PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between TAF6 and TAF5

The interaction score between TAF6 and TAF5 is 3.64E3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between TAF6 and TAF5 = 0.55

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

6.27E-3

Orthology

Organism	TAF6 Orthologue		TAF5 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YGL112C	1	YBR198C	1	Y2H Immunoprecipitation Other AffinityCaptureMS AffinityCaptureWestern CoPurification Get References From PubMed
worm	Q9GZI6	1	O01985	1
fly	P49847	1	P49846	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593

Domains

Domains present in TAF6 and TAF5:

Domains in TAF6

Domains in TAF5

IPR009072	Histone-fold
IPR004823	TATA box binding protein associated factor (TAF)
IPR007124	Histone-fold/TFIID-TAF/NF-Y
IPR011442	DUF1546.

IPR001680	G-protein beta WD-40 repeat
IPR006594	Lissencephaly type-1-like homology motif
IPR007582	WD40 associated region in TFIID subunit

The Chi square scores for co-occurrence of domains that are present in TAF6 and TAF5 are listed below.

Domain 1		Domain 2		Chi Square
IPR009072	Histone-fold	IPR001680	G-protein beta WD-40 repeat	5.98986
IPR007124	Histone-fold/TFIID-TAF/NF-Y	IPR001680	G-protein beta WD-40 repeat	5.81512

The background colour of the table refers to:

Blue Domain is only present in TAF6
Yellow Domain is only present in TAF5
Green Domain is present in both TAF6 and TAF5

0.027

Post-translational Modifications

Protein: TAF6

PTM	Residue	Reference
Phosphorylation	653	PubMed, HPRD
Phosphoserine	653	HPRD

Protein: TAF5

PTM	Residue	Reference

Localisation

Protein: TAF6

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Protein: TAF5

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD
Cytoskeleton	HPRD

Transitive Score

The common interactors between TAF6 and TAF5 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TAF6 andTAF5. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TAF6 has 1055 interactors and TAF5 has 131 interactors of which there are 77 common interactors.

Common Interactor	Name of Common Interactor	Score for TAF6-Interactor (?)	Score for TAF5-Interactor (?)
TAF9	TAF9, TAF2G, TAFII31: Transcription initiation factor TFIID subunit 9	80.90	32.60
TBP	TBP, GTF2D1, TF2D, TFIID: TATA-box-binding protein	80.90	1.10
H2AFX	H2AFX, H2AX: Histone H2A.x	72.80	0.074
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	45.20	0.060
TAF9B	TAF9B, TAF9L: Transcription initiation factor TFIID subunit 9B	32.20	1.27
PCAF	PCAF: Histone acetyltransferase PCAF	14.70	0.538
HIST1H2BG	HIST1H2BC, H2BFL, HIST1H2BE, H2BFH, HIST1H2BF, H2BFG, HIST1H2BG, H2BFA, HIST1H2B	9.63	0.036
HIST1H3A	HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD,	9.09	0.036
GCN5L2	GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2	7.38	0.082
TAF12	TAF12, TAF15, TAF2J, TAFII20: Transcription initiation factor TFIID subunit 12	7.31	15.90
HIST3H3	HIST3H3, H3FT: Histone H3.1t	5.88	0.028
CHD1	CHD1: Chromodomain-helicase-DNA-binding protein 1	5.20	0.160
TAF13	TAF13, TAF2K, TAFII18: Transcription initiation factor TFIID subunit 13	4.16	4.72
TAF7	TAF7, TAF2F, TAFII55: Transcription initiation factor TFIID subunit 7	2.36	0.179
H2BFS	H2BFS: Histone H2B type F-S	2.36	0.036
HIST1H2BK	HIST1H2BK, H2BFT, HIRIP1: Histone H2B type 1-K	2.36	0.036
HIST1H2AG	HIST1H2AG, H2AFP, HIST1H2AI, H2AFC, HIST1H2AK, H2AFD, HIST1H2AL, H2AFI, HIST1H2A	1.46	0.028
HIST1H2AB	N/A	1.46	0.036
HIST1H2BJ	HIST1H2BJ, H2BFR: Histone H2B type 1-J	1.17	0.028
TRRAP	TRRAP, PAF400: Transformation/transcription domain-associated protein	1.15	0.160
BRD7	BRD7, BP75, CELTIX1: Bromodomain-containing protein 7	0.890	1.82
TAF2	TAF2, CIF150, TAF2B: Transcription initiation factor TFIID subunit 2	0.593	0.593
ENY2	ENY2, DC6: Enhancer of yellow 2 transcription factor homolog	0.593	0.593
USP22		0.593	0.593
CPSF1	CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1	0.461	0.123
CENPA	CENPA: Histone H3-like centromeric protein A	0.416	0.067
TAF1L	TAF1L: Transcription initiation factor TFIID 210 kDa subunit	0.390	0.071
TAF10	TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10	0.372	0.060
SUPT3H	N/A	0.354	0.354
TAF1	N/A	0.354	0.354
TADA2L	TADA2L, KL04P: Transcriptional adapter 2-like	0.326	1.47
TAF7L	TAF7L, GHc-521F8.1-003: Transcription initiation factor TFIID subunit 7-like pro	0.326	0.326
CHD2	N/A	0.261	0.172
SOS1	SOS1: Son of sevenless homolog 1	0.171	0.044
NBN	NBN, NBS, NBS1, P95: Nibrin	0.155	0.0255
TOPBP1	TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1	0.139	0.038
NULL	N/A	0.119	0.119
NULL	N/A	0.119	0.119
BP75	N/A	0.119	0.119
NULL	N/A	0.119	0.119
DNMT1	DNMT1, AIM, DNMT: DNA	0.087	0.0255
C20orf18	N/A	0.083	0.027
EIF3S9	EIF3S9: Eukaryotic translation initiation factor 3 subunit 9	0.078	0.038
LSM2	LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2	0.078	0.060
SSB	SSB: Lupus La protein	0.078	0.038
TBPL2		0.071	0.071
BRD9	N/A	0.071	0.071
USP51	USP51: Ubiquitin carboxyl-terminal hydrolase 51	0.071	0.071
MATR3	MATR3, KIAA0723: Matrin-3	0.070	0.0255
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.070	0.042
RBM14	RBM14, SIP: RNA-binding protein 14	0.070	0.042
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.070	0.0255
TIAL1	TIAL1: Nucleolysin TIAR	0.063	0.038
SYNCRIP	SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q	0.063	0.038
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	0.063	0.038
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	0.063	0.123
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	0.063	0.038
HNRPF	HNRPF: Heterogeneous nuclear ribonucleoprotein F	0.063	0.038
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	0.063	0.123
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.063	0.038
H2AFZ	H2AFZ, H2AZ: Histone H2A.Z	0.060	0.074
POLE3	POLE3, CHRAC17: DNA polymerase epsilon subunit 3	0.060	0.123
TAF11	TAF11, TAF2I, PRO2134: Transcription initiation factor TFIID subunit 11	0.060	0.074
SF3B3	N/A	0.060	0.123
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.052	0.0278
ZNF638	ZNF638, NP220, ZFML: Zinc finger protein 638	0.052	0.0255
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.046	0.038
TAF4	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135: Transcription initiation factor	0.044	0.074
JMJD1A	JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr	0.0425	0.0255
CCT2	CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta	0.040	1.01
CUL5	CUL5, VACM1: Cullin-5	0.038	0.060
DDB1	DDB1, XAP1: DNA damage-binding protein 1	0.036	0.028
DR1	DR1: TATA-binding protein-associated phosphoprotein	0.036	0.060
TBCE	TBCE: Tubulin-specific chaperone E	0.032	0.047
NFYB	NFYB, HAP3: Nuclear transcription factor Y subunit beta	0.028	0.044
HIST1H2AD	HIST1H2AD, H2AFG: Histone H2A type 1-D	0.027	0.027
H2AFY2	H2AFY2, MACROH2A2: Core histone macro-H2A.2	0.027	0.027

0.572

Total Score

3.64E3