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Evidence of Interaction Between HSF1 and CREBBP

The interaction score between HSF1 and CREBBP is 16.20.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between HSF1 and CREBBP = 0.20

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 2.30E-3
Orthology
OrganismHSF1 OrthologueCREBBP OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00012878 0.135 IPI00478752 0.421
human IPI00220197 0.097 IPI00478752 0.421
human IPI00412469 0.794 IPI00478752 0.421
worm Q9XW45 1 P34545 0.421
fly P22813 1 O01368 0.385

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in HSF1 and CREBBP:
Domains in HSF1Domains in CREBBP
IPR000232 Heat shock factor (HSF)-type DNA-binding domain
IPR010542 Vertebrate heat shock transcription factor
IPR002341 HSF/ETS, DNA-binding
IPR011991 Wing_hlx_DNA_bd.
IPR001487 Bromodomain
IPR000197 TAZ finger
IPR000433 Zn-finger, ZZ type
IPR003101 Coactivator CBP, KIX
IPR009255 Protein of unknown function DUF906
IPR010303 Protein of unknown function DUF902

The Chi square scores for co-occurrence of domains that are present in HSF1 and CREBBP are listed below.

Domain 1Domain 2Chi Square
IPR011991 Wing_hlx_DNA_bd. IPR001487 Bromodomain 0.956527

The background colour of the table refers to:

  • Blue Domain is only present in HSF1
  • Yellow Domain is only present in CREBBP
  • Green Domain is present in both HSF1 and CREBBP

 0.165
Post-translational Modifications

Protein: HSF1

PTMResidueReference
Phosphorylation 142 PubMed, HPRD
Phosphorylation 230 PubMed, HPRD
Phosphorylation 303 PubMed, HPRD
Phosphorylation 307 PubMed, HPRD
Phosphorylation 363 PubMed, HPRD
Phosphoserine 303 HPRD
Phosphoserine 307 HPRD
Sumoylation 298 PubMed, HPRD

Protein: CREBBP

PTMResidueReference
Methylation 702 PubMed, HPRD
Methylation 714 PubMed, HPRD
Methylation 742 PubMed, HPRD
Methylation 768 PubMed, HPRD
Phosphorylation 302 PubMed, HPRD
Phosphorylation 437 PubMed, HPRD
Localisation

Protein: HSF1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: CREBBP

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between HSF1 and CREBBP that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between HSF1 andCREBBP. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , HSF1 has 862 interactors and CREBBP has 1102 interactors of which there are 669 common interactors.

Common InteractorName of Common InteractorScore for HSF1-Interactor (?)Score for CREBBP-Interactor (?)
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 65.60 0.029
EWSR1 EWSR1, EWS: RNA-binding protein EWS 1.37 0.137
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.416 0.127
MTA1 MTA1: Metastasis-associated protein MTA1 0.372 0.114
TP53 TP53, P53: Cellular tumor antigen p53 0.284 0.086
SRF SRF: Serum response factor 0.275 0.038
BRPF1 BRPF1, BR140: Peregrin 0.275 0.114
BATF BATF: Basic leucine zipper transcriptional factor ATF-like 0.251 0.251
RB1 RB1: Retinoblastoma-associated protein 0.251 0.0425
SMARCA4 SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4 0.251 0.060
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.233 0.188
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.233 0.038
ATF1 ATF1: Cyclic AMP-dependent transcription factor ATF-1 0.225 0.275
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.225 0.046
MAFG MAFG: Transcription factor MafG 0.225 0.171
BAZ2A BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A 0.225 0.188
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.225 0.118
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.216 0.158
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.208 0.344
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.208 0.038
EP300 N/A 0.208 0.063
BAZ1B BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain 0.191 0.096
NFATC1 N/A 0.191 0.127
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.188 0.029
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.188 0.038
CEBPE CEBPE: CCAAT/enhancer-binding protein epsilon 0.171 0.136
JUNB JUNB: Transcription factor jun-B 0.171 0.275
RERE RERE, ARG, ARP, ATN1L, KIAA0458: Arginine-glutamic acid dipeptide repeats protei 0.171 0.275
JUND JUND: Transcription factor jun-D 0.171 0.372
MAPK15 N/A 0.165 0.028
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.165 0.083
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.165 0.028
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.165 0.083
CENPA CENPA: Histone H3-like centromeric protein A 0.155 0.062
IRF3 IRF3: Interferon regulatory factor 3 0.155 0.307
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.155 0.026
STK16 N/A 0.155 0.032
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.152 0.152
DDIT3 DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3 0.152 0.123
BACH1 BACH1: Transcription regulator protein BACH1 0.152 0.416
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.148 0.027
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.148 0.025
BRD4 N/A 0.148 0.047
CREB1 CREB1: cAMP response element-binding protein 0.148 0.148
RBL1 RBL1: Retinoblastoma-like protein 1 0.148 0.025
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.148 0.025
GATAD2B GATAD2B, KIAA1150: Transcriptional repressor p66 beta 0.148 0.025
CCNT2 CCNT2: Cyclin-T2 0.148 0.025
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.139 0.139
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.139 0.275
TAF6 TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6 0.139 0.114
SYMPK SYMPK, SPK: Symplekin 0.139 0.029
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.139 0.038
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.139 0.046
NKX2-5 NKX2-5, CSX, NKX2.5, NKX2E: Homeobox protein Nkx-2.5 0.139 0.088
AKAP8L AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like 0.139 0.114
YY1 YY1: Transcriptional repressor protein YY1 0.139 0.188
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.139 0.188
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.137 0.137
FOS FOS, G0S7: Proto-oncogene protein c-fos 0.136 0.225
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 0.136 0.087
NFE2L2 NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2 0.136 0.225
JUN JUN: Transcription factor AP-1 0.136 0.225
GCN5L2 GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2 0.136 26.00
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.136 0.038
CCNL1 CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1 0.136 0.046
CCNH CCNH: Cyclin-H 0.136 0.029
PCAF PCAF: Histone acetyltransferase PCAF 0.136 0.054
RBL2 RBL2, RB2: Retinoblastoma-like protein 2 0.136 0.063
CEBPB CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta 0.136 0.225
SIRT1 SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1 0.136 0.372
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.127 0.123
NBN NBN, NBS, NBS1, P95: Nibrin 0.127 0.210
SNAPC4 SNAPC4, SNAP190: snRNA-activating protein complex subunit 4 0.127 0.251
UBTF UBTF, UBF, UBF1: Nucleolar transcription factor 1 0.127 0.052
XRCC1 XRCC1: DNA-repair protein XRCC1 0.127 0.0425
ZNF318 ZNF318, HRIHFB2436: Zinc finger protein 318 0.127 0.127
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.127 0.0425
ID3 ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3 0.127 0.062
TGIF2 TGIF2: Homeobox protein TGIF2 0.127 0.251
PRKAA1 N/A 0.127 0.032
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.126 0.057
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.123 0.152
TAF1 TAF1, BA2R, CCG1, CCGS, TAF2A: Transcription initiation factor TFIID subunit 1 0.123 0.039
HIST1H1B HIST1H1B, H1F5: Histone H1.5 0.123 0.111
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.114 0.029
H2AFX H2AFX, H2AX: Histone H2A.x 0.114 0.069
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.114 0.063
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.114 0.038
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.114 0.188
MYBL2 MYBL2, BMYB: Myb-related protein B 0.114 0.111
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.114 0.038
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.114 0.029
TCF3 TCF3, E2A, ITF1: Transcription factor E2-alpha 0.114 41.40
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.114 0.029
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.114 0.188
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.114 0.046
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.114 0.372
RELA RELA, NFKB3: Transcription factor p65 0.114 0.188
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.114 0.046
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.114 0.029
SUZ12 SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12 0.114 0.114
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.111 11.40
ATF6 ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha 0.111 0.275
MLL MLL, ALL1, HRX, HTRX, TRX1: Zinc finger protein HRX 0.111 0.114
RFX1 RFX1: MHC class II regulatory factor RFX1 0.097 0.097
FOSL2 FOSL2, FRA2: Fos-related antigen 2 0.097 0.136
H1FX H1FX: Histone H1x 0.096 0.251
ROCK1 ROCK1: Rho-associated protein kinase 1 0.096 0.155
GTF2F2 N/A 0.096 0.152
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.096 0.096
ELF1 ELF1: ETS-related transcription factor Elf-1 0.096 0.416
SP100 N/A 0.096 0.307
TP53BP1 TP53BP1: Tumor suppressor p53-binding protein 1 0.096 0.0425
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.096 0.026
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.096 0.026
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.096 0.0425
ZNF267 ZNF267: Zinc finger protein 267 0.096 0.307
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.096 0.026
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.096 0.096
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.096 0.026
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.096 0.0425
ZNF148 ZNF148, ZBP89: Zinc finger protein 148 0.096 0.210
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.087 0.046
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.087 0.063
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.087 0.046
SP1 SP1, TSFP1: Transcription factor Sp1 0.086 33.10
TAL1 TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1 0.086 0.056
SMAD3 SMAD3, MADH3: Mothers against decapentaplegic homolog 3 0.086 41.40
ZNF224 ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224 0.086 0.136
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.086 0.063
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.086 111.00
TOPBP1 TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1 0.086 0.038
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.086 0.097
ZBTB7A ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A 0.086 41.40
STK10 STK10: Uncharacterized protein STK10 0.086 0.063
RPS6KB1 N/A 0.086 0.046
APEX1 APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase 0.086 0.038
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.086 0.046
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 0.086 0.136
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.086 0.275
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.086 0.038
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.086 0.139
KLF1 KLF1, EKLF: Krueppel-like factor 1 0.086 26.80
MEF2D MEF2D: Myocyte-specific enhancer factor 2D 0.086 0.029
SMAD2 SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2 0.086 90.40
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.086 0.097
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.086 0.063
SP3 SP3: Transcription factor Sp3 0.086 0.233
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.086 0.046
MTF1 MTF1: Metal regulatory transcription factor 1 0.086 0.139
ZNF217 ZNF217, ZABC1: Zinc finger protein 217 0.086 0.188
KLF13 KLF13, BTEB3, NSLP1: Krueppel-like factor 13 0.086 0.114
ZNF335 ZNF335: Zinc finger protein 335 0.086 0.114
PPP1R8 N/A 0.086 0.046
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.086 0.029
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.083 0.028
CUTL1 CUTL1: Homeobox protein cut-like 1 0.083 0.165
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.083 0.083
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.083 0.165
ARNT ARNT: Aryl hydrocarbon receptor nuclear translocator 0.083 0.083
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.083 0.028
KIAA1443 HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez 0.083 0.165
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.083 0.165
POGZ POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain 0.083 0.083
ZFP91 ZFP91, FKSG11: Zinc finger protein 91 homolog 0.083 0.083
UHRF1 0.083 0.083
ZNF579 ZNF579: Zinc finger protein 579 0.083 0.083
SGK2 SGK2: Serine/threonine-protein kinase Sgk2 0.083 0.028
C20orf18 N/A 0.083 0.083
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.083 0.165
HES6 HES6: Transcription cofactor HES-6 0.083 0.083
ZNF644 ZNF644, KIAA1221, ZEP2: Zinc finger protein 644 0.083 0.083
ZHX1 ZHX1: Zinc fingers and homeoboxes protein 1 0.083 0.165
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.080 0.251
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.080 0.032
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.077 0.307
HIVEP1 N/A 0.077 0.127
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.077 0.032
POU2F1 POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1 0.077 0.251
ID2 ID2: DNA-binding protein inhibitor ID-2 0.077 0.155
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.077 0.0425
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.077 0.026
SAT SAT1, SAT: Diamine acetyltransferase 1 0.077 0.0425
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.077 0.0971
TERF2IP TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1 0.077 0.251
ERF ERF: ETS domain-containing transcription factor ERF 0.077 0.191
GRK1 GRK1, RHOK: Rhodopsin kinase precursor 0.077 0.026
MATR3 MATR3, KIAA0723: Matrin-3 0.077 0.127
SF3A1 SF3A1, SAP114: Splicing factor 3 subunit 1 0.076 0.035
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.075 0.100
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.075 0.025
CAMK1D CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D 0.075 0.025
PRDM2 PRDM2, RIZ: PR domain zinc finger protein 2 0.075 0.075
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.075 0.148
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.075 0.025
NCOA3 NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3 0.075 0.075
PRKACA PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit 0.075 0.025
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.075 0.025
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.075 0.025
CDC2 CDC2: Cell division control protein 2 homolog 0.075 0.025
ELMO1 N/A 0.075 0.075
ISL2 ISL2: Insulin gene enhancer protein ISL-2 0.075 0.148
RNF20 0.075 0.025
DHX8 DHX8, DDX8: ATP-dependent RNA helicase DHX8 0.075 0.025
OSR1 OSR1, ODD: Protein odd-skipped-related 1 0.075 0.075
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.075 0.025
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.075 0.025
DLX3 DLX3: Homeobox protein DLX-3 0.075 0.148
SOX8 SOX8: Transcription factor SOX-8 0.075 0.025
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.075 0.025
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.075 0.148
ZFPM1 ZFPM1, FOG1: Zinc finger protein ZFPM1 0.075 0.075
CARHSP1 CARHSP1: Calcium-regulated heat stable protein 1 0.075 0.025
SMAD1 SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1 0.075 0.075
TAL2 TAL2: T-cell acute lymphocytic leukemia protein 2 0.075 35.90
TFAP4 TFAP4: Transcription factor AP-4 0.075 0.075
MKNK1 MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1 0.075 0.025
MLXIPL MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein 0.075 0.075
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.075 0.075
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.075 0.025
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 0.075 0.025
MAX MAX: Protein max 0.075 0.075
NIPBL N/A 0.075 0.025
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.075 0.025
raptor RAPTOR, KIAA1303: Regulatory-associated protein of mTOR 0.075 0.025
HOXA10 HOXA10, HOX1H: Homeobox protein Hox-A10 0.075 0.148
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.075 0.025
ZNF174 ZNF174, ZSCAN8: Zinc finger protein 174 0.075 0.075
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.075 0.075
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.075 0.025
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.075 0.075
TRERF1 TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1 0.075 0.075
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.075 35.90
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.075 0.075
RPS6KA2 RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2 0.075 0.025
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.071 0.071
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.070 0.032
UBAP2 N/A 0.070 0.0425
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.070 0.052
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.070 0.032
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.069 0.063
ZNF24 ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24 0.069 0.188
BNC1 BNC1, BNC: Zinc finger protein basonuclin-1 0.069 0.044
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.069 0.038
ATM ATM: Serine-protein kinase ATM 0.069 0.038
EIF4G3 EIF4G3: Eukaryotic translation initiation factor 4 gamma 3 0.069 0.029
HES1 HES1, HL, HRY: Transcription factor HES-1 0.069 0.044
HIF1A HIF1A, MOP1: Hypoxia-inducible factor 1 alpha 0.069 0.114
SOS1 SOS1: Son of sevenless homolog 1 0.069 0.139
ZNF76 ZNF76, D6S229E: Zinc finger protein 76 0.069 0.114
ZBTB40 ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40 0.069 0.086
KIAA0690 N/A 0.069 0.038
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 0.069 0.114
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.069 0.188
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.069 0.063
HIST1H1E HIST1H1E, H1F4: Histone H1.4 0.069 0.171
HIST1H1D HIST1H1D, H1F3: Histone H1.3 0.069 0.225
ETV6 ETV6, TEL, TEL1: Transcription factor ETV6 0.069 0.225
HAND1 HAND1, EHAND: Heart- and neural crest derivatives-expressed protein 1 0.069 23.60
ETS1 ETS1, EWSR2: Protein C-ets-1 0.069 0.225
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.069 0.171
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.069 0.063
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.069 0.046
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.069 0.038
AHR AHR: Aryl hydrocarbon receptor precursor 0.069 0.086
NCOR1 NCOR1, KIAA1047: Nuclear receptor corepressor 1 0.069 0.275
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.069 0.029
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.067 0.111
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.067 13.60
SKIV2L SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti 0.063 0.038
TOPORS TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors 0.063 0.063
COPE COPE: Coatomer subunit epsilon 0.063 0.038
STAT2 STAT2: Signal transducer and activator of transcription 2 0.062 0.096
MYB MYB: Myb proto-oncogene protein 0.062 0.123
REST REST, NRSF, XBR: RE1-silencing transcription factor 0.062 0.055
TERF2 TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2 0.062 0.251
TERF1 TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1 0.062 0.251
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.062 0.052
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.062 0.060
SH3BP3 0.062 0.127
ETS2 ETS2: Protein C-ets-2 0.062 0.191
ZFX ZFX: Zinc finger X-chromosomal protein 0.062 0.096
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.060 0.087
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.060 0.032
SMARCA3 HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor 0.060 0.026
HD HD, IT15: Huntingtin 0.057 0.075
HIST2H2BE HIST2H2BE, H2BFQ: Histone H2B type 2-E 0.056 0.069
STAT4 STAT4: Signal transducer and activator of transcription 4 0.056 0.086
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.056 0.046
HIST1H4A HIST1H4A, H4/A, HIST1H4B, H4/I, H4/G, HIST1H4D, H4/B, H4/J, HIST1H4F, HIST4H4, H 0.056 0.049
ZNF551 N/A 0.056 0.136
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.056 0.046
TCF8 ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1 0.056 0.171
SMAD4 SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4 0.056 0.114
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.056 0.038
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.056 0.046
ZBTB16 ZBTB16, PLZF, ZNF145: Zinc finger and BTB domain-containing protein 16 0.056 0.056
ELK1 ELK1: ETS domain-containing protein Elk-1 0.056 0.111
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.056 0.038
HIST3H3 HIST3H3, H3FT: Histone H3.1t 0.056 0.086
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.056 0.136
SATB1 SATB1: DNA-binding protein SATB1 0.056 0.225
HIST1H1A HIST1H1A, H1F1: Histone H1.1 0.056 0.097
FOXO1A FOXO1A, FKHR: Forkhead box protein O1A 0.056 0.171
MEF2A N/A 0.055 0.052
ICK ICK, KIAA0936: Serine/threonine-protein kinase ICK 0.055 0.026
ZBTB33 KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso 0.055 0.062
SMAD7 SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7 0.055 0.096
ZHX3 ZHX3, KIAA0395, TIX1: Zinc fingers and homeoboxes protein 3 0.055 0.123
ERG ERG: Transcriptional regulator ERG 0.055 0.123
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.054 0.040
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.054 0.114
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.054 0.029
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.054 0.038
SUPT5H SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5 0.054 0.054
MAPKAPK5 N/A 0.052 0.028
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.052 0.028
SMARCAD1 SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator 0.052 0.028
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.052 0.028
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.052 0.028
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.052 0.028
GRLF1 N/A 0.052 0.026
AOF2 AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1 0.052 0.026
ARFGAP1 N/A 0.052 0.0425
EMD EMD, EDMD, STA: Emerin 0.052 0.032
COIL COIL, CLN80: Coilin 0.052 0.032
TRRAP N/A 0.052 0.0425
XRCC6 XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1 0.052 0.0425
ABCF1 N/A 0.052 0.0425
MAPK7 mitogen-activated protein kinase 7 isoform 1 0.052 0.0425
RBM14 RBM14, SIP: RNA-binding protein 14 0.052 0.052
DNMT1 DNMT1, AIM, DNMT: DNA 0.052 0.0425
UBAP2L UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like 0.052 0.052
ATF2 N/A 0.051 0.051
STAT6 STAT6: Signal transducer and activator of transcription 6 0.051 66.00
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.051 4.05
NFIB N/A 0.049 0.055
ETV1 ETV1, ER81: ETS translocation variant 1 0.049 0.109
MYF5 MYF5: Myogenic factor 5 0.049 0.049
KLF5 KLF5, BTEB2, CKLF, IKLF: Krueppel-like factor 5 0.049 0.044
EEA1 EEA1, ZFYVE2: Early endosome antigen 1 0.049 0.056
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.049 0.063
SNAI1 SNAI1, SNAH: Zinc finger protein SNAI1 0.049 0.056
MYCN MYCN, NMYC: N-myc proto-oncogene protein 0.049 0.069
HOXB6 HOXB6, HOX2B: Homeobox protein Hox-B6 0.049 0.088
EN2 EN2: Homeobox protein engrailed-2 0.049 0.136
WNK4 WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4 0.047 0.025
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.047 0.025
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.047 0.025
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.047 0.075
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.047 0.025
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.046 0.038
PIK4CB PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic, 0.046 0.063
TIAL1 TIAL1: Nucleolysin TIAR 0.046 0.046
EIF3S4 EIF3S4: Eukaryotic translation initiation factor 3 subunit 4 0.046 0.046
DUSP22 DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22 0.046 0.046
POLR2A POLR2A: Uncharacterized protein POLR2A 0.046 0.038
ZNF330 ZNF330, NOA36: Zinc finger protein 330 0.046 0.038
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 0.046 0.038
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.046 0.046
FZR1 N/A 0.046 0.038
SF3B4 SF3B4, SAP49: Splicing factor 3B subunit 4 0.046 0.046
NOC2L NOC2L: Nucleolar complex protein 2 homolog 0.046 0.029
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.046 0.063
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.046 0.046
AIP AIP, XAP2: AH receptor-interacting protein 0.046 0.046
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.046 0.038
SNRPC SNRPC: U1 small nuclear ribonucleoprotein C 0.046 0.029
WBSCR20A N/A 0.046 0.046
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.046 0.029
CPSF1 CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1 0.046 0.038
ESRRA ESRRA, ERR1, ESRL1, NR3B1: Steroid hormone receptor ERR1 0.046 0.111
KIAA0683 DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized 0.046 0.038
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.046 0.038
DDX41 DDX41, ABS: Probable ATP-dependent RNA helicase DDX41 0.046 0.038
DHX16 DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN 0.046 0.038
LSM2 LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2 0.046 0.029
SUMO2 SUMO2, SMT3B, SMT3H2: Small ubiquitin-related modifier 2 precursor 0.046 0.035
FOXL2 FOXL2: Forkhead box protein L2 0.044 0.097
SATB2 SATB2, KIAA1034: DNA-binding protein SATB2 0.044 0.097
SALL1 SALL1, SAL1: Sal-like protein 1 0.044 0.049
CDX2 CDX2, CDX3: Homeobox protein CDX-2 0.044 0.088
MEF2C MEF2C: Myocyte-specific enhancer factor 2C 0.044 11.10
EGR1 EGR1, ZNF225: Early growth response protein 1 0.044 0.056
STAT3 0.044 0.044
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.043 0.029
IKBKG IKBKG, FIP3, NEMO: NF-kappa-B essential modulator 0.0425 0.070
GTF3C1 N/A 0.0425 0.0425
DDX21 DDX21: Nucleolar RNA helicase 2 0.0425 0.0425
HMGN2 HMGN2, HMG17: Non-histone chromosomal protein HMG-17 0.0425 0.052
SREBF2 N/A 0.0425 0.032
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.0425 0.0425
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.0425 0.0425
NUP214 N/A 0.0425 0.0425
PTMA N/A 0.0425 0.052
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.0425 0.032
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.0425 0.0425
WDR1 N/A 0.0425 0.052
JMJD1A JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr 0.0425 0.052
GNB2L1 Lung cancer oncogene 7 0.0425 0.052
TCOF1 N/A 0.0425 0.0425
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.041 0.041
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.041 77.30
RFX5 RFX5: DNA-binding protein RFX5 0.041 0.050
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.040 0.049
DAPK2 DAPK2: Death-associated protein kinase 2 0.039 0.026
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.039 0.026
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 0.038 0.029
GSK3B N/A 0.038 0.046
SMC1L1 SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos 0.038 0.038
SAPS3 N/A 0.038 0.038
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.038 0.038
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.038 0.038
TDG TDG: G/T mismatch-specific thymine DNA glycosylase 0.038 0.038
SAFB SAFB, HAP, HET, SAFB1: Scaffold attachment factor B 0.038 0.046
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.038 0.038
SNRPB2 SNRPB2: U2 small nuclear ribonucleoprotein B'' 0.038 0.038
PHF10 N/A 0.038 0.114
NUP153 N/A 0.038 0.038
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.038 0.029
CBX3 CBX3: Chromobox protein homolog 3 0.038 0.225
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.038 0.029
HDAC3 HDAC3: Histone deacetylase 3 0.038 0.071
NRBP1 NRBP1, BCON3, NRBP: Nuclear receptor-binding protein 0.038 0.046
MSH6 MSH6, GTBP: DNA mismatch repair protein MSH6 0.038 0.029
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.038 0.046
MBD3 MBD3: Methyl-CpG-binding domain protein 3 0.038 0.029
SSB SSB: Lupus La protein 0.038 0.038
LIG1 LIG1: DNA ligase 1 0.038 0.029
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.038 0.029
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.038 0.038
RANBP9 RANBP9, RANBPM: Ran-binding protein 9 0.038 0.029
SFRS4 SFRS4, SRP75: Splicing factor, arginine/serine-rich 4 0.038 0.046
COPB2 COPB2: Coatomer subunit beta' 0.038 0.029
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.038 0.046
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.038 0.046
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.038 0.038
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.038 0.046
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.038 0.038
CSPG6 SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3 0.038 0.038
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.038 0.063
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.038 0.046
SND1 SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1 0.038 0.029
KLHDC4 N/A 0.038 0.046
UBA2 SAE2, UBA2, HRIHFB2115, UBLE1B: SUMO-activating enzyme subunit 2 0.038 0.038
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.038 0.046
ANP32B ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb 0.038 0.038
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.038 0.046
DAXX DAXX, BING2, DAP6: Death domain-associated protein 6 0.038 0.046
POLA2 POLA2: DNA polymerase subunit alpha B 0.038 0.029
ACIN1 ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus 0.038 0.038
DIAPH1 Diaphanous 1 0.038 0.063
C20orf4 C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4 0.038 0.029
ZCCHC8 ZCCHC8: Zinc finger CCHC domain-containing protein 8 0.038 0.046
STAG2 STAG2, SA2: Cohesin subunit SA-2 0.038 0.046
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.038 0.029
HDAC2 HDAC2: Histone deacetylase 2 0.038 0.054
PAPOLA PAPOLA, PAP: Poly(A) polymerase alpha 0.038 0.063
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.038 0.046
DOK1 DOK1: Docking protein 1 0.038 0.139
HDAC1 HDAC1, RPD3L1: Histone deacetylase 1 0.038 0.087
LIMK2 LIMK2: LIM domain kinase 2 0.037 0.075
GTF2E2 GTF2E2, TF2E2: Transcription initiation factor IIE subunit beta 0.036 0.036
CEBPG CEBPG: CCAAT/enhancer-binding protein gamma 0.036 0.036
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.036 0.057
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.035 0.029
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.035 0.038
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.033 0.033
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.033 0.067
PPP2R5A PPP2R5A: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha 0.033 0.032
EXOC2 N/A 0.033 0.067
RXRA RXRA, NR2B1: Retinoic acid receptor RXR-alpha 0.032 0.251
SH2BP1 CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog 0.032 0.052
PLEK PLEK, P47: Pleckstrin 0.032 0.155
VCPIP1 VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135 0.032 0.032
AFF1 N/A 0.032 0.0425
NCOA3 N/A 0.032 0.052
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.032 0.052
SMARCC2 N/A 0.032 0.052
SET SET: Protein SET 0.032 0.032
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.032 0.307
RBM6 RBM6, DEF3: RNA-binding protein 6 0.032 0.0425
KIAA0853 N/A 0.032 0.052
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.032 0.210
MYBBP1A MYBBP1A, P160: Myb-binding protein 1A 0.032 0.0425
IFI16 N/A 0.032 0.052
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.032 0.026
CHUK N/A 0.032 0.0425
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.032 0.0425
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.032 0.052
PHF8 PHF8, KIAA1111, ZNF422: PHD finger protein 8 0.032 0.032
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.032 0.029
PLXND1 PLXND1, KIAA0620: Plexin-D1 precursor 0.031 0.039
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.0308 0.029
SP110 SP110: Sp110 nuclear body protein 0.0308 0.067
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.029 0.026
BAG3 BAG3, BIS: BAG family molecular chaperone regulator 3 0.029 0.056
JARID1A JARID1A, RBBP2, RBP2: Histone demethylase JARID1A 0.029 0.188
MDN1 MDN1, KIAA0301: Midasin 0.029 0.029
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.029 0.046
YEATS2 KIAA1197, YEATS2: YEATS domain-containing protein 2 0.029 0.038
MYH9 MYH9: Myosin-9 0.029 0.275
CXorf9 N/A 0.029 0.046
SNRP70 SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa 0.029 0.038
FNBP1 N/A 0.029 0.063
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.029 0.029
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.029 0.046
MRE11A MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A 0.029 0.029
KIAA1012 KIAA1012: Protein TRS85 homolog 0.029 0.063
FKBP1A FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A 0.029 0.038
WBSCR1 EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H 0.029 0.038
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.029 0.063
NOL1 N/A 0.029 0.038
POLB POLB: DNA polymerase beta 0.029 0.038
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.029 0.046
RBM7 0.029 0.038
UNG N/A 0.029 0.029
CORO6 N/A 0.028 0.028
NIPA1 NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1 0.028 0.083
AR AR, DHTR, NR3C4: Androgen receptor 0.028 0.028
JDP2 jdp2, JDP2: Jun dimerization protein 2 0.028 0.028
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.028 0.028
RAB4A N/A 0.028 0.028
NF2 NF2, SCH: Merlin 0.028 0.052
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.028 0.083
TCF20 TCF20, KIAA0292, SPBP: Transcription factor 20 0.028 0.083
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.028 0.028
DKFZp434K1815 DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815 0.028 0.028
WDR54 N/A 0.028 0.028
CBFA2T2 CBFA2T2, EHT, MTGR1: Protein CBFA2T2 0.028 0.028
SYTL4 Endocrine transmitter regulatory protein 0.028 0.028
CCAR1 CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1 0.028 0.028
GPRASP2 GPRASP2: G-protein coupled receptor-associated sorting protein 2 0.028 0.028
PTBP1 PTBP1: Polypyrimidine tract binding protein 1 0.028 0.028
HDAC8 N/A 0.028 0.052
ZCCHC3 ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3 0.028 0.028
MITF MITF: Microphthalmia-associated transcription factor 0.028 0.028
BID BID: BH3-interacting domain death agonist 0.028 0.028
SNRPB N/A 0.028 0.028
ATXN2L ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein 0.028 0.028
KIF1B N/A 0.028 0.028
PPEF1 N/A 0.028 0.083
C14orf151 C14orf151: Uncharacterized protein C14orf151 (Fragment) 0.028 0.028
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.028 0.028
DUSP15 N/A 0.028 0.028
ILF3 ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3 0.028 0.028
HNRPC HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2 0.028 0.028
PPP1R12C PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C 0.028 0.028
DSP DSP: Desmoplakin 0.028 0.165
NFIA NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A 0.028 0.028
C13orf8 N/A 0.028 0.028
NES N/A 0.028 0.028
FLJ21816 PALB2, FANCN: Partner and localizer of BRCA2 0.028 0.028
FBXO4 FBXO4, FBX4: F-box only protein 4 0.028 0.028
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.028 0.028
ZNF265 N/A 0.028 0.028
IRF7 N/A 0.028 0.028
TMPO TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha 0.028 0.028
NSBP1 NSBP1: Nucleosome-binding protein 1 0.028 0.028
PHLDB2 N/A 0.028 0.028
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.028 0.028
CABLES1 N/A 0.028 0.028
ZNF687 ZNF687, KIAA1441: Zinc finger protein 687 0.028 0.028
SMARCA1 SMARCA1, SNF2L, SNF2L1: Probable global transcription activator SNF2L1 0.028 0.044
GATA6 GATA6: Transcription factor GATA-6 0.028 0.422
CREM CREM, RP11-324I22.1-005: cAMP responsive element modulator 0.027 0.027
DMD dystrophin: Dystrophin protein (Fragment) 0.027 0.027
CREM hCREM-1: HCREM 1alpha protein 0.027 0.027
DNM2 N/A 0.027 0.027
CDKN2D CDKN2D: Cyclin-dependent kinase 4 inhibitor D 0.026 0.052
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.026 0.052
TRIM16 TRIM16, EBBP: Tripartite motif-containing protein 16 0.026 0.055
FNBP4 FNBP4, FBP30, KIAA1014: Formin-binding protein 4 0.026 0.0425
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.026 0.210
STRN3 STRN3, GS2NA, SG2NA: Striatin-3 0.026 0.032
ITGB1BP1 ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1 0.026 0.032
TOP2B N/A 0.026 0.052
RGS14 N/A 0.026 0.052
VIM VIM: Vimentin 0.026 0.026
USP24 USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24 0.026 0.0425
DEF6 DEF6, IBP: Differentially expressed in FDCP 6 0.026 0.052
FAM65A FAM65A, KIAA1930: Protein FAM65A 0.026 0.026
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.026 0.416
MARK2 N/A 0.026 0.052
SFRS15 SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15 0.026 0.032
XRCC4 N/A 0.026 0.026
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.026 0.0425
RFXDC2 RFXDC2: Regulatory factor X domain-containing protein 2. 0.026 0.0425
PDE8B PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies 0.025 0.075
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.025 0.025
HTATIP N/A 0.025 0.025
SMU1 SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog 0.025 0.025
PURB PURB: Transcriptional activator protein Pur-beta 0.025 0.025
HNRPM HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M 0.025 0.025
NHN1 NHN1: Conserved nuclear protein NHN1 0.025 0.025
MAP2K3 N/A 0.025 0.025
SAP14 SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14 0.025 0.025
LMNA LMNA, LMN1: Lamin-A/C 0.025 0.025
HDAC7A N/A 0.025 0.025
DIDO1 N/A 0.025 0.075
CAMKK1 N/A 0.025 0.025
NEDD4 NEDD4: Uncharacterized protein NEDD4 0.025 0.025
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.025 0.075
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.025
GEMIN5 GEMIN5: Gem-associated protein 5 0.025 0.025
TCEA1 N/A 0.025 0.025
SETD3 SETD3, C14orf154: SET domain-containing protein 3 0.025 0.025
CETN1 CETN1, CEN1, CETN: Centrin-1 0.025 0.075
MAPK8IP3 N/A 0.025 0.025
C14orf4 C14orf4, KIAA1865, My039: RING finger protein C14orf4 0.025 0.025
SEC13L1 N/A 0.025 0.025
EEF2K EEF2K: Elongation factor 2 kinase 0.025 0.025
DDX20 DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20 0.025 0.025
SMN2 SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein 0.025 0.025
FLJ40432 FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227 0.025 0.025
MSL3L1 MSL3L1: Male-specific lethal 3-like 1 0.025 0.148
GRK6 N/A 0.025 0.025
PRKCB1 N/A 0.025 0.025
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.025 0.025
BCOR N/A 0.025 0.025
HEXIM2 HEXIM2, L3: Protein HEXIM2 0.025 0.025
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.025 0.025
SYAP1 SYAP1, PRO3113: Synapse-associated protein 1 0.025 0.025
SON 0.025 0.025
CDC25A CDC25A: M-phase inducer phosphatase 1 0.025 0.025
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.025 0.025
RBBP6 RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6 0.025 0.025
MLL4 WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7 0.025 0.075
NUP98 N/A 0.025 0.025
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.025 0.025
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.025 0.025
ATXN2L N/A 0.025 0.025
NFYA NFYA: Nuclear transcription factor Y subunit alpha 0.025 0.025
KCTD1 0.025 0.025
MKI67IP MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein 0.025 0.025
SFRS9 SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9 0.025 0.025
HNRPD HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0 0.025 0.025
BUB3 BUB3: Mitotic checkpoint protein BUB3 0.025 0.025
FAF1 FAF1, CGI-03: FAS-associated factor 1 0.025 0.025
MIER1 MIER1, KIAA1610: Mesoderm induction early response protein 1 0.025 0.075
PHF16 PHF16, JADE3, KIAA0215: Protein Jade-3 0.025 0.075
PPP1R9B PPP1R9B, PPP1R6: Neurabin-2 0.025 0.025
NSUN2 NSUN2, SAKI, TRM4: tRNA 0.025 0.025
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.025 0.025
GIT2 N/A 0.025 0.025
CAMK2A N/A 0.025 0.025
ZNF598 ZNF598: Zinc finger protein 598 0.025 0.025
SMARCA2 SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2 0.025 0.025
IWS1 IWS1, IWS1L: IWS1 homolog 0.025 0.025
RAD51 RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1 0.025 0.025
HNRPUL1 HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1 0.025 0.025
FLJ23436 N/A 0.025 0.025
C20orf77 N/A 0.025 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.025 0.025
POLR1C POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1 0.025 0.025
RNF113A RNF113A, RNF113, ZNF183: RING finger protein 113A 0.025 0.025
ADK ADK: Adenosine kinase 0.025 0.025
HIST3H2A HIST3H2A: Histone H2A type 3 0.025 0.025
RFFL RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin 0.025 0.025
HNRPA2B1 HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1 0.025 0.025
ARID4A ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A 0.025 0.148
REXO1 REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog 0.025 0.025
SSBP4 SSBP4: Single-stranded DNA-binding protein 4 0.025 0.025
TIA1 TIA1: Nucleolysin TIA-1 isoform p40 0.025 0.025
WWTR1 WWTR1, TAZ: WW domain-containing transcription regulator protein 1 0.025 0.075
CPNE1 RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12 0.025 0.025
EDF1 EDF1: Endothelial differentiation-related factor 1 0.025 0.025
PSIP1 PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein 0.025 0.025
0.299
Total Score 16.20