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Evidence of Interaction Between SOCS1 and INSR

The interaction score between SOCS1 and INSR is 29.30.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SOCS1 and INSR = -0.05

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

1.62E-3
Orthology
OrganismSOCS1 OrthologueINSR OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly Q8INY1 1 P09208 0.377

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3
Domains Domains present in SOCS1 and INSR:
Domains in SOCS1Domains in INSR
IPR000980 SH2 motif
IPR001496 SOCS protein, C-terminal
IPR000494 Epidermal growth-factor receptor (EGFR), L domain
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR006211 Furin-like cysteine rich region
IPR006212 Furin-like repeat
IPR008266 Tyrosine protein kinase, active site
IPR003961 Fibronectin, type III
IPR002011 Receptor tyrosine kinase, class II

The Chi square scores for co-occurrence of domains that are present in SOCS1 and INSR are listed below.

Domain 1Domain 2Chi Square
IPR000980 SH2 motif IPR008266 Tyrosine protein kinase, active site 383.26
IPR000980 SH2 motif IPR001245 Tyrosine protein kinase 238.73
IPR000980 SH2 motif IPR003961 Fibronectin, type III 184.508
IPR000980 SH2 motif IPR000719 Protein kinase 82.1364
IPR001496 SOCS protein, C-terminal IPR003961 Fibronectin, type III 73.3816
IPR000980 SH2 motif IPR000494 Epidermal growth-factor receptor (EGFR), L domain 46.2087
IPR000980 SH2 motif IPR006211 Furin-like cysteine rich region 46.2087
IPR000980 SH2 motif IPR006212 Furin-like repeat 43.075
IPR000980 SH2 motif IPR002011 Receptor tyrosine kinase, class II 24.6768
IPR001496 SOCS protein, C-terminal IPR008266 Tyrosine protein kinase, active site 19.5756
IPR001496 SOCS protein, C-terminal IPR001245 Tyrosine protein kinase 12.3822
IPR001496 SOCS protein, C-terminal IPR000494 Epidermal growth-factor receptor (EGFR), L domain 7.71735
IPR001496 SOCS protein, C-terminal IPR006211 Furin-like cysteine rich region 7.71735
IPR001496 SOCS protein, C-terminal IPR006212 Furin-like repeat 7.35881
IPR001496 SOCS protein, C-terminal IPR000719 Protein kinase 2.92744

The background colour of the table refers to:

  • Blue Domain is only present in SOCS1
  • Yellow Domain is only present in INSR
  • Green Domain is present in both SOCS1 and INSR

0.217
Post-translational Modifications

Protein: SOCS1

PTMResidueReference

Protein: INSR

PTMResidueReference
Dephosphorylation 999 PubMed, HPRD
Dephosphorylation 1185 PubMed, HPRD
Dephosphorylation 1189 PubMed, HPRD
Dephosphorylation 1190 PubMed, HPRD
Glycosylation 43 PubMed, HPRD
Glycosylation 52 PubMed, HPRD
Glycosylation 105 PubMed, HPRD
Glycosylation 138 PubMed, HPRD
Glycosylation 424 PubMed, HPRD
Glycosylation 445 PubMed, HPRD
Glycosylation 769 PubMed, HPRD
Glycosylation 782 PubMed, HPRD
Glycosylation 920 PubMed, HPRD
Glycosylation 933 PubMed, HPRD
N-linked 541 PubMed, HPRD
Phosphorylation 992 PubMed, HPRD
Phosphorylation 999 PubMed, HPRD
Phosphorylation 1062 PubMed, HPRD
Phosphorylation 1064 PubMed, HPRD
Phosphorylation 1185 PubMed, HPRD
Phosphorylation 1189 PubMed, HPRD
Phosphorylation 1190 PubMed, HPRD
Phosphorylation 1314 PubMed, HPRD
Phosphorylation 1332 PubMed, HPRD
Phosphorylation 1333 PubMed, HPRD
Phosphorylation 1348 PubMed, HPRD
Phosphorylation 1354 PubMed, HPRD
Phosphorylation 1355 PubMed, HPRD
Phosphorylation 1361 PubMed, HPRD
Phosphorylation 1362 PubMed, HPRD
Phosphorylation 1375 PubMed, HPRD
Phosphotyrosine 992 PubMed, HPRD
Phosphotyrosine 999 PubMed, HPRD
Phosphotyrosine 1011 PubMed, HPRD
Phosphotyrosine 1185 PubMed, HPRD
Phosphotyrosine 1189 PubMed, HPRD
Phosphotyrosine 1190 PubMed, HPRD
Phosphotyrosine 1355 PubMed, HPRD
Phosphotyrosine 1361 PubMed, HPRD
Localisation

Protein: SOCS1

LocalisationReference
Cytoplasm HPRD

Protein: INSR

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Transitive Score

The common interactors between SOCS1 and INSR that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SOCS1 andINSR. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SOCS1 has 344 interactors and INSR has 1177 interactors of which there are 160 common interactors.

Common InteractorName of Common InteractorScore for SOCS1-Interactor (?)Score for INSR-Interactor (?)
CSK CSK: Tyrosine-protein kinase CSK 0.440 0.520
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.402 0.731
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.360 0.577
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.360 0.577
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.330 0.097
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.305 0.644
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.305 0.577
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.274 0.577
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.265 0.878
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.265 0.980
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.265
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.265 0.980
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.244 0.644
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.244 0.072
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.237 0.878
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.237 0.098
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.225 0.111
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.225 0.097
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.225 0.111
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.218 0.577
FGFR2 N/A 0.217 0.027
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.217 0.165
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.217 0.165
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.217 0.165
FYN N/A 0.197 0.129
BMX N/A 0.197 0.902
LYN LYN: Tyrosine-protein kinase Lyn 0.197 0.577
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.197 0.581
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.195 0.148
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.195 0.148
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.195 0.148
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.195 0.148
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.179 0.111
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.179 0.097
SYK SYK: Tyrosine-protein kinase SYK 0.177 0.577
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.177 0.577
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.177 277.00
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.174 0.644
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.174 0.577
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.174 0.129
HCK N/A 0.174 0.577
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.162 0.111
MET MET: Hepatocyte growth factor receptor precursor 0.162 0.123
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.156 0.520
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.156 0.064
JAK1 0.156 0.520
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.156 0.655
ALK ALK: ALK tyrosine kinase receptor precursor 0.145 0.064
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.145 0.097
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.145 0.111
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.145 0.111
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.145 0.136
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.145 0.171
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.143 0.136
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.143 0.171
KIT KIT: Mast/stem cell growth factor receptor precursor 0.143 0.111
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.143 0.191
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.129 0.171
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.129 0.191
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.128 0.088
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.128 0.088
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.128 0.111
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.126 0.098
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.115 0.097
APS SH2B2, APS: SH2B adapter protein 2 0.074 0.577
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.067 0.032
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.065 0.098
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.053 0.123
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.053 0.098
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.050 0.026
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.050 0.058
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.050 0.065
PLD1 PLD1: Phospholipase D1 0.044 0.090
STK16 N/A 0.041 0.065
GRAP GRAP: GRB2-related adapter protein 0.041 61.50
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.041 0.065
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.041 0.073
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.041 0.065
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.041 0.081
IL9R IL9R: Interleukin-9 receptor precursor 0.039 0.098
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.039 0.109
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.039 0.109
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.039 0.109
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.036 0.064
TLN1 TLN1: Uncharacterized protein TLN1 0.036 0.073
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.036 0.064
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.036 0.064
FNBP1 N/A 0.036 0.064
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.036 0.064
PVR PVR, PVS: Poliovirus receptor precursor 0.032 0.109
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.032 0.037
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.032 0.098
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.0308 0.072
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.0308 0.072
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.0308 0.731
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.0308 0.081
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0308 0.032
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.0308 0.029
WASPIP N/A 0.0308 0.026
ROCK1 ROCK1: Rho-associated protein kinase 1 0.0308 0.065
CD2AP CD2AP: CD2-associated protein 0.0308 0.064
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.0308 0.109
GAB1 GAB1: GRB2-associated-binding protein 1 0.0308 0.081
GRB7 GRB7: Growth factor receptor-bound protein 7 0.0308 0.200
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.0288 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.0288 0.051
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.0288 0.051
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.0288 0.051
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.029 0.041
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.028 0.058
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.028 0.058
CXorf9 N/A 0.028 0.058
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.028 0.064
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.028 0.064
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.028 0.064
DOK1 DOK1: Docking protein 1 0.028 0.058
SHB SHB: SH2 domain-containing adapter protein B 0.028 0.145
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.028 0.064
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.028 0.090
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.028 0.058
CRKL CRKL: Crk-like protein 0.028 277.00
PLD2 PLD2: Phospholipase D2 0.028 0.073
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.028 0.064
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.028 0.033
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
PSCD2 N/A 0.027 0.109
MAP2K5 N/A 0.027 0.049
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.027 0.098
CNN2 CNN2: Calponin-2 0.027 0.109
MAPK15 N/A 0.027 0.109
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.049
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.027 0.098
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.217
NF2 NF2, SCH: Merlin 0.027 0.109
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.027 0.098
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.027 0.980
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.027 0.025
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.049
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
DNM3 DNM3: Uncharacterized protein DNM3 0.027 0.109
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.027 0.109
EEF2K EEF2K: Elongation factor 2 kinase 0.027 0.098
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.217
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.027 0.109
STAT3 0.027 0.878
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.027 0.098
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.217
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.217
LNK SH2B3, LNK: SH2B adapter protein 3 0.027 0.980
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.027 0.980
AMPH AMPH, AMPH1: Amphiphysin 0.027 0.109
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.027 0.109
FLT4 VEGFR3 long form 0.0258 0.046
FES N/A 0.0258 0.0258
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.0258 0.046
0.572
Total Score 29.30