cells family member 1 0.051 0.049
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.051 0.026
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.051 0.044
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.051 0.056
GJB1 GJB1, CX32: Gap junction beta-1 protein 0.051 0.038
CD7 CD7: T-cell antigen CD7 precursor 0.051 0.029
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.051 0.083
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.051 0.065
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.051 0.029
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.051 0.072
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.051 0.029
ETS2 ETS2: Protein C-ets-2 0.051 0.037
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.051 0.109
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.051 0.044
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.051 0.065
KIR3DL1 N/A 0.051 0.109
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.051 0.065
NF2 NF2, SCH: Merlin 0.051 0.165
IRS2 IRS2: Insulin receptor substrate 2 0.051 0.123
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.051 0.081
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.051 1.05
NULL A1BG: Alpha-1B-glycoprotein precursor 0.051 0.109
VASP VASP: Vasodilator-stimulated phosphoprotein 0.051 0.110
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.051 0.044
STAT2 STAT2: Signal transducer and activator of transcription 2 0.051 0.581
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.051 0.859
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.051 0.077
TP73 TP73, P73: Tumor protein p73 0.051 0.037
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.051 0.100
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.617
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.051 0.058
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
MCF2 MCF2, DBL: Proto-oncogene DBL 0.051 0.064
PSCD2 N/A 0.051 0.165
PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 0.051 0.034
GJA1 GJA1, GJAL: Gap junction alpha-1 protein 0.051 0.160
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.051 0.872
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.051 0.126
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.051 0.859
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.051 0.109
IRS1 IRS1: Insulin receptor substrate 1 0.051 0.152
STAT3 0.051 1.17
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.051 0.109
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.051 1.35
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.051 0.064
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.051 0.100
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.051 0.081
IL9R IL9R: Interleukin-9 receptor precursor 0.051 0.072
DOK2 DOK2: Docking protein 2 0.051 0.051
CENTA1 CENTA1: Centaurin-alpha 1 0.051 0.105
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.051 0.519
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.051 0.058
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.051 0.029
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.051 0.0727
GHR GHR: Growth hormone receptor precursor 0.051 0.065
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.051 0.111
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
PVR PVR, PVS: Poliovirus receptor precursor 0.051 0.033
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.051 0.065
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.051 0.065
DNM3 DNM3: Uncharacterized protein DNM3 0.051 0.165
COBL N/A 0.051 0.260
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.051 0.693
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.051 0.075
CRK CRK: Proto-oncogene C-crk 0.051 0.617
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.051 0.033
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.051 0.109
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.051 0.073
STK16 N/A 0.051 0.049
STAT4 STAT4: Signal transducer and activator of transcription 4 0.051 0.520
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.051 0.165
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.051
PLEK PLEK, P47: Pleckstrin 0.051 0.0727
SORL1 SORL1: Sortilin-related receptor precursor 0.051 0.026
CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 0.051 0.038
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.051 0.139
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.051 0.072
GAB2 N/A 0.051 0.191
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.051 0.109
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.051
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.051 0.109
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.051 1.30
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.051 0.693
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.051 0.165
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.617
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.051 0.975
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.051 0.033
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.051 0.026
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.051 0.065
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.051 0.049
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.051 0.065
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.051 0.082
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.051 0.111
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.051 0.152
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.051 0.033
MET MET: Hepatocyte growth factor receptor precursor 0.051 0.100
SYN2 SYN2: Synapsin-2 0.051 0.0407
PRLR PRLR: Prolactin receptor precursor 0.051 0.065
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.051 0.072
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.051 0.026
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.051 0.109
GJA5 GJA5: Gap junction alpha-5 protein 0.051 0.038
LYN LYN: Tyrosine-protein kinase Lyn 0.051 0.694
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.051 0.049
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.051 0.056
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.051 0.153
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.051 0.0727
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.051 0.975
ROCK1 ROCK1: Rho-associated protein kinase 1 0.051 0.098
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.051 0.0727
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.051 0.034
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.051 0.109
GPA33 GPA33: Cell surface A33 antigen precursor 0.051 0.026
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.051 0.775
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.051 0.100
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.051 0.152
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.051 0.109
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.051 0.032
MAPK15 N/A 0.051 0.083
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.051 0.148
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.051 0.100
LILRB1 N/A 0.051 0.065
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.051 0.109
BMX N/A 0.051 0.859
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.051 0.123
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.051 0.126
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.051 0.029
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.046 0.097
WASPIP N/A 0.046 0.050
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.046 0.033
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.046 0.275
CNTN1 CNTN1: Contactin-1 precursor 0.046 0.040
STAM2 STAM2: Signal transducing adapter molecule 2 0.046 0.097
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.046 46.90
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.046 0.136
VWF VWF, F8VWF: von Willebrand factor precursor 0.046 0.046
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.046 0.044
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.046 0.098
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.046 0.136
NEO1 NEO1, NGN: Neogenin precursor 0.046 0.060
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.046 0.553
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.046 0.148
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.046 1.17
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.046 0.577
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.046 0.044
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.046 0.049
TTN N/A 0.046 0.097
VAV2 VAV2: Uncharacterized protein VAV2 0.046 0.553
STAT6 STAT6: Signal transducer and activator of transcription 6 0.046 0.620
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.046 0.078
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.046 0.148
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.046 0.100
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.046 0.136
CXorf9 N/A 0.046 0.078
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.046 0.075
INSR INSR: Insulin receptor precursor 0.046 0.064
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.046 0.050
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.046 0.098
KIT KIT: Mast/stem cell growth factor receptor precursor 0.046 43.20
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.046 0.225
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.046 0.098
MSN MSN: Moesin 0.046 0.099
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.046 0.090
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.046 0.225
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.046 375.00
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.046 0.046
DCC DCC: Netrin receptor DCC precursor 0.046 0.030
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.046 0.111
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.046 0.088
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.046 0.188
DAB1 DAB1: Disabled homolog 1 0.046 0.097
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.046 0.046
ARHGEF7 N/A 0.046 0.148
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.046 0.0735
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.046 0.044
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.046 43.20
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.046 0.139
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.046 0.058
ALK ALK: ALK tyrosine kinase receptor precursor 0.046 0.046
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.046 0.114
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.046 0.148
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.046 0.781
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.046 375.00
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.046 1.07
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.046 0.090
PLD1 PLD1: Phospholipase D1 0.046 0.088
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.046 0.148
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.046 0.073
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.046 0.088
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.046 0.073
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.046 74.00
ELMO1 N/A 0.046 0.148
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.046 0.056
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.046 0.078
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.046 0.114
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.046 0.098
RPS6KB1 N/A 0.046 0.044
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.046 0.0735
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.046 0.694
SYK SYK: Tyrosine-protein kinase SYK 0.046 0.694
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.046 0.056
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.046 0.029
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.046 0.148
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.046 0.036
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.046 0.046
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.046 0.694
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.046 0.148
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.046 0.044
RASA3 RASA3: Ras GTPase-activating protein 3 0.046 0.088
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.046 0.050
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.046 30.80
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.046 0.030
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.046 0.136
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.046 0.694
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.046 0.372
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.046 0.097
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.046 0.036
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.046 0.097
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.046 0.073
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.046 0.088
BSG N/A 0.046 0.040
PTPRZ1 N/A 0.046 0.100
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.046 0.046
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.046 0.694
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.046 0.090
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.046 0.275
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.046 0.073
APS SH2B2, APS: SH2B adapter protein 2 0.046 0.770
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.046 0.148
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.046 333.00
SOS1 SOS1: Son of sevenless homolog 1 0.046 0.064
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.046 0.056
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.046 0.171
RIN1 RIN1: Ras and Rab interactor 1 0.046 1.08
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.046 0.097
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.046 0.148
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.046 0.781
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.046 0.056
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.046 0.111
VIL2 N/A 0.046 0.097
DOK1 DOK1: Docking protein 1 0.046 0.099
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.046 0.763
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.046 0.090
CSK CSK: Tyrosine-protein kinase CSK 0.046 0.781
RDX RDX: Radixin 0.046 0.275
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.046 281.00
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.046 1.17
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.046 0.062
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.046 0.781
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.046 0.586
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.046 0.056
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.046 0.097
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.046 0.148
CNTN4 CNTN4: Contactin-4 precursor 0.046 0.040
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.046 0.088
EPB41 EPB41, E41P: Protein 4.1 0.046 0.046
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.046 0.044
VAV1 VAV1, VAV: Proto-oncogene vav 0.046 0.620
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.046 0.037
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.046 0.113
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.046 0.148
PSCD4 PSCD4, CYT4: Cytohesin-4 0.046 0.099
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.046 0.058
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.046 0.275
TNC TNC, HXB: Tenascin precursor 0.046 0.036
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.046 0.098
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.046 1.07
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.046 0.181
PSD TYL: TYL protein 0.046 0.225
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.046 0.073
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.046 0.148
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.046 0.275
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.046 0.097
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.046 1.17
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.046 0.058
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.046 0.088
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.046 30.80
HCK N/A 0.046 0.781
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.046 0.171
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.046 0.029
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.046 0.874
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.046 0.044
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.046 0.078
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.046 0.113
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.046 0.098
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.046 0.878
JAK1 0.046 0.694
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.046 0.073
DAB2 DAB2, DOC2: Disabled homolog 2 0.046 0.111
PLD2 PLD2: Phospholipase D2 0.046 0.136
SUPT5H SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5 0.029 0.027
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.029 0.087
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.026 0.030
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.026 0.030
2.15E-3
Total Score 19.10