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Evidence of Interaction Between SOCS1 and CSF1R

The interaction score between SOCS1 and CSF1R is 32.70.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SOCS1 and CSF1R = -0.05

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.62E-3
Orthology N/A N/A
Domains Domains present in SOCS1 and CSF1R:
Domains in SOCS1Domains in CSF1R
IPR000980 SH2 motif
IPR001496 SOCS protein, C-terminal
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR003598 Immunoglobulin C-2 type
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like
IPR001824 Receptor tyrosine kinase, class III
IPR013151 Immunoglobulin.
IPR013106 V-set.

The Chi square scores for co-occurrence of domains that are present in SOCS1 and CSF1R are listed below.

Domain 1Domain 2Chi Square
IPR000980 SH2 motif IPR008266 Tyrosine protein kinase, active site 383.26
IPR000980 SH2 motif IPR001245 Tyrosine protein kinase 238.73
IPR000980 SH2 motif IPR001824 Receptor tyrosine kinase, class III 101.074
IPR000980 SH2 motif IPR007110 Immunoglobulin-like 94.9752
IPR000980 SH2 motif IPR000719 Protein kinase 82.1364
IPR000980 SH2 motif IPR003599 Immunoglobulin subtype 66.4833
IPR000980 SH2 motif IPR003598 Immunoglobulin C-2 type 64.7072
IPR000980 SH2 motif IPR011009 Protein kinase-like 59.6059
IPR000980 SH2 motif IPR013151 Immunoglobulin. 36.9251
IPR001496 SOCS protein, C-terminal IPR008266 Tyrosine protein kinase, active site 19.5756
IPR000980 SH2 motif IPR013106 V-set. 15.1643
IPR001496 SOCS protein, C-terminal IPR001245 Tyrosine protein kinase 12.3822
IPR001496 SOCS protein, C-terminal IPR011009 Protein kinase-like 3.49909
IPR001496 SOCS protein, C-terminal IPR000719 Protein kinase 2.92744
IPR001496 SOCS protein, C-terminal IPR007110 Immunoglobulin-like 0.260623

The background colour of the table refers to:

  • Blue Domain is only present in SOCS1
  • Yellow Domain is only present in CSF1R
  • Green Domain is present in both SOCS1 and CSF1R

 0.217
Post-translational Modifications

Protein: SOCS1

PTMResidueReference

Protein: CSF1R

PTMResidueReference
N-linked 302 PubMed, HPRD
N-linked 353 PubMed, HPRD
Phosphorylation 723 PubMed, HPRD
Phosphorylation 809 PubMed, HPRD
Localisation

Protein: SOCS1

LocalisationReference
Cytoplasm HPRD

Protein: CSF1R

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between SOCS1 and CSF1R that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SOCS1 andCSF1R. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SOCS1 has 344 interactors and CSF1R has 1458 interactors of which there are 178 common interactors.

Common InteractorName of Common InteractorScore for SOCS1-Interactor (?)Score for CSF1R-Interactor (?)
CSK CSK: Tyrosine-protein kinase CSK 0.440 1.33
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.402 0.902
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.360 1.48
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.360 0.577
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.330 0.088
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.305 0.644
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.305 2.73
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.274 1.81
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.265 422.00
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.265 0.980
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.265
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.265 0.980
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.244 0.581
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.244 0.081
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.237 0.980
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.237 0.098
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.225 53.10
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.225 0.097
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.225 53.10
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.218 0.520
FGFR2 N/A 0.217 0.027
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.217 0.165
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.217 0.165
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.217 0.165
FYN N/A 0.197 0.330
BMX N/A 0.197 0.644
LYN LYN: Tyrosine-protein kinase Lyn 0.197 2.73
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.197 0.731
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.195 0.148
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.195 0.148
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.195 0.165
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.195 71.20
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.179 0.088
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.179 42.20
SYK SYK: Tyrosine-protein kinase SYK 0.177 1.81
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.177 0.731
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.177 1.06E3
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.174 0.581
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.174 0.520
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.174 0.162
HCK N/A 0.174 4.52
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.162 0.136
TIE1 TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor 0.162 0.0308
MET MET: Hepatocyte growth factor receptor precursor 0.162 0.098
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.156 0.655
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.156 30.80
JAK1 0.156 1.13
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.156 0.808
ALK ALK: ALK tyrosine kinase receptor precursor 0.145 0.073
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.145 0.097
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.145 0.136
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.145 112.00
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.145 0.136
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.145 53.10
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.143 112.00
KIT KIT: Mast/stem cell growth factor receptor precursor 0.143 46.80
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.143 0.123
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.129 46.80
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.129 0.123
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.128 0.098
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.128 53.10
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.128 0.111
INSR INSR: Insulin receptor precursor 0.128 0.171
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.126 46.90
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.115 0.088
APS SH2B2, APS: SH2B adapter protein 2 0.074 0.655
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.067 0.037
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.065 0.109
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.053 0.098
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.053 0.109
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.050 0.026
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.050 30.80
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.050 0.202
PLD1 PLD1: Phospholipase D1 0.044 0.064
STK16 N/A 0.041 0.037
GRAP GRAP: GRB2-related adapter protein 0.041 61.50
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.041 0.166
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.041 0.058
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.041 0.081
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.041 0.166
IL9R IL9R: Interleukin-9 receptor precursor 0.039 0.098
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.039 0.109
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.039 0.109
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.039 0.109
CDK2 CDK2: Cell division protein kinase 2 0.036 0.029
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.036 0.029
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.036 0.113
GSK3A GSK3A: Glycogen synthase kinase-3 alpha 0.036 0.029
WEE1 WEE1: Wee1-like protein kinase 0.036 0.032
TLN1 TLN1: Uncharacterized protein TLN1 0.036 0.181
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.036 0.090
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.036 0.032
CDK4 CDK4: Cell division protein kinase 4 0.036 0.029
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.036 0.051
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.036 0.069
FNBP1 N/A 0.036 0.113
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.036 0.058
PVR PVR, PVS: Poliovirus receptor precursor 0.032 0.109
IL1R2 IL1R2, IL1RB: Interleukin-1 receptor type II precursor 0.032 0.041
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.032 0.057
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.032 0.109
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.0308 0.065
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.0308 0.0453
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.0308 0.902
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.0308 0.0727
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0308 0.072
WASPIP N/A 0.0308 0.067
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.0308 0.029
MAPK4 MAPK4, ERK4, PRKM4: Mitogen-activated protein kinase 4 0.0308 0.032
ROCK1 ROCK1: Rho-associated protein kinase 1 0.0308 0.126
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.0308 0.032
CD2AP CD2AP: CD2-associated protein 0.0308 0.073
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.0308 0.109
GAB1 GAB1: GRB2-associated-binding protein 1 0.0308 0.081
GRB7 GRB7: Growth factor receptor-bound protein 7 0.0308 0.162
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.0288 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.0288 0.051
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.0288 0.051
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.0288 0.051
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.029 0.071
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.029 0.035
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.028 0.090
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.028 0.051
CXorf9 N/A 0.028 0.181
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.028 0.029
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.028 0.065
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.028 0.029
CDK7 CDK7, MO15: Cell division protein kinase 7 0.028 0.029
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.028 0.026
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.028 0.181
DOK1 DOK1: Docking protein 1 0.028 0.245
SHB SHB: SH2 domain-containing adapter protein B 0.028 0.115
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.028 0.029
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.028 0.029
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.028 0.113
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.028 0.113
CRKL CRKL: Crk-like protein 0.028 388.00
PLD2 PLD2: Phospholipase D2 0.028 0.064
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.028 0.033
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.028 0.026
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.028 0.029
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
PSCD2 N/A 0.027 0.109
MAP2K5 N/A 0.027 0.049
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.027 0.098
CNN2 CNN2: Calponin-2 0.027 0.109
MAPK15 N/A 0.027 0.049
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.049
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.027 0.044
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.217
NF2 NF2, SCH: Merlin 0.027 0.109
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.027 0.044
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.027 0.980
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.027 0.075
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.049
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
DNM3 DNM3: Uncharacterized protein DNM3 0.027 0.109
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.027 0.109
EEF2K EEF2K: Elongation factor 2 kinase 0.027 0.098
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.217
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.027 0.109
CDC2 CDC2: Cell division control protein 2 homolog 0.027 0.044
STAT3 0.027 0.878
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.027 0.098
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.217
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.217
LNK SH2B3, LNK: SH2B adapter protein 3 0.027 0.980
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.027 0.980
AMPH AMPH, AMPH1: Amphiphysin 0.027 0.109
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.027 0.109
FLT4 VEGFR3 long form 0.0258 0.046
FES N/A 0.0258 0.0258
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.0258 0.046
0.572
Total Score 32.70