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Evidence of Interaction Between F2 and SERPINA5

The interaction score between F2 and SERPINA5 is 323.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between F2 and SERPINA5 = 0.16

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

2.30E-3
Orthology N/A N/A
Domains Domains present in F2 and SERPINA5:
Domains in F2Domains in SERPINA5
IPR000001 Kringle
IPR001254 Peptidase S1, chymotrypsin
IPR001314 Peptidase S1A, chymotrypsin
IPR009003 Peptidase, trypsin-like serine and cysteine proteases
IPR000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic region
IPR002383 Coagulation factor, Gla region
IPR003966 Peptidase S1A, prothrombin
IPR012051 Thrombin.
IPR000215 Proteinase inhibititor I4, serpin

The Chi square scores for co-occurrence of domains that are present in F2 and SERPINA5 are listed below.

Domain 1Domain 2Chi Square
IPR001314 Peptidase S1A, chymotrypsin IPR000215 Proteinase inhibititor I4, serpin 1406.06
IPR001254 Peptidase S1, chymotrypsin IPR000215 Proteinase inhibititor I4, serpin 1376.58
IPR009003 Peptidase, trypsin-like serine and cysteine proteases IPR000215 Proteinase inhibititor I4, serpin 1072.84
IPR000001 Kringle IPR000215 Proteinase inhibititor I4, serpin 235.847
IPR003966 Peptidase S1A, prothrombin IPR000215 Proteinase inhibititor I4, serpin 232.955
IPR012051 Thrombin. IPR000215 Proteinase inhibititor I4, serpin 173.322
IPR002383 Coagulation factor, Gla region IPR000215 Proteinase inhibititor I4, serpin 155.785
IPR000294 Vitamin K-dependent carboxylation/gamma-carboxyglutamic region IPR000215 Proteinase inhibititor I4, serpin 148.856

The background colour of the table refers to:

  • Blue Domain is only present in F2
  • Yellow Domain is only present in SERPINA5
  • Green Domain is present in both F2 and SERPINA5

1.53
Post-translational Modifications

Protein: F2

PTMResidueReference
4-carboxyglutamate 49 HPRD
4-carboxyglutamate 50 HPRD
4-carboxyglutamate 57 HPRD
4-carboxyglutamate 59 HPRD
4-carboxyglutamate 62 HPRD
4-carboxyglutamate 63 HPRD
4-carboxyglutamate 68 HPRD
4-carboxyglutamate 69 HPRD
4-carboxyglutamate 72 HPRD
4-carboxyglutamate 75 HPRD
Carboxylation 49 PubMed, HPRD
Carboxylation 50 PubMed, HPRD
Carboxylation 57 PubMed, HPRD
Carboxylation 59 PubMed, HPRD
Carboxylation 62 PubMed, HPRD
Carboxylation 63 PubMed, HPRD
Carboxylation 68 PubMed, HPRD
Carboxylation 69 PubMed, HPRD
Carboxylation 72 PubMed, HPRD
Carboxylation 75 PubMed, HPRD
Glycosylation 121 PubMed, HPRD
Glycosylation 143 PubMed, HPRD
N-linked 121 PubMed, HPRD
N-linked 143 PubMed, HPRD
N-linked 416 PubMed, HPRD
Proteolytic Cleavage 198 PubMed, HPRD
Proteolytic Cleavage 314 PubMed, HPRD
Proteolytic Cleavage 327 PubMed, HPRD
Proteolytic Cleavage 436 PubMed, HPRD

Protein: SERPINA5

PTMResidueReference
Glycosylation 249 PubMed, HPRD
Glycosylation 262 PubMed, HPRD
Glycosylation 338 PubMed, HPRD
N-linked 249 PubMed, HPRD
N-linked 262 PubMed, HPRD
N-linked 338 PubMed, HPRD
Proteolytic Cleavage 373 PubMed, HPRD
Localisation

Protein: F2

LocalisationReference
Secreted HPRD

Protein: SERPINA5

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Secreted HPRD
Transitive Score

The common interactors between F2 and SERPINA5 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between F2 andSERPINA5. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , F2 has 909 interactors and SERPINA5 has 435 interactors of which there are 352 common interactors.

Common InteractorName of Common InteractorScore for F2-Interactor (?)Score for SERPINA5-Interactor (?)
F10 F10: Coagulation factor X precursor 2.47E3 1.41
PLG PLG: Plasminogen precursor 826.00 1.50
F9 F9: Coagulation factor IX precursor 386.00 1.41
ITIH1 ITIH1, IGHEP1: Inter-alpha-trypsin inhibitor heavy chain H1 precursor 50.50 0.026
SERPING1 SERPING1, C1IN, C1NH: Plasma protease C1 inhibitor precursor 50.50 0.026
ITIH4 ITIH4, IHRP, PRO1851, ITIHL1, PK120: Inter-alpha-trypsin inhibitor heavy chain H 50.50 0.026
SERPINA4 SERPINA4, KST, PI4: Kallistatin precursor 50.50 0.026
SERPINF2 SERPINF2, AAP, PLI: Alpha-2-antiplasmin precursor 50.50 0.026
SERPIND1 SERPIND1, HCF2: Heparin cofactor 2 precursor 50.50 0.026
SERPINC1 SERPINC1, AT3, PRO0309: Antithrombin-III precursor 45.20 0.026
SERPINA6 SERPINA6, CBG: Corticosteroid-binding globulin precursor 16.80 0.032
SERPINA1 SERPINA1, AAT, PRO0684, PI, PRO2209: Alpha-1-antitrypsin precursor 16.80 0.026
AGT AGT, SERPINA8: Angiotensinogen precursor 16.80 0.026
SERPINA10 SERPINA10, ZPI, UNQ707/PRO1358: Protein Z-dependent protease inhibitor precursor 7.89 0.026
IGFALS IGFALS, ALS: Insulin-like growth factor-binding protein complex acid labile chai 6.17 0.026
APCS APCS, PTX2: Serum amyloid P-component precursor 5.75 0.026
HGFAC HGFAC: Hepatocyte growth factor activator precursor 5.75 1.50
AMBP AMBP, HCP, ITIL: AMBP protein precursor [Contains: Alpha-1-microglobulin 5.75 0.026
C8A C8A: Complement component C8 alpha chain precursor 5.75 0.152
HPX HPX: Hemopexin precursor 5.75 0.077
HP HP: Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta c 5.75 1.20
F12 F12: Coagulation factor XII precursor 5.75 1.20
VTN VTN: Vitronectin precursor 5.75 0.077
PROC PROC: Vitamin K-dependent protein C precursor 5.15 1.41
C6 C6: Complement component C6 precursor 5.15 0.152
APOA2 APOA2: Apolipoprotein A-II precursor 5.03 0.032
APOC4 APOC2, APC2: Apolipoprotein C-II precursor 5.03 0.026
ORM1 ORM1, AGP1: Alpha-1-acid glycoprotein 1 precursor 5.03 0.026
PON1 N/A 5.03 0.026
APOC3 APOC3: Apolipoprotein C-III precursor 5.03 0.026
AHSG AHSG, FETUA, PRO2743: Alpha-2-HS-glycoprotein precursor 5.03 0.026
PON3 PON3: Serum paraoxonase/lactonase 3 5.03 0.032
HAMP HAMP, HEPC, UNQ487/PRO1003, LEAP1: Hepcidin precursor 5.03 0.026
C8G C8G: Complement component C8 gamma chain precursor 5.03 0.026
APOA1 APOA1: Apolipoprotein A-I precursor 5.03 0.032
ORM2 ORM2, AGP2: Alpha-1-acid glycoprotein 2 precursor 5.03 0.026
RNASE4 ANG, RNASE5: Angiogenin precursor 5.03 0.026
HRG HRG: Histidine-rich glycoprotein precursor 5.03 0.026
F5 F5: Coagulation factor V precursor 4.77 0.026
SERPINA3 N/A 4.77 0.026
SERPINF1 SERPINF1, PEDF: Pigment epithelium-derived factor precursor 3.85 0.032
ASGR2 ASGR2: Asialoglycoprotein receptor 2 3.16 0.0453
SERPINA7 SERPINA7, TBG: Thyroxine-binding globulin precursor 2.84 0.026
HPN HPN, TMPRSS1: Serine protease hepsin 2.83 0.902
CFB CFB, BF, BFD: Complement factor B precursor 1.91 1.20
C4BPB C4BPB: C4b-binding protein beta chain precursor 1.91 0.152
C3 1.91 0.026
APOH APOH, B2G1: Beta-2-glycoprotein 1 precursor 1.91 0.191
C4BPA C4BPA, C4BP: C4b-binding protein alpha chain precursor 1.91 0.152
C2 C2: Complement C2 precursor 1.91 1.20
C8B C8B: Complement component C8 beta chain precursor 1.71 0.191
ALB ALB: Uncharacterized protein ALB 1.67 0.026
ANPEP ANPEP, APN, CD13, PEPN: Aminopeptidase N 1.60 0.031
ASGR1 ASGR1: Asialoglycoprotein receptor 1 1.07 0.0453
HPR HPR: Haptoglobin-related protein precursor 0.881 0.244
HABP2 HABP2, HGFAL, PHBP: Hyaluronan-binding protein 2 precursor 0.881 0.305
APOE APOE: Apolipoprotein E precursor 0.785 0.032
AFM AFM, ALB2, ALBA: Afamin precursor 0.785 0.032
KNG1 N/A 0.785 0.032
TTR TTR, PALB: Transthyretin precursor 0.785 0.026
APOM APOM, G3A, HSPC336, NG20: Apolipoprotein M 0.785 0.032
MST1 N/A 0.704 0.0425
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.575 0.034
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.575 0.0688
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.575 0.0688
C1R C1R: Complement C1r subcomponent precursor 0.543 1.20
CFHR2 CFHR2, CFHL2, FHR2, HFL3: Complement factor H-related protein 2 precursor 0.543 0.152
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.543 1.41
LPA LPA: Apolipoprotein(a) precursor 0.486 0.975
CTSB CTSB, CPSB: Cathepsin B precursor 0.474 0.041
PCOLCE PCOLCE, PCPE1: Procollagen C-endopeptidase enhancer 1 precursor 0.438 0.123
MBL2 MBL2, MBL: Mannose-binding protein C precursor 0.393 0.192
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.393 0.109
FGB FGB: Fibrinogen beta chain precursor [Contains: Fibrinopeptide B] 0.393 0.191
CTSL CTSL: Cathepsin L precursor 0.384 0.045
ITIH2 N/A 0.384 0.032
CTSC CTSC, CPPI: Dipeptidyl-peptidase 1 precursor 0.378 0.041
CTSS CTSS: Cathepsin S precursor 0.378 0.045
CTSZ CTSZ: Cathepsin Z precursor 0.378 0.041
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.354 0.063
ENPEP ENPEP: Glutamyl aminopeptidase 0.338 0.025
CTSL2 CTSL2, CATL2, UNQ268/PRO305, CTSU, CTSV: Cathepsin L2 precursor 0.338 0.0794
CFH CFH, HF, HF1, HF2: Complement factor H precursor 0.324 0.123
CCL14 CCL14, NCC2, SCYA14: Small-inducible cytokine A14 precursor 0.318 0.026
C1S C1S: Complement C1s subcomponent precursor 0.265 0.975
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.265 0.039
SHBG SHBG: Sex hormone-binding globulin precursor 0.265 0.026
A2M A2M, FWP007: Alpha-2-macroglobulin precursor 0.265 0.026
CNTNAP1 CNTNAP1, CASPR, NRXN4: Contactin-associated protein 1 precursor 0.237 0.027
CNTNAP4 CASPR4: Cell recognition protein CASPR4 0.237 0.027
FN1 N/A 0.209 0.028
THPO THPO, MGDF: Thrombopoietin precursor 0.209 0.028
CSF3 CSF3, GCSF: Granulocyte colony-stimulating factor precursor 0.209 0.028
KITLG KITLG, MGF, SCF: Kit ligand precursor 0.209 0.028
CCL26 CCL26, SCYA26, UNQ216/PRO242: Small-inducible cytokine A26 precursor 0.209 0.028
DCN DCN: Decorin precursor 0.209 0.028
IFNG IFNG: Interferon gamma precursor 0.209 0.028
C1QC C1QC, C1QG: Complement C1q subcomponent subunit C precursor 0.209 0.083
CCL15 CCL15, MIP5, NCC3, SCYA15: Small-inducible cytokine A15 precursor 0.209 0.028
IL4 IL4: Interleukin-4 precursor 0.209 0.028
OPTC OPTC, OPT: Opticin precursor 0.209 0.028
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.209 0.028
LOC643930 CCL3L1, D17S1718, G0S19-2, SCYA3L1: Small-inducible cytokine A3-like 1 precursor 0.209 0.028
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.209 0.028
PZP PZP: Pregnancy zone protein precursor 0.201 0.026
C1QA C1QA: Complement C1q subcomponent subunit A precursor 0.192 0.055
BGN BGN: Biglycan precursor 0.192 0.026
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.187 0.083
FGA N/A 0.180 0.191
CRP CRP, PTX1: C-reactive protein precursor [Contains: C-reactive protein(1-205)] 0.176 0.026
CFHR1 CFHR1, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2: Complement factor H-relate 0.174 0.165
F11 F11: Coagulation factor XI precursor 0.174 1.30
C4A C4A: Complement C4-A precursor 0.174 0.028
TFPI TFPI, LACI, TFPI1: Tissue factor pathway inhibitor precursor 0.174 0.028
BGLAP BGLAP: Osteocalcin precursor 0.174 0.174
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.174 0.083
GRN GRN: Granulins precursor 0.174 0.028
CD46 N/A 0.165 0.165
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.161 0.034
CFI CFI, IF: Complement factor I precursor 0.161 1.50
F13B F13B: Coagulation factor XIII B chain precursor 0.161 0.152
CMA1 CMA1, CYH, CYM: Chymase precursor 0.161 0.859
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.161 0.039
ANGPTL3 ANGPTL3, ANGPT5, UNQ153/PRO179: Angiopoietin-related protein 3 precursor 0.161 0.152
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.156 0.165
PLAT PLAT: Tissue-type plasminogen activator precursor 0.156 1.30
COL18A1 N/A 0.156 0.083
CPB2 CPB2: Carboxypeptidase B2 precursor 0.156 0.028
FCN3 FCN3, FCNH, HAKA1: Ficolin-3 precursor 0.156 0.174
HGF HGF, HPTA: Hepatocyte growth factor precursor 0.156 1.30
BMP1 N/A 0.156 0.165
LOC653509 SFTPA1, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A1 precursor 0.156 0.083
F7 F7: Coagulation factor VII precursor 0.156 1.53
KLK3 KLK3, APS: Prostate-specific antigen precursor 0.156 1.30
SPOCK1 SPOCK1, SPOCK, TIC1, TICN1: Testican-1 precursor 0.156 0.083
FGG FGG, PRO2061: Fibrinogen gamma chain precursor 0.156 0.165
ANGPTL6 AGF, UNQ152/PRO178, ANGPTL6, ARP5: Angiopoietin-related protein 6 precursor 0.156 0.165
MMRN2 MMRN2, EMILIN3: Multimerin-2 precursor 0.152 0.028
GRP Gastrin-releasing peptide 0.152 0.028
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.152 0.028
PTHLH N/A 0.152 0.028
GUCA2A GUCA2A, GUCA2: Guanylin precursor 0.152 0.028
CCL14 N/A 0.152 0.028
NULL A1BG: Alpha-1B-glycoprotein precursor 0.152 0.028
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.152 0.028
CST4 CST4: Cystatin-S precursor 0.152 0.028
PCSK6 N/A 0.152 0.028
ACCN3 ACCN3, ASIC3, SLNAC1, TNAC1: Amiloride-sensitive cation channel 3 0.152 0.028
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.152 0.028
LECT1 LECT1, CHMI: Chondromodulin-1 precursor 0.152 0.028
NOG NOG: Noggin precursor 0.152 0.028
PLAU Plasminogen activator, urokinase 0.152 0.028
ZP3 ZP3, ZP3A, ZP3B, ZPC: Zona pellucida sperm-binding protein 3 precursor 0.152 0.028
PLTP PLTP: Phospholipid transfer protein precursor 0.152 0.028
CSF1 CSF1: Macrophage colony-stimulating factor 1 precursor 0.152 0.028
GHRL GHRL, MTLRP, UNQ524/PRO1066: Appetite-regulating hormone precursor 0.152 0.028
ECM1 ECM1: Extracellular matrix protein 1 precursor 0.152 0.028
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.144 0.307
IL22 IL22, ILTIF, UNQ3099/PRO10096: Interleukin-22 precursor 0.140 0.026
IGF2 IGF2, PP1446: Insulin-like growth factor II precursor 0.140 0.026
AFP AFP, HPAFP: Alpha-fetoprotein precursor 0.140 0.026
AGRP AGRP, AGRT, ART: Agouti-related protein precursor 0.140 0.026
COL17A1 COL17A1, BP180, BPAG2: Collagen alpha-1(XVII) chain 0.137 0.055
COL1A1 COL1A1: Collagen alpha-1(I) chain precursor 0.137 0.055
COL3A1 COL3A1: Collagen alpha-1(III) chain precursor 0.137 0.055
ADIPOQ ADIPOQ, ACDC, ACRP30, APM1, GBP28: Adiponectin precursor 0.137 0.055
COL5A2 N/A 0.137 0.055
VNN1 VNN1: Pantetheinase precursor 0.137 0.028
CA11 CA11, CARP2, UNQ211/PRO237: Carbonic anhydrase-related protein 11 precursor 0.137 0.028
CNTN1 CNTN1: Contactin-1 precursor 0.137 0.028
LOC641705 AMY2A: Pancreatic alpha-amylase precursor 0.137 0.028
ITM2C ITM2C, BRI3, hucep-14, NPD018, PSEC0047: Integral membrane protein 2C 0.137 0.028
CNTN4 CNTN4: Contactin-4 precursor 0.137 0.028
THBD THBD, THRM: Thrombomodulin precursor 0.130 0.109
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.130 0.115
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.130 0.109
CLEC3B CLEC3B, TNA: Tetranectin precursor 0.130 0.062
PRSS22 PRSS22, BSSP4, SP001LA, PRSS26, UNQ302/PRO343: Brain-specific serine protease 4 0.130 0.975
MMP11 MMP11, STMY3: Stromelysin-3 precursor 0.117 0.109
PRG4 PRG4, MSF, SZP: Proteoglycan-4 precursor 0.117 0.055
MMP8 CLG1, MMP8: Neutrophil collagenase precursor 0.117 0.123
ELA3B ELA3B: Elastase-3B precursor 0.115 0.975
PRG2 PRG2, MBP: Bone marrow proteoglycan precursor 0.115 0.055
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.115 0.062
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.115 0.152
GZMB Endogenous granzyme B 0.115 0.859
MMP9 MMP9, CLG4B: Matrix metalloproteinase-9 precursor 0.115 0.109
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.115 0.034
NOTCH4 N/A 0.115 0.109
ELA2 ELA2: Leukocyte elastase precursor 0.115 0.859
REG1B REG1B, REGL: Lithostathine 1 beta precursor 0.115 0.062
CSPG2 N/A 0.115 0.109
MUC2 MUC2, SMUC: Mucin-2 precursor 0.115 0.109
AZU1 AZU1: Azurocidin precursor 0.115 0.859
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.115 0.048
COL5A1 N/A 0.115 0.137
SFTPA2 SFTPA2, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A2 precursor 0.115 0.055
MMP13 MMP13: Collagenase 3 precursor 0.115 0.109
CTSG CTSG: Cathepsin G precursor 0.115 0.859
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.115 0.055
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.115 0.026
REG1B REG1A, PSPS, REG: Lithostathine 1 alpha precursor 0.115 0.062
REG3A REG3A, HIP, PAP, PAP1: Regenerating islet-derived protein 3 alpha precursor 0.115 0.062
COL15A1 COL15A1: Collagen alpha-1(XV) chain precursor [Contains: Endostatin 0.115 0.096
UMOD UMOD: Uromodulin precursor 0.115 0.123
IL2RA IL2RA: Interleukin-2 receptor alpha chain precursor 0.115 0.109
PRTN3 PRTN3, MBN: Myeloblastin precursor 0.115 0.859
PRSS1 PRSS1, TRP1, TRY1, TRYP1: Trypsin-1 precursor 0.115 0.975
IFNB1 IFNB1, IFB, IFNB: Interferon beta precursor 0.114 0.026
LGALS3BP LGALS3BP, M2BP: Galectin-3-binding protein precursor 0.114 0.026
CORT CORT, UNQ307/PRO350: Cortistatin precursor [Contains: Cortistatin-29; Cortistati 0.114 0.0425
IL15RA IL15RA: Interleukin-15 receptor alpha chain precursor 0.109 0.098
MGP MGP, MGLAP, GIG36: Matrix Gla protein precursor 0.109 0.152
LAMA2 LAMA2: Uncharacterized protein LAMA2 0.103 0.123
KLK6 KLK6, PRSS18, PRSS9: Kallikrein-6 precursor 0.103 0.775
THBS1 THBS1, TSP, TSP1: Thrombospondin-1 precursor 0.103 0.109
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.103 0.109
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.103 0.109
MMP7 MMP7, MPSL1, PUMP1: Matrilysin precursor 0.103 0.109
KLK1 KLK1: Kallikrein-1 precursor 0.103 0.975
MMP1 MMP1, CLG: Interstitial collagenase precursor 0.103 0.109
SFTPD SFTPD, PSPD, SFTP4: Pulmonary surfactant-associated protein D precursor 0.103 0.055
C7 C7: Complement component C7 precursor 0.103 0.191
MMP2 MMP2, CLG4A: 72 kDa type IV collagenase precursor 0.103 0.109
MFAP4 MFAP4: Microfibril-associated glycoprotein 4 precursor 0.103 0.109
FGL2 FGL2: Fibroleukin precursor 0.103 0.109
TNC TNC, HXB: Tenascin precursor 0.103 0.098
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.103 0.109
COL4A1 N/A 0.103 0.109
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.103 0.109
RNASE1 RNASE1, RIB1, RNS1: Ribonuclease pancreatic precursor 0.100 0.052
INHA INHA: Inhibin alpha chain precursor 0.100 0.307
PTGDS PTGDS, PDS: Prostaglandin-H2 D-isomerase precursor 0.100 0.032
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.098 0.109
ALK ALK: ALK tyrosine kinase receptor precursor 0.097 0.062
TMPRSS9 N/A 0.096 0.980
KLRD1 KLRD1, CD94: Natural killer cells antigen CD94 0.096 0.049
DLK1 DLK1, DLK: Delta-like protein precursor 0.096 0.109
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.096 0.109
SLIT2 SLIT2, SLIL3: Slit homolog 2 protein precursor 0.093 0.109
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.090 0.072
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.088 0.032
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.087 0.109
EDA N/A 0.087 0.049
JAG2 JAG2: Jagged-2 precursor 0.086 0.109
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.086 0.109
ACE ACE, DCP, DCP1: Angiotensin-converting enzyme, somatic isoform precursor 0.086 0.049
ATRN N/A 0.086 0.109
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.081 0.072
SELE SELE, ELAM1: E-selectin precursor 0.081 0.081
MEP1B MEP1B: Meprin A subunit beta precursor 0.079 0.081
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.078 0.04
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.073 0.081
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.073 0.072
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.072 0.072
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.072 0.037
KEL KEL: Kell blood group glycoprotein 0.071 0.037
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.071 0.072
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.071 0.032
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.071 0.065
SORL1 SORL1: Sortilin-related receptor precursor 0.071 0.065
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.065 0.027
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.064 0.072
ITGB7 ITGB7: Integrin beta-7 precursor 0.064 0.065
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.064 0.072
MBTPS2 MBTPS2, S2P: Membrane-bound transcription factor site-2 protease 0.064 0.032
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.064 0.065
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.064 0.644
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.063 0.065
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.063 0.0727
CD69 CD69: Early activation antigen CD69 0.063 0.029
AREG AREG, SDGF: Amphiregulin precursor 0.063 0.072
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.063 0.065
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.063 0.065
MME MME, EPN: Neprilysin 0.063 0.032
EGF EGF: Pro-epidermal growth factor precursor 0.063 0.081
ITGB4 N/A 0.063 0.065
ACE ACE, DCP, DCP1: Angiotensin-converting enzyme, testis-specific isoform precursor 0.063 0.057
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.062 0.034
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.060 0.033
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.060 0.0407
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.056 0.081
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.056 0.065
ST14 ST14, PRSS14, SNC19, TADG15: Suppressor of tumorigenicity protein 14 0.056 0.581
LDLR LDLR: Low-density lipoprotein receptor precursor 0.056 0.100
MEP1A MEP1A: Meprin A subunit alpha precursor 0.056 0.081
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.051 0.031
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.051 0.0263
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.050 0.056
CIC CIC, KIAA0306: Protein capicua homolog 0.048 0.026
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.044 0.044
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.041 0.0263
MASP1 MASP1, CRARF, CRARF1, PRSS5: Complement-activating component of Ra-reactive fact 0.041 0.174
TPSG1 TPSG1, PRSS31, TMT: Tryptase gamma precursor 0.041 0.197
CD55 CD55, CR, DAF: Complement decay-accelerating factor precursor 0.037 0.037
PRSS8 PRSS8: Prostasin precursor 0.0308 0.174
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.030 0.029
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.029 0.030
RAD18 RAD18, RNF73: E3 ubiquitin-protein ligase RAD18 0.028 0.028
LNX1 N/A 0.028 0.028
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.028 0.028
CGN N/A 0.028 0.028
C1QTNF4 C1QTNF4, CTRP4: Complement C1q tumor necrosis factor-related protein 4 precursor 0.028 0.028
DSP DSP: Desmoplakin 0.028 0.028
IRF2BP2 IRF2BP2, RP4-781K5.1-002: Interferon regulatory factor 2-binding protein 2. 0.028 0.028
TUBGCP6 TUBGCP6, GCP6, KIAA1669: Gamma-tubulin complex component 6 0.028 0.028
PCGF6 N/A 0.028 0.028
KLK5 KLK5, SCTE, UNQ570/PRO1132: Kallikrein-5 precursor 0.028 0.244
PLAU PLAU: Urokinase-type plasminogen activator precursor 0.027 0.617
ITGB1 ITGB1, FNRB, MDF2, MSK12: Integrin beta-1 precursor 0.027 0.051
KLKB1 N/A 0.027 0.617
COL4A2 COL4A2: Collagen alpha-2(IV) chain precursor [Contains: Canstatin] 0.027 0.051
MMRN1 MMRN1, ECM, EMILIN4, MMRN: Multimerin-1 precursor 0.027 0.051
PAPPA PAPPA: Pappalysin-1 precursor 0.027 0.051
CSPG5 N/A 0.027 0.051
LTBP1 LTBP1: Latent-transforming growth factor beta-binding protein, isoform 1S precur 0.027 0.051
ELTD1 ELTD1, RP11-143H12.1-002: EGF, latrophilin and seven transmembrane domain contai 0.027 0.051
FN1 FN1, FN: Fibronectin precursor 0.027 0.051
MST1 MST1, D3F15S2, DNF15S2, HGFL: Hepatocyte growth factor-like protein precursor 0.027 0.617
CFC1 CFC1: Cryptic protein precursor 0.027 0.027
NTN4 NTN4: Netrin-4 precursor 0.027 0.027
NETO1 N/A 0.027 0.027
NELL2 NELL2, NRP2: Protein kinase C-binding protein NELL2 precursor 0.027 0.027
ELA2A ELA2A: Elastase-2A precursor 0.027 0.265
TPSAB1 N/A 0.027 0.265
PRSS36 PRSS36: Polyserase-2 precursor 0.027 0.265
CR1L complement component (3b/4b) receptor 1-like 0.027 0.027
HHIP HHIP, HIP, UNQ5825/PRO19644: Hedgehog-interacting protein precursor 0.027 0.027
PRRG4 PRRG4, TMG4: Transmembrane gamma-carboxyglutamic acid protein 4 precursor 0.027 0.027
KLK9 KLK9: Kallikrein-9 precursor 0.027 0.265
CFHR3 CFHR3, CFHL3, FHR3: Complement factor H-related protein 3 precursor 0.027 0.027
PRSS21 PRSS21, ESP1, UNQ266/PRO303, TEST1: Testisin precursor 0.027 0.265
MASP2 MASP2: Mannan-binding lectin serine protease 2 precursor 0.027 0.265
CSPG3 CSPG3, NCAN, NEUR: Neurocan core protein precursor 0.027 0.027
PAPPA2 PAPPA2, PLAC3: Pappalysin-2 precursor 0.027 0.027
KLK12 KLK12, KLKL5, UNQ669/PRO1303: Kallikrein-12 precursor 0.027 0.265
CLEC14A CLEC14A, C14orf27, UNQ236/PRO269, EGFR5: C-type lectin domain family 14 member A 0.027 0.027
KREMEN2 KREMEN2, KRM2: Kremen protein 2 precursor 0.027 0.027
NTNG2 N/A 0.027 0.027
PRSS27 PRSS27, MPN, UNQ1884/PRO4327: Serine protease 27 precursor 0.027 0.265
MUC13 MUC13, DRCC1, UNQ6194/PRO20221, RECC: Mucin-13 precursor 0.027 0.027
GP2 GP2: Pancreatic secretory granule membrane major glycoprotein GP2 precursor 0.027 0.027
PLGLA1 PLGLA1, PLGP2: Plasminogen-related protein A precursor 0.027 0.027
ITLN1 ITLN1, INTL, UNQ640/PRO1270, ITLN, LFR: Intelectin-1 precursor 0.027 0.027
PRRG1 PRRG1, PRGP1, TMG1: Transmembrane gamma-carboxyglutamic acid protein 1 precursor 0.027 0.027
LAMC2 LAMC2, LAMB2T, LAMNB2: Laminin subunit gamma-2 precursor 0.027 0.027
ITLN2 ITLN2, UNQ2789/PRO7179: Intelectin-2 precursor 0.027 0.027
SCARF2 SCARF2, SREC2, SREPCR: Scavenger receptor class F member 2 precursor 0.027 0.027
PRRG2 PRRG2, PRGP2, TMG2: Transmembrane gamma-carboxyglutamic acid protein 2 precursor 0.027 0.027
UNC5D N/A 0.025 0.028
SCRIB N/A 0.025 0.028
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.025 0.028
0.572
Total Score 323.00