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Evidence of Interaction Between EFNA1 and EPHA4

The interaction score between EFNA1 and EPHA4 is 566.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismEFNA1 OrthologueEPHA4 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00005123 0.219 IPI00016645 0.514
  • Other
  • InVivo

Get References From PubMed
human IPI00005125 0.17 IPI00016645 0.514
  • Other

Get References From PubMed
human IPI00005517 0.23 IPI00016645 0.514
  • Other
  • InVitro

Get References From PubMed
worm O44516 1 O61460 0.514
  • pullDown

Get References From PubMed

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 3.01
Domains Domains present in EFNA1 and EPHA4:
Domains in EFNA1Domains in EPHA4
IPR001799 Ephrin
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR001090 Ephrin receptor, ligand binding
IPR001426 Receptor tyrosine kinase, class V
IPR001660 Sterile alpha motif SAM
IPR003961 Fibronectin, type III
IPR003962 Fibronectin, type III subdomain
IPR008957 Fibronectin, type III-like fold
IPR008979 Galactose-binding like
IPR011510 SAM_2.
IPR013761 Sterile alpha motif-type

The Chi square scores for co-occurrence of domains that are present in EFNA1 and EPHA4 are listed below.

Domain 1Domain 2Chi Square
IPR001799 Ephrin IPR001090 Ephrin receptor, ligand binding 1988.46
IPR001799 Ephrin IPR001426 Receptor tyrosine kinase, class V 1988.46
IPR001799 Ephrin IPR001660 Sterile alpha motif SAM 683.581
IPR001799 Ephrin IPR003962 Fibronectin, type III subdomain 427.381
IPR001799 Ephrin IPR013761 Sterile alpha motif-type 387.685
IPR001799 Ephrin IPR008979 Galactose-binding like 246.01
IPR001799 Ephrin IPR003961 Fibronectin, type III 147.446
IPR001799 Ephrin IPR008957 Fibronectin, type III-like fold 99.447
IPR001799 Ephrin IPR008266 Tyrosine protein kinase, active site 73.3233
IPR001799 Ephrin IPR001245 Tyrosine protein kinase 64.1366
IPR001799 Ephrin IPR011510 SAM_2. 43.5343
IPR001799 Ephrin IPR000719 Protein kinase 30.3648

The background colour of the table refers to:

  • Blue Domain is only present in EFNA1
  • Yellow Domain is only present in EPHA4
  • Green Domain is present in both EFNA1 and EPHA4

 0.543
Post-translational Modifications

Protein: EFNA1

PTMResidueReference
Glycosyl phosphatidyl inositol GPI 186 PubMed, HPRD

Protein: EPHA4

PTMResidueReference
Phosphorylation 596 PubMed, HPRD
Phosphorylation 602 PubMed, HPRD
Phosphotyrosine 779 PubMed, HPRD
Phosphotyrosine 928 PubMed, HPRD
Localisation

Protein: EFNA1

LocalisationReference
Plasma membrane HPRD
Secreted HPRD

Protein: EPHA4

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between EFNA1 and EPHA4 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EFNA1 andEPHA4. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EFNA1 has 323 interactors and EPHA4 has 1361 interactors of which there are 197 common interactors.

Common InteractorName of Common InteractorScore for EFNA1-Interactor (?)Score for EPHA4-Interactor (?)
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 1.27E3 46.90
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 654.00 71.20
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 654.00 0.097
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 654.00 53.10
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 654.00 46.80
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 654.00 47.50
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 654.00 65.60
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 654.00 46.80
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 654.00 46.80
EPHB6 EPHB6: Ephrin type-B receptor 6 precursor 16.60 0.044
SCML2 SCML2: Sex comb on midleg-like protein 2 1.53 0.045
TP73 TP73, P73: Tumor protein p73 1.53 0.041
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 1.53 0.051
STIM1 STIM1, GOK: Stromal interaction molecule 1 precursor 1.53 0.051
LCP2 LCP2: Lymphocyte cytosolic protein 2 1.53 0.355
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 1.53 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 1.53 0.051
FN1 FN1, FN: Fibronectin precursor 1.53 0.051
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 1.37 0.046
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 1.37 0.073
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 1.37 0.062
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 1.37 0.098
CASKIN2 CASKIN2, KIAA1139: Caskin-2 1.37 0.073
CXorf9 N/A 1.37 0.058
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 1.37 0.245
FN1 N/A 1.30 0.165
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.944 0.275
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.543 0.165
ITGB4 N/A 0.543 0.109
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.543 0.110
DCC DCC: Netrin receptor DCC precursor 0.486 0.097
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.486 0.148
NEO1 NEO1, NGN: Neogenin precursor 0.486 0.171
PTPRT PTPRT, KIAA0283: Receptor-type tyrosine-protein phosphatase T precursor 0.265 0.027
PTPRD PTPRD: PTPRD protein 0.217 0.027
PTPRD PTPRD: Protein tyrosine phosphatase receptor type D 0.195 0.074
C6 C6: Complement component C6 precursor 0.165 0.064
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.165 0.072
C8A C8A: Complement component C8 alpha chain precursor 0.165 0.072
C7 C7: Complement component C7 precursor 0.148 0.058
C8B C8B: Complement component C8 beta chain precursor 0.148 0.064
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.148 0.064
THBS1 THBS1, TSP, TSP1: Thrombospondin-1 precursor 0.148 0.058
SASH1 SASH1, KIAA0790, PEPE1: SAM and SH3 domain-containing protein 1 0.141 0.029
PPFIA3 PPFIA3, KIAA0654: Liprin-alpha-3 0.126 0.027
PPFIA2 PPFIA2: Liprin-alpha-2 0.126 0.0331
PLAT PLAT: Tissue-type plasminogen activator precursor 0.056 0.098
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.056 0.0727
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.056 0.072
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.056 0.109
CRLF3 N/A 0.056 0.098
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.056 0.0727
PROC PROC: Vitamin K-dependent protein C precursor 0.056 0.064
MUC2 MUC2, SMUC: Mucin-2 precursor 0.056 0.081
CSPG2 N/A 0.056 0.065
F7 F7: Coagulation factor VII precursor 0.056 0.098
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.056 0.065
C1R C1R: Complement C1r subcomponent precursor 0.056 0.065
UMOD UMOD: Uromodulin precursor 0.056 0.109
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.056 0.109
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.056 0.109
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.056 0.165
C1S C1S: Complement C1s subcomponent precursor 0.056 0.065
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.056 0.165
F12 F12: Coagulation factor XII precursor 0.056 0.072
THBD THBD, THRM: Thrombomodulin precursor 0.056 0.037
F5 F5: Coagulation factor V precursor 0.056 0.581
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.050 0.111
TNC TNC, HXB: Tenascin precursor 0.050 0.088
SPOCK1 SPOCK1, SPOCK, TIC1, TICN1: Testican-1 precursor 0.050 0.040
BMP1 N/A 0.050 0.098
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.050 0.113
DLG2 DLG2: Disks large homolog 2 0.050 0.181
CNTN1 CNTN1: Contactin-1 precursor 0.050 0.148
CNTN4 CNTN4: Contactin-4 precursor 0.050 0.148
NOTCH4 N/A 0.050 0.136
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.050 0.097
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.050 0.058
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.050 0.136
ALK ALK: ALK tyrosine kinase receptor precursor 0.050 0.064
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.050 0.097
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.050 0.064
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.050 0.064
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.050 0.098
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.050 0.040
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.050 0.090
F9 F9: Coagulation factor IX precursor 0.050 0.058
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.050 0.058
LAMA2 LAMA2: Uncharacterized protein LAMA2 0.050 0.064
F10 F10: Coagulation factor X precursor 0.050 0.097
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.050 0.058
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.050 0.111
SLIT2 SLIT2, SLIL3: Slit homolog 2 protein precursor 0.050 0.090
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.044 0.109
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.044 0.191
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.044 0.109
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.044 0.109
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.044 0.098
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.044 0.416
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.044 0.109
MET MET: Hepatocyte growth factor receptor precursor 0.044 0.109
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.044 0.515
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.044 0.109
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.044 0.165
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.044 0.165
SORL1 SORL1: Sortilin-related receptor precursor 0.044 0.123
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.044 0.109
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.044 0.165
EGF EGF: Pro-epidermal growth factor precursor 0.044 0.098
DLK1 DLK1, DLK: Delta-like protein precursor 0.044 0.165
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.044 0.123
F3 F3: Tissue factor precursor 0.044 0.109
PRLR PRLR: Prolactin receptor precursor 0.044 0.109
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.044 0.109
PTPRZ1 N/A 0.044 0.275
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.044 0.165
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.044 0.098
GHR GHR: Growth hormone receptor precursor 0.044 0.098
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.044 0.109
SELE SELE, ELAM1: E-selectin precursor 0.044 0.098
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.044 0.098
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.044 0.148
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.044 0.123
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.044 0.109
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.044 0.098
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.044 0.165
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.044 0.165
IL9R IL9R: Interleukin-9 receptor precursor 0.044 0.109
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.044 0.165
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.044 0.098
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.044 0.110
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.044 0.123
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.044 0.109
AREG AREG, SDGF: Amphiregulin precursor 0.044 0.098
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.044 0.372
EPOR EPOR: Erythropoietin receptor precursor 0.044 0.098
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.040 0.088
JAG2 JAG2: Jagged-2 precursor 0.040 0.148
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.040 0.099
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.040 0.088
STK39 STK39, SPAK: STE20/SPS1-related proline-alanine-rich protein kinase 0.040 0.038
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.040 0.088
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.097
LDLR LDLR: Low-density lipoprotein receptor precursor 0.040 0.088
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.040 0.088
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.040 0.097
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.111
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.040 0.049
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.040 0.136
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.040 0.0308
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.040 0.025
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.040 0.148
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.040 0.099
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.040 0.088
KIT KIT: Mast/stem cell growth factor receptor precursor 0.040 0.111
ATRN N/A 0.040 0.148
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.040 0.088
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.040 0.025
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.040 0.111
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.040 0.148
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.097
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.040 0.111
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.040 0.097
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.040 0.111
MBTPS2 MBTPS2, S2P: Membrane-bound transcription factor site-2 protease 0.040 0.088
INSR INSR: Insulin receptor precursor 0.040 0.097
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.040 0.097
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.040 0.097
MEP1A MEP1A: Meprin A subunit alpha precursor 0.040 0.097
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.040 0.088
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.040 0.148
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.040 0.111
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.040 0.099
MEP1B MEP1B: Meprin A subunit beta precursor 0.040 0.097
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.040 0.148
SUPT5H SUPT5H, SPT5, SPT5H: Transcription elongation factor SPT5 0.029 0.033
CFB CFB, BF, BFD: Complement factor B precursor 0.028 0.065
CFP CFP, PFC: Properdin precursor 0.028 0.072
IL22RA2 IL22RA2, UNQ5793/PRO19598/PRO19822: Interleukin-22 receptor alpha-2 chain precur 0.027 0.027
ROBO1 N/A 0.027 0.027
NELL1 NELL1, NRP1: Protein kinase C-binding protein NELL1 precursor 0.027 0.039
NELL2 NELL2, NRP2: Protein kinase C-binding protein NELL2 precursor 0.027 0.027
CRLF1 CRLF1, ZCYTOR5, UNQ288/PRO327: Cytokine receptor-like factor 1 precursor 0.027 0.027
TRIM42 TRIM42: Tripartite motif-containing protein 42 0.027 0.027
MUC13 MUC13, DRCC1, UNQ6194/PRO20221, RECC: Mucin-13 precursor 0.027 0.027
CNTNAP2 CNTNAP2, CASPR2, KIAA0868: Contactin-associated protein-like 2 precursor 0.027 0.053
NTN4 NTN4: Netrin-4 precursor 0.027 0.027
LRP1B LRP1B, LRPDIT: Low-density lipoprotein receptor-related protein 1B precursor 0.027 0.044
IL5RA N/A 0.027 0.027
FLRT2 FLRT2, KIAA0405, UNQ232/PRO265: Leucine-rich repeat transmembrane protein FLRT2 0.027 0.050
WIF1 WIF1, UNQ191/PRO217: Wnt inhibitory factor 1 precursor 0.027 0.029
EDIL3 EDIL3, DEL1: EGF-like repeat and discoidin I-like domain-containing protein 3 pr 0.027 0.032
GP2 GP2: Pancreatic secretory granule membrane major glycoprotein GP2 precursor 0.027 0.027
CLEC14A CLEC14A, C14orf27, UNQ236/PRO269, EGFR5: C-type lectin domain family 14 member A 0.027 0.027
INPPL1 INPPL1, SHIP2: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 0.0258 0.0258
VWF VWF, F8VWF: von Willebrand factor precursor 0.025 0.064
SPON1 SPON1, KIAA0762, VSGP: Spondin-1 precursor 0.025 0.090
2.15E-3
Total Score 566.00