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Evidence of Interaction Between FOXO3A and SMAD3

The interaction score between FOXO3A and SMAD3 is 11.60.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between FOXO3A and SMAD3 = -0.05

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology
OrganismFOXO3A OrthologueSMAD3 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00289866 0.334 IPI00019548 0.72
human IPI00654651 0.22 IPI00019548 0.72
human IPI00289866 0.334 IPI00019549 0.219
human IPI00654651 0.22 IPI00019549 0.219
worm Q86S42 1 Q02330 0.219

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in FOXO3A and SMAD3:
Domains in FOXO3ADomains in SMAD3
IPR001766 Fork head transcription factor
IPR011991 Wing_hlx_DNA_bd.
IPR008984 SMAD/FHA
IPR003619 Dwarfin protein, domain A
IPR001132 Dwarfin protein
IPR013019 MAD_MH1.

The Chi square scores for co-occurrence of domains that are present in FOXO3A and SMAD3 are listed below.

Domain 1Domain 2Chi Square
IPR001766 Fork head transcription factor IPR001132 Dwarfin protein 46.3494
IPR001766 Fork head transcription factor IPR013019 MAD_MH1. 46.3494
IPR001766 Fork head transcription factor IPR003619 Dwarfin protein, domain A 45.9487
IPR001766 Fork head transcription factor IPR008984 SMAD/FHA 17.0771
IPR011991 Wing_hlx_DNA_bd. IPR008984 SMAD/FHA 1.2739
IPR011991 Wing_hlx_DNA_bd. IPR003619 Dwarfin protein, domain A 1.21319
IPR011991 Wing_hlx_DNA_bd. IPR001132 Dwarfin protein 0.326137
IPR011991 Wing_hlx_DNA_bd. IPR013019 MAD_MH1. 0.326137

The background colour of the table refers to:

  • Blue Domain is only present in FOXO3A
  • Yellow Domain is only present in SMAD3
  • Green Domain is present in both FOXO3A and SMAD3

 0.165
Post-translational Modifications

Protein: FOXO3A

PTMResidueReference
Phosphorylation 32 PubMed, HPRD
Phosphorylation 253 PubMed, HPRD
Phosphorylation 315 PubMed, HPRD
Phosphoserine 315 PubMed, HPRD

Protein: SMAD3

PTMResidueReference
Phosphorylation 8 PubMed, HPRD
Phosphorylation 179 PubMed, HPRD
Phosphorylation 204 PubMed, HPRD
Phosphorylation 208 PubMed, HPRD
Phosphorylation 213 PubMed, HPRD
Phosphorylation 422 PubMed, HPRD
Phosphorylation 423 PubMed, HPRD
Phosphorylation 425 PubMed, HPRD
Localisation

Protein: FOXO3A

LocalisationReference
Cytosol HPRD
Nucleus HPRD
Cytoplasm HPRD

Protein: SMAD3

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between FOXO3A and SMAD3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between FOXO3A andSMAD3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , FOXO3A has 785 interactors and SMAD3 has 962 interactors of which there are 561 common interactors.

Common InteractorName of Common InteractorScore for FOXO3A-Interactor (?)Score for SMAD3-Interactor (?)
JUP JUP, CTNNG, DP3: Junction plakoglobin 13.90 19.80
PCAF PCAF: Histone acetyltransferase PCAF 1.62 0.049
CDK2 CDK2: Cell division protein kinase 2 1.53 0.029
KLF1 KLF1, EKLF: Krueppel-like factor 1 0.822 0.044
MAFG MAFG: Transcription factor MafG 0.461 0.069
TERF2IP TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1 0.416 0.049
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.372 0.038
MYBL2 MYBL2, BMYB: Myb-related protein B 0.307 0.056
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.275 0.114
AKAP8L AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like 0.260 0.069
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.251 0.191
KLF13 KLF13, BTEB3, NSLP1: Krueppel-like factor 13 0.233 0.086
MLLT7 N/A 0.225 0.111
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 0.225 0.054
RXRA RXRA, NR2B1: Retinoic acid receptor RXR-alpha 0.210 0.032
BAZ1B BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain 0.191 0.060
JUND JUND: Transcription factor jun-D 0.171 0.114
MCM3 MCM3: DNA replication licensing factor MCM3 0.171 0.029
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.171 0.071
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.165 0.028
CUTL1 CUTL1: Homeobox protein cut-like 1 0.165 0.083
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.165 0.028
KIAA1443 HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez 0.165 0.083
ZHX1 ZHX1: Zinc fingers and homeoboxes protein 1 0.165 0.083
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.165 0.165
TERF2 TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2 0.152 0.096
RB1 RB1: Retinoblastoma-associated protein 0.152 0.060
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.152 0.127
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.148 0.027
HOXA10 HOXA10, HOX1H: Homeobox protein Hox-A10 0.148 0.075
BRD4 N/A 0.148 0.047
RBL1 RBL1: Retinoblastoma-like protein 1 0.148 0.047
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.148 0.075
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.148 0.025
DLX3 DLX3: Homeobox protein DLX-3 0.148 0.075
CREB1 CREB1: cAMP response element-binding protein 0.148 0.075
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.148 0.025
CCNT2 CCNT2: Cyclin-T2 0.148 0.025
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.148 35.90
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.139 0.069
JUNB JUNB: Transcription factor jun-B 0.136 0.139
NCOR1 NCOR1, KIAA1047: Nuclear receptor corepressor 1 0.136 0.139
BRPF1 BRPF1, BR140: Peregrin 0.136 0.086
FOS FOS, G0S7: Proto-oncogene protein c-fos 0.136 0.086
BAZ2A BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A 0.136 0.087
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.136 0.086
CEBPE CEBPE: CCAAT/enhancer-binding protein epsilon 0.136 0.056
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.136 66.70
JUN JUN: Transcription factor AP-1 0.136 0.086
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.136 0.038
CREBBP CREBBP, CBP: CREB-binding protein 0.136 41.40
AANAT AANAT, SNAT: Serotonin N-acetyltransferase 0.127 0.062
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.127 0.114
MKI67 MKI67: Antigen KI-67 0.127 0.077
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.127 0.062
H1FX H1FX: Histone H1x 0.127 0.096
POU2F1 POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1 0.123 0.096
BACH1 BACH1: Transcription regulator protein BACH1 0.123 0.127
IRF3 IRF3: Interferon regulatory factor 3 0.123 0.155
NBN NBN, NBS, NBS1, P95: Nibrin 0.123 0.155
NFATC1 N/A 0.123 0.070
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.123 0.060
MYB MYB: Myb proto-oncogene protein 0.123 0.062
TGIF2 TGIF2: Homeobox protein TGIF2 0.123 0.210
TERF1 TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1 0.123 0.077
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.123 0.096
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.123 0.208
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.114 0.038
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.114 0.046
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.114 0.038
YY1 YY1: Transcriptional repressor protein YY1 0.114 0.139
ATF6 ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha 0.111 0.114
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.111 0.054
SATB1 SATB1: DNA-binding protein SATB1 0.111 0.069
NFE2L2 NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2 0.111 0.114
SIRT1 SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1 0.111 0.029
SMAD4 SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4 0.111 0.114
MLL MLL, ALL1, HRX, HTRX, TRX1: Zinc finger protein HRX 0.111 0.071
FOSL2 FOSL2, FRA2: Fos-related antigen 2 0.111 0.086
TCF8 ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1 0.111 0.114
NKX2-5 NKX2-5, CSX, NKX2.5, NKX2E: Homeobox protein Nkx-2.5 0.111 0.049
SNAPC4 SNAPC4, SNAP190: snRNA-activating protein complex subunit 4 0.109 0.077
CDX2 CDX2, CDX3: Homeobox protein CDX-2 0.109 0.069
SMAD7 SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7 0.109 0.062
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.109 0.048
NFIB N/A 0.109 0.077
ZHX3 ZHX3, KIAA0395, TIX1: Zinc fingers and homeoboxes protein 3 0.109 0.055
ESR1 ESR1, ESR, NR3A1: Estrogen receptor 0.109 0.055
DDIT3 DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3 0.098 0.062
TAF1 TAF1, BA2R, CCG1, CCGS, TAF2A: Transcription initiation factor TFIID subunit 1 0.098 0.039
FOXO1A FOXO1A, FKHR: Forkhead box protein O1A 0.097 0.225
HOXB6 HOXB6, HOX2B: Homeobox protein Hox-B6 0.097 0.049
SATB2 SATB2, KIAA1034: DNA-binding protein SATB2 0.097 0.044
RFX1 RFX1: MHC class II regulatory factor RFX1 0.097 0.049
EN2 EN2: Homeobox protein engrailed-2 0.097 0.044
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.096 0.070
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.096 0.038
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.096 0.127
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.096 0.210
SP100 N/A 0.096 0.210
GCN5L2 GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2 0.088 26.80
RERE RERE, ARG, ARP, ATN1L, KIAA0458: Arginine-glutamic acid dipeptide repeats protei 0.088 0.069
FOXL2 FOXL2: Forkhead box protein L2 0.088 0.097
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.086 0.114
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.086 0.056
MTF1 MTF1: Metal regulatory transcription factor 1 0.086 54.60
PPP1R8 N/A 0.086 0.114
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.086 0.139
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.086 0.086
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.086 0.038
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.086 0.038
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.086 0.069
SRF SRF: Serum response factor 0.086 0.139
ZNF24 ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24 0.086 0.114
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.086 0.139
SP1 SP1, TSFP1: Transcription factor Sp1 0.086 0.069
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.086 0.029
ZBTB7A ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A 0.086 0.114
POGZ POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain 0.083 0.083
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.083 0.083
ZFP91 ZFP91, FKSG11: Zinc finger protein 91 homolog 0.083 0.083
ZFPM1 ZFPM1, FOG1: Zinc finger protein ZFPM1 0.083 0.075
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.083 0.083
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.083 0.083
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.028
ZNF644 ZNF644, KIAA1221, ZEP2: Zinc finger protein 644 0.083 0.083
ZNF579 ZNF579: Zinc finger protein 579 0.083 0.083
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.083 0.083
SOX8 SOX8: Transcription factor SOX-8 0.083 0.075
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.080 0.0277
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.077 0.052
ID2 ID2: DNA-binding protein inhibitor ID-2 0.077 0.032
REST REST, NRSF, XBR: RE1-silencing transcription factor 0.077 0.096
XRCC1 XRCC1: DNA-repair protein XRCC1 0.077 0.032
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.077 0.062
ETS2 ETS2: Protein C-ets-2 0.077 0.077
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.077 0.032
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.077 0.087
MATR3 MATR3, KIAA0723: Matrin-3 0.077 0.096
ELF1 ELF1: ETS-related transcription factor Elf-1 0.077 0.210
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.025
DHX8 DHX8, DDX8: ATP-dependent RNA helicase DHX8 0.075 0.025
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.075 0.025
ELMO1 N/A 0.075 0.025
TFAP4 TFAP4: Transcription factor AP-4 0.075 0.025
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.075 0.028
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.075 0.075
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.025
ZNF174 ZNF174, ZSCAN8: Zinc finger protein 174 0.075 0.075
OSR1 OSR1, ODD: Protein odd-skipped-related 1 0.075 0.075
GATAD2B GATAD2B, KIAA1150: Transcriptional repressor p66 beta 0.075 0.025
RNF20 0.075 0.025
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.075 0.025
PRDM2 PRDM2, RIZ: PR domain zinc finger protein 2 0.075 0.075
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.075 0.025
NIPBL N/A 0.075 0.047
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.047
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.047
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.075 0.075
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.025
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.075 0.025
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.075 0.075
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.075 0.075
TRERF1 TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1 0.075 0.075
TAL2 TAL2: T-cell acute lymphocytic leukemia protein 2 0.075 0.025
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.075 0.075
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.075 0.025
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.071 0.046
TCF3 TCF3, E2A, ITF1: Transcription factor E2-alpha 0.071 0.038
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.070 0.032
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.069 0.087
BRCA1 BRCA1, RNF53: Breast cancer type 1 susceptibility protein 0.069 0.069
SYMPK SYMPK, SPK: Symplekin 0.069 0.054
ZNF224 ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224 0.069 0.086
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.069 0.046
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.069 0.035
SP3 SP3: Transcription factor Sp3 0.069 0.086
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.069 0.087
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.069 0.038
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.069 0.139
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.069 0.029
RPS6KB1 N/A 0.069 0.046
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.069 0.063
ZBTB16 ZBTB16, PLZF, ZNF145: Zinc finger and BTB domain-containing protein 16 0.069 0.049
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.069 0.029
LEF1 LEF1: Lymphoid enhancer-binding factor 1 0.069 0.049
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.069 0.046
MEF2D MEF2D: Myocyte-specific enhancer factor 2D 0.069 0.114
KIAA0690 N/A 0.069 0.054
CDC34 CDC34, UBE2R1: Ubiquitin-conjugating enzyme E2 R1 0.066 0.033
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.063 0.029
SOX4 SOX4: Transcription factor SOX-4 0.062 0.069
ERG ERG: Transcriptional regulator ERG 0.062 0.062
PPARA PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha 0.062 0.026
ZNF318 ZNF318, HRIHFB2436: Zinc finger protein 318 0.062 0.127
ZBTB33 KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso 0.062 0.096
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.062 0.096
GTF2F2 N/A 0.062 0.127
ZFX ZFX: Zinc finger X-chromosomal protein 0.062 0.155
ERF ERF: ETS domain-containing transcription factor ERF 0.062 0.127
SAT SAT1, SAT: Diamine acetyltransferase 1 0.062 0.096
RELA RELA, NFKB3: Transcription factor p65 0.056 0.046
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.056 0.139
ETS1 ETS1, EWSR2: Protein C-ets-1 0.056 0.139
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.056 0.029
WDHD1 WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1 0.056 0.069
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.056 0.029
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.056 0.086
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.056 26.80
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.056 0.038
AHR AHR: Aryl hydrocarbon receptor precursor 0.056 0.029
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.056 0.029
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.056 0.056
VDR VDR, NR1I1: Vitamin D3 receptor 0.056 0.086
ZNF335 ZNF335: Zinc finger protein 335 0.056 0.114
NR5A1 NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1 0.056 0.056
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.056 0.029
ZNF76 ZNF76, D6S229E: Zinc finger protein 76 0.056 0.114
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.056 0.029
PRKG1 PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme 0.056 0.056
ATM ATM: Serine-protein kinase ATM 0.056 0.114
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.056 0.038
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.056 0.114
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.056 0.139
ZNF551 N/A 0.056 0.069
ZNF217 ZNF217, ZABC1: Zinc finger protein 217 0.056 0.114
HIVEP1 N/A 0.055 0.127
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.055 0.060
ROCK1 ROCK1: Rho-associated protein kinase 1 0.055 0.052
ZNF267 ZNF267: Zinc finger protein 267 0.055 0.077
SH3BP3 0.055 0.077
ID3 ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3 0.055 0.032
STAT2 STAT2: Signal transducer and activator of transcription 2 0.055 0.0425
MEF2A N/A 0.055 0.096
ETV1 ETV1, ER81: ETS translocation variant 1 0.055 0.049
TP53BP1 TP53BP1: Tumor suppressor p53-binding protein 1 0.055 0.026
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.054 0.086
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.052 0.028
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 0.052 0.028
C20orf18 N/A 0.052 0.052
HES6 HES6: Transcription cofactor HES-6 0.052 0.028
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 0.052 0.025
MAPK15 N/A 0.052 0.083
KIF22 KIF22, KID, KNSL4: Kinesin-like protein KIF22 0.052 0.026
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.051 0.067
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.049 0.049
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.049 0.049
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.049 0.054
NR1D1 NR1D1, EAR1, HREV, THRAL: Orphan nuclear receptor NR1D1 0.049 0.044
SOX11 SOX11: Transcription factor SOX-11 0.049 0.049
ZBTB40 ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40 0.049 0.114
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.049 0.086
SNAI1 SNAI1, SNAH: Zinc finger protein SNAI1 0.049 0.114
BNC1 BNC1, BNC: Zinc finger protein basonuclin-1 0.049 0.056
SLC4A1AP SLC4A1AP: Uncharacterized protein SLC4A1AP 0.049 0.069
EGR1 EGR1, ZNF225: Early growth response protein 1 0.049 0.049
ELK1 ELK1: ETS domain-containing protein Elk-1 0.049 0.049
KLF5 KLF5, BTEB2, CKLF, IKLF: Krueppel-like factor 5 0.049 0.056
MTA1 MTA1: Metastasis-associated protein MTA1 0.049 0.038
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.049 0.114
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.049 0.038
EEA1 EEA1, ZFYVE2: Early endosome antigen 1 0.049 0.114
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.049 0.029
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.049 0.086
MEF2C MEF2C: Myocyte-specific enhancer factor 2C 0.049 0.056
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.049 0.069
GAB1 GAB1: GRB2-associated-binding protein 1 0.048 0.032
MAX MAX: Protein max 0.047 0.025
MLXIPL MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein 0.047 0.025
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.047 0.025
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.047 0.025
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.047 0.025
PHF10 N/A 0.046 0.038
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.046 0.069
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.046 0.038
HD HD, IT15: Huntingtin 0.0453 0.061
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.044 0.086
SALL1 SALL1, SAL1: Sal-like protein 1 0.044 0.044
TP53 TP53, P53: Cellular tumor antigen p53 0.043 0.087
DOK1 DOK1: Docking protein 1 0.043 0.046
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.043 0.038
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.043 0.114
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.043 0.038
KIF23 N/A 0.0425 0.026
TDG TDG: G/T mismatch-specific thymine DNA glycosylase 0.0425 0.029
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.0425 0.052
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.0425 0.035
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.0425 0.152
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.0425 0.038
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.0425 0.0425
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.0425 0.0425
CENPA CENPA: Histone H3-like centromeric protein A 0.0425 0.026
HDAC3 HDAC3: Histone deacetylase 3 0.0425 0.038
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.041 0.032
XPO1 XPO1, CRM1: Exportin-1 0.041 0.054
STAT6 STAT6: Signal transducer and activator of transcription 6 0.041 0.032
AXIN1 0.04 0.049
PLEK PLEK, P47: Pleckstrin 0.039 0.052
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.039 0.052
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.039 0.028
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.039 0.210
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.039 0.0425
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.038 0.038
ACIN1 ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus 0.038 0.086
EP300 N/A 0.038 0.038
NUP153 N/A 0.038 0.029
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.038 0.046
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.038 0.038
CDC20 CDC20: Cell division cycle protein 20 homolog 0.038 0.056
FZR1 N/A 0.038 0.029
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.038 0.046
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.038 0.046
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.038 0.038
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.037 0.075
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.037 0.057
ARHGEF7 N/A 0.036 6.17
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.036 0.036
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.036 0.044
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.035 0.056
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.035 0.063
HIF1A HIF1A, MOP1: Hypoxia-inducible factor 1 alpha 0.035 0.046
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.035 0.114
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.034 0.055
GAB2 N/A 0.034 0.026
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.032 0.070
AFF1 N/A 0.032 0.032
TOPORS TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors 0.032 0.038
SMARCC2 N/A 0.032 0.032
FAM65A FAM65A, KIAA1930: Protein FAM65A 0.032 0.026
PTMA N/A 0.032 0.052
UBAP2 N/A 0.032 0.026
STRN3 STRN3, GS2NA, SG2NA: Striatin-3 0.032 0.026
IKBKG IKBKG, FIP3, NEMO: NF-kappa-B essential modulator 0.032 0.052
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.032 0.032
RBM14 RBM14, SIP: RNA-binding protein 14 0.032 0.0425
DAXX DAXX, BING2, DAP6: Death domain-associated protein 6 0.032 0.046
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.032 0.032
KIAA0853 N/A 0.032 0.052
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.032 0.052
CIC CIC, KIAA0306: Protein capicua homolog 0.031 0.031
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.031 0.032
IRS1 IRS1: Insulin receptor substrate 1 0.031 0.026
SOS1 SOS1: Son of sevenless homolog 1 0.0308 0.071
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.030 0.027
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.029 0.029
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.029 0.041
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.029 0.051
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.029 0.051
CBX3 CBX3: Chromobox protein homolog 3 0.029 0.038
CSPG6 SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3 0.029 0.038
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.029 0.038
COPB2 COPB2: Coatomer subunit beta' 0.029 0.139
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.029 0.046
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.029 0.038
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.029 0.063
COPA COPA: Coatomer subunit alpha 0.029 0.188
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.029 0.046
SFRS6 SFRS6, SRP55: Splicing factor, arginine/serine-rich 6 0.029 0.038
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.029 0.046
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.029 0.029
JARID1A JARID1A, RBBP2, RBP2: Histone demethylase JARID1A 0.029 0.046
RCP9 CRCP: DNA-directed RNA polymerase III subunit RPC9 0.029 0.029
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.029 0.029
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.029 0.038
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.029 0.114
TIAL1 TIAL1: Nucleolysin TIAR 0.029 0.038
SFRS4 SFRS4, SRP75: Splicing factor, arginine/serine-rich 4 0.029 0.038
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.029 0.029
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.029 0.086
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.029 0.114
KLHDC4 N/A 0.029 0.038
HDAC2 HDAC2: Histone deacetylase 2 0.029 0.029
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.029 0.038
SF3B4 SF3B4, SAP49: Splicing factor 3B subunit 4 0.029 0.038
SAPS3 N/A 0.029 0.046
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.029 0.038
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.029 0.046
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.029 0.038
PAPOLA PAPOLA, PAP: Poly(A) polymerase alpha 0.029 0.046
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.028 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.028 0.028
ILF3 ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3 0.028 0.028
DDX20 DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20 0.028 0.025
SYTL4 Endocrine transmitter regulatory protein 0.028 0.083
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
JDP2 jdp2, JDP2: Jun dimerization protein 2 0.028 0.028
PTBP1 PTBP1: Polypyrimidine tract binding protein 1 0.028 0.028
PPEF1 N/A 0.028 0.028
CBFA2T2 CBFA2T2, EHT, MTGR1: Protein CBFA2T2 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.165
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.028 0.025
MAPKAPK5 N/A 0.028 0.028
ATXN2L ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein 0.028 0.028
AR AR, DHTR, NR3C4: Androgen receptor 0.028 0.028
UHRF1 0.028 0.052
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.028 0.083
DSP DSP: Desmoplakin 0.028 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.028 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
HNRPC HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.028 0.028
MSL3L1 MSL3L1: Male-specific lethal 3-like 1 0.028 0.025
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.083
ZNF598 ZNF598: Zinc finger protein 598 0.028 0.025
MITF MITF: Microphthalmia-associated transcription factor 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
DUSP15 N/A 0.028 0.028
FLJ21816 PALB2, FANCN: Partner and localizer of BRCA2 0.028 0.028
CETN1 CETN1, CEN1, CETN: Centrin-1 0.028 0.025
ZCCHC3 ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3 0.028 0.028
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.028 0.028
KIF1B N/A 0.028 0.028
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.028 0.028
IRF7 N/A 0.028 0.028
NSBP1 NSBP1: Nucleosome-binding protein 1 0.028 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.028 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.028 0.028
CORO6 N/A 0.028 0.028
NF2 NF2, SCH: Merlin 0.028 0.028
TMPO TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha 0.028 0.028
NIPA1 NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 0.028 0.083
PHLDB2 N/A 0.028 0.028
BID BID: BH3-interacting domain death agonist 0.028 0.028
NHN1 NHN1: Conserved nuclear protein NHN1 0.028 0.025
WDR54 N/A 0.028 0.083
NFYA NFYA: Nuclear transcription factor Y subunit alpha 0.028 0.025
DKFZp434K1815 DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815 0.028 0.028
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.028 0.028
NFIA NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A 0.028 0.028
C13orf8 N/A 0.028 0.028
CABLES1 N/A 0.028 0.028
HDAC8 N/A 0.028 0.028
SNRPB N/A 0.028 0.028
TCF20 TCF20, KIAA0292, SPBP: Transcription factor 20 0.028 0.028
ZNF265 N/A 0.028 0.028
GEMIN5 GEMIN5: Gem-associated protein 5 0.028 0.075
RAB4A N/A 0.028 0.165
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.028 0.056
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.027 0.0818
VAV1 VAV1, VAV: Proto-oncogene vav 0.027 0.111
FOXQ1 FOXQ1, HFH1: Forkhead box protein Q1 0.027 0.027
MCF2 MCF2, DBL: Proto-oncogene DBL 0.0263 0.0263
NEDD4L NEDD4L, KIAA0439, NEDL3: E3 ubiquitin-protein ligase NEDD4-like protein 0.026 0.110
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.026 0.087
AFAP AFAP1, AFAP: Actin filament-associated protein 1 0.026 0.026
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.026 0.038
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.026 0.0425
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.026 0.155
MARK2 N/A 0.026 0.052
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.026 0.052
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.026 0.032
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.026 0.038
API5 N/A 0.026 0.032
GTF3C1 N/A 0.026 0.026
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.026 0.0425
ARFGAP1 N/A 0.026 0.052
DNMT1 DNMT1, AIM, DNMT: DNA 0.026 0.032
EMD EMD, EDMD, STA: Emerin 0.026 0.032
AOF2 AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1 0.026 0.032
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.026 0.139
RFXDC2 RFXDC2: Regulatory factor X domain-containing protein 2. 0.026 0.052
CHUK N/A 0.026 0.032
SFRS15 SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15 0.026 0.0425
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.026 0.032
RREB1 RREB1, FINB: RAS-responsive element-binding protein 1 0.026 0.038
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.026 0.052
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.026 0.052
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.026 0.032
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.026 0.032
ABCF1 N/A 0.026 0.0425
SETD3 SETD3, C14orf154: SET domain-containing protein 3 0.025 0.025
PRKCB1 N/A 0.025 0.025
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.025 0.025
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.025 0.025
HNRPD HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0 0.025 0.025
HEXIM2 HEXIM2, L3: Protein HEXIM2 0.025 0.025
BCOR N/A 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.148
SMARCA2 SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2 0.025 0.025
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.025 0.025
PURB PURB: Transcriptional activator protein Pur-beta 0.025 0.025
RBBP6 RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6 0.025 0.025
SEC13L1 N/A 0.025 0.025
MKI67IP MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein 0.025 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
SFRS9 SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9 0.025 0.025
HNRPA2B1 HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1 0.025 0.025
CAMK2A N/A 0.025 0.025
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.025 0.025
CAMKK1 N/A 0.025 0.025
BUB3 BUB3: Mitotic checkpoint protein BUB3 0.025 0.075
PSIP1 PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein 0.025 0.025
SON 0.025 0.025
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.025 0.025
C14orf4 C14orf4, KIAA1865, My039: RING finger protein C14orf4 0.025 0.025
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
GIT2 N/A 0.025 0.025
SAP14 SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14 0.025 0.025
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.148
ARID4A ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A 0.025 0.025
TIA1 TIA1: Nucleolysin TIA-1 isoform p40 0.025 0.025
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.025 0.025
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.025
ATXN2L N/A 0.025 0.025
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.075
ADK ADK: Adenosine kinase 0.025 0.025
SYAP1 SYAP1, PRO3113: Synapse-associated protein 1 0.025 0.025
KCTD1 0.025 0.025
LMNA LMNA, LMN1: Lamin-A/C 0.025 0.025
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
HNRPUL1 HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1 0.025 0.025
POLR1C POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1 0.025 0.025
C20orf77 N/A 0.025 0.025
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.025 0.025
TCEA1 N/A 0.025 0.025
SMN2 SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein 0.025 0.025
NEDD4 NEDD4: Uncharacterized protein NEDD4 0.025 0.025
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.025
PHF16 PHF16, JADE3, KIAA0215: Protein Jade-3 0.025 0.025
IWS1 IWS1, IWS1L: IWS1 homolog 0.025 0.025
SSBP4 SSBP4: Single-stranded DNA-binding protein 4 0.025 0.025
RNF113A RNF113A, RNF113, ZNF183: RING finger protein 113A 0.025 0.025
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.025
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.025 0.025
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.025 0.025
DIDO1 N/A 0.025 0.025
HIST3H2A HIST3H2A: Histone H2A type 3 0.025 0.025
GRK6 N/A 0.025 0.025
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.025 0.025
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.025 0.025
NES N/A 0.025 0.028
REXO1 REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog 0.025 0.025
FLJ23436 N/A 0.025 0.025
NSUN2 NSUN2, SAKI, TRM4: tRNA 0.025 0.025
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.025 0.025
MIER1 MIER1, KIAA1610: Mesoderm induction early response protein 1 0.025 0.025
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.025 0.075
WWTR1 WWTR1, TAZ: WW domain-containing transcription regulator protein 1 0.025 0.075
MLL4 WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7 0.025 0.025
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.025 0.025
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.025 0.025
HDAC7A N/A 0.025 0.025
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.025 0.025
NUP98 N/A 0.025 0.025
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.025
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.025 0.025
HNRPM HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M 0.025 0.025
MAPK8IP3 N/A 0.025 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.025 0.025
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.025 0.025
FAF1 FAF1, CGI-03: FAS-associated factor 1 0.025 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.025
CDC2 CDC2: Cell division control protein 2 homolog 0.025 0.025
FLJ40432 FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227 0.025 0.025
MAP2K3 N/A 0.025 0.025
EDF1 EDF1: Endothelial differentiation-related factor 1 0.025 0.025
HTATIP N/A 0.025 0.025
0.299
Total Score 11.60