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Evidence of Interaction Between EPHA2 and EFNA3

The interaction score between EPHA2 and EFNA3 is 15.20.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EPHA2 and EFNA3 = -0.12

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.48E-3
Orthology
OrganismEPHA2 OrthologueEFNA3 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm O61460 0.312 O44516 0.219
  • pullDown

Get References From PubMed

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.341
Domains Domains present in EPHA2 and EFNA3:
Domains in EPHA2Domains in EFNA3
IPR006209 EGF-like domain
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR001090 Ephrin receptor, ligand binding
IPR001426 Receptor tyrosine kinase, class V
IPR001660 Sterile alpha motif SAM
IPR003961 Fibronectin, type III
IPR008957 Fibronectin, type III-like fold
IPR008979 Galactose-binding like
IPR013032 IPR006209.
IPR013761 Sterile alpha motif-type
IPR008972 Cupredoxin
IPR001799 Ephrin

The Chi square scores for co-occurrence of domains that are present in EPHA2 and EFNA3 are listed below.

Domain 1Domain 2Chi Square
IPR001426 Receptor tyrosine kinase, class V IPR001799 Ephrin 1988.46
IPR001090 Ephrin receptor, ligand binding IPR001799 Ephrin 1988.46
IPR001426 Receptor tyrosine kinase, class V IPR008972 Cupredoxin 708.194
IPR001090 Ephrin receptor, ligand binding IPR008972 Cupredoxin 708.194
IPR001660 Sterile alpha motif SAM IPR001799 Ephrin 683.581
IPR013761 Sterile alpha motif-type IPR001799 Ephrin 387.685
IPR008979 Galactose-binding like IPR001799 Ephrin 246.01
IPR001660 Sterile alpha motif SAM IPR008972 Cupredoxin 235.778
IPR003961 Fibronectin, type III IPR001799 Ephrin 147.446
IPR013761 Sterile alpha motif-type IPR008972 Cupredoxin 100.303
IPR008957 Fibronectin, type III-like fold IPR001799 Ephrin 99.447
IPR006209 EGF-like domain IPR008972 Cupredoxin 96.6944
IPR008979 Galactose-binding like IPR008972 Cupredoxin 84.3596
IPR008266 Tyrosine protein kinase, active site IPR001799 Ephrin 73.3233
IPR013032 IPR006209. IPR008972 Cupredoxin 72.2435
IPR001245 Tyrosine protein kinase IPR001799 Ephrin 64.1366
IPR006209 EGF-like domain IPR001799 Ephrin 50.0861
IPR003961 Fibronectin, type III IPR008972 Cupredoxin 42.4026
IPR000719 Protein kinase IPR001799 Ephrin 30.3648
IPR008957 Fibronectin, type III-like fold IPR008972 Cupredoxin 21.2535
IPR008266 Tyrosine protein kinase, active site IPR008972 Cupredoxin 16.4698
IPR013032 IPR006209. IPR001799 Ephrin 15.905
IPR001245 Tyrosine protein kinase IPR008972 Cupredoxin 13.2721
IPR000719 Protein kinase IPR008972 Cupredoxin 2.76992
IPR011009 Protein kinase-like IPR001799 Ephrin 1.52758
IPR011009 Protein kinase-like IPR008972 Cupredoxin 0.0890287

The background colour of the table refers to:

  • Blue Domain is only present in EPHA2
  • Yellow Domain is only present in EFNA3
  • Green Domain is present in both EPHA2 and EFNA3

 0.217
Post-translational Modifications

Protein: EPHA2

PTMResidueReference
Phosphorylation 588 PubMed, HPRD
Phosphorylation 594 PubMed, HPRD
Phosphorylation 772 PubMed, HPRD
Phosphotyrosine 588 PubMed, HPRD
Phosphotyrosine 594 PubMed, HPRD
Phosphotyrosine 772 PubMed, HPRD
Phosphotyrosine 921 PubMed, HPRD

Protein: EFNA3

PTMResidueReference
Localisation

Protein: EPHA2

LocalisationReference
Plasma membrane HPRD

Protein: EFNA3

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between EPHA2 and EFNA3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EPHA2 andEFNA3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EPHA2 has 1476 interactors and EFNA3 has 178 interactors of which there are 65 common interactors.

Common InteractorName of Common InteractorScore for EPHA2-Interactor (?)Score for EFNA3-Interactor (?)
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 108.00 17.50
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 82.20 19.70
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 71.20 29.60
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 65.60 27.30
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 65.60 19.40
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 53.10 22.10
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 46.90 36.10
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 46.80 55.00
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 46.80 15.30
ITGB4 N/A 0.515 0.143
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.355 0.0924
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.217
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.027
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.027
FN1 N/A 0.165 0.265
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.152 0.143
CNTN1 CNTN1: Contactin-1 precursor 0.148 0.027
CNTN4 CNTN4: Contactin-4 precursor 0.148 0.027
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.148 0.195
NEO1 NEO1, NGN: Neogenin precursor 0.111 0.179
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.027
BGLAP BGLAP: Osteocalcin precursor 0.109 0.027
F11 F11: Coagulation factor XI precursor 0.109 0.027
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.098 0.032
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.098 0.053
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.098 0.126
KLK3 KLK3, APS: Prostate-specific antigen precursor 0.098 0.027
F7 F7: Coagulation factor VII precursor 0.098 0.027
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.098 0.027
PLAT PLAT: Tissue-type plasminogen activator precursor 0.098 0.027
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.097 0.044
DCC DCC: Netrin receptor DCC precursor 0.097 0.128
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.090 0.083
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.088 0.305
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.088 0.039
PTPRZ1 N/A 0.088 0.065
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.073 0.083
CXorf9 N/A 0.064 0.105
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.064 0.028
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.062 0.141
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.058 0.191
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 0.051 0.0288
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.0288
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.0288
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.0288
FN1 FN1, FN: Fibronectin precursor 0.051 0.0288
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.046 0.0288
SCML2 SCML2: Sex comb on midleg-like protein 2 0.045 0.0924
TP73 TP73, P73: Tumor protein p73 0.041 0.105
PTPRS PTPRS: Protein tyrosine phosphatase, receptor type, S 0.0308 0.143
PTPRD PTPRD: PTPRD protein 0.027 0.217
IL22RA2 IL22RA2, UNQ5793/PRO19598/PRO19822: Interleukin-22 receptor alpha-2 chain precur 0.027 0.027
GP2 GP2: Pancreatic secretory granule membrane major glycoprotein GP2 precursor 0.027 0.027
CRLF1 CRLF1, ZCYTOR5, UNQ288/PRO327: Cytokine receptor-like factor 1 precursor 0.027 0.027
IL5RA N/A 0.027 0.027
KREMEN2 KREMEN2, KRM2: Kremen protein 2 precursor 0.027 0.027
CLEC14A CLEC14A, C14orf27, UNQ236/PRO269, EGFR5: C-type lectin domain family 14 member A 0.027 0.027
ROBO1 N/A 0.027 0.027
NELL2 NELL2, NRP2: Protein kinase C-binding protein NELL2 precursor 0.027 0.027
NTN4 NTN4: Netrin-4 precursor 0.027 0.027
MUC13 MUC13, DRCC1, UNQ6194/PRO20221, RECC: Mucin-13 precursor 0.027 0.027
PTPRT PTPRT, KIAA0283: Receptor-type tyrosine-protein phosphatase T precursor 0.027 0.265
TRIM42 TRIM42: Tripartite motif-containing protein 42 0.027 0.027
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.026 0.027
INPPL1 INPPL1, SHIP2: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 0.0258 0.0288
2.15E-3
Total Score 15.20