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Evidence of Interaction Between PSMB1 and PSMB3

The interaction score between PSMB1 and PSMB3 is 597.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PSMB1 and PSMB3 = 0.81

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.027
Orthology
OrganismPSMB1 OrthologuePSMB3 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YBL041W 1 YER094C 1
  • Other

Get References From PubMed

worm P34286 1 Q23237 1
fly P40304 1 Q9XYN7 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593
Domains Domains present in PSMB1 and PSMB3:
Domains in PSMB1Domains in PSMB3
IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 20S proteasome, A and B subunits
IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 20S proteasome, A and B subunits

The Chi square scores for co-occurrence of domains that are present in PSMB1 and PSMB3 are listed below.

Domain 1Domain 2Chi Square
IPR001353 20S proteasome, A and B subunits IPR001353 20S proteasome, A and B subunits 972.655
IPR000243 Peptidase T1A, proteasome beta-subunit IPR001353 20S proteasome, A and B subunits 960.483

The background colour of the table refers to:

  • Blue Domain is only present in PSMB1
  • Yellow Domain is only present in PSMB3
  • Green Domain is present in both PSMB1 and PSMB3

0.265
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: PSMB1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: PSMB3

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PSMB1 and PSMB3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PSMB1 andPSMB3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PSMB1 has 205 interactors and PSMB3 has 165 interactors of which there are 154 common interactors.

Common InteractorName of Common InteractorScore for PSMB1-Interactor (?)Score for PSMB3-Interactor (?)
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 2.07E3 1.64E3
PSMB2 PSMB2: Proteasome subunit beta type-2 691.00 323.00
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 691.00 195.00
PSMA5 PSMA5: Proteasome subunit alpha type-5 691.00 1.22
PSMA6 PSMA6, PROS27: Proteasome subunit alpha type-6 691.00 195.00
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 691.00 195.00
PSMA7 PSMA7: Proteasome subunit alpha type-7 691.00 691.00
PSMA4 PSMA4, PSC9: Proteasome subunit alpha type-4 691.00 323.00
PSMB6 PSMB6, LMPY: Proteasome subunit beta type-6 precursor 323.00 691.00
PSMB9 PSMB9, LMP2, RING12: Proteasome subunit beta type-9 precursor 31.70 39.30
PSMA8 PSMA8, PSMA7L: Proteasome subunit alpha type-7-like 12.60 12.60
PSMA1 PSMA1, PROS30, PSC2: Proteasome subunit alpha type-1 8.73 1.36
PSMB4 N/A 3.89 3.89
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 2.15 1.01
NULL RcPSMB3 (Fragment) 1.37 0.0258
CTRL PSMB10, MECL1: Proteasome subunit beta type-10 precursor 1.36 0.824
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.596 0.440
PSMB5 DKFZp686I0180: Putative uncharacterized protein DKFZp686I0180 (Fragment) 0.593 0.593
PSMB8 PSMB8, DAQB-69D7.6-002, DASS-67H14.1-002, XXbac-BCX32M13.6-002, XXbac-BPG246D15. 0.366 0.221
PSMB5 PSMB5, LMPX: Proteasome subunit beta type-5 precursor 0.265 0.265
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.263 0.123
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.263 0.074
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.263 0.074
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.263 0.123
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.233 0.233
PLK3 PLK3, CNK, FNK, PRK: Serine/threonine-protein kinase PLK3 0.225 0.225
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.195 0.195
PLK2 PLK2, SNK: Serine/threonine-protein kinase PLK2 0.145 0.145
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.132 0.082
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.123 0.060
CSNK1A1 CSNK1A1: Casein kinase I isoform alpha 0.123 0.074
CSNK1G2 CSNK1G2: Casein kinase I isoform gamma-2 0.123 0.060
RP6-213H19.1 MST4, MASK: Serine/threonine-protein kinase MST4 0.123 0.060
NULL N/A 0.119 0.119
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.0968 0.047
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.083 0.067
CSNK1G3 CSNK1G3: Casein kinase I isoform gamma-3 0.083 0.050
RIPK2 RIPK2, CARDIAK, UNQ277/PRO314/PRO34092, RICK, RIP2: Receptor-interacting serine/ 0.083 0.050
CDK4 CDK4: Cell division protein kinase 4 0.074 0.074
RPS6KB1 N/A 0.074 0.044
CDK2 CDK2: Cell division protein kinase 2 0.074 0.060
CDK7 CDK7, MO15: Cell division protein kinase 7 0.074 0.060
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.074 0.074
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.074 0.060
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.074 0.074
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.074 0.074
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.074 0.060
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.074 0.044
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.074 0.074
ROCK1 ROCK1: Rho-associated protein kinase 1 0.067 0.041
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.067 0.041
CAMK2G Calcium/calmodulin-dependent protein kinase isoform A (Fragment) 0.067 0.041
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.067 0.050
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.060 0.074
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.060 0.074
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.060 0.044
CLK3 CLK3: Dual specificity protein kinase CLK3 0.060 0.060
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.060 0.044
AURKB AURKB, AIK2, AIM1, ARK2, STK12: Serine/threonine-protein kinase 12 0.060 0.060
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.060 0.036
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.060 0.036
STK10 STK10: Uncharacterized protein STK10 0.060 0.044
MAP4K2 MAP4K2, GCK, RAB8IP: Mitogen-activated protein kinase kinase kinase kinase 2 0.060 0.044
CSNK1D CSNK1D: Casein kinase I isoform delta 0.060 0.060
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.060 0.044
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.060 0.044
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.060 0.044
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.060 0.060
BUB1 0.060 0.044
BUB1B BUB1B, BUBR1, MAD3L: Mitotic checkpoint serine/threonine-protein kinase BUB1 bet 0.060 0.060
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.060 0.060
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.060 0.044
CDK9 CDK9, CDC2L4: Cell division protein kinase 9 0.059 0.047
VRK2 VRK2: Serine/threonine-protein kinase VRK2 0.059 0.047
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.050 0.041
VRK3 N/A 0.050 0.050
DYRK2 DYRK2: Dual specificity tyrosine-phosphorylation-regulated kinase 2 0.050 0.0308
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.050 0.041
GAK GAK: Cyclin G-associated kinase 0.047 0.035
TTK TTK, MPS1L1: Dual specificity protein kinase TTK 0.047 0.035
ACVR2A ACVR2A, ACVR2: Activin receptor type-2A precursor 0.047 0.029
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.044 0.036
STK17A STK17A, DRAK1: Serine/threonine-protein kinase 17A 0.044 0.036
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.044 0.036
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.044 0.074
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.044 0.036
WNK1 WNK1, KDP, KIAA0344, PRKWNK1: Serine/threonine-protein kinase WNK1 0.044 0.036
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.044 0.044
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.044 0.036
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.044 0.044
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.044 0.036
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.044 0.044
PRKX PRKX, PKX1: Serine/threonine-protein kinase PRKX 0.044 0.028
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.044 0.036
DYRK4 DYRK4: Dual specificity tyrosine-phosphorylation-regulated kinase 4 0.044 0.036
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.044 0.036
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.044 0.044
WEE1 WEE1: Wee1-like protein kinase 0.044 0.036
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.044 0.074
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.044 0.123
IRAK4 IRAK4: Interleukin-1 receptor-associated kinase 4 0.044 0.036
LIMK2 LIMK2: LIM domain kinase 2 0.041 0.050
STK16 N/A 0.041 0.067
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.041 0.050
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.041 0.041
EIF2AK1 N/A 0.041 0.041
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.041 0.041
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.041 0.0308
PRKR EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki 0.039 0.032
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.036 0.036
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.036 0.028
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.036 0.028
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.036 0.028
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.036 0.028
NEK2 NEK2, NLK1: Serine/threonine-protein kinase Nek2 0.036 0.028
SGK SGK, SGK1: Serine/threonine-protein kinase Sgk1 0.036 0.028
PIM1 N/A 0.036 0.036
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.036 0.044
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.036 0.036
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.036 0.028
MAP4K5 MAP4K5: Mitogen-activated protein kinase kinase kinase kinase 5 0.036 0.028
IRAK3 IRAK3: Interleukin-1 receptor-associated kinase 3 0.032 0.032
DAPK3 DAPK3, ZIPK: Death-associated protein kinase 3 0.0308 0.041
MAP3K14 MAP3K14, NIK: Mitogen-activated protein kinase kinase kinase 14 0.0308 0.041
PSMB8 PSMB8, LMP7, RING10, Y2: Proteasome subunit beta type-8 precursor 0.0288 0.0288
PSMB4 PSMB4: Proteasome subunit beta type-4 precursor 0.0288 0.0288
ULK1 ULK1, KIAA0722: Serine/threonine-protein kinase ULK1 0.028 0.028
CDK6 CDK6: Cell division protein kinase 6 0.028 0.028
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.028 0.028
NDUFA1 NDUFA1: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 0.027 0.027
UBE2V1 N/A 0.027 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.027 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.027 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.027 0.027
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.027 0.027
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.027 0.027
MAP2K5 N/A 0.027 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.027
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.027 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.027 0.027
CDC2L2 N/A 0.027 0.027
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
MAPKAPK5 N/A 0.027 0.027
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.027 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.027 0.027
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
MAPK15 N/A 0.027 0.027
2.15E-3
Total Score 597.00