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Evidence of Interaction Between PSMB1 and PSMA2

The interaction score between PSMB1 and PSMA2 is 597.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PSMB1 and PSMA2 = 0.80

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismPSMB1 OrthologuePSMA2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YBL041W 1 YML092C 1
  • AffinityCaptureMS

Get References From PubMed
worm P34286 1 Q27488 1
fly P40304 1 P40301 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in PSMB1 and PSMA2:
Domains in PSMB1Domains in PSMA2
IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 20S proteasome, A and B subunits
IPR001353 20S proteasome, A and B subunits
IPR000426 Proteasome alpha-subunit

The Chi square scores for co-occurrence of domains that are present in PSMB1 and PSMA2 are listed below.

Domain 1Domain 2Chi Square
IPR001353 20S proteasome, A and B subunits IPR000426 Proteasome alpha-subunit 1084.67
IPR000243 Peptidase T1A, proteasome beta-subunit IPR000426 Proteasome alpha-subunit 998.751
IPR001353 20S proteasome, A and B subunits IPR001353 20S proteasome, A and B subunits 972.655
IPR000243 Peptidase T1A, proteasome beta-subunit IPR001353 20S proteasome, A and B subunits 960.483

The background colour of the table refers to:

  • Blue Domain is only present in PSMB1
  • Yellow Domain is only present in PSMA2
  • Green Domain is present in both PSMB1 and PSMA2

 0.265
Post-translational Modifications

Protein: PSMB1

PTMResidueReference

Protein: PSMA2

PTMResidueReference
Phosphotyrosine 23 HPRD
Phosphotyrosine 97 HPRD
Localisation

Protein: PSMB1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: PSMA2

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PSMB1 and PSMA2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PSMB1 andPSMA2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PSMB1 has 205 interactors and PSMA2 has 927 interactors of which there are 169 common interactors.

Common InteractorName of Common InteractorScore for PSMB1-Interactor (?)Score for PSMA2-Interactor (?)
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 2.07E3 1.59E3
PSMB2 PSMB2: Proteasome subunit beta type-2 691.00 691.00
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 691.00 3.41E3
PSMA5 PSMA5: Proteasome subunit alpha type-5 691.00 1.02E4
PSMA6 PSMA6, PROS27: Proteasome subunit alpha type-6 691.00 195.00
PSMA7 PSMA7: Proteasome subunit alpha type-7 691.00 1.64E3
PSMA4 PSMA4, PSC9: Proteasome subunit alpha type-4 691.00 2.07E3
PSMB3 PSMB3: Proteasome subunit beta type-3 691.00 195.00
PSMB6 PSMB6, LMPY: Proteasome subunit beta type-6 precursor 323.00 323.00
PSMB9 PSMB9, LMP2, RING12: Proteasome subunit beta type-9 precursor 31.70 31.70
PSMA8 PSMA8, PSMA7L: Proteasome subunit alpha type-7-like 12.60 319.00
PSMA1 PSMA1, PROS30, PSC2: Proteasome subunit alpha type-1 8.73 2.91
PSMB4 N/A 3.89 1.82
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 2.15 10.50
NULL RcPSMB3 (Fragment) 1.37 1.37
CTRL PSMB10, MECL1: Proteasome subunit beta type-10 precursor 1.36 0.666
THUMPD1 N/A 1.29 0.770
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.596 0.596
PSMB5 DKFZp686I0180: Putative uncharacterized protein DKFZp686I0180 (Fragment) 0.593 3.01
PSMB8 PSMB8, DAQB-69D7.6-002, DASS-67H14.1-002, XXbac-BCX32M13.6-002, XXbac-BPG246D15. 0.366 5.60
PSMA1 N/A 0.354 1.79
PSMB5 PSMB5, LMPX: Proteasome subunit beta type-5 precursor 0.265 0.265
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.263 0.763
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.263 0.461
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.263 0.763
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.263 1.62
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.233 4.36
PLK3 PLK3, CNK, FNK, PRK: Serine/threonine-protein kinase PLK3 0.225 0.225
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.195 69.20
LOC391276 N/A 0.191 0.191
PLK2 PLK2, SNK: Serine/threonine-protein kinase PLK2 0.145 0.179
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.132 3.35
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.123 0.372
CSNK1A1 CSNK1A1: Casein kinase I isoform alpha 0.123 0.074
CSNK1G2 CSNK1G2: Casein kinase I isoform gamma-2 0.123 0.044
RP6-213H19.1 MST4, MASK: Serine/threonine-protein kinase MST4 0.123 0.060
NULL N/A 0.119 0.119
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.0968 0.304
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.083 0.852
CSNK1G3 CSNK1G3: Casein kinase I isoform gamma-3 0.083 0.083
RIPK2 RIPK2, CARDIAK, UNQ277/PRO314/PRO34092, RICK, RIP2: Receptor-interacting serine/ 0.083 0.083
CDK4 CDK4: Cell division protein kinase 4 0.074 0.763
RPS6KB1 N/A 0.074 0.372
CDK2 CDK2: Cell division protein kinase 2 0.074 0.461
CDK7 CDK7, MO15: Cell division protein kinase 7 0.074 0.763
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.074 0.372
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.074 0.372
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.074 0.461
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.074 0.372
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.074 0.123
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.074 0.275
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.074 0.225
ROCK1 ROCK1: Rho-associated protein kinase 1 0.067 0.416
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.067 0.103
CAMK2G Calcium/calmodulin-dependent protein kinase isoform A (Fragment) 0.067 0.050
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.067 0.515
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.060 0.275
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.060 0.036
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.060 0.225
CLK3 CLK3: Dual specificity protein kinase CLK3 0.060 0.044
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.060 0.275
AURKB AURKB, AIK2, AIM1, ARK2, STK12: Serine/threonine-protein kinase 12 0.060 0.123
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.060 0.044
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.060 0.225
STK10 STK10: Uncharacterized protein STK10 0.060 0.225
MAP4K2 MAP4K2, GCK, RAB8IP: Mitogen-activated protein kinase kinase kinase kinase 2 0.060 0.044
CSNK1D CSNK1D: Casein kinase I isoform delta 0.060 0.036
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.060 0.461
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.060 0.225
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.060 0.275
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.060 0.275
BUB1 0.060 0.074
BUB1B BUB1B, BUBR1, MAD3L: Mitotic checkpoint serine/threonine-protein kinase BUB1 bet 0.060 0.074
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.060 0.372
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.060 0.044
CDK9 CDK9, CDC2L4: Cell division protein kinase 9 0.059 0.035
VRK2 VRK2: Serine/threonine-protein kinase VRK2 0.059 0.0968
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.050 0.191
VRK3 N/A 0.050 0.0308
DYRK2 DYRK2: Dual specificity tyrosine-phosphorylation-regulated kinase 2 0.050 0.041
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.050 0.191
GAK GAK: Cyclin G-associated kinase 0.047 0.029
TTK TTK, MPS1L1: Dual specificity protein kinase TTK 0.047 0.047
ACVR2A ACVR2A, ACVR2: Activin receptor type-2A precursor 0.047 0.035
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.044 0.372
STK17A STK17A, DRAK1: Serine/threonine-protein kinase 17A 0.044 0.044
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.044 0.372
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.044 0.225
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.044 0.058
WNK1 WNK1, KDP, KIAA0344, PRKWNK1: Serine/threonine-protein kinase WNK1 0.044 0.028
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.044 0.275
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.044 0.044
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.044 0.171
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.044 0.372
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.044 0.058
PRKX PRKX, PKX1: Serine/threonine-protein kinase PRKX 0.044 0.036
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.044 0.275
DYRK4 DYRK4: Dual specificity tyrosine-phosphorylation-regulated kinase 4 0.044 0.044
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.044 0.093
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.044 0.126
WEE1 WEE1: Wee1-like protein kinase 0.044 0.372
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.044 0.275
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.044 0.171
IRAK4 IRAK4: Interleukin-1 receptor-associated kinase 4 0.044 0.036
LIMK2 LIMK2: LIM domain kinase 2 0.041 0.085
STK16 N/A 0.041 0.307
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.041 0.064
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.041 0.191
EIF2AK1 N/A 0.041 0.041
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.041 0.251
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.041 0.191
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.039 0.166
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.038 0.233
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.038 0.075
CSK CSK: Tyrosine-protein kinase CSK 0.038 0.233
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.038 0.188
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.036 0.372
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.036 0.136
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.036 0.275
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.036 0.225
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.036 0.171
NEK2 NEK2, NLK1: Serine/threonine-protein kinase Nek2 0.036 0.044
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.036 0.136
PIM1 N/A 0.036 0.028
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.036 0.225
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.036 0.111
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.036 0.058
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.036 0.372
MAP4K5 MAP4K5: Mitogen-activated protein kinase kinase kinase kinase 5 0.036 0.036
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.0308 0.152
DAPK3 DAPK3, ZIPK: Death-associated protein kinase 3 0.0308 0.0308
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.0308 0.191
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.0308 0.152
PSMB8 PSMB8, LMP7, RING10, Y2: Proteasome subunit beta type-8 precursor 0.0288 0.0288
PSMB4 PSMB4: Proteasome subunit beta type-4 precursor 0.0288 0.617
CSNK2A2 CSNK2A2, CK2A2: Casein kinase II subunit alpha' 0.028 0.028
CDK6 CDK6: Cell division protein kinase 6 0.028 0.136
PCTK2 PCTK2: Serine/threonine-protein kinase PCTAIRE-2 0.028 0.028
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.028 0.136
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.027 0.053
DGUOK N/A 0.027 0.027
RTCD1 RTCD1, RPC, RPC1, RTC1: RNA 3'-terminal phosphate cyclase 0.027 0.027
SERBP1 N/A 0.027 0.027
C11orf58 SMAP, C11orf58: Small acidic protein 0.027 0.025
EIF2AK3 EIF2AK3, PEK, PERK: Eukaryotic translation initiation factor 2-alpha kinase 3 pr 0.027 0.027
ERN2 ERN2, IRE2: Serine/threonine-protein kinase/endoribonuclease IRE2 precursor 0.027 0.0331
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.027 0.165
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.165
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.027 0.165
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.027 0.165
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.027 0.165
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.027 0.056
MAP2K5 N/A 0.027 0.056
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.165
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.027 0.056
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.027 0.165
CDC2L2 N/A 0.027 0.027
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
MAPKAPK5 N/A 0.027 0.165
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.027 0.056
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.027 0.165
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
MAPK15 N/A 0.027 0.165
2.15E-3
Total Score 597.00