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Evidence of Interaction Between PLG and SERPINE1

The interaction score between PLG and SERPINE1 is 320.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PLG and SERPINE1 = -0.03

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology
OrganismPLG OrthologueSERPINE1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00019590 0.057 IPI00016150 0.052
  • InVitro
  • InVivo

Get References From PubMed
human IPI00029168 0.515 IPI00016150 0.052
human IPI00025767 0.183 IPI00016150 0.052
human IPI00555830 0.191 IPI00016150 0.052
human IPI00385782 0.131 IPI00016150 0.052
worm Q23528 1 O17365 0.052

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 1.07
Domains Domains present in PLG and SERPINE1:
Domains in PLGDomains in SERPINE1
IPR000001 Kringle
IPR001254 Peptidase S1, chymotrypsin
IPR001314 Peptidase S1A, chymotrypsin
IPR009003 Peptidase, trypsin-like serine and cysteine proteases
IPR003014 N/apple PAN
IPR003966 Peptidase S1A, prothrombin
IPR003609 Apple-like
IPR011358 Pept_S1A_Plasmin.
IPR000215 Proteinase inhibititor I4, serpin

The Chi square scores for co-occurrence of domains that are present in PLG and SERPINE1 are listed below.

Domain 1Domain 2Chi Square
IPR001314 Peptidase S1A, chymotrypsin IPR000215 Proteinase inhibititor I4, serpin 1406.06
IPR001254 Peptidase S1, chymotrypsin IPR000215 Proteinase inhibititor I4, serpin 1376.58
IPR009003 Peptidase, trypsin-like serine and cysteine proteases IPR000215 Proteinase inhibititor I4, serpin 1072.84
IPR000001 Kringle IPR000215 Proteinase inhibititor I4, serpin 235.847
IPR003966 Peptidase S1A, prothrombin IPR000215 Proteinase inhibititor I4, serpin 232.955
IPR003014 N/apple PAN IPR000215 Proteinase inhibititor I4, serpin 93.1081
IPR003609 Apple-like IPR000215 Proteinase inhibititor I4, serpin 93.1081
IPR011358 Pept_S1A_Plasmin. IPR000215 Proteinase inhibititor I4, serpin 60.6525

The background colour of the table refers to:

  • Blue Domain is only present in PLG
  • Yellow Domain is only present in SERPINE1
  • Green Domain is present in both PLG and SERPINE1

 1.30
Post-translational Modifications

Protein: PLG

PTMResidueReference
Disulfide Bridge 316 PubMed, HPRD
Disulfide Bridge 543 PubMed, HPRD
Disulfide Bridge 555 PubMed, HPRD
Disulfide Bridge 560 PubMed, HPRD
Disulfide Bridge 567 PubMed, HPRD
Disulfide Bridge 577 PubMed, HPRD
Glycosylation 268 PubMed, HPRD
Glycosylation 308 PubMed, HPRD
Glycosylation 365 PubMed, HPRD
N-linked 308 PubMed, HPRD
O-linked 268 PubMed, HPRD
O-linked 365 PubMed, HPRD
Phosphorylation 597 PubMed, HPRD
Phosphoserine 597 HPRD
Proteolytic Cleavage 78 PubMed, HPRD
Proteolytic Cleavage 458 PubMed, HPRD
Proteolytic Cleavage 465 PubMed, HPRD
Proteolytic Cleavage 466 PubMed, HPRD
Proteolytic Cleavage 549 PubMed, HPRD
Proteolytic Cleavage 563 PubMed, HPRD
Proteolytic Cleavage 580 PubMed, HPRD
Proteolytic Cleavage 634 PubMed, HPRD
Proteolytic Cleavage 670 PubMed, HPRD
Proteolytic Cleavage 680 PubMed, HPRD
Proteolytic Cleavage 717 PubMed, HPRD
Proteolytic Cleavage 727 PubMed, HPRD

Protein: SERPINE1

PTMResidueReference
Glycosylation 232 PubMed, HPRD
Glycosylation 288 PubMed, HPRD
N-linked 232 PubMed, HPRD
N-linked 288 PubMed, HPRD
Proteolytic Cleavage 360 PubMed, HPRD
Proteolytic Cleavage 364 PubMed, HPRD
Proteolytic Cleavage 379 PubMed, HPRD
Localisation

Protein: PLG

LocalisationReference
Secreted HPRD

Protein: SERPINE1

LocalisationReference
Secreted HPRD
Transitive Score

The common interactors between PLG and SERPINE1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PLG andSERPINE1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PLG has 660 interactors and SERPINE1 has 443 interactors of which there are 318 common interactors.

Common InteractorName of Common InteractorScore for PLG-Interactor (?)Score for SERPINE1-Interactor (?)
F2 F2: Prothrombin precursor 826.00 0.902
F9 F9: Coagulation factor IX precursor 386.00 1.02
FGA N/A 221.00 0.097
FCN3 FCN3, FCNH, HAKA1: Ficolin-3 precursor 75.10 0.156
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 35.00 0.113
APOH APOH, B2G1: Beta-2-glycoprotein 1 precursor 5.45 0.109
C8A C8A: Complement component C8 alpha chain precursor 1.91 0.109
HP HP: Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta c 1.81 0.859
CFB CFB, BF, BFD: Complement factor B precursor 1.81 0.975
HPX HPX: Hemopexin precursor 1.81 0.055
VTN VTN: Vitronectin precursor 1.81 0.055
C2 C2: Complement C2 precursor 1.81 0.859
C4BPB C4BPB: C4b-binding protein beta chain precursor 1.81 0.109
CFHR2 CFHR2, CFHL2, FHR2, HFL3: Complement factor H-related protein 2 precursor 1.81 0.152
PROC PROC: Vitamin K-dependent protein C precursor 1.71 1.00
C8B C8B: Complement component C8 beta chain precursor 1.71 0.097
FGB FGB: Fibrinogen beta chain precursor [Contains: Fibrinopeptide B] 1.62 0.097
FN1 N/A 1.53 0.028
ASGR2 ASGR2: Asialoglycoprotein receptor 2 1.19 0.032
HPN HPN, TMPRSS1: Serine protease hepsin 1.07 0.644
GGCX GGCX, GC: Vitamin K-dependent gamma-carboxylase 0.956 0.028
HABP2 HABP2, HGFAL, PHBP: Hyaluronan-binding protein 2 precursor 0.881 0.174
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.852 0.859
C4BPA C4BPA, C4BP: C4b-binding protein alpha chain precursor 0.852 0.109
C3 0.852 0.026
F12 F12: Coagulation factor XII precursor 0.852 0.859
C6 C6: Complement component C6 precursor 0.804 0.109
F10 F10: Coagulation factor X precursor 0.804 0.902
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.543 1.41
ASGR1 ASGR1: Asialoglycoprotein receptor 1 0.503 0.029
MBL2 MBL2, MBL: Mannose-binding protein C precursor 0.486 0.140
CFI CFI, IF: Complement factor I precursor 0.416 0.859
C1R C1R: Complement C1r subcomponent precursor 0.416 1.20
ANGPTL3 ANGPTL3, ANGPT5, UNQ153/PRO179: Angiopoietin-related protein 3 precursor 0.372 0.097
LPA LPA: Apolipoprotein(a) precursor 0.372 0.770
F13B F13B: Coagulation factor XIII B chain precursor 0.307 0.098
PCOLCE PCOLCE, PCPE1: Procollagen C-endopeptidase enhancer 1 precursor 0.307 0.416
CFH CFH, HF, HF1, HF2: Complement factor H precursor 0.307 0.152
HPR HPR: Haptoglobin-related protein precursor 0.293 0.174
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.290 0.097
C1QC C1QC, C1QG: Complement C1q subcomponent subunit C precursor 0.209 0.083
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.201 0.161
C1QA C1QA: Complement C1q subcomponent subunit A precursor 0.192 0.055
ANPEP ANPEP, APN, CD13, PEPN: Aminopeptidase N 0.192 0.028
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.191 0.039
C1S C1S: Complement C1s subcomponent precursor 0.191 1.20
UMOD UMOD: Uromodulin precursor 0.191 0.109
EDN2 EDN2: Endothelin-2 precursor 0.191 0.026
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.191 0.132
BGLAP BGLAP: Osteocalcin precursor 0.174 0.174
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.165 0.083
TFPI TFPI, LACI, TFPI1: Tissue factor pathway inhibitor precursor 0.165 0.028
CD46 N/A 0.165 0.165
C4A C4A: Complement C4-A precursor 0.165 0.028
F11 F11: Coagulation factor XI precursor 0.165 1.30
CFHR1 CFHR1, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2: Complement factor H-relate 0.165 0.165
F7 F7: Coagulation factor VII precursor 0.156 1.53
COL1A1 COL1A1: Collagen alpha-1(I) chain precursor 0.156 0.917
CMA1 CMA1, CYH, CYM: Chymase precursor 0.152 0.975
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.152 0.0971
PRSS22 PRSS22, BSSP4, SP001LA, PRSS26, UNQ302/PRO343: Brain-specific serine protease 4 0.152 0.975
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.148 0.030
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.148 0.046
HGF HGF, HPTA: Hepatocyte growth factor precursor 0.148 1.17
CPB2 CPB2: Carboxypeptidase B2 precursor 0.148 0.025
KLK3 KLK3, APS: Prostate-specific antigen precursor 0.148 1.17
SPOCK1 SPOCK1, SPOCK, TIC1, TICN1: Testican-1 precursor 0.148 0.075
PLAT PLAT: Tissue-type plasminogen activator precursor 0.148 1.30
COL18A1 N/A 0.148 0.083
ANGPTL6 AGF, UNQ152/PRO178, ANGPTL6, ARP5: Angiopoietin-related protein 6 precursor 0.148 0.148
LOC653509 SFTPA1, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A1 precursor 0.148 0.075
FGG FGG, PRO2061: Fibrinogen gamma chain precursor 0.148 0.148
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.148 0.050
BMP1 N/A 0.148 0.148
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.148 0.148
GRN GRN: Granulins precursor 0.148 0.025
ADIPOQ ADIPOQ, ACDC, ACRP30, APM1, GBP28: Adiponectin precursor 0.137 0.062
COL3A1 COL3A1: Collagen alpha-1(III) chain precursor 0.137 0.917
IL2RA IL2RA: Interleukin-2 receptor alpha chain precursor 0.123 0.109
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.123 0.087
CLEC3B CLEC3B, TNA: Tetranectin precursor 0.123 0.055
MMP13 MMP13: Collagenase 3 precursor 0.123 0.109
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.115 0.062
COL5A1 N/A 0.115 2.29
TIMP1 TIMP1, CLGI, TIMP: Metalloproteinase inhibitor 1 precursor 0.111 0.129
KLK1 KLK1: Kallikrein-1 precursor 0.111 0.859
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.111 0.097
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.111 0.111
PRG4 PRG4, MSF, SZP: Proteoglycan-4 precursor 0.111 0.049
MMP11 MMP11, STMY3: Stromelysin-3 precursor 0.111 0.111
MMP8 CLG1, MMP8: Neutrophil collagenase precursor 0.111 0.097
KLRD1 KLRD1, CD94: Natural killer cells antigen CD94 0.109 0.049
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.109 0.109
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.109 0.044
DLK1 DLK1, DLK: Delta-like protein precursor 0.109 0.109
MGP MGP, MGLAP, GIG36: Matrix Gla protein precursor 0.109 0.152
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.109 0.109
CSPG2 N/A 0.109 0.152
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.109 0.127
REG3A REG3A, HIP, PAP, PAP1: Regenerating islet-derived protein 3 alpha precursor 0.109 0.055
FSTL1 FSTL1, FRP: Follistatin-related protein 1 precursor 0.109 0.144
ELA3B ELA3B: Elastase-3B precursor 0.109 0.859
SFTPA2 SFTPA2, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A2 precursor 0.109 0.055
PRTN3 PRTN3, MBN: Myeloblastin precursor 0.109 0.859
CXCL5 CXCL5, ENA78, SCYB5: Small-inducible cytokine B5 precursor 0.109 0.307
REG1B REG1B, REGL: Lithostathine 1 beta precursor 0.109 0.055
MMP9 MMP9, CLG4B: Matrix metalloproteinase-9 precursor 0.109 0.109
EDN1 EDN1: Endothelin-1 precursor 0.109 0.052
MUC2 MUC2, SMUC: Mucin-2 precursor 0.109 0.152
ELA2 ELA2: Leukocyte elastase precursor 0.109 0.859
COL15A1 COL15A1: Collagen alpha-1(XV) chain precursor [Contains: Endostatin 0.109 0.062
IL15RA IL15RA: Interleukin-15 receptor alpha chain precursor 0.109 0.152
PRG2 PRG2, MBP: Bone marrow proteoglycan precursor 0.109 0.062
GZMB Endogenous granzyme B 0.109 0.859
REG1B REG1A, PSPS, REG: Lithostathine 1 alpha precursor 0.109 0.055
CXCL1 CXCL1, GRO, GRO1, GROA, MGSA, SCYB1: Growth-regulated protein alpha precursor 0.109 0.307
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.109 0.163
THBD THBD, THRM: Thrombomodulin precursor 0.109 0.152
CTSG CTSG: Cathepsin G precursor 0.109 0.859
LGALS1 LGALS1: Galectin-1 0.109 0.025
IL8 IL8: Interleukin-8 precursor 0.109 0.070
AZU1 AZU1: Azurocidin precursor 0.109 0.859
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.109 0.034
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.109 0.070
PRSS1 PRSS1, TRP1, TRY1, TRYP1: Trypsin-1 precursor 0.109 0.859
C7 C7: Complement component C7 precursor 0.103 0.097
THBS1 THBS1, TSP, TSP1: Thrombospondin-1 precursor 0.103 0.763
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.100 0.126
EGF EGF: Pro-epidermal growth factor precursor 0.100 0.072
MFAP2 MFAP2, MAGP1: Microfibrillar-associated protein 2 precursor 0.100 0.144
COL16A1 COL16A1: Collagen alpha-1(XVI) chain precursor 0.098 0.051
TMPRSS9 N/A 0.098 0.878
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.098 0.098
ACE ACE, DCP, DCP1: Angiotensin-converting enzyme, somatic isoform precursor 0.098 0.044
ATRN N/A 0.098 0.098
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.098 0.098
JAG2 JAG2: Jagged-2 precursor 0.098 0.098
TNC TNC, HXB: Tenascin precursor 0.097 0.136
MMP1 MMP1, CLG: Interstitial collagenase precursor 0.097 4.88
LAMA2 LAMA2: Uncharacterized protein LAMA2 0.097 0.171
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.097 0.461
KLK6 KLK6, PRSS18, PRSS9: Kallikrein-6 precursor 0.097 0.770
CTGF CTGF, CCN2, HCS24: Connective tissue growth factor precursor 0.097 0.827
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.097 0.111
ALK ALK: ALK tyrosine kinase receptor precursor 0.097 0.056
NOTCH4 N/A 0.097 0.088
COL4A1 N/A 0.097 0.372
MMP7 MMP7, MPSL1, PUMP1: Matrilysin precursor 0.097 0.097
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.097 1.62
MFAP4 MFAP4: Microfibril-associated glycoprotein 4 precursor 0.097 0.111
MMP2 MMP2, CLG4A: 72 kDa type IV collagenase precursor 0.097 0.461
SFTPD SFTPD, PSPD, SFTP4: Pulmonary surfactant-associated protein D precursor 0.097 0.049
FGL2 FGL2: Fibroleukin precursor 0.097 0.097
CPD CPD: Carboxypeptidase D precursor 0.097 0.038
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.097 0.763
SPARC SPARC, ON: SPARC precursor 0.097 0.078
MEP1B MEP1B: Meprin A subunit beta precursor 0.090 0.073
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.090 0.033
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.090 0.030
SLIT2 SLIT2, SLIL3: Slit homolog 2 protein precursor 0.088 0.171
THPO THPO, MGDF: Thrombopoietin precursor 0.083 0.028
DCN DCN: Decorin precursor 0.083 0.028
KITLG KITLG, MGF, SCF: Kit ligand precursor 0.083 0.028
CSF3 CSF3, GCSF: Granulocyte colony-stimulating factor precursor 0.083 0.028
LOC643930 CCL3L1, D17S1718, G0S19-2, SCYA3L1: Small-inducible cytokine A3-like 1 precursor 0.083 0.028
IL4 IL4: Interleukin-4 precursor 0.083 0.028
OPTC OPTC, OPT: Opticin precursor 0.083 0.028
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.083 0.028
IFNG IFNG: Interferon gamma precursor 0.083 0.028
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.083 0.028
CCL15 CCL15, MIP5, NCC3, SCYA15: Small-inducible cytokine A15 precursor 0.083 0.028
CCL26 CCL26, SCYA26, UNQ216/PRO242: Small-inducible cytokine A26 precursor 0.083 0.028
SORL1 SORL1: Sortilin-related receptor precursor 0.081 0.065
KEL KEL: Kell blood group glycoprotein 0.081 0.037
SELE SELE, ELAM1: E-selectin precursor 0.081 0.072
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.081 0.166
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.081 0.0453
F2RL1 F2RL1, GPR11, PAR2: Proteinase-activated receptor 2 precursor 0.081 0.036
BGN BGN: Biglycan precursor 0.077 0.070
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.075 0.075
MEP1A MEP1A: Meprin A subunit alpha precursor 0.073 0.064
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.073 0.064
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.073 0.073
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.073 0.577
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.073 0.090
MBTPS2 MBTPS2, S2P: Membrane-bound transcription factor site-2 protease 0.073 0.033
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.073 0.090
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.072 0.072
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.072 0.100
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.072 0.072
AREG AREG, SDGF: Amphiregulin precursor 0.072 0.081
F2R F2R, CF2R, PAR1, TR: Proteinase-activated receptor 1 precursor 0.072 0.027
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.072 0.081
CD69 CD69: Early activation antigen CD69 0.072 0.032
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.072 0.032
ITGB4 N/A 0.072 0.081
ACE ACE, DCP, DCP1: Angiotensin-converting enzyme, testis-specific isoform precursor 0.072 0.037
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.072 0.037
MME MME, EPN: Neprilysin 0.072 0.037
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.0688 0.0688
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.065 0.072
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.065 0.072
ITGB7 ITGB7: Integrin beta-7 precursor 0.064 0.064
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.064 0.113
ST14 ST14, PRSS14, SNC19, TADG15: Suppressor of tumorigenicity protein 14 0.064 0.577
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.064 0.064
LDLR LDLR: Low-density lipoprotein receptor precursor 0.064 0.090
COL5A2 N/A 0.062 2.75
CCL7 MCP-3: Monocyte chemotactic protein-3 0.062 0.025
CCL24 CCL24, MPIF2, SCYA24: Small-inducible cytokine A24 precursor 0.062 0.032
CCL13 CCL13, MCP4, NCC1, SCYA13: Small-inducible cytokine A13 precursor 0.062 0.032
CCL8 CCL8, MCP2, SCYA10, SCYA8: Small-inducible cytokine A8 precursor 0.062 0.087
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.062 0.030
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.062 0.030
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.058 0.090
CCL11 CCL11, SCYA11: Eotaxin precursor 0.055 0.087
IL6 IL6, IFNB2: Interleukin-6 precursor 0.055 0.923
COL17A1 COL17A1, BP180, BPAG2: Collagen alpha-1(XVII) chain 0.055 0.062
CSF2 CSF2, GMCSF: Granulocyte-macrophage colony-stimulating factor precursor 0.055 0.032
LIF LIF, HILDA: Leukemia inhibitory factor precursor 0.055 0.144
CCL2 CCL2, MCP1, SCYA2: Small-inducible cytokine A2 precursor 0.055 0.923
PLAU PLAU: Urokinase-type plasminogen activator precursor 0.051 0.617
ITGB1 ITGB1, FNRB, MDF2, MSK12: Integrin beta-1 precursor 0.051 0.051
ELTD1 ELTD1, RP11-143H12.1-002: EGF, latrophilin and seven transmembrane domain contai 0.051 0.051
MMRN1 MMRN1, ECM, EMILIN4, MMRN: Multimerin-1 precursor 0.051 0.051
MST1 MST1, D3F15S2, DNF15S2, HGFL: Hepatocyte growth factor-like protein precursor 0.051 0.617
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
NRP1 NRP, NRP1, VEGF165R: Neuropilin-1 precursor 0.051 0.051
COL4A2 COL4A2: Collagen alpha-2(IV) chain precursor [Contains: Canstatin] 0.051 0.051
CSPG5 N/A 0.051 0.051
LTBP1 LTBP1: Latent-transforming growth factor beta-binding protein, isoform 1S precur 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
KLKB1 N/A 0.051 0.617
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.051 0.033
EDA N/A 0.049 0.049
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.049 0.109
AGC1 AGC1, CSPG1, MSK16: Aggrecan core protein precursor 0.046 0.051
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.044 0.036
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.041 0.027
ANGPT4 ANGPT4, ANG3, ANG4: Angiopoietin-4 precursor 0.036 0.036
TNN TNN: Tenascin-N precursor 0.034 0.034
CD55 CD55, CR, DAF: Complement decay-accelerating factor precursor 0.033 0.0416
PRSS8 PRSS8: Prostasin precursor 0.0308 0.197
TPSG1 TPSG1, PRSS31, TMT: Tryptase gamma precursor 0.0308 0.244
MASP1 MASP1, CRARF, CRARF1, PRSS5: Complement-activating component of Ra-reactive fact 0.0308 0.157
TPBG TPBG, 5T4: Trophoblast glycoprotein precursor 0.029 0.040
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.029 0.027
CSF1 CSF1: Macrophage colony-stimulating factor 1 precursor 0.028 0.028
TUBGCP6 TUBGCP6, GCP6, KIAA1669: Gamma-tubulin complex component 6 0.028 0.028
CST4 CST4: Cystatin-S precursor 0.028 0.028
PCGF6 N/A 0.028 0.028
ACCN3 ACCN3, ASIC3, SLNAC1, TNAC1: Amiloride-sensitive cation channel 3 0.028 0.028
PCSK6 N/A 0.028 0.028
RAD18 RAD18, RNF73: E3 ubiquitin-protein ligase RAD18 0.028 0.028
NULL A1BG: Alpha-1B-glycoprotein precursor 0.028 0.028
GUCA2A GUCA2A, GUCA2: Guanylin precursor 0.028 0.028
PLAU Plasminogen activator, urokinase 0.028 0.028
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.028 0.028
NOG NOG: Noggin precursor 0.028 0.028
PTHLH N/A 0.028 0.028
LNX1 N/A 0.028 0.028
IRF2BP2 IRF2BP2, RP4-781K5.1-002: Interferon regulatory factor 2-binding protein 2. 0.028 0.028
ECM1 ECM1: Extracellular matrix protein 1 precursor 0.028 0.028
LECT1 LECT1, CHMI: Chondromodulin-1 precursor 0.028 0.028
DSP DSP: Desmoplakin 0.028 0.028
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.028 0.028
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.028 0.028
MMRN2 MMRN2, EMILIN3: Multimerin-2 precursor 0.028 0.028
CGN N/A 0.028 0.028
CCL14 N/A 0.028 0.028
C1QTNF4 C1QTNF4, CTRP4: Complement C1q tumor necrosis factor-related protein 4 precursor 0.028 0.028
GHRL GHRL, MTLRP, UNQ524/PRO1066: Appetite-regulating hormone precursor 0.028 0.028
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.028 0.028
GRP Gastrin-releasing peptide 0.028 0.028
ZP3 ZP3, ZP3A, ZP3B, ZPC: Zona pellucida sperm-binding protein 3 precursor 0.028 0.028
LAMB2 LAMB2, LAMS: Laminin subunit beta-2 precursor 0.028 0.036
EGFL4 MEGF8, C19orf49, EGFL4, KIAA0817: Multiple epidermal growth factor-like domains 0.0273 0.047
CFC1 CFC1: Cryptic protein precursor 0.027 0.027
KLK9 KLK9: Kallikrein-9 precursor 0.027 0.265
PRRG2 PRRG2, PRGP2, TMG2: Transmembrane gamma-carboxyglutamic acid protein 2 precursor 0.027 0.027
KREMEN2 KREMEN2, KRM2: Kremen protein 2 precursor 0.027 0.027
KLK12 KLK12, KLKL5, UNQ669/PRO1303: Kallikrein-12 precursor 0.027 0.265
ITLN1 ITLN1, INTL, UNQ640/PRO1270, ITLN, LFR: Intelectin-1 precursor 0.027 0.027
LAMC2 LAMC2, LAMB2T, LAMNB2: Laminin subunit gamma-2 precursor 0.027 0.027
PRSS36 PRSS36: Polyserase-2 precursor 0.027 0.265
NELL2 NELL2, NRP2: Protein kinase C-binding protein NELL2 precursor 0.027 0.027
PRSS27 PRSS27, MPN, UNQ1884/PRO4327: Serine protease 27 precursor 0.027 0.265
PRSS21 PRSS21, ESP1, UNQ266/PRO303, TEST1: Testisin precursor 0.027 0.265
PLGLA1 PLGLA1, PLGP2: Plasminogen-related protein A precursor 0.027 0.027
ELA2A ELA2A: Elastase-2A precursor 0.027 0.265
CR1L complement component (3b/4b) receptor 1-like 0.027 0.027
CLEC14A CLEC14A, C14orf27, UNQ236/PRO269, EGFR5: C-type lectin domain family 14 member A 0.027 0.027
ITLN2 ITLN2, UNQ2789/PRO7179: Intelectin-2 precursor 0.027 0.027
MUC13 MUC13, DRCC1, UNQ6194/PRO20221, RECC: Mucin-13 precursor 0.027 0.027
NETO1 N/A 0.027 0.027
NTNG2 N/A 0.027 0.027
PRRG4 PRRG4, TMG4: Transmembrane gamma-carboxyglutamic acid protein 4 precursor 0.027 0.027
CFHR3 CFHR3, CFHL3, FHR3: Complement factor H-related protein 3 precursor 0.027 0.027
MASP2 MASP2: Mannan-binding lectin serine protease 2 precursor 0.027 0.265
CSPG3 CSPG3, NCAN, NEUR: Neurocan core protein precursor 0.027 0.027
SCARF2 SCARF2, SREC2, SREPCR: Scavenger receptor class F member 2 precursor 0.027 0.027
HHIP HHIP, HIP, UNQ5825/PRO19644: Hedgehog-interacting protein precursor 0.027 0.027
NTN4 NTN4: Netrin-4 precursor 0.027 0.027
PAPPA2 PAPPA2, PLAC3: Pappalysin-2 precursor 0.027 0.027
GP2 GP2: Pancreatic secretory granule membrane major glycoprotein GP2 precursor 0.027 0.027
PRRG1 PRRG1, PRGP1, TMG1: Transmembrane gamma-carboxyglutamic acid protein 1 precursor 0.027 0.027
TPSAB1 N/A 0.027 0.265
ITGAV ITGAV, MSK8, VNRA: Integrin alpha-V precursor 0.026 0.040
UNC5D N/A 0.025 0.025
VNN1 VNN1: Pantetheinase precursor 0.025 0.025
ITM2C ITM2C, BRI3, hucep-14, NPD018, PSEC0047: Integral membrane protein 2C 0.025 0.025
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.025 0.025
CA11 CA11, CARP2, UNQ211/PRO237: Carbonic anhydrase-related protein 11 precursor 0.025 0.025
CNTN1 CNTN1: Contactin-1 precursor 0.025 0.025
SCRIB N/A 0.025 0.025
CNTN4 CNTN4: Contactin-4 precursor 0.025 0.025
LOC641705 AMY2A: Pancreatic alpha-amylase precursor 0.025 0.025
PLTP PLTP: Phospholipid transfer protein precursor 0.025 0.025
2.15E-3
Total Score 320.00