PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between POLR2C and POLR2L

The interaction score between POLR2C and POLR2L is 37.10.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between POLR2C and POLR2L = 0.23

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

2.88E-3

Orthology

Organism	POLR2C Orthologue		POLR2L Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YIL021W	1	YOR210W	1	Other AffinityCaptureMS Get References From PubMed
worm	Q93338	1	Q9GR61	1
fly	O97183	1	Q9VC49	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593

Domains

No domains were used in calculating likelihood of interaction

1.48E-3

Post-translational Modifications

No PTMs were used in calculating likelihood of interaction

Localisation

Protein: POLR2C

Localisation	Reference
Nucleus	HPRD

Protein: POLR2L

Localisation	Reference
Nucleus	HPRD
Nucleolus	HPRD

Transitive Score

The common interactors between POLR2C and POLR2L that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between POLR2C andPOLR2L. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , POLR2C has 54 interactors and POLR2L has 129 interactors of which there are 11 common interactors.

Common Interactor	Name of Common Interactor	Score for POLR2C-Interactor (?)	Score for POLR2L-Interactor (?)
GTF2F2	GTF2F2: Uncharacterized protein GTF2F2	0.593	0.593
POLR2J	N/A	0.593	0.593
POLR2E	POLR2E: DNA-directed RNA polymerases I, II, and III subunit RPABC1	0.538	1.82
POLR2H	POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3	0.538	0.890
POLR2G	POLR2G: DNA-directed RNA polymerase II subunit RPB7	0.538	0.890
POLR2B	POLR2B: DNA-directed RNA polymerase II subunit RPB2	0.538	0.657
POLR2D	POLR2D: DNA-directed RNA polymerase II subunit RPB4	0.408	0.408
POLR2F	POLR2F, POLRF: DNA-directed RNA polymerases I, II, and III subunit RPABC2	0.408	1.82
POLR2I	POLR2I: DNA-directed RNA polymerase II subunit RPB9	0.354	0.354
POLR2A	POLR2A: Uncharacterized protein POLR2A	0.326	0.538
ZC3HAV1	ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1	0.027	0.027

0.228

Total Score

37.10