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Evidence of Interaction Between CDC6 and ORC6L

The interaction score between CDC6 and ORC6L is 28.2.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between CDC6 and ORC6L = 0.77

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismCDC6 OrthologueORC6L OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly Q9VSM9 1 Q9Y1B2 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 0.027
Post-translational Modifications

Protein: CDC6

PTMResidueReference
Phosphorylation 54 PubMed, HPRD
Phosphorylation 74 PubMed, HPRD
Phosphorylation 106 PubMed, HPRD

Protein: ORC6L

PTMResidueReference
Localisation

Protein: CDC6

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: ORC6L

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between CDC6 and ORC6L that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CDC6 andORC6L. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CDC6 has 931 interactors and ORC6L has 57 interactors of which there are 53 common interactors.

Common InteractorName of Common InteractorScore for CDC6-Interactor (?)Score for ORC6L-Interactor (?)
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 431.00 0.123
MCM7 MCM7, CDC47, MCM2: DNA replication licensing factor MCM7 69.60 0.123
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 65.00 0.047
MCM5 MCM5, CDC46: DNA replication licensing factor MCM5 32.60 0.123
MCM3 MCM3: DNA replication licensing factor MCM3 1.62 0.123
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 1.62 0.123
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.763 0.074
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.515 0.083
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.503 0.059
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.503 0.065
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.461 0.074
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.461 0.123
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.461 0.074
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.416 0.067
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.372 0.060
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.275 0.044
MDN1 MDN1, KIAA0301: Midasin 0.275 0.060
MCM6 MCM6: DNA replication licensing factor MCM6 0.263 0.123
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.245 0.047
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.245 0.047
RFC5 RFC5: Replication factor C subunit 5 0.207 0.0968
RFC3 RFC3: Replication factor C subunit 3 0.207 0.207
RFC4 RFC4: Replication factor C subunit 4 0.207 0.207
VCP VCP: Transitional endoplasmic reticulum ATPase 0.181 0.029
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.156 0.074
ABCE1 ABCE1, RLI, OK/SW-cl.40, RNASEL1, RNASELI, RNS4I: ATP-binding cassette sub-famil 0.123 0.123
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.083 0.137
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 0.074 0.074
RUVBL1 RUVBL1, NMP238, TIP49, TIP49A: RuvB-like 1 0.059 0.059
ATAD3A ATAD3A: ATPase family AAA domain-containing protein 3A 0.059 0.059
PSMC3 PSMC3, TBP1: 26S protease regulatory subunit 6A 0.059 0.047
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.053 0.065
DARS DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic 0.047 0.059
SCYE1 SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe 0.044 0.074
EIF1AX EIF1AX, EIF1A, EIF4C: Eukaryotic translation initiation factor 1A, X-chromosomal 0.044 0.060
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.044 0.060
EIF1AY EIF1AY: Eukaryotic translation initiation factor 1A, Y-chromosomal 0.044 0.036
POLR2G POLR2G: DNA-directed RNA polymerase II subunit RPB7 0.036 0.044
GCLC GCLC, GLCL, GLCLC: Glutamate--cysteine ligase catalytic subunit 0.036 0.028
SRP54 SRP54: Signal recognition particle 54 kDa protein 0.035 0.047
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.035 0.059
RUVBL2 RUVBL2, TIP48, CGI-46, TIP49B: RuvB-like 2 0.035 0.035
SSBP1 SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor 0.0331 0.055
BCS1L BCS1L, BCS1: Mitochondrial chaperone BCS1 0.029 0.029
NARS NARS, ASNS: Asparaginyl-tRNA synthetase, cytoplasmic 0.029 0.047
RAD51AP1 N/A 0.027 0.027
KIAA0101 PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor 0.027 0.027
SMC4L1 N/A 0.027 0.027
XAB1 XAB1, MBDIN, HUSSY-23: XPA-binding protein 1 0.027 0.027
PRSS15 LONP1, PRSS15: Lon protease homolog, mitochondrial precursor 0.027 0.0331
ABCF2 ABCF2, HUSSY-18: ATP-binding cassette sub-family F member 2 0.027 0.027
RPA3 RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit 0.027 0.027
DNAH11 N/A 0.027 0.027
0.572
Total Score 28.2