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Evidence of Interaction Between PDGFRB and SHB

The interaction score between PDGFRB and SHB is 33.20.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PDGFRB and SHB = 0.09

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.85E-3
Orthology
OrganismPDGFRB OrthologueSHB OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00022296 0.132 IPI00394693 0.287
human IPI00027721 0.325 IPI00394693 0.287
human IPI00018335 1 IPI00394693 0.287
human IPI00021396 1 IPI00394693 0.287
human IPI00293565 0.322 IPI00394693 0.287
human IPI00005722 0.081 IPI00394693 0.287
human IPI00022296 0.132 IPI00402077 0.219
human IPI00027721 0.325 IPI00402077 0.219
human IPI00018335 1 IPI00402077 0.219
human IPI00021396 1 IPI00402077 0.219
human IPI00293565 0.322 IPI00402077 0.219
human IPI00005722 0.081 IPI00402077 0.219
human IPI00022296 0.132 IPI00400780 1
human IPI00027721 0.325 IPI00400780 1
human IPI00018335 1 IPI00400780 1
human IPI00021396 1 IPI00400780 1
human IPI00293565 0.322 IPI00400780 1
human IPI00005722 0.081 IPI00400780 1
worm P34892 0.084 Q7YWN4 1
worm O76698 1 Q7YWN4 1
worm Q21038 1 Q7YWN4 1
worm Q21041 1 Q7YWN4 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in PDGFRB and SHB:
Domains in PDGFRBDomains in SHB
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR003598 Immunoglobulin C-2 type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR001824 Receptor tyrosine kinase, class III
IPR009134 Vascular endothelial growth factor receptor, VEGFR
IPR013151 Immunoglobulin.
IPR000980 SH2 motif

The Chi square scores for co-occurrence of domains that are present in PDGFRB and SHB are listed below.

Domain 1Domain 2Chi Square
IPR008266 Tyrosine protein kinase, active site IPR000980 SH2 motif 383.26
IPR001245 Tyrosine protein kinase IPR000980 SH2 motif 238.73
IPR001824 Receptor tyrosine kinase, class III IPR000980 SH2 motif 101.074
IPR007110 Immunoglobulin-like IPR000980 SH2 motif 94.9752
IPR000719 Protein kinase IPR000980 SH2 motif 82.1364
IPR003599 Immunoglobulin subtype IPR000980 SH2 motif 66.4833
IPR003598 Immunoglobulin C-2 type IPR000980 SH2 motif 64.7072
IPR011009 Protein kinase-like IPR000980 SH2 motif 59.6059
IPR009134 Vascular endothelial growth factor receptor, VEGFR IPR000980 SH2 motif 49.095
IPR013151 Immunoglobulin. IPR000980 SH2 motif 36.9251

The background colour of the table refers to:

  • Blue Domain is only present in PDGFRB
  • Yellow Domain is only present in SHB
  • Green Domain is present in both PDGFRB and SHB

 0.217
Post-translational Modifications

Protein: PDGFRB

PTMResidueReference
Dephosphorylation 562 PubMed, HPRD
Dephosphorylation 579 PubMed, HPRD
Dephosphorylation 740 PubMed, HPRD
Dephosphorylation 751 PubMed, HPRD
Dephosphorylation 771 PubMed, HPRD
Dephosphorylation 857 PubMed, HPRD
Dephosphorylation 1009 PubMed, HPRD
Dephosphorylation 1021 PubMed, HPRD
Phosphorylation 579 PubMed, HPRD
Phosphorylation 581 PubMed, HPRD
Phosphorylation 716 PubMed, HPRD
Phosphorylation 740 PubMed, HPRD
Phosphorylation 751 PubMed, HPRD
Phosphorylation 763 PubMed, HPRD
Phosphorylation 771 PubMed, HPRD
Phosphorylation 775 PubMed, HPRD
Phosphorylation 857 PubMed, HPRD
Phosphorylation 1009 PubMed, HPRD
Phosphorylation 1021 PubMed, HPRD
Phosphotyrosine 751 PubMed, HPRD
Phosphotyrosine 857 PubMed, HPRD

Protein: SHB

PTMResidueReference
Localisation

Protein: PDGFRB

LocalisationReference
Plasma membrane HPRD

Protein: SHB

LocalisationReference
Cytoplasm HPRD
Transitive Score

The common interactors between PDGFRB and SHB that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PDGFRB andSHB. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PDGFRB has 1323 interactors and SHB has 282 interactors of which there are 142 common interactors.

Common InteractorName of Common InteractorScore for PDGFRB-Interactor (?)Score for SHB-Interactor (?)
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 1.01E3 0.237
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 532.00 0.179
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 281.00 0.158
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 277.00 0.360
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 277.00 0.141
HCK N/A 250.00 0.141
JAK2 JAK2: Tyrosine-protein kinase JAK2 250.00 0.126
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 183.00 0.225
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 112.00 0.115
KIT KIT: Mast/stem cell growth factor receptor precursor 112.00 0.128
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 84.00 0.044
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 82.20 0.179
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 74.00 0.218
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 15.80 0.044
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 1.13 0.305
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.980 0.027
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.980 0.265
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.980 0.237
LNK SH2B3, LNK: SH2B adapter protein 3 0.980 0.027
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.980 0.265
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.980 0.027
BMX N/A 0.902 0.305
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.808 0.360
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.731 0.244
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.731 0.402
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.655 0.177
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.654 0.158
SYK SYK: Tyrosine-protein kinase SYK 0.654 0.126
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.654 0.158
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.644 0.158
JAK1 0.644 0.126
LYN LYN: Tyrosine-protein kinase Lyn 0.586 0.126
CSK CSK: Tyrosine-protein kinase CSK 0.586 0.158
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.581 0.244
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.581 0.176
RIN1 RIN1: Ras and Rab interactor 1 0.520 0.028
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.520 0.158
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.265
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.251 0.330
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.217 0.027
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.217 0.027
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.217 0.027
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.217 0.027
CNN3 CNN3: Calponin-3 0.202 0.0308
SOCS5 SOCS5, CIS6, CISH5, CISH6, KIAA0671: Suppressor of cytokine signaling 5 0.200 0.0308
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.181 0.028
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.171 0.296
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.217
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.217
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.217
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.165 0.195
GRB7 GRB7: Growth factor receptor-bound protein 7 0.162 0.067
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.152 0.200
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.152 0.039
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.152 0.032
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.148 0.195
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.148 0.195
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.148 0.195
SOCS1 SOCS1, SSI1, TIP3: Suppressor of cytokine signaling 1 0.143 0.028
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.136 0.296
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.136 0.179
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.136 0.296
INSR INSR: Insulin receptor precursor 0.136 0.145
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.136 0.361
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.136 0.361
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.129 0.176
FYN N/A 0.129 0.176
CTTN CTTN, EMS1: Src substrate cortactin 0.126 0.050
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.126 0.041
IRS1 IRS1: Insulin receptor substrate 1 0.126 0.0308
MET MET: Hepatocyte growth factor receptor precursor 0.123 0.330
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.123 0.032
PVR PVR, PVS: Poliovirus receptor precursor 0.123 0.065
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.111 0.225
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.111 0.296
NEO1 NEO1, NGN: Neogenin precursor 0.111 0.029
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.111 0.361
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.027
CNN2 CNN2: Calponin-2 0.109 0.027
NF2 NF2, SCH: Merlin 0.109 0.027
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.027
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.027
PSCD2 N/A 0.109 0.027
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.027
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.027
IL9R IL9R: Interleukin-9 receptor precursor 0.109 0.032
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.109 0.179
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.109 0.032
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.109 0.032
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.098 0.126
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.098 0.237
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.097 0.179
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.097 0.128
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.097 0.225
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.090 0.036
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.088 0.145
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.081 0.197
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.081 0.0308
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.073 0.036
PLD1 PLD1: Phospholipase D1 0.073 0.036
SORBS3 SORBS3, SCAM1: Vinexin 0.073 0.044
PLD2 PLD2: Phospholipase D2 0.073 0.036
TTN N/A 0.073 0.028
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.073 0.060
IL1R1 IL1R1, IL1R, IL1RA, IL1RT1: Interleukin-1 receptor type I precursor 0.067 0.032
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.064 0.027
ALK ALK: ALK tyrosine kinase receptor precursor 0.064 0.116
ROR1 ROR1, NTRKR1: Tyrosine-protein kinase transmembrane receptor ROR1 precursor 0.060 0.145
PLEKHC1 PLEKHC1, KIND2, MIG2: Pleckstrin homology domain-containing family C member 1 0.059 0.028
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.0288
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.0288
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.0288
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.0288
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.051 0.036
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.027
MAPK15 N/A 0.049 0.027
MAP2K5 N/A 0.049 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.049 0.027
EPS8 EPS8: Epidermal growth factor receptor kinase substrate 8 0.047 0.028
FLT4 VEGFR3 long form 0.046 0.0258
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.046 0.0258
MOS MOS: Proto-oncogene serine/threonine-protein kinase mos 0.0453 0.044
TIE1 TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor 0.041 0.162
SASH1 SASH1, KIAA0790, PEPE1: SAM and SH3 domain-containing protein 1 0.039 0.028
TRIP10 N/A 0.039 0.067
PHLDA3 PHLDA3, TIH1: Pleckstrin homology-like domain family A member 3 0.039 0.041
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.035 0.029
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.033 0.044
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.033 0.028
CAMK1 CAMK1: Calcium/calmodulin-dependent protein kinase type 1 0.033 0.028
STK16 N/A 0.032 0.041
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.029 0.044
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
FGFR2 N/A 0.027 0.217
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.026 0.028
FES N/A 0.0258 0.0258
0.572
Total Score 33.20