PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between SMAD3 and FOXO1A

The interaction score between SMAD3 and FOXO1A is 26.80.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between SMAD3 and FOXO1A = 0.38

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

3.80E-3

Orthology

Organism	SMAD3 Orthologue		FOXO1A Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
worm	Q02330	0.219	Q86S42	0.285

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3

Domains

Domains present in SMAD3 and FOXO1A:

Domains in SMAD3

Domains in FOXO1A

IPR008984	SMAD/FHA
IPR003619	Dwarfin protein, domain A
IPR001132	Dwarfin protein
IPR013019	MAD_MH1.

IPR001766	Fork head transcription factor
IPR011991	Wing_hlx_DNA_bd.

The Chi square scores for co-occurrence of domains that are present in SMAD3 and FOXO1A are listed below.

Domain 1		Domain 2		Chi Square
IPR001132	Dwarfin protein	IPR001766	Fork head transcription factor	46.3494
IPR013019	MAD_MH1.	IPR001766	Fork head transcription factor	46.3494
IPR003619	Dwarfin protein, domain A	IPR001766	Fork head transcription factor	45.9487
IPR008984	SMAD/FHA	IPR001766	Fork head transcription factor	17.0771
IPR008984	SMAD/FHA	IPR011991	Wing_hlx_DNA_bd.	1.2739
IPR003619	Dwarfin protein, domain A	IPR011991	Wing_hlx_DNA_bd.	1.21319
IPR001132	Dwarfin protein	IPR011991	Wing_hlx_DNA_bd.	0.326137
IPR013019	MAD_MH1.	IPR011991	Wing_hlx_DNA_bd.	0.326137

The background colour of the table refers to:

Blue Domain is only present in SMAD3
Yellow Domain is only present in FOXO1A
Green Domain is present in both SMAD3 and FOXO1A

0.165

Post-translational Modifications

Protein: SMAD3

PTM	Residue	Reference
Phosphorylation	8	PubMed, HPRD
Phosphorylation	179	PubMed, HPRD
Phosphorylation	204	PubMed, HPRD
Phosphorylation	208	PubMed, HPRD
Phosphorylation	213	PubMed, HPRD
Phosphorylation	422	PubMed, HPRD
Phosphorylation	423	PubMed, HPRD
Phosphorylation	425	PubMed, HPRD

Protein: FOXO1A

PTM	Residue	Reference
Phosphorylation	24	PubMed, HPRD
Phosphorylation	256	PubMed, HPRD
Phosphorylation	319	PubMed, HPRD
Phosphorylation	322	PubMed, HPRD
Phosphorylation	325	PubMed, HPRD
Phosphorylation	329	PubMed, HPRD
Phosphoserine	256	PubMed, HPRD
Phosphoserine	319	PubMed, HPRD
Phosphothreonine	24	PubMed, HPRD

Localisation

Protein: SMAD3

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Protein: FOXO1A

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between SMAD3 and FOXO1A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SMAD3 andFOXO1A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SMAD3 has 962 interactors and FOXO1A has 805 interactors of which there are 634 common interactors.

Common Interactor	Name of Common Interactor	Score for SMAD3-Interactor (?)	Score for FOXO1A-Interactor (?)
SMAD2	SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2	66.70	0.225
MTF1	MTF1: Metal regulatory transcription factor 1	54.60	0.086
CREBBP	CREBBP, CBP: CREB-binding protein	41.40	0.171
SMAD1	SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1	35.90	0.148
MAPK3	MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3	26.80	0.049
GCN5L2	GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2	26.80	0.111
JUP	JUP, CTNNG, DP3: Junction plakoglobin	19.80	0.033
ARHGEF7	N/A	6.17	0.036
HOXA7	HOXA7, HOX1A: Homeobox protein Hox-A7	4.07	0.028
ELF1	ELF1: ETS-related transcription factor Elf-1	0.210	0.155
ZNF148	ZNF148, ZBP89: Zinc finger protein 148	0.210	0.210
WDR1	N/A	0.210	0.032
GNB2L1	Lung cancer oncogene 7	0.210	0.052
TGIF2	TGIF2: Homeobox protein TGIF2	0.210	0.307
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.210	0.080
SP100	N/A	0.210	0.210
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.208	0.216
FOXJ2	FOXJ2, FHX: Forkhead box protein J2	0.191	0.152
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.188	0.046
SEC31L1	N/A	0.188	0.038
ARPC1B	ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B	0.188	0.029
FBXO4	FBXO4, FBX4: F-box only protein 4	0.165	0.028
RAB4A	N/A	0.165	0.028
FOXM1	FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1	0.165	0.165
ZFX	ZFX: Zinc finger X-chromosomal protein	0.155	0.127
IRF3	IRF3: Interferon regulatory factor 3	0.155	0.307
NBN	NBN, NBS, NBS1, P95: Nibrin	0.155	0.191
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.155	0.032
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.148	0.025
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.148	0.025
ETS1	ETS1, EWSR2: Protein C-ets-1	0.139	0.139
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.139	0.077
NCOR1	NCOR1, KIAA1047: Nuclear receptor corepressor 1	0.139	0.307
CXorf9	N/A	0.139	0.0425
SRF	SRF: Serum response factor	0.139	0.069
JUNB	JUNB: Transcription factor jun-B	0.139	0.225
YY1	YY1: Transcriptional repressor protein YY1	0.139	0.127
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.139	0.086
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.139	0.0425
AKAP8	AKAP8, AKAP95: A-kinase anchor protein 8	0.139	0.127
HIST1H1D	HIST1H1D, H1F3: Histone H1.3	0.139	0.139
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.139	0.114
BATF	BATF: Basic leucine zipper transcriptional factor ATF-like	0.127	0.251
ZNF318	ZNF318, HRIHFB2436: Zinc finger protein 318	0.127	0.127
GTF2F2	N/A	0.127	0.062
UBTF	UBTF, UBF, UBF1: Nucleolar transcription factor 1	0.127	0.127
ERF	ERF: ETS domain-containing transcription factor ERF	0.127	0.062
LCP2	LCP2: Lymphocyte cytosolic protein 2	0.127	0.0425
BACH1	BACH1: Transcription regulator protein BACH1	0.127	0.152
HIVEP1	N/A	0.127	0.096
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.118	0.063
ZNF217	ZNF217, ZABC1: Zinc finger protein 217	0.114	0.114
PPP1R8	N/A	0.114	0.086
SMAD4	SMAD4, DPC4, MADH4: Mothers against decapentaplegic homolog 4	0.114	0.225
HGS	HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate	0.114	0.043
TCF8	ZEB1, AREB6, TCF8: Zinc finger E-box-binding homeobox 1	0.114	0.225
SNAI1	SNAI1, SNAH: Zinc finger protein SNAI1	0.114	0.069
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.114	0.069
ZNF24	ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24	0.114	0.155
PIK3CG	PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i	0.114	0.043
HIST1H1E	HIST1H1E, H1F4: Histone H1.4	0.114	0.114
MEF2D	MEF2D: Myocyte-specific enhancer factor 2D	0.114	0.069
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.114	0.114
ZNF335	ZNF335: Zinc finger protein 335	0.114	0.114
EML4	EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4	0.114	0.046
ZBTB40	ZBTB40, KIAA0478: Zinc finger and BTB domain-containing protein 40	0.114	0.114
EEA1	EEA1, ZFYVE2: Early endosome antigen 1	0.114	0.056
ZNF76	ZNF76, D6S229E: Zinc finger protein 76	0.114	0.114
ATM	ATM: Serine-protein kinase ATM	0.114	0.188
ATF1	ATF1: Cyclic AMP-dependent transcription factor ATF-1	0.114	0.225
ATF6	ATF6: Cyclic AMP-dependent transcription factor ATF-6 alpha	0.114	0.171
SUZ12	SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12	0.114	0.127
NFE2L2	NFE2L2, NRF2: Nuclear factor erythroid 2-related factor 2	0.114	0.136
JUND	JUND: Transcription factor jun-D	0.114	0.225
ZBTB7A	ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A	0.114	0.062
VAV1	VAV1, VAV: Proto-oncogene vav	0.111	0.054
MLLT7	N/A	0.111	0.097
FOXO3A	FOXO3A, FKHRL1: Forkhead box protein O3A	0.097	0.097
FOXL2	FOXL2: Forkhead box protein L2	0.097	0.097
IKBKB	IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta	0.0971	0.070
TERF2	TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2	0.096	0.152
CEBPA	CEBPA: CCAAT/enhancer-binding protein alpha	0.096	0.109
POU2F1	POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1	0.096	0.191
H1FX	H1FX: Histone H1x	0.096	0.096
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.096	0.062
SAT	SAT1, SAT: Diamine acetyltransferase 1	0.096	0.077
REST	REST, NRSF, XBR: RE1-silencing transcription factor	0.096	0.062
MATR3	MATR3, KIAA0723: Matrin-3	0.096	0.096
MEF2A	N/A	0.096	0.077
ZBTB33	KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso	0.096	0.077
NCOA3	N/A	0.087	0.070
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.087	0.052
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.087	0.155
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.087	0.114
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.087	0.188
BAZ2A	BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A	0.087	0.225
TP53	TP53, P53: Cellular tumor antigen p53	0.087	0.060
CBLB	CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B	0.087	0.063
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.086	0.029
SP3	SP3: Transcription factor Sp3	0.086	0.086
VDR	VDR, NR1I1: Vitamin D3 receptor	0.086	0.049
HSF1	HSF1, HSTF1: Heat shock factor protein 1	0.086	0.056
JUN	JUN: Transcription factor AP-1	0.086	0.171
KLF13	KLF13, BTEB3, NSLP1: Krueppel-like factor 13	0.086	0.086
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.086	0.086
MAPK12	MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12	0.086	0.049
MAPK1	MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1	0.086	0.035
BRPF1	BRPF1, BR140: Peregrin	0.086	0.171
FOS	FOS, G0S7: Proto-oncogene protein c-fos	0.086	0.123
MYST4	MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4	0.086	0.077
FOSL2	FOSL2, FRA2: Fos-related antigen 2	0.086	0.152
ZNF224	ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27: Zinc finger protein 224	0.086	0.114
ACIN1	ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus	0.086	0.029
HSF2	HSF2, HSTF2: Heat shock factor protein 2	0.086	0.086
CEBPB	CEBPB, TCF5, PP9092: CCAAT/enhancer-binding protein beta	0.086	0.123
ELF2	ELF2, NERF: ETS-related transcription factor Elf-2	0.083	0.083
NIPA1	NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1	0.083	0.028
ZNF579	ZNF579: Zinc finger protein 579	0.083	0.083
CUTL1	CUTL1: Homeobox protein cut-like 1	0.083	0.165
ZNF295	ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295	0.083	0.083
MAPK15	N/A	0.083	0.052
POGZ	POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain	0.083	0.083
SYTL4	Endocrine transmitter regulatory protein	0.083	0.028
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.083	0.028
HTATIP	HTATIP, TIP60: Histone acetyltransferase HTATIP	0.083	0.083
ZFP91	ZFP91, FKSG11: Zinc finger protein 91 homolog	0.083	0.083
ZNF644	ZNF644, KIAA1221, ZEP2: Zinc finger protein 644	0.083	0.083
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.083	0.028
WDR54	N/A	0.083	0.028
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.083	0.083
ZHX1	ZHX1: Zinc fingers and homeoboxes protein 1	0.083	0.165
KIAA1443	HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez	0.083	0.165
ARHGEF6	ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6	0.0818	0.054
NFIB	N/A	0.077	0.109
TERF1	TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1	0.077	0.152
SH3BP3		0.077	0.062
ETS2	ETS2: Protein C-ets-2	0.077	0.062
ZNF267	ZNF267: Zinc finger protein 267	0.077	0.062
MKI67	MKI67: Antigen KI-67	0.077	0.055
SNAPC4	SNAPC4, SNAP190: snRNA-activating protein complex subunit 4	0.077	0.152
MGMT	MGMT: Methylated-DNA--protein-cysteine methyltransferase	0.075	0.037
RFFL	RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin	0.075	0.028
ZFPM1	ZFPM1, FOG1: Zinc finger protein ZFPM1	0.075	0.083
OSR1	OSR1, ODD: Protein odd-skipped-related 1	0.075	0.075
SMU1	SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog	0.075	0.025
BUB3	BUB3: Mitotic checkpoint protein BUB3	0.075	0.025
ISL2	ISL2: Insulin gene enhancer protein ISL-2	0.075	0.148
PRDM2	PRDM2, RIZ: PR domain zinc finger protein 2	0.075	0.075
WWTR1	WWTR1, TAZ: WW domain-containing transcription regulator protein 1	0.075	0.025
HOXA10	HOXA10, HOX1H: Homeobox protein Hox-A10	0.075	0.148
CHEK2	CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2	0.075	0.075
CREB1	CREB1: cAMP response element-binding protein	0.075	0.148
FARSLA	FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain	0.075	0.075
raptor	RAPTOR, KIAA1303: Regulatory-associated protein of mTOR	0.075	0.075
SOX8	SOX8: Transcription factor SOX-8	0.075	0.083
ZNF174	ZNF174, ZSCAN8: Zinc finger protein 174	0.075	0.075
DLX3	DLX3: Homeobox protein DLX-3	0.075	0.148
HIST1H1C	HIST1H1C, H1F2: Histone H1.2	0.075	0.075
GEMIN5	GEMIN5: Gem-associated protein 5	0.075	0.028
TRERF1	TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1	0.075	0.075
RBM10	RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10	0.075	0.075
BRD2	BRD2, KIAA9001, RING3: Bromodomain-containing protein 2	0.071	0.225
MLL	MLL, ALL1, HRX, HTRX, TRX1: Zinc finger protein HRX	0.071	0.225
SOS1	SOS1: Son of sevenless homolog 1	0.071	0.087
IFI16	N/A	0.070	0.052
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.070	0.0425
NFATC1	N/A	0.070	0.416
VIM	VIM: Vimentin	0.070	0.032
VCPIP1	VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135	0.070	0.0425
NR3C1	NR3C1, GRL: Glucocorticoid receptor	0.070	0.127
AKAP8L	AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like	0.069	0.077
RERE	RERE, ARG, ARP, ATN1L, KIAA0458: Arginine-glutamic acid dipeptide repeats protei	0.069	0.136
MAFG	MAFG: Transcription factor MafG	0.069	0.109
SATB1	SATB1: DNA-binding protein SATB1	0.069	0.225
CDC6	CDC6, CDC18L: Cell division control protein 6 homolog	0.069	0.044
ZNF551	N/A	0.069	0.056
SOX4	SOX4: Transcription factor SOX-4	0.069	0.055
BRCA1	BRCA1, RNF53: Breast cancer type 1 susceptibility protein	0.069	0.049
SP1	SP1, TSFP1: Transcription factor Sp1	0.069	0.056
HIST1H1B	HIST1H1B, H1F5: Histone H1.5	0.069	0.069
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.069	0.056
CDX2	CDX2, CDX3: Homeobox protein CDX-2	0.069	0.109
HMGB2	HMGB2, HMG2: High mobility group protein B2	0.069	0.056
SLC4A1AP	SLC4A1AP: Uncharacterized protein SLC4A1AP	0.069	0.056
RAPGEF6	RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6	0.067	0.032
DPF2	DPF2, REQ, UBID4: Zinc finger protein ubi-d4	0.067	0.051
KIAA1012	KIAA1012: Protein TRS85 homolog	0.063	0.046
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.063	0.114
PABPC1	PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1	0.063	0.046
PIK4CB	PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic,	0.063	0.038
EIF3S4	EIF3S4: Eukaryotic translation initiation factor 3 subunit 4	0.063	0.046
NEK7	NEK7: Serine/threonine-protein kinase Nek7	0.063	0.038
PRKD2	PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2	0.063	0.118
DDIT3	DDIT3, CHOP, GADD153: DNA damage-inducible transcript 3	0.062	0.109
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.062	0.055
AANAT	AANAT, SNAT: Serotonin N-acetyltransferase	0.062	0.055
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.062	0.049
SMAD7	SMAD7, MADH7, MADH8: Mothers against decapentaplegic homolog 7	0.062	0.109
MYB	MYB: Myb proto-oncogene protein	0.062	0.109
ERG	ERG: Transcriptional regulator ERG	0.062	0.062
HD	HD, IT15: Huntingtin	0.061	0.057
BAZ1B	BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain	0.060	0.152
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.060	0.152
DRIM	UTP20, DRIM: Small subunit processome component 20 homolog	0.060	0.062
RB1	RB1: Retinoblastoma-associated protein	0.060	0.152
SQSTM1	SQSTM1: Uncharacterized protein SQSTM1	0.057	0.037
MYBL2	MYBL2, BMYB: Myb-related protein B	0.056	0.109
CEBPE	CEBPE: CCAAT/enhancer-binding protein epsilon	0.056	0.109
PIK3CB	PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit	0.056	0.028
MEF2C	MEF2C: Myocyte-specific enhancer factor 2C	0.056	0.056
ORC1L	ORC1L, ORC1, PARC1: Origin recognition complex subunit 1	0.056	0.049
HIST1H1A	HIST1H1A, H1F1: Histone H1.1	0.056	0.049
NR5A1	NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1	0.056	0.069
KLF5	KLF5, BTEB2, CKLF, IKLF: Krueppel-like factor 5	0.056	0.049
BNC1	BNC1, BNC: Zinc finger protein basonuclin-1	0.056	0.055
PIK3C2A	PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po	0.056	0.0308
PRKG1	PRKG1, PRKG1B, PRKGR1B: cGMP-dependent protein kinase 1, beta isozyme	0.056	0.049
ZHX3	ZHX3, KIAA0395, TIX1: Zinc fingers and homeoboxes protein 3	0.055	0.109
ESR1	ESR1, ESR, NR3A1: Estrogen receptor	0.055	0.123
PLEKHA5	PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member	0.055	0.034
XPO1	XPO1, CRM1: Exportin-1	0.054	0.051
RBL2	RBL2, RB2: Retinoblastoma-like protein 2	0.054	0.372
BRD3	BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3	0.054	0.111
SYMPK	SYMPK, SPK: Symplekin	0.054	0.049
EIF4G3	EIF4G3: Eukaryotic translation initiation factor 4 gamma 3	0.054	0.049
KIAA0690	N/A	0.054	0.049
C20orf18	N/A	0.052	0.052
UHRF1		0.052	0.028
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	0.052	0.062
DDX21	DDX21: Nucleolar RNA helicase 2	0.052	0.032
RGS14	N/A	0.052	0.026
MARK2	N/A	0.052	0.052
DEF6	DEF6, IBP: Differentially expressed in FDCP 6	0.052	0.070
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.052	0.052
PTMA	N/A	0.052	0.052
MAP3K14	MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14	0.052	0.0425
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.052	0.032
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.052	0.032
MAPKAPK2	MAPKAPK2: MAP kinase-activated protein kinase 2	0.052	0.026
RFXDC2	RFXDC2: Regulatory factor X domain-containing protein 2.	0.052	0.0425
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.052	0.060
IKBKG	IKBKG, FIP3, NEMO: NF-kappa-B essential modulator	0.052	0.032
ROCK1	ROCK1: Rho-associated protein kinase 1	0.052	0.096
ARFGAP1	N/A	0.052	0.032
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.052	0.032
PHF3	PHF3, KIAA0244: PHD finger protein 3	0.052	0.070
KIAA0853	N/A	0.052	0.0425
PLEK	PLEK, P47: Pleckstrin	0.052	0.048
MAPK13	MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13	0.051	0.051
PRKCI	PRKCI, DXS1179E: Protein kinase C iota type	0.051	0.029
SP140	SP140, LYSP100: Nuclear body protein SP140	0.050	0.083
TERF2IP	TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1	0.049	0.109
ETV1	ETV1, ER81: ETS translocation variant 1	0.049	0.049
MAPK10	MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10	0.049	0.049
MAPK8	MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8	0.049	0.049
AXIN1		0.049	0.04
NKX2-5	NKX2-5, CSX, NKX2.5, NKX2E: Homeobox protein Nkx-2.5	0.049	0.088
SOX11	SOX11: Transcription factor SOX-11	0.049	0.055
EGR1	EGR1, ZNF225: Early growth response protein 1	0.049	0.049
LEF1	LEF1: Lymphoid enhancer-binding factor 1	0.049	0.056
HOXB6	HOXB6, HOX2B: Homeobox protein Hox-B6	0.049	0.097
RFX1	RFX1: MHC class II regulatory factor RFX1	0.049	0.097
ZBTB16	ZBTB16, PLZF, ZNF145: Zinc finger and BTB domain-containing protein 16	0.049	0.069
PCAF	PCAF: Histone acetyltransferase PCAF	0.049	0.111
ELK1	ELK1: ETS domain-containing protein Elk-1	0.049	0.050
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.048	0.109
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.047	0.075
NIPBL	N/A	0.047	0.075
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.047	0.075
BRD4	N/A	0.047	0.148
RBL1	RBL1: Retinoblastoma-like protein 1	0.047	0.148
JARID1A	JARID1A, RBBP2, RBP2: Histone demethylase JARID1A	0.046	0.046
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.046	0.038
ZNF330	ZNF330, NOA36: Zinc finger protein 330	0.046	0.032
RELA	RELA, NFKB3: Transcription factor p65	0.046	0.127
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.046	0.046
TAOK3	TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3	0.046	0.038
RPS6KB2	RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2	0.046	0.114
PSMD4	PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4	0.046	0.054
RPS6KB1	N/A	0.046	0.139
APEX1	APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase	0.046	0.086
PABPC4	PABPC4, APP1, PABP4: Polyadenylate-binding protein 4	0.046	0.029
KIAA0683	DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized	0.046	0.038
DAXX	DAXX, BING2, DAP6: Death domain-associated protein 6	0.046	0.0425
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.046	0.029
NEK9	NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9	0.046	0.046
STK10	STK10: Uncharacterized protein STK10	0.046	0.038
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	0.046	0.038
KHDRBS1	KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate	0.046	0.032
STK4	STK4, MST1: Serine/threonine-protein kinase 4	0.046	0.046
HNRPF	HNRPF: Heterogeneous nuclear ribonucleoprotein F	0.046	0.029
SAPS3	N/A	0.046	0.038
SEC24C	SEC24C, KIAA0079: Protein transport protein Sec24C	0.046	0.029
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	0.046	0.038
HIF1A	HIF1A, MOP1: Hypoxia-inducible factor 1 alpha	0.046	0.048
FNBP1	N/A	0.046	0.046
WBSCR20A	N/A	0.046	0.046
HDAC1	HDAC1, RPD3L1: Histone deacetylase 1	0.046	0.046
STK38	STK38, NDR1: Serine/threonine-protein kinase 38	0.046	0.139
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.046	0.032
NAP1L1	NAP1L1, NRP: Nucleosome assembly protein 1-like 1	0.046	0.038
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	0.046	0.029
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.046	0.038
CUL4B	N/A	0.046	0.038
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.046	0.038
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.046	0.038
MYH9	MYH9: Myosin-9	0.046	0.038
SYNCRIP	SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q	0.046	0.029
DDX51	DDX51: ATP-dependent RNA helicase DDX51	0.046	0.029
EIF4G2	EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2	0.046	0.029
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.046	0.038
SFRS5	SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5	0.046	0.063
DOK1	DOK1: Docking protein 1	0.046	0.048
PAPOLA	PAPOLA, PAP: Poly(A) polymerase alpha	0.046	0.046
KLF1	KLF1, EKLF: Krueppel-like factor 1	0.044	0.049
SATB2	SATB2, KIAA1034: DNA-binding protein SATB2	0.044	0.088
EN2	EN2: Homeobox protein engrailed-2	0.044	0.088
NR1D1	NR1D1, EAR1, HREV, THRAL: Orphan nuclear receptor NR1D1	0.044	0.049
SALL1	SALL1, SAL1: Sal-like protein 1	0.044	0.044
DGKD	DGKD, KIAA0145: Diacylglycerol kinase delta	0.044	0.036
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.0425	0.032
MAPK7	mitogen-activated protein kinase 7 isoform 1	0.0425	0.026
USP24	USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24	0.0425	0.0425
OSBPL11	OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11	0.0425	0.060
ABCF1	N/A	0.0425	0.032
FNBP4	FNBP4, FBP30, KIAA1014: Formin-binding protein 4	0.0425	0.052
MYBBP1A	MYBBP1A, P160: Myb-binding protein 1A	0.0425	0.026
TCOF1	N/A	0.0425	0.026
ITGB1BP1	ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1	0.0425	0.026
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.0425	0.032
JMJD1A	JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr	0.0425	0.052
STAT2	STAT2: Signal transducer and activator of transcription 2	0.0425	0.062
SFRS15	SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15	0.0425	0.0425
SH2BP1	CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog	0.0425	0.032
SET	SET: Protein SET	0.0425	0.032
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.0425	0.0425
RBM6	RBM6, DEF3: RNA-binding protein 6	0.0425	0.052
RBM14	RBM14, SIP: RNA-binding protein 14	0.0425	0.032
CTNNB1	CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1	0.041	0.041
TAF1	TAF1, BA2R, CCG1, CCGS, TAF2A: Transcription initiation factor TFIID subunit 1	0.039	0.109
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.038	0.114
NOL1	N/A	0.038	0.029
STAG2	STAG2, SA2: Cohesin subunit SA-2	0.038	0.038
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.038	0.171
SNRPB2	SNRPB2: U2 small nuclear ribonucleoprotein B''	0.038	0.029
SFRS4	SFRS4, SRP75: Splicing factor, arginine/serine-rich 4	0.038	0.038
TCF3	TCF3, E2A, ITF1: Transcription factor E2-alpha	0.038	0.060
SFRS6	SFRS6, SRP55: Splicing factor, arginine/serine-rich 6	0.038	0.038
TOPORS	TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors	0.038	0.032
SKIIP	SNW1, SKIIP, SKIP: SNW domain-containing protein 1	0.038	0.029
TMEM1	TMEM1, EHOC1: Transmembrane protein 1	0.038	0.0425
DIAPH1	Diaphanous 1	0.038	0.029
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.038	0.038
PHF10	N/A	0.038	0.046
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.038	0.046
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.038	0.086
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.038	0.029
CENTB2	CENTB2, KIAA0041: Centaurin-beta 2	0.038	0.054
GRK5	GRK5, GPRK5: G protein-coupled receptor kinase 5	0.038	0.114
HIST3H3	HIST3H3, H3FT: Histone H3.1t	0.038	0.038
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.038	0.054
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.038	0.069
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.038	0.046
PPP1R12A	PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A	0.038	0.038
MAP3K11	MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11	0.038	0.026
ZCCHC8	ZCCHC8: Zinc finger CCHC domain-containing protein 8	0.038	0.032
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.038	0.029
TIAL1	TIAL1: Nucleolysin TIAR	0.038	0.029
KLHDC4	N/A	0.038	0.038
USP34	USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34	0.038	0.070
WDR44	WDR44: WD repeat-containing protein 44	0.038	0.029
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.038	0.069
HIST1H3A	HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD,	0.038	0.038
FKBP5	FKBP5, AIG6, FKBP51: FK506-binding protein 5	0.038	0.038
EP300	N/A	0.038	0.029
NFKBIA	NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha	0.038	0.026
DUSP1	DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1	0.038	0.029
LIMD1	LIMD1: LIM domain-containing protein 1	0.038	0.026
ANAPC5	ANAPC5, APC5: Anaphase-promoting complex subunit 5	0.038	0.029
STK38L	STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like	0.038	0.056
RBMX2	RBMX2, CGI-79: RNA-binding motif protein, X-linked 2	0.038	0.029
CTDP1	CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase	0.038	0.077
MTA1	MTA1: Metastasis-associated protein MTA1	0.038	0.056
AIP	AIP, XAP2: AH receptor-interacting protein	0.038	0.029
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.038	0.056
CCNL1	CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1	0.038	0.225
HDAC3	HDAC3: Histone deacetylase 3	0.038	0.032
CSPG6	SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3	0.038	0.029
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	0.038	0.038
DUSP22	DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22	0.038	0.026
ELAVL1	ELAVL1, HUR: ELAV-like protein 1	0.038	0.029
RBM8A	RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A	0.038	0.029
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.038	0.069
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	0.038	0.029
RREB1	RREB1, FINB: RAS-responsive element-binding protein 1	0.038	0.026
CUL5	CUL5, VACM1: Cullin-5	0.038	0.038
TRADD	TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein	0.036	0.036
SPTBN1	SPTBN1, SPTB2: Spectrin beta chain, brain 1	0.036	0.036
CLASP1	CLASP1, KIAA0622, MAST1: CLIP-associating protein 1	0.035	0.049
ARHGAP12	ARHGAP12: Rho GTPase-activating protein 12	0.033	0.041
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.032	0.026
AFF1	N/A	0.032	0.032
SMARCC2	N/A	0.032	0.026
KIAA0528	KIAA0528: Uncharacterized protein KIAA0528	0.032	0.032
SRPK2	SRPK2: Serine/threonine-protein kinase SRPK2	0.032	0.026
PRKAA1	N/A	0.032	0.032
APPL	APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha	0.032	0.048
PHF8	PHF8, KIAA1111, ZNF422: PHD finger protein 8	0.032	0.026
TRAFD1	TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1	0.032	0.026
ID3	ID3, 1R21, HEIR-1: DNA-binding protein inhibitor ID-3	0.032	0.077
PRKR	EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki	0.032	0.026
HNRPA0	HNRPA0: Heterogeneous nuclear ribonucleoprotein A0	0.032	0.032
TRRAP	N/A	0.032	0.026
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.032	0.026
RXRA	RXRA, NR2B1: Retinoic acid receptor RXR-alpha	0.032	0.055
TOP2B	N/A	0.032	0.032
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.032	0.032
ZNF638	ZNF638, NP220, ZFML: Zinc finger protein 638	0.032	0.032
COIL	COIL, CLN80: Coilin	0.032	0.026
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.032	0.062
CHUK	N/A	0.032	0.026
XRCC1	XRCC1: DNA-repair protein XRCC1	0.032	0.096
ID2	ID2: DNA-binding protein inhibitor ID-2	0.032	0.096
GAB1	GAB1: GRB2-associated-binding protein 1	0.032	0.034
API5	N/A	0.032	0.032
RPL3	RPL3, OK/SW-cl.32: 60S ribosomal protein L3	0.032	0.032
STAT6	STAT6: Signal transducer and activator of transcription 6	0.032	0.0818
MAD1L1	MAD1L1, MAD1, TXBP181: Mitotic spindle assembly checkpoint protein MAD1	0.032	0.027
RPS10	RPS10: 40S ribosomal protein S10	0.032	0.032
EEF1B2	EEF1B2, EEF1B, EF1B: Elongation factor 1-beta	0.032	0.032
EEF1G	EEF1G, EF1G, PRO1608: Elongation factor 1-gamma	0.032	0.032
DOCK2	DOCK2, KIAA0209: Dedicator of cytokinesis protein 2	0.032	0.067
PRKCZ	PRKCZ, PKC2: Protein kinase C zeta type	0.029	0.029
RPS6KA5	RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5	0.029	0.114
FHOD1	FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1	0.029	0.056
SIRT1	SIRT1, SIR2L1: NAD-dependent deacetylase sirtuin-1	0.029	0.275
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.029	0.069
YARS	YARS: Tyrosyl-tRNA synthetase, cytoplasmic	0.029	0.056
EXOSC2	EXOSC2, RRP4: Exosome complex exonuclease RRP4	0.029	0.086
MCM3	MCM3: DNA replication licensing factor MCM3	0.029	0.111
TOPBP1	TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1	0.029	0.086
MDN1	MDN1, KIAA0301: Midasin	0.029	0.029
AHR	AHR: Aryl hydrocarbon receptor precursor	0.029	0.056
CPSF1	CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1	0.029	0.029
SNRK	SNRK, KIAA0096, SNFRK: SNF-related serine/threonine-protein kinase	0.029	0.029
UTX	UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein	0.029	0.046
CSTF2T	CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant	0.029	0.029
SGK	SGK, SGK1: Serine/threonine-protein kinase Sgk1	0.029	0.049
SGK3	SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3	0.029	0.056
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	0.029	0.114
NUP153	N/A	0.029	0.029
TDG	TDG: G/T mismatch-specific thymine DNA glycosylase	0.029	0.032
CDK2	CDK2: Cell division protein kinase 2	0.029	0.533
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.028	0.028
CORO6	N/A	0.028	0.028
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.028	0.052
KIF1B	N/A	0.028	0.028
HMGA1	HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y	0.028	0.028
AR	AR, DHTR, NR3C4: Androgen receptor	0.028	0.028
JDP2	jdp2, JDP2: Jun dimerization protein 2	0.028	0.028
NES	N/A	0.028	0.025
ZC3HAV1	ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1	0.028	0.028
HES6	HES6: Transcription cofactor HES-6	0.028	0.052
DSP	DSP: Desmoplakin	0.028	0.028
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.028	0.028
FLJ21816	PALB2, FANCN: Partner and localizer of BRCA2	0.028	0.028
ARNT	ARNT: Aryl hydrocarbon receptor nuclear translocator	0.028	0.052
RAVER1	RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1	0.028	0.028
BID	BID: BH3-interacting domain death agonist	0.028	0.028
ATXN2L	ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein	0.028	0.028
NFIA	NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A	0.028	0.028
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
HDAC8	N/A	0.028	0.028
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.028	0.075
MLL2	MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2	0.028	0.028
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.028	0.028
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.028	0.028
DKFZp434K1815	DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815	0.028	0.028
LOC642558	FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1	0.028	0.028
IRF7	N/A	0.028	0.028
NSBP1	NSBP1: Nucleosome-binding protein 1	0.028	0.028
ILF3	ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3	0.028	0.028
ZNF265	N/A	0.028	0.028
C13orf8	N/A	0.028	0.028
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.028	0.028
NF2	NF2, SCH: Merlin	0.028	0.028
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.028	0.028
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
ZCCHC3	ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3	0.028	0.028
MAPKAPK5	N/A	0.028	0.028
HNRPC	HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2	0.028	0.028
CABLES1	N/A	0.028	0.028
PTBP1	PTBP1: Polypyrimidine tract binding protein 1	0.028	0.028
PPEF1	N/A	0.028	0.028
TCF20	TCF20, KIAA0292, SPBP: Transcription factor 20	0.028	0.028
TMPO	TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha	0.028	0.028
NFATC2	NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2	0.028	0.165
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.028	0.083
CBFA2T2	CBFA2T2, EHT, MTGR1: Protein CBFA2T2	0.028	0.028
MITF	MITF: Microphthalmia-associated transcription factor	0.028	0.028
PHLDB2	N/A	0.028	0.028
SNRPB	N/A	0.028	0.028
NFATC3	NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3	0.028	0.165
DUSP15	N/A	0.028	0.028
TIAM1	TIAM1: T-lymphoma invasion and metastasis-inducing protein 1	0.028	0.031
ARHGEF12	ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12	0.0277	0.035
FOXP1	FOXP1, HSPC215: Forkhead box protein P1	0.028	0.036
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.027	0.064
FOXQ1	FOXQ1, HFH1: Forkhead box protein Q1	0.027	0.027
FUBP1	N/A	0.027	0.027
SH3BP2	SH3BP2: Uncharacterized protein SH3BP2	0.027	0.061
MCF2	MCF2, DBL: Proto-oncogene DBL	0.0263	0.0263
TP53BP1	TP53BP1: Tumor suppressor p53-binding protein 1	0.026	0.077
STRN3	STRN3, GS2NA, SG2NA: Striatin-3	0.026	0.026
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.026	0.052
GAB2	N/A	0.026	0.031
PPARA	PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha	0.026	0.055
GTF3C1	N/A	0.026	0.026
IRS1	IRS1: Insulin receptor substrate 1	0.026	0.048
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.026	0.026
ATXN7	ATXN7, SCA7: Ataxin-7	0.0253	0.0407
POLR1C	POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1	0.025	0.025
FAF1	FAF1, CGI-03: FAS-associated factor 1	0.025	0.025
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.025	0.028
CCNT2	CCNT2: Cyclin-T2	0.025	0.148
TFAP4	TFAP4: Transcription factor AP-4	0.025	0.075
MAX	MAX: Protein max	0.025	0.047
PHF16	PHF16, JADE3, KIAA0215: Protein Jade-3	0.025	0.025
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.025	0.025
KCTD1		0.025	0.028
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.025	0.025
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.025	0.025
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.025	0.075
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.025	0.075
ATRX	ATRX, RAD54L, XH2: Transcriptional regulator ATRX	0.025	0.047
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.025	0.083
PHC2	PHC2, EDR2, PH2: Polyhomeotic-like protein 2	0.025	0.028
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.025	0.025
C10orf9	CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y	0.025	0.148
HDAC7A	N/A	0.025	0.025
TCEA1	N/A	0.025	0.025
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.025	0.025
NSUN2	NSUN2, SAKI, TRM4: tRNA	0.025	0.025
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.025	0.028
TAL2	TAL2: T-cell acute lymphocytic leukemia protein 2	0.025	0.083
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.025	0.047
MAP2K3	N/A	0.025	0.025
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.025	0.075
BCOR	N/A	0.025	0.025
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.025	0.025
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.025	0.075
CDC2	CDC2: Cell division control protein 2 homolog	0.025	0.025
LMNA	LMNA, LMN1: Lamin-A/C	0.025	0.025
EWSR1	EWSR1, EWS: RNA-binding protein EWS	0.025	0.047
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.025	0.025
WNK4	WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4	0.025	0.025
PURB	PURB: Transcriptional activator protein Pur-beta	0.025	0.025
REXO1	REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog	0.025	0.025
FLJ23436	N/A	0.025	0.025
SEC13L1	N/A	0.025	0.025
RNF113A	RNF113A, RNF113, ZNF183: RING finger protein 113A	0.025	0.025
EXO1	EXO1, EXOI, HEX1: Exonuclease 1	0.025	0.025
MIER1	MIER1, KIAA1610: Mesoderm induction early response protein 1	0.025	0.025
ATXN2L	N/A	0.025	0.025
ELMO1	N/A	0.025	0.075
DIDO1	N/A	0.025	0.025
SYAP1	SYAP1, PRO3113: Synapse-associated protein 1	0.025	0.025
RNF20		0.025	0.075
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	0.025	0.025
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.025	0.025
HNRPM	HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M	0.025	0.025
DHX8	DHX8, DDX8: ATP-dependent RNA helicase DHX8	0.025	0.075
EEF2K	EEF2K: Elongation factor 2 kinase	0.025	0.025
HIST2H2AC	HIST2H2AC, H2AFQ: Histone H2A type 2-C	0.025	0.025
PKN3	PKN3, PKNBETA: Serine/threonine-protein kinase N3	0.025	0.075
SSH2	SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2	0.025	0.025
EDF1	EDF1: Endothelial differentiation-related factor 1	0.025	0.025
PSIP1	PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein	0.025	0.028
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.025	0.025
CAMKK1	N/A	0.025	0.025
FLJ40432	FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227	0.025	0.025
GATAD2B	GATAD2B, KIAA1150: Transcriptional repressor p66 beta	0.025	0.075
NEDD4	NEDD4: Uncharacterized protein NEDD4	0.025	0.025
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	0.025	0.025
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.025	0.025
MKI67IP	MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein	0.025	0.025
NFYA	NFYA: Nuclear transcription factor Y subunit alpha	0.025	0.028
HNRPD	HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0	0.025	0.028
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.025	0.075
MLXIPL	MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein	0.025	0.047
NHN1	NHN1: Conserved nuclear protein NHN1	0.025	0.028
TIA1	TIA1: Nucleolysin TIA-1 isoform p40	0.025	0.025
SMN2	SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein	0.025	0.025
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.025	0.025
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.025
MSL3L1	MSL3L1: Male-specific lethal 3-like 1	0.025	0.028
GRK6	N/A	0.025	0.025
HTATIP	N/A	0.025	0.025
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
HNRPUL1	HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1	0.025	0.025
HNRPA2B1	HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1	0.025	0.025
H2-ALPHA	TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain	0.025	0.025
SETD3	SETD3, C14orf154: SET domain-containing protein 3	0.025	0.025
MAPK8IP3	N/A	0.025	0.025
MLL4	WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7	0.025	0.025
SAP14	SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14	0.025	0.025
NEK8	NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8	0.025	0.025
NCOA3	NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3	0.025	0.052
ZNF598	ZNF598: Zinc finger protein 598	0.025	0.028
HEXIM2	HEXIM2, L3: Protein HEXIM2	0.025	0.028
CETN1	CETN1, CEN1, CETN: Centrin-1	0.025	0.028
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.025	0.025
IWS1	IWS1, IWS1L: IWS1 homolog	0.025	0.025
SFRS9	SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9	0.025	0.025
SSBP4	SSBP4: Single-stranded DNA-binding protein 4	0.025	0.025
CCNE1	CCNE1, CCNE: G1/S-specific cyclin-E1	0.025	0.148
PRKCB1	N/A	0.025	0.025
ARID4A	ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A	0.025	0.028
HNRPH3	HNRPH3: Heterogeneous nuclear ribonucleoprotein H3	0.025	0.025
DDX20	DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20	0.025	0.028
STAT1	STAT1: Signal transducer and activator of transcription 1-alpha/beta	0.025	0.075
CAMK2A	N/A	0.025	0.025
HIST3H2A	HIST3H2A: Histone H2A type 3	0.025	0.025
NUP98	N/A	0.025	0.025
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.025	0.025
ADK	ADK: Adenosine kinase	0.025	0.025
SMARCA2	SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2	0.025	0.025
C14orf4	C14orf4, KIAA1865, My039: RING finger protein C14orf4	0.025	0.028
SON		0.025	0.025
GIT2	N/A	0.025	0.025
C20orf77	N/A	0.025	0.025
RBBP6	RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6	0.025	0.025

0.299

Total Score

26.80