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Evidence of Interaction Between IKBKE and CDC37

The interaction score between IKBKE and CDC37 is 5.50.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismIKBKE OrthologueCDC37 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
fly Q8INU8 0.194 Q24276 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains No domains were used in calculating likelihood of interaction 0.051
Post-translational Modifications

Protein: IKBKE

PTMResidueReference
Phosphoserine 172 HPRD

Protein: CDC37

PTMResidueReference
Phosphorylation 13 PubMed, HPRD
Phosphotyrosine 298 HPRD
Localisation

Protein: IKBKE

LocalisationReference
Cytoplasm HPRD

Protein: CDC37

LocalisationReference
Cytoplasm HPRD
Transitive Score

The common interactors between IKBKE and CDC37 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between IKBKE andCDC37. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , IKBKE has 184 interactors and CDC37 has 276 interactors of which there are 39 common interactors.

Common InteractorName of Common InteractorScore for IKBKE-Interactor (?)Score for CDC37-Interactor (?)
HSP90AA1 Hsp89-alpha-delta-N 9.44 1.49
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.051 0.029
EEF2K EEF2K: Elongation factor 2 kinase 0.051 0.046
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.051 0.0338
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.051 0.0782
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.051 0.0955
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.051 0.030
BMX N/A 0.051 0.034
ROCK1 ROCK1: Rho-associated protein kinase 1 0.051 0.0955
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.051 0.059
INSL3 JAK3: Tyrosine-protein kinase JAK3 0.051 0.034
LYN LYN: Tyrosine-protein kinase Lyn 0.051 0.116
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.046 0.046
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.046 0.070
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.046 0.030
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.046 0.086
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.046 0.143
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.046 0.034
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.046 0.046
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.046 0.143
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.046 0.237
CSK CSK: Tyrosine-protein kinase CSK 0.046 0.143
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.046 0.030
HCK N/A 0.046 0.070
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.046 0.053
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.046 0.086
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.046 0.116
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.046 0.031
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.046 0.116
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.046 0.046
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.046 0.116
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.046 0.116
SYK SYK: Tyrosine-protein kinase SYK 0.046 0.116
SOS1 SOS1: Son of sevenless homolog 1 0.046 0.086
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.046 0.034
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.046 0.116
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.046 0.046
JAK1 0.046 0.116
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.026 0.039
0.299
Total Score 5.50