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Evidence of Interaction Between TBP and GTF2A1

The interaction score between TBP and GTF2A1 is 564.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TBP and GTF2A1 = 0.06

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

1.85E-3
Orthology
OrganismTBP OrthologueGTF2A1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00395431 0.192 IPI00337314 0.148
bakers yeast YER148W 1 YOR194C 1
  • Other
  • GelRetardationAssay
  • AffinityChromatography
  • CoCrystalStructure
  • ReconstitutedComplex
  • DosageRescue

Get References From PubMed

worm P32085 1 O44625 1
fly P20227 1 P52654 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593
Domains No domains were used in calculating likelihood of interaction 0.027
Post-translational Modifications

Protein: TBP

PTMResidueReference

Protein: GTF2A1

PTMResidueReference
Phosphorylation 280 PubMed, HPRD
Phosphorylation 281 PubMed, HPRD
Phosphorylation 316 PubMed, HPRD
Phosphorylation 321 PubMed, HPRD
Phosphoserine 280 PubMed, HPRD
Phosphoserine 281 PubMed, HPRD
Phosphoserine 316 PubMed, HPRD
Phosphoserine 321 PubMed, HPRD
Localisation

Protein: TBP

LocalisationReference
Nucleus HPRD

Protein: GTF2A1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between TBP and GTF2A1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TBP andGTF2A1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TBP has 180 interactors and GTF2A1 has 523 interactors of which there are 12 common interactors.

Common InteractorName of Common InteractorScore for TBP-Interactor (?)Score for GTF2A1-Interactor (?)
GTF2A2 GTF2A2, TF2A2: Transcription initiation factor IIA gamma chain 19.70 0.326
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 11.70 4.95
H2AFX H2AFX, H2AX: Histone H2A.x 9.63 0.029
HIST1H4A HIST1H4A, H4/A, HIST1H4B, H4/I, H4/G, HIST1H4D, H4/B, H4/J, HIST1H4F, HIST4H4, H 4.72 0.038
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 1.27 0.025
EDF1 EDF1: Endothelial differentiation-related factor 1 0.354 0.025
SMARCA2 SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2 0.354 0.025
HIST3H2A HIST3H2A: Histone H2A type 3 0.071 0.025
BRD4 N/A 0.071 0.025
TBPL2 0.071 0.071
SOS1 SOS1: Son of sevenless homolog 1 0.044 0.049
CENPA CENPA: Histone H3-like centromeric protein A 0.041 0.032
0.299
Total Score 564.00