PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between JUNB and BRCA1

The interaction score between JUNB and BRCA1 is 25.3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between JUNB and BRCA1 = 0.00

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

1.85E-3

Orthology

Organism	JUNB Orthologue		BRCA1 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
worm	Q22753	1	O44486	0.143
worm	Q22753	1	Q93335	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3

Domains

Domains present in JUNB and BRCA1:

Domains in JUNB

Domains in BRCA1

IPR004827	Basic-leucine zipper (bZIP) transcription factor
IPR008917	Eukaryotic transcription factor, DNA-binding
IPR002112	Transcription factor Jun
IPR005643	Jun-like transcription factor
IPR011616	bZIP_1.

IPR001841	Zn-finger, RING
IPR001990	Chromogranin/secretogranin
IPR001357	BRCT
IPR002378	Breast cancer type I susceptibility protein
IPR011364	BRCA1.

The Chi square scores for co-occurrence of domains that are present in JUNB and BRCA1 are listed below.

Domain 1		Domain 2		Chi Square
IPR004827	Basic-leucine zipper (bZIP) transcription factor	IPR001841	Zn-finger, RING	0.746523
IPR011616	bZIP_1.	IPR001841	Zn-finger, RING	0.390168
IPR008917	Eukaryotic transcription factor, DNA-binding	IPR001841	Zn-finger, RING	0.0586952
IPR002112	Transcription factor Jun	IPR001841	Zn-finger, RING	0.0221438
IPR005643	Jun-like transcription factor	IPR001841	Zn-finger, RING	0.0221438

The background colour of the table refers to:

Blue Domain is only present in JUNB
Yellow Domain is only present in BRCA1
Green Domain is present in both JUNB and BRCA1

0.165

Post-translational Modifications

Protein: JUNB

PTM	Residue	Reference
Phosphorylation	102	PubMed, HPRD
Phosphorylation	104	PubMed, HPRD
Phosphorylation	259	PubMed, HPRD
Phosphoserine	259	HPRD

Protein: BRCA1

PTM	Residue	Reference
Phosphorylation	308	PubMed, HPRD
Phosphorylation	509	PubMed, HPRD
Phosphorylation	988	PubMed, HPRD
Phosphorylation	1143	PubMed, HPRD
Phosphorylation	1189	PubMed, HPRD
Phosphorylation	1280	PubMed, HPRD
Phosphorylation	1330	PubMed, HPRD
Phosphorylation	1387	PubMed, HPRD
Phosphorylation	1394	PubMed, HPRD
Phosphorylation	1423	PubMed, HPRD
Phosphorylation	1457	PubMed, HPRD
Phosphorylation	1466	PubMed, HPRD
Phosphorylation	1497	PubMed, HPRD
Phosphorylation	1524	PubMed, HPRD
Phosphorylation	1542	PubMed, HPRD
Phosphorylation	1572	PubMed, HPRD
Phosphoserine	1143	PubMed, HPRD
Phosphoserine	1280	PubMed, HPRD
Phosphoserine	1387	PubMed, HPRD
Phosphoserine	1423	PubMed, HPRD
Phosphoserine	1457	PubMed, HPRD
Phosphoserine	1524	PubMed, HPRD
Phosphothreonine	1394	PubMed, HPRD
Proteolytic Cleavage	1155	PubMed, HPRD

Localisation

Protein: JUNB

Localisation	Reference
Nucleus	HPRD

Protein: BRCA1

Localisation	Reference
Nucleus	HPRD
Mitochondrion	HPRD
Centrosome	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between JUNB and BRCA1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between JUNB andBRCA1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , JUNB has 1001 interactors and BRCA1 has 1040 interactors of which there are 667 common interactors.

Common Interactor	Name of Common Interactor	Score for JUNB-Interactor (?)	Score for BRCA1-Interactor (?)
FOS	FOS, G0S7: Proto-oncogene protein c-fos	6.19E3	0.123
FOSL2	FOSL2, FRA2: Fos-related antigen 2	1.04E3	0.098
JUND	JUND: Transcription factor jun-D	84.80	0.111
ZBTB7A	ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A	65.60	0.077
JUN	JUN: Transcription factor AP-1	24.40	0.097
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	3.89	0.025
BATF	BATF: Basic leucine zipper transcriptional factor ATF-like	2.42	0.251
MAFG	MAFG: Transcription factor MafG	1.78	0.251
CEBPB	CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta	0.763	0.055
ELF1	ELF1: ETS-related transcription factor Elf-1	0.515	0.096
BACH1	BACH1: Transcription regulator protein BACH1	0.515	0.123
STAT6	STAT6: Signal transducer and activator of transcription 6	0.484	0.041
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.430	0.026
IRF3	IRF3: Interferon regulatory factor 3	0.416	0.096
H1FX	H1FX: Histone H1x	0.416	0.077
CCNL1	CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1	0.385	0.069
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.385	0.038
BRD2	BRD2, KIAA9001, RING3: Bromodomain-containing protein 2	0.372	0.029
ARPC1B	ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B	0.276	0.069
ATF6	ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha	0.275	0.097
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.275	0.139
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.275	0.127
BAZ2A	BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A	0.275	0.114
BRPF1	BRPF1, BR140: Peregrin	0.275	0.077
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.275	0.139
ATF1	ATF1: Cyclic AMP-dependent transcription factor ATF-1	0.275	0.225
LCP2	LCP2: Lymphocyte cytosolic protein 2	0.260	0.039
ETS2	ETS2: Protein C-ets-2	0.251	0.062
FOXJ2	FOXJ2, FHX: Forkhead box protein J2	0.251	0.077
CXorf9	N/A	0.233	0.080
JARID1A	JARID1A, RBBP2, RBP2: Histone demethylase JARID1A	0.233	0.069
TAOK3	TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3	0.233	0.029
MTF1	MTF1: Metal regulatory transcription factor 1	0.233	0.096
ETS1	ETS1, EWSR2: Protein C-ets-1	0.225	0.056
NFE2L2	NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2	0.225	0.136
HIST1H1E	HIST1H1E, H1F4: Histone H1.4	0.225	0.069
FOXO1A	FOXO1A, FKHR: Forkhead box protein O1A	0.225	0.049
ZNF148	ZNF148, ZBP89: Zinc finger protein 148	0.210	0.096
NR3C1	NR3C1, GRL: Glucocorticoid receptor	0.210	0.080
PHF3	PHF3, KIAA0244: PHD finger protein 3	0.210	0.127
SP100	N/A	0.210	0.032
CEBPA	CEBPA: CCAAT/enhancer-binding protein alpha	0.191	0.055
ERF	ERF: ETS domain-containing transcription factor ERF	0.191	0.077
AKAP8	AKAP8, AKAP95: A-kinase anchor protein 8	0.188	0.155
YY1	YY1: Transcriptional repressor protein YY1	0.188	0.155
RPS6KB2	RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2	0.188	0.029
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	0.188	0.086
SMAD2	SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2	0.188	0.114
TCF8	ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1	0.188	0.049
CTDP1	CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase	0.188	0.152
SP3	SP3: Transcription factor Sp3	0.188	0.114
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.188	0.038
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.188	0.046
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.172	0.486
HIST1H1D	HIST1H1D, H1F3: Histone H1.3	0.171	0.069
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.171	0.114
HSF1	HSF1, HSTF1: Heat shock factor protein 1	0.171	0.114
ELF2	ELF2, NERF: ETS-related transcription factor Elf-2	0.165	0.083
MAPK15	N/A	0.165	0.028
HTATIP	HTATIP, TIP60: Histone acetyltransferase HTATIP	0.165	0.083
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.165	0.028
FOXM1	FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1	0.165	0.083
NBN	NBN, NBS, NBS1, P95: Nibrin	0.155	0.416
TGIF2	TGIF2: Homeobox protein TGIF2	0.155	0.155
ROCK1	ROCK1: Rho-associated protein kinase 1	0.155	0.0425
NFATC1	N/A	0.155	0.096
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.155	0.026
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.155	0.026
GTF2F2	N/A	0.152	0.127
BAZ1B	BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain	0.152	0.260
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.152	0.515
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.152	0.260
HIST1H1C	HIST1H1C, H1F2: Histone H1.2	0.148	0.075
CREB1	CREB1: cAMP response element-binding protein	0.148	0.148
FARSLA	FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain	0.148	0.075
DLX3	DLX3: Homeobox protein DLX-3	0.148	0.075
BRD4	N/A	0.148	0.025
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.146	0.251
IQGAP2	IQGAP2: Ras GTPase-activating-like protein IQGAP2	0.146	0.029
RBL2	RBL2, RB2: Retinoblastoma-like protein 2	0.139	0.049
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.139	0.038
KLF13	KLF13, BTEB3, NSLP1: Krueppel-like factor 13	0.139	0.069
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.139	0.114
ZNF217	ZNF217, ZABC1: Zinc finger protein 217	0.139	0.086
ZNF24	ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24	0.139	0.096
PHF10	N/A	0.139	0.139
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.139	0.063
RPS6KB1	N/A	0.139	0.038
STK38L	STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like	0.139	0.038
SMAD3	SMAD3, MADH3: Mothers against decapentaplegic homolog 3	0.139	0.069
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.139	0.060
NEK9	NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9	0.139	0.063
RELA	RELA, NFKB3: Transcription factor p65	0.139	0.077
GMCL1L	GMCL1L, GCL: Germ cell-less protein-like 1-like	0.136	0.086
FOXO3A	FOXO3A, FKHRL1: Forkhead box protein O3A	0.136	0.069
HSF2	HSF2, HSTF2: Heat shock factor protein 2	0.136	0.114
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.129	0.086
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.129	0.069
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	0.129	0.086
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.127	0.052
RB1	RB1: Retinoblastoma-associated protein	0.127	0.210
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.127	0.152
ZNF267	ZNF267: Zinc finger protein 267	0.127	0.096
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.127	0.210
XRCC1	XRCC1: DNA-repair protein XRCC1	0.127	0.251
STAT2	STAT2: Signal transducer and activator of transcription 2	0.127	0.096
SH3BP3		0.127	0.062
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.127	0.0425
UBTF	UBTF, UBF, UBF1: Nucleolar transcription factor 1	0.127	0.0425
MYB	MYB: Myb proto-oncogene protein	0.123	0.155
SRF	SRF: Serum response factor	0.114	0.0425
ZNF335	ZNF335: Zinc finger protein 335	0.114	0.069
ZNF76	ZNF76, D6S229E: Zinc finger protein 76	0.114	0.077
NCOR1	NCOR1, KIAA1047: Nuclear receptor corepressor 1	0.114	0.155
TOPBP1	TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1	0.114	0.461
SMAD4	SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4	0.114	0.056
ZBTB40	ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40	0.114	0.077
SUZ12	SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12	0.114	0.260
EGR1	EGR1, ZNF225: Early growth response protein 1	0.114	0.055
DPF2	DPF2, REQ, UBID4: Zinc finger protein ubi-d4	0.111	0.067
CEBPE	CEBPE: CCAAT/enhancer-binding protein epsilon	0.111	0.152
MLL	MLL, ALL1, HRX, HTRX, TRX1: Zinc finger protein HRX	0.111	0.069
HIST1H1B	HIST1H1B, H1F5: Histone H1.5	0.111	0.069
ETV1	ETV1, ER81: ETS translocation variant 1	0.110	0.055
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.109	0.852
ERG	ERG: Transcriptional regulator ERG	0.109	0.127
MGMT	MGMT: Methylated-DNA--protein-cysteine methyltransferase	0.100	0.0453
DDIT3	DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3	0.098	0.096
TAF1	TAF1, BA2R, CCG1, CCGS, TAF2A: Transcription initiation factor TFIID subunit 1	0.098	0.026
RFX1	RFX1: MHC class II regulatory factor RFX1	0.097	0.056
ORC1L	ORC1L, ORC1, PARC1: Origin recognition complex subunit 1	0.097	0.385
HIST1H1A	HIST1H1A, H1F1: Histone H1.1	0.097	0.049
EN2	EN2: Homeobox protein engrailed-2	0.097	0.049
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.0971	0.416
MATR3	MATR3, KIAA0723: Matrin-3	0.096	0.210
ZFX	ZFX: Zinc finger X-chromosomal protein	0.096	0.096
ZNF318	ZNF318, HRIHFB2436: Zinc finger protein 318	0.096	0.210
MYST4	MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4	0.088	0.062
CDC6	CDC6, CDC18L: Cell division control protein 6 homolog	0.088	0.385
CDX2	CDX2, CDX3: Homeobox protein CDX-2	0.088	0.096
ELK1	ELK1: ETS domain-containing protein Elk-1	0.088	0.069
MAPK12	MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12	0.088	0.0425
FOXL2	FOXL2: Forkhead box protein L2	0.088	0.056
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.087	0.152
NCOA3	N/A	0.087	0.032
PLEK	PLEK, P47: Pleckstrin	0.087	0.032
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.087	0.0425
NUP214	N/A	0.087	0.077
MAPK7	mitogen-activated protein kinase 7 isoform 1	0.087	0.026
IKBKG	IKBKG, FIP3, NEMO: NF-kappa-B essential modulator	0.087	0.0425
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.087	0.046
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.087	0.155
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.086	0.129
STK3	STK3, MST2: Serine/threonine-protein kinase 3	0.086	0.029
EEA1	EEA1, ZFYVE2: Early endosome antigen 1	0.086	0.069
CSNK2A1	CSNK2A1: CSNK2A1 protein	0.086	0.146
AKAP8L	AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like	0.086	0.127
HMGB2	HMGB2, HMG2: High mobility group protein B2	0.086	0.129
ZNF224	ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224	0.086	0.086
STK11	STK11, LKB1, PJS: Serine/threonine-protein kinase 11	0.086	0.029
SATB1	SATB1: DNA-binding protein SATB1	0.086	0.056
SP1	SP1, TSFP1: Transcription factor Sp1	0.086	0.056
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.083	0.028
ZHX1	ZHX1: Zinc fingers and homeoboxes protein 1	0.083	0.083
KIAA1443	HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez	0.083	0.083
C20orf18	N/A	0.083	0.165
ZNF295	ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295	0.083	0.083
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.083	0.028
ZFP91	ZFP91, FKSG11: Zinc finger protein 91 homolog	0.083	0.083
CUTL1	CUTL1: Homeobox protein cut-like 1	0.083	0.083
ZNF644	ZNF644, KIAA1221, ZEP2: Zinc finger protein 644	0.083	0.083
MLL2	MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2	0.083	0.083
POGZ	POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain	0.083	0.083
NFATC2	NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2	0.083	0.083
ZNF579	ZNF579: Zinc finger protein 579	0.083	0.083
NFATC3	NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3	0.083	0.083
UHRF1		0.083	0.083
TCF20	TCF20, KIAA0292, SPBP: Transcription factor 20	0.083	0.083
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.083	0.028
STAT5A	STAT5A, STAT5: Signal transducer and activator of transcription 5A	0.0818	0.067
PRKR	EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki	0.080	0.0425
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.078	0.086
KIAA1012	KIAA1012: Protein TRS85 homolog	0.078	0.054
EP300	N/A	0.078	0.038
DIAPH1	Diaphanous 1	0.078	0.038
PABPC1	PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1	0.078	0.046
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	0.078	0.046
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.078	0.086
SFRS5	SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5	0.078	0.029
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.078	0.046
PAPOLA	PAPOLA, PAP: Poly(A) polymerase alpha	0.078	0.046
DOK1	DOK1: Docking protein 1	0.078	0.032
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.078	0.054
EIF3S4	EIF3S4: Eukaryotic translation initiation factor 3 subunit 4	0.078	0.029
HIVEP1	N/A	0.077	0.096
TERF2	TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2	0.077	0.155
SNAPC4	SNAPC4, SNAP190: snRNA-activating protein complex subunit 4	0.077	0.155
TP53BP1	TP53BP1: Tumor suppressor p53-binding protein 1	0.077	0.191
ZAK	MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT	0.077	0.032
TERF1	TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1	0.077	0.077
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.077	0.032
PRKAA1	N/A	0.077	0.026
REST	REST, NRSF, XBR: RE1-silencing transcription factor	0.077	0.191
ZBTB33	KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso	0.077	0.077
STK16	N/A	0.077	0.032
POU2F1	POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1	0.077	0.191
CUL2	CUL2: Cullin-2	0.076	0.093
HOXA10	HOXA10, HOX1H: Homeobox protein Hox-A10	0.075	0.075
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.075	0.025
ZFPM1	ZFPM1, FOG1: Zinc finger protein ZFPM1	0.075	0.083
CDC2	CDC2: Cell division control protein 2 homolog	0.075	0.025
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.075	0.025
PHF16	PHF16, JADE3, KIAA0215: Protein Jade-3	0.075	0.075
ATRX	ATRX, RAD54L, XH2: Transcriptional regulator ATRX	0.075	0.075
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.075	0.025
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.075	0.028
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.075	0.083
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.075	0.025
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.075	0.025
NEK8	NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8	0.075	0.025
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.075	0.025
CCNE1	CCNE1, CCNE: G1/S-specific cyclin-E1	0.075	0.148
STAT1	STAT1: Signal transducer and activator of transcription 1-alpha/beta	0.075	0.075
SMAD1	SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1	0.075	0.075
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.075	0.025
CHEK2	CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2	0.075	0.075
RBL1	RBL1: Retinoblastoma-like protein 1	0.075	0.075
ZNF174	ZNF174, ZSCAN8: Zinc finger protein 174	0.075	0.083
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.075	0.025
OSR1	OSR1, ODD: Protein odd-skipped-related 1	0.075	0.075
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.075	0.025
RBM10	RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10	0.075	0.075
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.075	0.025
SOX8	SOX8: Transcription factor SOX-8	0.075	0.028
C10orf9	CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y	0.075	0.075
DIDO1	N/A	0.075	0.083
TRERF1	TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1	0.075	0.075
PRDM2	PRDM2, RIZ: PR domain zinc finger protein 2	0.075	0.083
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.075	0.025
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.075	0.025
MLL4	WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7	0.075	0.075
PKN3	PKN3, PKNBETA: Serine/threonine-protein kinase N3	0.075	0.025
CCNT2	CCNT2: Cyclin-T2	0.075	0.075
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.075	0.025
ISL2	ISL2: Insulin gene enhancer protein ISL-2	0.075	0.075
CFLAR	CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec	0.074	0.081
CBLB	CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B	0.071	0.056
ACIN1	ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus	0.071	0.114
IFI16	N/A	0.070	0.0425
WDR1	N/A	0.070	0.077
DEF6	DEF6, IBP: Differentially expressed in FDCP 6	0.070	0.026
OSBPL11	OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11	0.070	0.026
RGS14	N/A	0.070	0.026
GNB2L1	Lung cancer oncogene 7	0.070	0.155
RERE	RERE, ARG, ARP, ATN1L, KIAA0458: Arginine-glutamic acid dipeptide repeats protei	0.069	0.049
SNAI1	SNAI1, SNAH: Zinc finger protein SNAI1	0.069	0.056
ZNF551	N/A	0.069	0.114
CDK6	CDK6: Cell division protein kinase 6	0.069	0.0425
CDK7	CDK7, MO15: Cell division protein kinase 7	0.069	0.046
PSKH1	PSKH1: Serine/threonine-protein kinase H1	0.069	0.029
CCNH	CCNH: Cyclin-H	0.069	0.086
NR5A1	NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1	0.069	0.038
STAT4	STAT4: Signal transducer and activator of transcription 4	0.069	0.049
DAPK1	DAPK1, DAPK: Death-associated protein kinase 1	0.067	0.073
EXOC2	N/A	0.067	0.033
SYK	SYK: Tyrosine-protein kinase SYK	0.066	0.046
DOCK2	DOCK2, KIAA0209: Dedicator of cytokinesis protein 2	0.066	0.054
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.064	0.227
HDAC1	HDAC1, RPD3L1: Histone deacetylase 1	0.063	0.139
HGS	HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate	0.063	0.029
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.063	0.114
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.063	0.063
EIF4G2	EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2	0.063	0.032
FNBP1	N/A	0.063	0.029
HIST3H3	HIST3H3, H3FT: Histone H3.1t	0.063	0.049
TAF10	TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10	0.063	0.114
GSK3B	N/A	0.063	0.029
SFRS6	SFRS6, SRP55: Splicing factor, arginine/serine-rich 6	0.063	0.046
PIK3CG	PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i	0.063	0.136
PSMD4	PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4	0.063	0.139
STAG2	STAG2, SA2: Cohesin subunit SA-2	0.063	0.046
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.063	0.069
KIAA0690	N/A	0.063	0.043
PLXND1	PLXND1, KIAA0620: Plexin-D1 precursor	0.063	0.025
TERF2IP	TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1	0.062	0.152
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.062	0.052
SMAD7	SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7	0.062	0.056
MAP2K3	MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki	0.060	0.032
E2F3	E2F3, KIAA0075: Transcription factor E2F3	0.060	0.044
SPOP	SPOP: Speckle-type POZ protein	0.060	0.028
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.056	141.00
SOX4	SOX4: Transcription factor SOX-4	0.056	0.032
ESRRA	ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1	0.056	0.032
LIG4	LIG4: DNA ligase 4	0.056	0.171
ZBTB16	ZBTB16, PLZF, ZNF145: Zinc finger and BTB domain-containing protein 16	0.056	0.056
CDK2	CDK2: Cell division protein kinase 2	0.056	0.144
CDK4	CDK4: Cell division protein kinase 4	0.056	0.144
ESR1	ESR1, ESR, NR3A1: Estrogen receptor	0.056	0.034
NFIB	N/A	0.056	0.056
PPARA	PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha	0.055	0.026
MAPK4	MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4	0.055	0.026
ZHX3	ZHX3, KIAA0395, TIX1: Zinc fingers and homeoboxes protein 3	0.055	0.056
TCF3	TCF3, E2A, ITF1: Transcription factor E2-alpha	0.054	0.087
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.054	0.188
TRIM25	TRIM25, EFP, RNF147, ZNF147: Tripartite motif-containing protein 25	0.054	0.136
ARNT	ARNT: Aryl hydrocarbon receptor nuclear translocator	0.052	0.028
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.052	0.028
HMGA1	HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y	0.052	0.028
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.052	0.083
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.052	0.028
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.052	0.028
HES6	HES6: Transcription cofactor HES-6	0.052	0.028
MAPKAPK5	N/A	0.052	0.028
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.052	0.028
NIPA1	NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1	0.052	0.028
TRAFD1	TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1	0.052	0.096
KIAA0528	KIAA0528: Uncharacterized protein KIAA0528	0.052	0.0425
KIAA0853	N/A	0.052	0.052
ARFGAP1	N/A	0.052	0.052
PTMA	N/A	0.052	0.070
FNBP4	FNBP4, FBP30, KIAA1014: Formin-binding protein 4	0.052	0.0425
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.052	0.210
RBM14	RBM14, SIP: RNA-binding protein 14	0.052	0.070
DDX21	DDX21: Nucleolar RNA helicase 2	0.052	0.210
VCPIP1	VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135	0.052	0.062
ATF2	N/A	0.051	0.051
SALL1	SALL1, SAL1: Sal-like protein 1	0.050	0.044
NEK1	NEK1, KIAA1901: Serine/threonine-protein kinase Nek1	0.049	0.0425
CCNB1	Cyclin B1	0.049	0.763
CCND1	CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1	0.049	0.111
SATB2	SATB2, KIAA1034: DNA-binding protein SATB2	0.049	0.044
KLF1	KLF1, EKLF: Krueppel-like factor 1	0.049	0.127
KLF5	KLF5, BTEB2, CKLF, IKLF: Krueppel-like factor 5	0.049	0.049
CHEK1	CHEK1, CHK1: Serine/threonine-protein kinase Chk1	0.049	0.276
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.049	0.188
MYBL2	MYBL2, BMYB: Myb-related protein B	0.049	0.260
SNF1LK2	SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2	0.049	0.070
NKX2-5	NKX2-5, CSX, NKX2.5, NKX2E: Homeobox protein Nkx-2.5	0.049	0.056
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.047	0.025
C14orf4	C14orf4, KIAA1865, My039: RING finger protein C14orf4	0.047	0.083
RNF20		0.047	0.075
MLXIPL	MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein	0.047	0.025
RFFL	RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin	0.047	0.083
MIER1	MIER1, KIAA1610: Mesoderm induction early response protein 1	0.047	0.075
TAL2	TAL2: T-cell acute lymphocytic leukemia protein 2	0.047	0.028
RNF113A	RNF113A, RNF113, ZNF183: RING finger protein 113A	0.047	0.075
WWTR1	WWTR1, TAZ: WW domain-containing transcription regulator protein 1	0.047	0.025
TFAP4	TFAP4: Transcription factor AP-4	0.047	0.025
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.047	0.025
MAX	MAX: Protein max	0.047	0.025
PSIP1	PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein	0.047	0.028
WNK4	WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4	0.047	0.025
NCOA3	NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3	0.047	0.028
EWSR1	EWSR1, EWS: RNA-binding protein EWS	0.047	0.025
DUSP22	DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22	0.046	0.032
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.046	0.307
USP34	USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34	0.046	0.251
ELMO2	ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2	0.046	0.0308
HNRPF	HNRPF: Heterogeneous nuclear ribonucleoprotein F	0.046	0.078
ATM	ATM: Serine-protein kinase ATM	0.046	0.111
KIAA0683	DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized	0.046	0.038
COPE	COPE: Coatomer subunit epsilon	0.046	0.054
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.046	0.086
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.046	0.188
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	0.046	0.078
CORO1C	CORO1C, CRNN4: Coronin-1C	0.046	0.114
COPA	COPA: Coatomer subunit alpha	0.046	0.086
DDX51	DDX51: ATP-dependent RNA helicase DDX51	0.046	0.038
SIRT1	SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1	0.046	0.029
CPSF1	CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1	0.046	0.063
WBSCR20A	N/A	0.046	0.046
TMEM1	TMEM1, EHOC1: Transmembrane protein 1	0.046	0.048
DAXX	DAXX, BING2, DAP6: Death domain-associated protein 6	0.046	0.0425
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.046	0.046
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.046	0.063
TDG	TDG: G/T mismatch-specific thymine DNA glycosylase	0.046	0.070
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.046	0.139
UTX	UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein	0.046	0.071
ZCCHC8	ZCCHC8: Zinc finger CCHC domain-containing protein 8	0.046	0.087
PPP1R8	N/A	0.046	0.139
SKIIP	SNW1, SKIIP, SKIP: SNW domain-containing protein 1	0.046	0.063
AIP	AIP, XAP2: AH receptor-interacting protein	0.046	0.054
SF3B4	SF3B4, SAP49: Splicing factor 3B subunit 4	0.046	0.046
HDAC3	HDAC3: Histone deacetylase 3	0.046	0.210
SAPS3	N/A	0.046	0.038
KLHDC4	N/A	0.046	0.0425
CUL5	CUL5, VACM1: Cullin-5	0.046	0.225
SEC24C	SEC24C, KIAA0079: Protein transport protein Sec24C	0.046	0.038
RBM8A	RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A	0.046	0.029
TIAL1	TIAL1: Nucleolysin TIAR	0.046	0.063
SFRS4	SFRS4, SRP75: Splicing factor, arginine/serine-rich 4	0.046	0.046
TRAF2	TRAF2, TRAP3: TNF receptor-associated factor 2	0.046	0.202
TRIM24	TRIM24, RNF82, TIF1, TIF1A: Transcription intermediary factor 1-alpha	0.046	0.051
CHGB	CHGB, SCG1: Secretogranin-1 precursor	0.045	0.045
CHGA	CHGA: Chromogranin-A precursor	0.045	0.045
TRADD	TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein	0.0446	0.081
TRIM33	TRIM33, KIAA1113, RFG7, TIF1G: E3 ubiquitin-protein ligase TRIM33	0.044	0.050
BNC1	BNC1, BNC: Zinc finger protein basonuclin-1	0.044	0.055
PBK	PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase	0.044	0.144
CDK5R1	CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor	0.044	0.049
AURKA	AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6	0.044	0.129
DYRK3	N/A	0.044	0.029
SMCX	JARID1C, DXS1272E, SMCX, XE169: Histone demethylase JARID1C	0.044	0.069
HOXB6	HOXB6, HOX2B: Homeobox protein Hox-B6	0.044	0.056
STAT3		0.044	0.044
MTA1	MTA1: Metastasis-associated protein MTA1	0.043	0.139
CRKRS	CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7	0.043	0.038
VRK1	VRK1: Serine/threonine-protein kinase VRK1	0.043	0.078
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.0425	0.087
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.0425	0.052
SH2BP1	CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog	0.0425	0.0425
RBM6	RBM6, DEF3: RNA-binding protein 6	0.0425	0.0425
USP24	USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24	0.0425	0.307
JMJD1A	JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr	0.0425	0.032
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.0425	0.087
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.0425	0.087
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.0425	0.087
RFXDC2	RFXDC2: Regulatory factor X domain-containing protein 2.	0.0425	0.032
TNFRSF1B	TNFRSF1B, TNFBR, TNFR2: Tumor necrosis factor receptor superfamily member 1B pre	0.042	0.051
TRIM39	TRIM39, RNF23, TFP: Tripartite motif-containing protein 39	0.04	0.109
PPP2R5A	PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha	0.040	0.033
MDM4	MDM4, MDMX: Mdm4 protein	0.039	0.062
ID3	ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3	0.039	0.026
CBX3	CBX3: Chromobox protein homolog 3	0.038	0.233
PABPC4	PABPC4, APP1, PABP4: Polyadenylate-binding protein 4	0.038	0.078
CSTF2T	CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant	0.038	0.046
NOL1	N/A	0.038	0.078
ANAPC5	ANAPC5, APC5: Anaphase-promoting complex subunit 5	0.038	0.118
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	0.038	0.078
CUL4B	N/A	0.038	0.0425
APEX1	APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase	0.038	0.233
EML4	EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4	0.038	0.069
CSPG6	SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3	0.038	0.461
FHOD1	FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1	0.038	0.071
RREB1	RREB1, FINB: RAS-responsive element-binding protein 1	0.038	0.0425
SNRPB2	SNRPB2: U2 small nuclear ribonucleoprotein B''	0.038	0.078
ANP32B	ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb	0.038	0.078
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.038	0.029
ARID3A	ARID3A, DRIL1, DRIL3, DRX, E2FBP1: AT-rich interactive domain-containing protein	0.038	0.029
WBSCR1	EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H	0.038	0.046
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.038	0.114
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	0.038	0.078
SEC31L1	N/A	0.038	0.086
KHDRBS1	KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate	0.038	0.070
SMC1L1	SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos	0.038	0.461
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.038	0.063
TOPORS	TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors	0.038	0.032
HDAC4	HDAC4, KIAA0288: Histone deacetylase 4	0.038	0.035
SOS1	SOS1: Son of sevenless homolog 1	0.038	0.086
SPEN	SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein	0.038	0.046
MRE11A	MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A	0.038	0.046
SYNCRIP	SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q	0.038	0.078
TUBA1	TUBA4A, TUBA1: Tubulin alpha-4A chain	0.038	0.114
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.038	0.139
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.038	0.139
ELAVL1	ELAVL1, HUR: ELAV-like protein 1	0.038	0.078
NAP1L1	NAP1L1, NRP: Nucleosome assembly protein 1-like 1	0.038	0.063
ZNF330	ZNF330, NOA36: Zinc finger protein 330	0.038	0.070
TLR2	TLR2, TIL4: Toll-like receptor 2 precursor	0.038	0.025
MYCBP2	MYCBP2, KIAA0916, PAM: Probable E3 ubiquitin-protein ligase MYCBP2	0.035	0.057
CBL	CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL	0.035	0.086
MYCN	MYCN, NMYC: N-myc proto-oncogene protein	0.035	0.026
CDC7	CDC7, CDC7L1: Cell division cycle 7-related protein kinase	0.035	0.144
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.034	0.191
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.034	0.210
CBLC	CBLC, CBL3, RNF57: Signal transduction protein CBL-C	0.034	0.055
H1F0	H1F0, H1FV: Histone H1.0	0.033	0.077
STRN3	STRN3, GS2NA, SG2NA: Striatin-3	0.032	0.026
EIF4G1	EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1	0.032	0.0425
API5	N/A	0.032	0.052
TCOF1	N/A	0.032	0.087
TRRAP	N/A	0.032	0.0425
SET	SET: Protein SET	0.032	0.087
SREBF2	N/A	0.032	0.052
CHUK	N/A	0.032	0.052
ITGB1BP1	ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1	0.032	0.032
PHF8	PHF8, KIAA1111, ZNF422: PHD finger protein 8	0.032	0.032
TOP2B	N/A	0.032	0.052
ZNF638	ZNF638, NP220, ZFML: Zinc finger protein 638	0.032	0.052
SMARCC2	N/A	0.032	0.0425
SFRS15	SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15	0.032	0.032
HNRPA0	HNRPA0: Heterogeneous nuclear ribonucleoprotein A0	0.032	0.052
MYBBP1A	MYBBP1A, P160: Myb-binding protein 1A	0.032	0.0425
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.032	0.052
DNMT1	DNMT1, AIM, DNMT: DNA	0.032	0.087
ABCF1	N/A	0.032	0.070
RPL8	RPL8: 60S ribosomal protein L8	0.032	0.027
EIF3S6	EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6	0.032	0.067
MAPRE1	MAPRE1: Microtubule-associated protein RP/EB family member 1	0.032	0.032
EEF1G	EEF1G, EF1G, PRO1608: Elongation factor 1-gamma	0.032	0.067
RPS10	RPS10: 40S ribosomal protein S10	0.032	0.148
BTK	BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK	0.032	0.036
USP10	USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10	0.032	0.202
EEF1A1	EEF1A1: Elongation factor 1-alpha	0.032	0.067
SMARCA1	SMARCA1, SNF2L, SNF2L1: Probable global transcription activator SNF2L1	0.031	0.044
PLEKHA5	PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member	0.031	0.026
TAL1	TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1	0.0308	0.0425
RNF11	RNF11, CGI-123: RING finger protein 11	0.0308	0.050
BIRC4	BIRC4, API3, IAP3, XIAP: Baculoviral IAP repeat-containing protein 4	0.030	0.075
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.029	0.114
NUP153	N/A	0.029	0.087
MBD3	MBD3: Methyl-CpG-binding domain protein 3	0.029	0.0425
FKBP5	FKBP5, AIG6, FKBP51: FK506-binding protein 5	0.029	0.054
YEATS2	KIAA1197, YEATS2: YEATS domain-containing protein 2	0.029	0.052
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.029	0.233
UBA2	SAE2, UBA2, HRIHFB2115, UBLE1B: SUMO-activating enzyme subunit 2	0.029	0.078
C20orf4	C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4	0.029	0.071
EIF3S9	EIF3S9: Eukaryotic translation initiation factor 3 subunit 9	0.029	0.078
RUNX1	N/A	0.029	0.038
LMNB1	LMNB1, LMN2, LMNB: Lamin-B1	0.029	0.129
POLB	POLB: DNA polymerase beta	0.029	0.032
EIF3S2	EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2	0.029	0.233
DDX24	DDX24: ATP-dependent RNA helicase DDX24	0.029	0.069
TCEB3	TCEB3, MSTP059: Transcription elongation factor B polypeptide 3	0.029	0.086
RBMX2	RBMX2, CGI-79: RNA-binding motif protein, X-linked 2	0.029	0.038
ERCC3	ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit	0.029	0.114
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.029	0.078
POLR2A	POLR2A: Uncharacterized protein POLR2A	0.029	0.114
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.029	0.063
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.029	0.233
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.029	0.078
SNRPC	SNRPC: U1 small nuclear ribonucleoprotein C	0.029	0.078
COPB2	COPB2: Coatomer subunit beta'	0.029	0.114
FZR1	N/A	0.029	0.029
PIK3CB	PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit	0.029	0.136
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.029	0.155
HIST1H3A	HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD,	0.029	0.086
TP53	TP53, P53: Cellular tumor antigen p53	0.029	0.260
SSB	SSB: Lupus La protein	0.029	0.078
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
ZC3HAV1	ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1	0.028	0.083
KIF1B	N/A	0.028	0.028
RAB4A	N/A	0.028	0.028
MITF	MITF: Microphthalmia-associated transcription factor	0.028	0.028
CORO6	N/A	0.028	0.028
CABLES1	N/A	0.028	0.028
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.028	0.083
ILF3	ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3	0.028	0.028
DSP	DSP: Desmoplakin	0.028	0.028
RAVER1	RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1	0.028	0.028
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.028	0.083
IRF7	N/A	0.028	0.028
NFIA	NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A	0.028	0.028
NF2	NF2, SCH: Merlin	0.028	0.028
TMPO	TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha	0.028	0.028
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.028	0.028
HDAC8	N/A	0.028	0.083
DUSP15	N/A	0.028	0.028
WDR54	N/A	0.028	0.083
PTBP1	PTBP1: Polypyrimidine tract binding protein 1	0.028	0.028
BID	BID: BH3-interacting domain death agonist	0.028	0.028
PHLDB2	N/A	0.028	0.028
SYTL4	Endocrine transmitter regulatory protein	0.028	0.028
DKFZp434K1815	DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815	0.028	0.028
ZNF265	N/A	0.028	0.028
NES	N/A	0.028	0.028
NSBP1	NSBP1: Nucleosome-binding protein 1	0.028	0.028
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
ATXN2L	ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein	0.028	0.028
LOC642558	FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1	0.028	0.028
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
C13orf8	N/A	0.028	0.028
SNRPB	N/A	0.028	0.028
ZCCHC3	ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3	0.028	0.028
FBXO4	FBXO4, FBX4: F-box only protein 4	0.028	0.052
HNRPC	HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2	0.028	0.028
AR	AR, DHTR, NR3C4: Androgen receptor	0.028	0.028
JDP2	jdp2, JDP2: Jun dimerization protein 2	0.028	0.028
FLJ21816	PALB2, FANCN: Partner and localizer of BRCA2	0.028	0.028
PPEF1	N/A	0.028	0.028
CBFA2T2	CBFA2T2, EHT, MTGR1: Protein CBFA2T2	0.028	0.028
PKMYT1	PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito	0.028	0.078
WEE1	WEE1: Wee1-like protein kinase	0.028	0.087
CREBL1	N/A	0.028	0.028
RNF7	RNF7, RBX2, ROC2, SAG: RING-box protein 2	0.027	0.030
THOP1	THOP1: Thimet oligopeptidase	0.027	0.032
CREM	CREM, RP11-324I22.1-005: cAMP responsive element modulator	0.027	0.027
CREM	hCREM-1: HCREM 1alpha protein	0.027	0.027
FUBP1	N/A	0.027	0.027
UBAP2	N/A	0.026	0.087
XRCC4	N/A	0.026	0.0425
COIL	COIL, CLN80: Coilin	0.026	0.0425
APPL	APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha	0.026	0.026
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	0.026	0.070
AOF2	AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1	0.026	0.070
AFF1	N/A	0.026	0.032
EMD	EMD, EDMD, STA: Emerin	0.026	0.032
CETN1	CETN1, CEN1, CETN: Centrin-1	0.025	0.028
HNRPD	HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0	0.025	0.028
REXO1	REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog	0.025	0.025
FLJ23436	N/A	0.025	0.025
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.025	0.047
ADK	ADK: Adenosine kinase	0.025	0.025
CAMKK1	N/A	0.025	0.025
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.025
LMNA	LMNA, LMN1: Lamin-A/C	0.025	0.025
HNRPA2B1	HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1	0.025	0.025
SYAP1	SYAP1, PRO3113: Synapse-associated protein 1	0.025	0.025
PURB	PURB: Transcriptional activator protein Pur-beta	0.025	0.025
ARID4A	ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A	0.025	0.083
HNRPUL1	HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1	0.025	0.025
HNRPM	HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M	0.025	0.025
DHX8	DHX8, DDX8: ATP-dependent RNA helicase DHX8	0.025	0.148
EEF2K	EEF2K: Elongation factor 2 kinase	0.025	0.047
POLR1C	POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1	0.025	0.025
FAF1	FAF1, CGI-03: FAS-associated factor 1	0.025	0.025
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.025	0.028
PHC2	PHC2, EDR2, PH2: Polyhomeotic-like protein 2	0.025	0.165
MSL3L1	MSL3L1: Male-specific lethal 3-like 1	0.025	0.083
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.025	0.025
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	0.025	0.025
TIA1	TIA1: Nucleolysin TIA-1 isoform p40	0.025	0.025
SSBP4	SSBP4: Single-stranded DNA-binding protein 4	0.025	0.025
NHN1	NHN1: Conserved nuclear protein NHN1	0.025	0.028
NSUN2	NSUN2, SAKI, TRM4: tRNA	0.025	0.025
CAMK2A	N/A	0.025	0.025
BCOR	N/A	0.025	0.025
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.025	0.025
HDAC7A	N/A	0.025	0.047
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
SFRS9	SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9	0.025	0.025
H2-ALPHA	TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain	0.025	0.075
SETD3	SETD3, C14orf154: SET domain-containing protein 3	0.025	0.025
GIT2	N/A	0.025	0.025
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.025	0.148
MAPK8IP3	N/A	0.025	0.025
SEC13L1	N/A	0.025	0.025
SSH2	SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2	0.025	0.028
GEMIN5	GEMIN5: Gem-associated protein 5	0.025	0.083
TCEA1	N/A	0.025	0.025
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.025	0.025
IWS1	IWS1, IWS1L: IWS1 homolog	0.025	0.075
SMARCA2	SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2	0.025	0.025
HNRPH3	HNRPH3: Heterogeneous nuclear ribonucleoprotein H3	0.025	0.025
SON		0.025	0.025
C20orf77	N/A	0.025	0.025
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.025	0.028
MAP2K3	N/A	0.025	0.025
HIST2H2AC	HIST2H2AC, H2AFQ: Histone H2A type 2-C	0.025	0.165
NIPBL	N/A	0.025	0.047
raptor	RAPTOR, KIAA1303: Regulatory-associated protein of mTOR	0.025	0.075
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.025	0.025
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	0.025	0.025
PRKCB1	N/A	0.025	0.025
SAP14	SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14	0.025	0.025
EDF1	EDF1: Endothelial differentiation-related factor 1	0.025	0.025
FLJ40432	FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227	0.025	0.025
ELMO1	N/A	0.025	0.047
HTATIP	N/A	0.025	0.025
SMU1	SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog	0.025	0.075
MKI67IP	MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein	0.025	0.025
KCTD1		0.025	0.028
RBBP6	RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6	0.025	0.025
NUP98	N/A	0.025	0.025
EXO1	EXO1, EXOI, HEX1: Exonuclease 1	0.025	0.025
BUB3	BUB3: Mitotic checkpoint protein BUB3	0.025	0.075
HIST3H2A	HIST3H2A: Histone H2A type 3	0.025	0.028
HEXIM2	HEXIM2, L3: Protein HEXIM2	0.025	0.028
ATXN2L	N/A	0.025	0.025
NEDD4	NEDD4: Uncharacterized protein NEDD4	0.025	0.025
DDX20	DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20	0.025	0.083
SMN2	SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein	0.025	0.025
ZNF598	ZNF598: Zinc finger protein 598	0.025	0.028
GATAD2B	GATAD2B, KIAA1150: Transcriptional repressor p66 beta	0.025	0.025
GRK6	N/A	0.025	0.025
NFYA	NFYA: Nuclear transcription factor Y subunit alpha	0.025	0.028

0.572

Total Score

25.3