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Evidence of Interaction Between EFNA1 and EPHA7

The interaction score between EFNA1 and EPHA7 is 566.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

N/A
Orthology
OrganismEFNA1 OrthologueEPHA7 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00005123 0.219 IPI00005222 0.175
human IPI00005125 0.17 IPI00005222 0.175
human IPI00005517 0.23 IPI00005222 0.175
human IPI00005123 0.219 IPI00419636 0.07
  • Other

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human IPI00005125 0.17 IPI00419636 0.07
human IPI00005517 0.23 IPI00419636 0.07
  • Other

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human IPI00005123 0.219 IPI00418427 0.503
human IPI00005125 0.17 IPI00418427 0.503
human IPI00005517 0.23 IPI00418427 0.503
  • Other

Get References From PubMed

worm O44516 1 O61460 1
  • pullDown

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The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

3.01
Domains Domains present in EFNA1 and EPHA7:
Domains in EFNA1Domains in EPHA7
IPR001799 Ephrin
IPR006209 EGF-like domain
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR002290 Serine/threonine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR001090 Ephrin receptor, ligand binding
IPR001426 Receptor tyrosine kinase, class V
IPR001660 Sterile alpha motif SAM
IPR003961 Fibronectin, type III
IPR003962 Fibronectin, type III subdomain

The Chi square scores for co-occurrence of domains that are present in EFNA1 and EPHA7 are listed below.

Domain 1Domain 2Chi Square
IPR001799 Ephrin IPR001090 Ephrin receptor, ligand binding 1988.46
IPR001799 Ephrin IPR001426 Receptor tyrosine kinase, class V 1988.46
IPR001799 Ephrin IPR001660 Sterile alpha motif SAM 683.581
IPR001799 Ephrin IPR003962 Fibronectin, type III subdomain 427.381
IPR001799 Ephrin IPR003961 Fibronectin, type III 147.446
IPR001799 Ephrin IPR008266 Tyrosine protein kinase, active site 73.3233
IPR001799 Ephrin IPR001245 Tyrosine protein kinase 64.1366
IPR001799 Ephrin IPR006209 EGF-like domain 50.0861
IPR001799 Ephrin IPR000719 Protein kinase 30.3648

The background colour of the table refers to:

  • Blue Domain is only present in EFNA1
  • Yellow Domain is only present in EPHA7
  • Green Domain is present in both EFNA1 and EPHA7

0.543
Post-translational Modifications

Protein: EFNA1

PTMResidueReference
Glycosyl phosphatidyl inositol GPI 186 PubMed, HPRD

Protein: EPHA7

PTMResidueReference
Phosphotyrosine 608 PubMed, HPRD
Phosphotyrosine 614 PubMed, HPRD
Phosphotyrosine 791 PubMed, HPRD
Phosphotyrosine 940 PubMed, HPRD
Localisation

Protein: EFNA1

LocalisationReference
Plasma membrane HPRD
Secreted HPRD

Protein: EPHA7

LocalisationReference
Plasma membrane HPRD
Secreted HPRD
Transitive Score

The common interactors between EFNA1 and EPHA7 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EFNA1 andEPHA7. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EFNA1 has 323 interactors and EPHA7 has 1175 interactors of which there are 183 common interactors.

Common InteractorName of Common InteractorScore for EFNA1-Interactor (?)Score for EPHA7-Interactor (?)
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 1.27E3 46.90
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 654.00 71.20
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 654.00 65.60
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 654.00 65.60
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 654.00 65.60
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 654.00 0.171
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 654.00 0.097
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 654.00 46.80
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 654.00 46.80
SCML2 SCML2: Sex comb on midleg-like protein 2 1.53 0.051
TP73 TP73, P73: Tumor protein p73 1.53 0.051
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 1.53 0.051
LCP2 LCP2: Lymphocyte cytosolic protein 2 1.53 0.320
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 1.53 0.051
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 1.37 0.058
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 1.37 0.062
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 1.37 0.098
CASKIN2 CASKIN2, KIAA1139: Caskin-2 1.37 0.073
CXorf9 N/A 1.37 0.058
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 1.37 0.090
FN1 N/A 1.30 0.165
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.944 0.037
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.543 0.056
ITGB4 N/A 0.543 0.033
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.543 0.0416
DCC DCC: Netrin receptor DCC precursor 0.486 0.037
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.486 0.148
NEO1 NEO1, NGN: Neogenin precursor 0.486 0.046
PTPRT PTPRT, KIAA0283: Receptor-type tyrosine-protein phosphatase T precursor 0.265 0.027
PTPRD PTPRD: PTPRD protein 0.217 0.027
C6 C6: Complement component C6 precursor 0.165 0.073
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.165 0.0407
C8A C8A: Complement component C8 alpha chain precursor 0.165 0.0407
C7 C7: Complement component C7 precursor 0.148 0.026
C8B C8B: Complement component C8 beta chain precursor 0.148 0.046
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.148 0.073
THBS1 THBS1, TSP, TSP1: Thrombospondin-1 precursor 0.148 0.090
PLAT PLAT: Tissue-type plasminogen activator precursor 0.056 0.098
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.056 0.051
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.056 0.029
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.056 0.064
CRLF3 N/A 0.056 0.037
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.056 0.029
PROC PROC: Vitamin K-dependent protein C precursor 0.056 0.030
MUC2 MUC2, SMUC: Mucin-2 precursor 0.056 0.0407
CSPG2 N/A 0.056 0.033
F7 F7: Coagulation factor VII precursor 0.056 0.040
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.056 0.051
C1R C1R: Complement C1r subcomponent precursor 0.056 0.081
UMOD UMOD: Uromodulin precursor 0.056 0.0416
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.056 0.0416
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.056 0.109
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.056 0.056
C1S C1S: Complement C1s subcomponent precursor 0.056 0.072
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.056 0.165
F12 F12: Coagulation factor XII precursor 0.056 0.033
THBD THBD, THRM: Thrombomodulin precursor 0.056 0.0416
F5 F5: Coagulation factor V precursor 0.056 0.731
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.050 0.111
TNC TNC, HXB: Tenascin precursor 0.050 0.033
SPOCK1 SPOCK1, SPOCK, TIC1, TICN1: Testican-1 precursor 0.050 0.040
BMP1 N/A 0.050 0.040
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.050 0.073
DLG2 DLG2: Disks large homolog 2 0.050 0.073
CNTN1 CNTN1: Contactin-1 precursor 0.050 0.050
CNTN4 CNTN4: Contactin-4 precursor 0.050 0.050
NOTCH4 N/A 0.050 0.037
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.050 0.037
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.050 0.030
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.050 0.033
ALK ALK: ALK tyrosine kinase receptor precursor 0.050 0.113
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.050 0.136
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.050 0.064
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.050 0.030
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.050 0.040
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.050 0.040
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.050 0.073
F9 F9: Coagulation factor IX precursor 0.050 0.113
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.050 0.030
LAMA2 LAMA2: Uncharacterized protein LAMA2 0.050 0.064
F10 F10: Coagulation factor X precursor 0.050 0.037
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.050 0.064
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.050 0.171
SLIT2 SLIT2, SLIL3: Slit homolog 2 protein precursor 0.050 0.030
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.044 0.098
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.044 0.033
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.044 0.152
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.044 0.123
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.044 0.037
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.044 0.152
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.044 0.191
MET MET: Hepatocyte growth factor receptor precursor 0.044 0.152
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.044 0.0416
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.044 0.051
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.044 0.165
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.044 0.165
SORL1 SORL1: Sortilin-related receptor precursor 0.044 0.037
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.044 0.152
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.044 0.165
EGF EGF: Pro-epidermal growth factor precursor 0.044 0.051
DLK1 DLK1, DLK: Delta-like protein precursor 0.044 0.056
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.044 0.152
F3 F3: Tissue factor precursor 0.044 0.109
PRLR PRLR: Prolactin receptor precursor 0.044 0.152
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.044 0.123
PTPRZ1 N/A 0.044 0.046
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.044 0.165
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.044 0.051
GHR GHR: Growth hormone receptor precursor 0.044 0.109
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.044 0.109
SELE SELE, ELAM1: E-selectin precursor 0.044 0.123
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.044 0.037
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.044 0.148
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.044 0.098
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.044 0.191
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.044 0.123
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.044 0.165
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.044 0.165
IL9R IL9R: Interleukin-9 receptor precursor 0.044 0.123
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.044 0.165
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.044 0.109
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.044 0.123
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.044 0.123
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.044 0.123
AREG AREG, SDGF: Amphiregulin precursor 0.044 0.033
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.044 0.058
EPOR EPOR: Erythropoietin receptor precursor 0.044 0.123
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.040 0.097
NPR2 NPR2, ANPRB: Atrial natriuretic peptide receptor B precursor 0.040 0.086
JAG2 JAG2: Jagged-2 precursor 0.040 0.050
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.040 0.111
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.040 0.097
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.040 0.111
ITGB7 ITGB7: Integrin beta-7 precursor 0.040 0.088
LDLR LDLR: Low-density lipoprotein receptor precursor 0.040 0.097
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.040 0.088
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.040 0.111
UNC84B UNC84B, FRIGG, KIAA0668, RAB5IP, SUN2: Sad1/unc-84-like protein 2 0.040 0.088
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.040 0.049
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.040 0.058
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.040 0.086
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.040 0.025
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.040 0.148
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.040 0.097
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.040 0.097
KIT KIT: Mast/stem cell growth factor receptor precursor 0.040 0.097
ATRN N/A 0.040 0.050
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.040 0.171
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.040 0.025
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.040 0.033
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.040 0.148
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.040 0.097
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.040 0.097
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.040 0.097
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.040 0.037
MBTPS2 MBTPS2, S2P: Membrane-bound transcription factor site-2 protease 0.040 0.046
INSR INSR: Insulin receptor precursor 0.040 0.097
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.040 0.097
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.040 0.136
MEP1A MEP1A: Meprin A subunit alpha precursor 0.040 0.033
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.040 0.111
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.040 0.148
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.040 0.111
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.040 0.037
MEP1B MEP1B: Meprin A subunit beta precursor 0.040 0.136
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.040 0.050
CFB CFB, BF, BFD: Complement factor B precursor 0.028 0.0407
SERPINF2 SERPINF2, AAP, PLI: Alpha-2-antiplasmin precursor 0.028 0.100
CFP CFP, PFC: Properdin precursor 0.028 0.029
MFAP2 MFAP2, MAGP1: Microfibrillar-associated protein 2 precursor 0.028 0.081
IL22RA2 IL22RA2, UNQ5793/PRO19598/PRO19822: Interleukin-22 receptor alpha-2 chain precur 0.027 0.027
ROBO1 N/A 0.027 0.027
NELL2 NELL2, NRP2: Protein kinase C-binding protein NELL2 precursor 0.027 0.027
CRLF1 CRLF1, ZCYTOR5, UNQ288/PRO327: Cytokine receptor-like factor 1 precursor 0.027 0.027
TRIM42 TRIM42: Tripartite motif-containing protein 42 0.027 0.027
MUC13 MUC13, DRCC1, UNQ6194/PRO20221, RECC: Mucin-13 precursor 0.027 0.027
NTN4 NTN4: Netrin-4 precursor 0.027 0.027
IL5RA N/A 0.027 0.027
GP2 GP2: Pancreatic secretory granule membrane major glycoprotein GP2 precursor 0.027 0.027
CLEC14A CLEC14A, C14orf27, UNQ236/PRO269, EGFR5: C-type lectin domain family 14 member A 0.027 0.027
INPPL1 INPPL1, SHIP2: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 0.0258 0.0258
VWF VWF, F8VWF: von Willebrand factor precursor 0.025 0.058
SPON1 SPON1, KIAA0762, VSGP: Spondin-1 precursor 0.025 0.036
2.15E-3
Total Score 566.00