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Evidence of Interaction Between CTNNB1 and PSEN1

The interaction score between CTNNB1 and PSEN1 is 11.60.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

N/A
Orthology
OrganismCTNNB1 OrthologuePSEN1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm O44326 1 P52166 1
fly P18824 1 O02194 0.215

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3
Domains Domains present in CTNNB1 and PSEN1:
Domains in CTNNB1Domains in PSEN1
IPR000225 Armadillo
IPR000357 HEAT
IPR011989 ARM-like.
IPR001108 Peptidase A22A, presenilin
IPR002031 Peptidase A22A, presenilin 1

The Chi square scores for co-occurrence of domains that are present in CTNNB1 and PSEN1 are listed below.

Domain 1Domain 2Chi Square
IPR000225 Armadillo IPR001108 Peptidase A22A, presenilin 15.5997
IPR000225 Armadillo IPR002031 Peptidase A22A, presenilin 1 14.0721
IPR011989 ARM-like. IPR002031 Peptidase A22A, presenilin 1 3.62983
IPR011989 ARM-like. IPR001108 Peptidase A22A, presenilin 3.52311

The background colour of the table refers to:

  • Blue Domain is only present in CTNNB1
  • Yellow Domain is only present in PSEN1
  • Green Domain is present in both CTNNB1 and PSEN1

0.109
Post-translational Modifications

Protein: CTNNB1

PTMResidueReference
Acetylation 49 PubMed, HPRD
Dephosphorylation 654 PubMed, HPRD
Phosphorylation 29 PubMed, HPRD
Phosphorylation 33 PubMed, HPRD
Phosphorylation 37 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 45 PubMed, HPRD
Phosphorylation 86 PubMed, HPRD
Phosphorylation 102 PubMed, HPRD
Phosphorylation 112 PubMed, HPRD
Phosphorylation 142 PubMed, HPRD
Phosphorylation 393 PubMed, HPRD
Phosphorylation 654 PubMed, HPRD
Phosphoserine 23 PubMed, HPRD
Phosphoserine 29 PubMed, HPRD
Phosphoserine 33 PubMed, HPRD
Phosphoserine 37 PubMed, HPRD
Phosphoserine 45 HPRD
Phosphothreonine 41 PubMed, HPRD
Phosphotyrosine 86 PubMed, HPRD
Phosphotyrosine 654 PubMed, HPRD

Protein: PSEN1

PTMResidueReference
Phosphorylation 310 PubMed, HPRD
Phosphorylation 346 PubMed, HPRD
Phosphorylation 353 PubMed, HPRD
Phosphorylation 354 PubMed, HPRD
Phosphorylation 357 PubMed, HPRD
Phosphorylation 367 PubMed, HPRD
Proteolytic Cleavage 298 PubMed, HPRD
Proteolytic Cleavage 333 PubMed, HPRD
Proteolytic Cleavage 345 PubMed, HPRD
Localisation

Protein: CTNNB1

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD

Protein: PSEN1

LocalisationReference
ER HPRD
Golgi HPRD
Nucleus HPRD
Plasma membrane HPRD
Centrosome HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between CTNNB1 and PSEN1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CTNNB1 andPSEN1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CTNNB1 has 1159 interactors and PSEN1 has 468 interactors of which there are 154 common interactors.

Common InteractorName of Common InteractorScore for CTNNB1-Interactor (?)Score for PSEN1-Interactor (?)
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.655 0.062
KPNB1 KPNB1, NTF97: Importin subunit beta-1 0.372 0.040
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.372 0.044
XPO1 XPO1, CRM1: Exportin-1 0.275 0.044
IPO7 IPO7: Uncharacterized protein IPO7 0.251 0.049
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.210 0.028
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.210 0.049
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.188 46.90
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.188 0.044
NRAS NRAS, HRAS1: GTPase NRas precursor 0.188 0.025
RAN RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran 0.188 0.025
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.155 0.028
EDD1 EDD1, EDD, HYD, KIAA0896: E3 ubiquitin-protein ligase EDD1 0.148 0.025
PKP3 PKP3: Plakophilin-3 0.127 0.109
HD HD, IT15: Huntingtin 0.127 0.049
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.114 0.025
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.114 0.044
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.114 0.044
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.114 0.044
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.114 0.098
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.114 0.025
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.114 0.044
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.114 0.098
VDP DKFZp451D234: Putative uncharacterized protein DKFZp451D234 0.111 0.148
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.111 0.044
PPL PPL, KIAA0568: Periplakin 0.100 0.028
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.096 0.049
PSEN2 PSEN2, AD4, PS2, PSNL2, STM2: Presenilin-2 0.090 0.025
ACTN1 ACTN1: Alpha-actinin-1 0.087 0.098
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.086 0.044
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.086 0.044
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.086 0.044
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.086 0.044
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.086 0.075
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.086 0.044
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.083 0.049
DNAJC13 DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13 0.083 0.165
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.083 0.109
PKP4 PKP4: Plakophilin-4 0.083 0.109
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.0818 0.030
FLNB FLNB, FLN1L, FLN3, TABP, TAP: Filamin-B 0.078 0.098
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.077 0.049
KRT20 KRT20: Keratin, type I cytoskeletal 20 0.075 0.028
NIPBL N/A 0.075 0.044
GIT2 N/A 0.075 0.098
ELMO1 N/A 0.075 0.044
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.075 0.044
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.075 0.044
RASD1 RASD1, AGS1, DEXRAS1: Dexamethasone-induced Ras-related protein 1 precursor 0.075 0.025
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.075 0.044
TSC2 TSC2, TSC4: Tuberin 0.075 0.075
RAB5B RAB5B: Ras-related protein Rab-5B 0.075 0.025
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.075 0.044
CASP3 CASP3, CPP32: Caspase-3 precursor 0.071 46.90
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.071 0.044
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.070 0.049
RRAS RRAS: Ras-related protein R-Ras precursor 0.069 0.025
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.069 0.098
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.069 0.044
AP2M1 AP2M1, CLAPM1, KIAA0109: AP-2 complex subunit mu-1 0.067 0.025
ARFGEF2 ARFGEF2, ARFGEP2, BIG2: Brefeldin A-inhibited guanine nucleotide-exchange protei 0.067 0.075
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.067 0.030
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.067 0.062
TXN TXN, TRDX, TRX, TRX1: Thioredoxin 0.063 0.025
MICAL-L1 MICALL1, KIAA1668, MIRAB13: MICAL-like protein 1 0.063 0.044
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.063 0.044
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.063 0.098
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.062 0.049
RHOB RHOB, ARH6, ARHB: Rho-related GTP-binding protein RhoB precursor 0.062 0.028
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.060 0.109
AP2B1 AP2B1: Uncharacterized protein AP2B1 0.057 0.165
VIM VIM: Vimentin 0.057 0.028
PRKAR1A PRKAR1A, PKR1, PRKAR1, TSE1: cAMP-dependent protein kinase type I-alpha regulato 0.056 0.025
KRT1 KRT1, KRTA: Keratin, type II cytoskeletal 1 0.055 0.028
CASP1 CASP1, IL1BC, IL1BCE: Caspase-1 precursor 0.052 0.109
CASP9 CASP9, MCH6: Caspase-9 precursor 0.052 0.109
CASP8 CASP8, MCH5: Caspase-8 precursor 0.052 0.109
CASP6 CASP6, MCH2: Caspase-6 precursor 0.052 0.109
CASP14 CASP14: Caspase-14 precursor 0.052 0.109
SRPR SRPR: Uncharacterized protein SRPR 0.052 0.028
FLNA FLNA, FLN, FLN1: Filamin-A 0.052 0.109
PLEC1 PLEC1: Plectin-1 0.051 0.051
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.049 0.0688
C20orf18 N/A 0.049 0.034
RAB4A N/A 0.049 0.028
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.049 0.044
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.047 0.098
ACTN4 ACTN4: Alpha-actinin-4 0.047 0.098
EHBP1 EHBP1, KIAA0903, NACSIN: EH domain-binding protein 1 0.046 0.044
LCP1 LCP1, PLS2: Plastin-2 0.046 0.098
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.046 0.044
PPP1R12A PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A 0.046 0.098
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.046 0.044
ARVCF ARVCF: Armadillo repeat protein deleted in velo-cardio-facial syndrome 0.044 46.90
CTNND2 CTNND2, NPRAP: Catenin delta-2 0.044 0.098
FKBP8 DKFZp686M22160: Putative uncharacterized protein DKFZp686M22160 (Fragment) 0.044 0.025
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.044 0.030
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.044 0.030
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.0425 0.049
MVP MVP, LRP: Major vault protein 0.0425 0.049
GAS2 GAS2: Growth arrest-specific protein 2 0.0425 0.049
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.041 0.030
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.041 0.030
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.041 0.030
STAT6 STAT6: Signal transducer and activator of transcription 6 0.038 0.044
CHP CHP: Calcium-binding protein p22 0.038 0.044
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.038 0.098
RPS10 RPS10: 40S ribosomal protein S10 0.038 0.044
AREG AREG, SDGF: Amphiregulin precursor 0.036 0.0688
FADD FADD, MORT1: Protein FADD 0.036 0.034
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.036 0.034
ITGB4 N/A 0.036 0.034
ATRN N/A 0.036 0.062
CASP2 CASP2, ICH1, NEDD2: Caspase-2 precursor 0.035 0.098
NOS1 NOS1: Nitric-oxide synthase, brain 0.035 0.025
LMAN1 LMAN1, ERGIC53, F5F8D: Protein ERGIC-53 precursor 0.035 0.025
SPTAN1 N/A 0.034 0.049
TGM2 TGM2: Protein-glutamine gamma-glutamyltransferase 2 0.034 0.028
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.032 0.0688
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.032 0.049
CNN3 CNN3: Calponin-3 0.032 0.049
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.032 0.049
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.032 0.049
TMED9 TMED9, GP25L2: Transmembrane emp24 domain-containing protein 9 precursor 0.032 0.025
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.031 0.049
CHGB CHGB, SCG1: Secretogranin-1 precursor 0.030 0.028
CHGA CHGA: Chromogranin-A precursor 0.030 0.028
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.029 0.025
VAV1 VAV1, VAV: Proto-oncogene vav 0.029 0.044
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.029 0.044
THOC1 THOC1, HPR1: THO complex subunit 1 0.029 0.044
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.029 0.098
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.029 0.098
COL5A2 COL5A2: Collagen alpha-2(V) chain precursor 0.029 0.029
COL1A2 COL1A2: Collagen alpha-2(I) chain precursor 0.029 0.029
PPEF1 N/A 0.028 0.049
PSCD2 N/A 0.028 0.028
S100A16 S100A16, AAG13: Protein S100-A16 0.028 0.049
CNN2 CNN2: Calponin-2 0.028 0.049
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.028 0.049
CDC42 N/A 0.028 0.028
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.028 0.028
PRKAR2A PRKAR2A, PKR2, PRKAR2: cAMP-dependent protein kinase type II-alpha regulatory su 0.028 0.025
F13A1 F13A1, F13A: Coagulation factor XIII A chain precursor 0.028 0.025
TOM1L1 TOM1L1, SRCASM: TOM1-like protein 1 0.027 0.028
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.026 0.049
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.026 0.049
S100A3 S100A3, S100E: Protein S100-A3 0.026 0.049
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.025 0.044
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.098
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.025 0.044
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.025 0.044
RAC1 N/A 0.025 0.025
STAT3 0.025 0.044
0.299
Total Score 11.60