<<< Back to MET

Evidence of Interaction Between MET and CBL

The interaction score between MET and CBL is 36.60.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MET and CBL = 0.07

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

1.85E-3
Orthology N/A N/A
Domains Domains present in MET and CBL:
Domains in METDomains in CBL
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR008266 Tyrosine protein kinase, active site
IPR011009 Protein kinase-like
IPR001627 Semaphorin/CD100 antigen
IPR002165 Plexin
IPR002909 Cell surface receptor IPT/TIG
IPR001841 Zn-finger, RING
IPR000449 Ubiquitin-associated domain
IPR000980 SH2 motif
IPR000217 Tubulin
IPR003153 Adaptor protein Cbl, N-terminal
IPR011992 EF-Hand_type.
IPR013090 Phospholip_A2_AS.

The Chi square scores for co-occurrence of domains that are present in MET and CBL are listed below.

Domain 1Domain 2Chi Square
IPR008266 Tyrosine protein kinase, active site IPR000980 SH2 motif 383.26
IPR001245 Tyrosine protein kinase IPR000980 SH2 motif 238.73
IPR000719 Protein kinase IPR000980 SH2 motif 82.1364
IPR011009 Protein kinase-like IPR000980 SH2 motif 59.6059
IPR008266 Tyrosine protein kinase, active site IPR001841 Zn-finger, RING 16.2425
IPR011009 Protein kinase-like IPR001841 Zn-finger, RING 15.6712
IPR000719 Protein kinase IPR011992 EF-Hand_type. 15.5567
IPR001245 Tyrosine protein kinase IPR001841 Zn-finger, RING 15.1425
IPR000719 Protein kinase IPR001841 Zn-finger, RING 14.0542
IPR008266 Tyrosine protein kinase, active site IPR003153 Adaptor protein Cbl, N-terminal 13.6309
IPR011009 Protein kinase-like IPR011992 EF-Hand_type. 9.34155
IPR001245 Tyrosine protein kinase IPR003153 Adaptor protein Cbl, N-terminal 9.19853
IPR001245 Tyrosine protein kinase IPR011992 EF-Hand_type. 6.38624
IPR000719 Protein kinase IPR003153 Adaptor protein Cbl, N-terminal 3.06419
IPR011009 Protein kinase-like IPR003153 Adaptor protein Cbl, N-terminal 3.04324
IPR002165 Plexin IPR000980 SH2 motif 1.44497
IPR001627 Semaphorin/CD100 antigen IPR000980 SH2 motif 1.25013
IPR008266 Tyrosine protein kinase, active site IPR011992 EF-Hand_type. 1.24952
IPR002909 Cell surface receptor IPT/TIG IPR000980 SH2 motif 0.785186
IPR011009 Protein kinase-like IPR000217 Tubulin 0.524874
IPR011009 Protein kinase-like IPR000449 Ubiquitin-associated domain 0.41941
IPR001245 Tyrosine protein kinase IPR000449 Ubiquitin-associated domain 0.348773
IPR008266 Tyrosine protein kinase, active site IPR000217 Tubulin 0.0503676
IPR000719 Protein kinase IPR000217 Tubulin 0.0254403
IPR008266 Tyrosine protein kinase, active site IPR000449 Ubiquitin-associated domain 0.00515077
IPR000719 Protein kinase IPR000449 Ubiquitin-associated domain 0.00138935
IPR001245 Tyrosine protein kinase IPR000217 Tubulin 0.00033966
IPR002909 Cell surface receptor IPT/TIG IPR001841 Zn-finger, RING 0.00000814112

The background colour of the table refers to:

  • Blue Domain is only present in MET
  • Yellow Domain is only present in CBL
  • Green Domain is present in both MET and CBL

0.540
Post-translational Modifications

Protein: MET

PTMResidueReference
Dephosphorylation 1349 PubMed, HPRD
Dephosphorylation 1356 PubMed, HPRD
Phosphorylation 985 PubMed, HPRD
Phosphorylation 1003 PubMed, HPRD
Phosphorylation 1230 PubMed, HPRD
Phosphorylation 1234 PubMed, HPRD
Phosphorylation 1235 PubMed, HPRD
Phosphorylation 1295 PubMed, HPRD
Phosphorylation 1331 PubMed, HPRD
Phosphorylation 1338 PubMed, HPRD
Phosphorylation 1349 PubMed, HPRD
Phosphorylation 1356 PubMed, HPRD
Phosphorylation 1365 PubMed, HPRD
Phosphotyrosine 1235 PubMed, HPRD

Protein: CBL

PTMResidueReference
Phosphorylation 371 PubMed, HPRD
Phosphorylation 619 PubMed, HPRD
Phosphorylation 623 PubMed, HPRD
Phosphorylation 639 PubMed, HPRD
Phosphorylation 642 PubMed, HPRD
Phosphorylation 667 PubMed, HPRD
Phosphorylation 669 PubMed, HPRD
Phosphorylation 674 PubMed, HPRD
Phosphorylation 675 PubMed, HPRD
Phosphorylation 700 PubMed, HPRD
Phosphorylation 731 PubMed, HPRD
Phosphorylation 774 PubMed, HPRD
Phosphoserine 669 HPRD
Phosphotyrosine 371 PubMed, HPRD
Phosphotyrosine 674 HPRD
Phosphotyrosine 700 HPRD
Phosphotyrosine 774 HPRD
Localisation

Protein: MET

LocalisationReference
Plasma membrane HPRD

Protein: CBL

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between MET and CBL that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MET andCBL. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MET has 1181 interactors and CBL has 1376 interactors of which there are 681 common interactors.

Common InteractorName of Common InteractorScore for MET-Interactor (?)Score for CBL-Interactor (?)
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 1.81 0.731
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 1.68 0.123
INSL3 JAK3: Tyrosine-protein kinase JAK3 1.13 0.902
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 1.13 0.577
LNK SH2B3, LNK: SH2B adapter protein 3 0.980 0.109
STAT3 0.980 0.098
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.980 0.980
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.980 0.109
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.980 0.098
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.980 0.109
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.980 0.878
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 0.980 0.878
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.980 8.34
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 0.980 0.980
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.908 0.140
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 0.902 0.577
APS SH2B2, APS: SH2B adapter protein 2 0.731 0.073
BMX N/A 0.731 0.644
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.731 1.01
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.731 0.081
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.731 1.13
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.731 0.090
RIN1 RIN1: Ras and Rab interactor 1 0.731 0.097
STAT6 STAT6: Signal transducer and activator of transcription 6 0.654 0.073
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.654 0.731
HCK N/A 0.654 0.655
SYK SYK: Tyrosine-protein kinase SYK 0.654 0.808
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.654 0.072
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.654 0.655
CSK CSK: Tyrosine-protein kinase CSK 0.654 0.655
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 0.654 0.655
LYN LYN: Tyrosine-protein kinase Lyn 0.654 0.655
JAK1 0.654 0.577
VAV1 VAV1, VAV: Proto-oncogene vav 0.654 0.073
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.654 0.064
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.644 0.644
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.644 0.073
NCK2 NCK2: Cytoplasmic protein NCK2 0.644 30.80
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.644 0.072
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.617 0.051
GRB10 N/A 0.617 0.051
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.617 0.051
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.617 0.046
CRK CRK: Proto-oncogene C-crk 0.617 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.617 0.046
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.581 0.577
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.581 277.00
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.581 0.100
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 0.581 0.577
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.581 0.081
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.581 0.081
CRKL CRKL: Crk-like protein 0.581 0.064
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.540 0.148
JAK2 JAK2: Tyrosine-protein kinase JAK2 0.519 0.655
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.519 0.064
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.519 0.655
F3 F3: Tissue factor precursor 0.515 0.051
ITGB4 N/A 0.416 0.051
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.360 0.097
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.360 0.109
STAT4 STAT4: Signal transducer and activator of transcription 4 0.355 0.111
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.340 0.051
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.320 0.097
STAT2 STAT2: Signal transducer and activator of transcription 2 0.320 0.152
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.307 0.445
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.217
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.251 0.361
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.251 0.445
TNC TNC, HXB: Tenascin precursor 0.251 0.037
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.251 0.361
PVR PVR, PVS: Poliovirus receptor precursor 0.251 0.051
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.251 0.051
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.251 0.045
IRS1 IRS1: Insulin receptor substrate 1 0.202 0.152
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.191 0.041
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.191 0.320
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.191 0.057
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.191 0.051
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.191 0.051
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.191 0.361
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.191 0.051
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.191 0.051
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.191 0.286
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.191 0.051
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.191 0.063
PRLR PRLR: Prolactin receptor precursor 0.191 0.063
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.191 214.00
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.191 0.045
NEO1 NEO1, NGN: Neogenin precursor 0.191 0.057
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.166 0.136
ATRN N/A 0.165 0.030
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.165 0.0688
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.165 0.540
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.165 0.0688
BSG N/A 0.165 0.062
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.165 0.062
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.165 0.0688
CNTN1 CNTN1: Contactin-1 precursor 0.165 0.062
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.165 0.0688
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.0688
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.165 0.540
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.165 0.0688
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.165 0.483
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.165 0.062
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.165 0.0688
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.165 0.0688
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.165 0.0688
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.165 0.0688
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.165 0.062
GPR126 DREG: Developmentally regulated G-protein-coupled receptor alpha 1 0.165 0.034
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.165 0.0688
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.165 0.062
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.0688
CNTN4 CNTN4: Contactin-4 precursor 0.165 0.062
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.165 0.0688
KIR3DL1 N/A 0.165 0.0688
SEMA4B SEMA4B: Sema domain, immunoglobulin domain 0.165 0.034
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.165 0.540
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.165 0.0688
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.165 0.0688
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.165 0.0688
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.165 0.0688
FN1 N/A 0.165 0.0688
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.165 0.0688
ANXA3 ANXA3, ANX3: Annexin A3 0.163 0.051
SHC3 SHC3, NSHC, SHCC: SHC-transforming protein 3 0.162 5.94
DCC DCC: Netrin receptor DCC precursor 0.152 0.057
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.152 0.445
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.152 0.063
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.152 0.041
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.152 0.063
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.152 0.073
MEP1A MEP1A: Meprin A subunit alpha precursor 0.152 0.037
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.152 173.00
MEP1B MEP1B: Meprin A subunit beta precursor 0.152 0.057
IL9R IL9R: Interleukin-9 receptor precursor 0.152 0.051
GPA33 GPA33: Cell surface A33 antigen precursor 0.152 0.051
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.152 0.045
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.152 0.051
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.152 0.063
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.152 0.318
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.152 0.041
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.152 0.051
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.152 0.045
FYN N/A 0.145 0.143
GRAP GRAP: GRB2-related adapter protein 0.143 2.13
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.129 0.143
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.127 0.318
CNN3 CNN3: Calponin-3 0.126 0.065
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.126 0.032
ACTN1 ACTN1: Alpha-actinin-1 0.126 0.064
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.126 0.041
CTTN CTTN, EMS1: Src substrate cortactin 0.126 0.065
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.126 0.072
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.126 0.090
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.123 0.318
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.123 0.046
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.123 0.286
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.123 0.051
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.123 0.045
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.123 0.318
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.123 137.00
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.123 0.403
EGF EGF: Pro-epidermal growth factor precursor 0.123 0.051
INSR INSR: Insulin receptor precursor 0.123 0.318
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.123 0.045
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.123 0.051
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.123 0.045
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.110 0.045
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.110 0.046
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.110 0.051
SORL1 SORL1: Sortilin-related receptor precursor 0.110 0.051
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.110 0.051
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.110 0.045
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.110 0.051
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.110 0.045
CRLF3 N/A 0.110 0.045
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.110 0.051
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.110 0.051
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.110 0.051
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.110 0.045
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.110 0.051
LILRB1 N/A 0.110 0.063
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.110 0.051
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.109 0.148
DNM3 DNM3: Uncharacterized protein DNM3 0.109 0.109
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.109 0.109
PPEF1 N/A 0.109 0.165
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.109 0.049
S100A16 S100A16, AAG13: Protein S100-A16 0.109 0.049
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.109 0.049
CDC25C CDC25C: M-phase inducer phosphatase 3 0.109 0.025
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.109 0.109
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.109 0.044
PSCD2 N/A 0.109 0.109
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.109 0.036
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.109 0.109
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.109 0.036
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.109 0.098
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.109 0.148
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.109 0.062
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.109 0.878
AMPH AMPH, AMPH1: Amphiphysin 0.109 0.109
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.109 0.098
EEF2K EEF2K: Elongation factor 2 kinase 0.109 0.148
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.109 0.036
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.109 0.098
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.109 0.148
ACTN4 ACTN4: Alpha-actinin-4 0.109 0.098
ELMO1 N/A 0.109 0.148
CNN2 CNN2: Calponin-2 0.109 0.109
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.109 0.0688
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.109 0.148
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.109 0.148
CDC25A CDC25A: M-phase inducer phosphatase 1 0.109 0.025
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.109 0.098
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.109 0.098
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.109 0.098
RASGRP2 RASGRP2: RAS guanyl-releasing protein 2 0.109 0.044
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.109 0.148
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.109 0.148
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.109 0.098
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.109 0.483
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.109 0.0688
NF2 NF2, SCH: Merlin 0.109 0.165
ARHGEF7 N/A 0.109 0.098
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.109 0.098
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.109 0.445
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.109 0.041
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.109 0.063
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.109 0.361
PTPRZ1 N/A 0.109 0.037
KIT KIT: Mast/stem cell growth factor receptor precursor 0.109 0.318
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.109 0.045
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.109 0.051
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.109 0.063
GHR GHR: Growth hormone receptor precursor 0.109 0.051
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.109 0.045
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.109 0.041
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.109 0.041
EPOR EPOR: Erythropoietin receptor precursor 0.109 0.051
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.109 0.045
ALK ALK: ALK tyrosine kinase receptor precursor 0.100 0.445
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.100 0.088
PLD2 PLD2: Phospholipase D2 0.100 0.064
S100A3 S100A3, S100E: Protein S100-A3 0.100 0.037
GAB1 GAB1: GRB2-associated-binding protein 1 0.100 0.109
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.100 0.081
DAB2 DAB2, DOC2: Disabled homolog 2 0.100 0.097
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.100 0.051
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.100 0.045
SORBS3 SORBS3, SCAM1: Vinexin 0.100 43.20
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.100 0.577
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.098 0.051
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.098 0.318
CD7 CD7: T-cell antigen CD7 precursor 0.098 0.045
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.098 0.100
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.098 0.051
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.098 0.051
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.098 0.063
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.098 0.051
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.098 0.045
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.098 0.041
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.098 0.051
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.098 0.051
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.098 0.051
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.098 0.045
GLRA1 N/A 0.096 0.057
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.096 0.025
GABRR1 N/A 0.096 0.051
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.096 0.051
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.096 0.152
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.091 0.027
BNC1 BNC1, BNC: Zinc finger protein basonuclin-1 0.085 0.069
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.083 0.062
LAT LAT: Linker for activation of T-cells family member 1 0.083 0.0688
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.083 0.483
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.083 0.062
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.083 0.030
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.083 0.034
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.083 0.030
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.083 0.034
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.083 0.0688
EDAR EDAR, DL: Tumor necrosis factor receptor superfamily member EDAR precursor 0.083 0.0688
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.083 0.483
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.083 0.483
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.083 0.0688
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.081 0.073
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.081 0.097
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.081 0.073
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.081 0.109
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.081 0.045
DAB1 DAB1: Disabled homolog 1 0.081 0.097
STAM2 STAM2: Signal transducing adapter molecule 2 0.081 0.148
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.081 0.058
F5 F5: Coagulation factor V precursor 0.081 0.031
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.081 0.029
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.081 0.097
RDX RDX: Radixin 0.081 0.064
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.081 0.064
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.081 0.073
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.081 0.058
S100A7 S100A7, PSOR1: Protein S100-A7 0.081 0.032
VWF VWF, F8VWF: von Willebrand factor precursor 0.081 0.041
PLD1 PLD1: Phospholipase D1 0.081 0.073
MCF2 MCF2, DBL: Proto-oncogene DBL 0.081 0.081
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.081 0.111
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.081 0.041
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.081 0.064
TTN N/A 0.081 0.136
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.081 0.035
CIB1 CIB1, CIB, KIP, PRKDCIP: Calcium and integrin-binding protein 1 0.081 0.030
GRLF1 N/A 0.081 0.127
VIL2 N/A 0.081 0.064
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.081 0.097
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.081 0.045
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.081 0.064
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.081 0.041
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.081 0.123
ANXA2 ANXA2, ANX2, ANX2L4, CAL1H, LPC2D: Annexin A2 0.080 0.045
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.0794 0.098
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.077 0.025
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.077 0.152
HPN HPN, TMPRSS1: Serine protease hepsin 0.077 0.028
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.077 0.025
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.075 0.041
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.075 0.111
PDLIM1 PDLIM1, CLIM1, CLP36: PDZ and LIM domain protein 1 0.075 0.072
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.075 0.090
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.0727 0.029
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.0727 0.111
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.0727 0.123
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.0727 0.081
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.0727 0.064
DOK1 DOK1: Docking protein 1 0.0727 0.111
CXorf9 N/A 0.0727 0.111
CSPG2 N/A 0.0727 0.051
GMIP GMIP: GEM-interacting protein 0.0727 0.033
PSCD4 PSCD4, CYT4: Cytohesin-4 0.0727 0.090
GAB2 N/A 0.0727 0.109
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.0727 0.073
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.0727 0.111
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.0727 0.111
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.0727 0.029
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.0727 0.027
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.0727 0.081
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.072 0.123
ROCK1 ROCK1: Rho-associated protein kinase 1 0.072 0.152
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.072 0.073
SPTAN1 N/A 0.072 0.072
RASA3 RASA3: Ras GTPase-activating protein 3 0.072 0.073
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.072 0.072
PSD TYL: TYL protein 0.072 0.058
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.072 0.051
TLN2 TLN2: Uncharacterized protein TLN2 0.072 0.064
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.072 0.111
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.072 0.064
TLN1 TLN1: Uncharacterized protein TLN1 0.072 0.064
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.072 0.097
VSNL1 VSNL1, VISL1: Visinin-like protein 1 0.072 0.0263
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.072 0.058
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.072 0.0263
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.072 0.037
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.072 0.090
DLG2 DLG2: Disks large homolog 2 0.072 0.046
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.072 0.073
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.072 0.041
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.072 0.171
NSBP1 NSBP1: Nucleosome-binding protein 1 0.0688 0.028
CETN1 CETN1, CEN1, CETN: Centrin-1 0.0688 0.047
NFATC3 NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3 0.0688 0.083
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.0688 0.148
NFATC2 NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2 0.0688 0.083
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.0688 0.148
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.067 0.037
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.065 0.073
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.065 0.097
CD2AP CD2AP: CD2-associated protein 0.065 0.090
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.065 0.037
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.065 0.111
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.065 0.058
IRS2 IRS2: Insulin receptor substrate 2 0.065 0.109
EXOC2 N/A 0.065 0.027
S100B S100B: Protein S100-B 0.065 0.029
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.065 0.111
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.065 0.033
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.065 0.136
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.065 0.123
VASP VASP: Vasodilator-stimulated phosphoprotein 0.065 0.072
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.065 0.072
MSN MSN: Moesin 0.065 0.064
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.065 0.111
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.065 0.029
KLF5 KLF5, BTEB2, CKLF, IKLF: Krueppel-like factor 5 0.063 0.056
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.062 0.073
NGFR NGFR, TNFRSF16: Tumor necrosis factor receptor superfamily member 16 precursor 0.062 0.051
GABRB1 GABRB1: Gamma-aminobutyric acid receptor subunit beta-1 precursor 0.062 0.041
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.062 0.051
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.062 0.063
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.062 0.318
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.062 0.025
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.062 0.045
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.062 0.046
ANXA9 ANXA9, ANX31: Annexin A9 0.060 0.063
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.058 0.111
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.058 0.111
FNBP1 N/A 0.058 0.111
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.058 0.073
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.058 0.064
LCP1 LCP1, PLS2: Plastin-2 0.058 0.073
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.058 0.090
PARD3 N/A 0.057 0.029
LIMK2 LIMK2: LIM domain kinase 2 0.057 0.081
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.057 0.090
ADPRT PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1 0.057 0.140
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.056 0.051
MT3 MT3: Metallothionein-3 0.055 0.026
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.055 0.028
TNFRSF1A TNFRSF1A, TNFAR, TNFR1: Tumor necrosis factor receptor superfamily member 1A pre 0.055 0.051
GLRB GLRB: Glycine receptor subunit beta precursor 0.055 0.037
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.055 0.051
FADD FADD, MORT1: Protein FADD 0.055 0.045
GRIA3 GRIA3, GLUR3, GLURC: Glutamate receptor 3 precursor 0.052 0.030
IFNAR2 IFNAR2, IFNABR, IFNARB: Interferon-alpha/beta receptor beta chain precursor 0.051 0.051
MARK2 N/A 0.051 0.051
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.051 0.046
PTPNS1 SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP: Tyrosine-protein phosphatase non-rec 0.051 0.051
LMO7 N/A 0.051 0.046
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.051 0.046
IGHM N/A 0.051 0.051
IGHG3 N/A 0.051 0.051
PTPRA N/A 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.617
LOC649805 Ig heavy chain V-II region COR 0.051 0.051
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.051 0.617
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
NULL Ig kappa chain V-I region CAR 0.051 0.051
IGHA1 N/A 0.051 0.051
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-27 alpha chain precursor 0.051 0.051
NCAM1 N/A 0.051 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.051 0.617
NULL Ig lambda chain V-II region NEI 0.051 0.051
HLA-DQB1 HLA-DQB1: HLA class II histocompatibility antigen, DQB1*0602 beta chain precurso 0.051 0.051
IGHA2 IGHA2: Ig alpha-2 chain C region 0.051 0.051
C6orf21 LY6G6F, C6orf21, G6F, LY6G6D, NG32: Lymphocyte antigen 6 complex locus protein G 0.051 0.051
MARK1 MARK1, KIAA1477, MARK: Serine/threonine-protein kinase MARK1 0.051 0.051
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 0.051 0.617
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.046
AGC1 AGC1, CSPG1, MSK16: Aggrecan core protein precursor 0.051 0.046
UBAP2L N/A 0.051 0.051
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-68 alpha chain precursor 0.051 0.051
PAPPA PAPPA: Pappalysin-1 precursor 0.051 0.051
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.046
IGHG1 N/A 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.046
EPB41 EPB41, E41P: Protein 4.1 0.051 0.046
FCGR2A FCGR2A, CD32, FCG2, FCGR2A1, IGFR2: Low affinity immunoglobulin gamma Fc region 0.051 0.051
EVL EVL, RNB6: Ena/VASP-like protein 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
HLA-A N/A 0.051 0.051
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
HLA-DRA HLA-DRA, HLA-DRA1: HLA class II histocompatibility antigen, DR alpha chain precu 0.051 0.051
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.051 0.553
TRB@ TCRB: T-cell receptor beta chain V region CTL-L17 precursor 0.051 0.051
IGHE IGHE: Ig epsilon chain C region 0.051 0.051
NULL Ig lambda chain V-I region EPS 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
NFKB2 N/A 0.051 0.051
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
NULL Ig heavy chain V-III region WEA 0.051 0.051
NULL TCRA: T-cell receptor alpha chain V region CTL-L17 precursor 0.051 0.051
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.051 0.046
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
RAPH1 N/A 0.051 0.051
DOK2 DOK2: Docking protein 2 0.051 0.051
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
NULL Ig heavy chain V-III region BUR 0.051 0.051
HLA-DRB2 HLA class II histocompatibility antigen, DW2.2/DR2.2 beta chain (Fragment) 0.051 0.051
C9orf88 N/A 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
DLG1 DLG1: Disks large homolog 1 0.051 0.051
FLT4 VEGFR3 long form 0.051 0.553
TBC1D4 TBC1D4: TBC1D4 protein 0.051 0.046
IGHD N/A 0.051 0.051
NULL Ig kappa chain V region EV15 precursor 0.051 0.051
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.051 0.111
RYR1 0.051 0.071
RYR2 RYR2: Ryanodine receptor 2 0.051 0.045
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.051 0.123
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.051 0.152
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.051 0.097
TUBB3 TUBB3, TUBB4: Tubulin beta-3 chain 0.051 0.109
RELA RELA, NFKB3: Transcription factor p65 0.051 0.056
OCLN OCLN: Occludin 0.0513 0.031
CCR5 CCR5: CCR5 receptor (Fragment) 0.049 0.063
YWHAG YWHAG: 14-3-3 protein gamma 0.049 0.049
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.049 0.165
MAP2K5 N/A 0.049 0.109
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.049 0.044
GIT2 N/A 0.049 0.047
EXO1 EXO1, EXOI, HEX1: Exonuclease 1 0.049 0.025
MYO18A 0.049 0.098
CASP8 CASP8, MCH5: Caspase-8 precursor 0.049 0.109
GOPC GOPC, CAL, FIG: Golgi-associated PDZ and coiled-coil motif-containing protein 0.049 0.044
PDZD2 CDNA FLJ46853 fis, clone UTERU3009775, moderately similar to Rattus norvegicus P 0.049 0.049
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.049 0.044
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.048 0.046
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.047 0.0338
CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 0.047 0.047
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.046 0.097
PLEK PLEK, P47: Pleckstrin 0.046 0.152
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.046 0.111
NOS1 NOS1: Nitric-oxide synthase, brain 0.0453 0.033
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.0453 0.064
YWHAE YWHAE: 14-3-3 protein epsilon 0.0453 0.029
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.0453 0.111
MGMT MGMT: Methylated-DNA--protein-cysteine methyltransferase 0.0453 0.0453
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.045 0.088
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.045 0.111
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.044 0.050
SOS1 SOS1: Son of sevenless homolog 1 0.041 0.136
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.041 0.097
NFATC1 N/A 0.041 0.062
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.041 0.097
IRF3 IRF3: Interferon regulatory factor 3 0.041 0.062
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.041 0.097
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.041 0.088
CENTA1 CENTA1: Centaurin-alpha 1 0.041 0.041
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.04 0.04
ARID1A ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A 0.04 0.025
NIPBL N/A 0.04 0.025
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.04 0.083
HNRPK HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K 0.04 0.049
ANXA1 ANXA1, ANX1, LPC1: Annexin A1 0.039 0.045
TAF1 TAF1, BA2R, CCG1, CCGS, TAF2A: Transcription initiation factor TFIID subunit 1 0.039 0.026
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.038 0.042
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.038 0.053
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.038 0.034
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.037 0.045
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.037 0.029
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.037 0.041
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.037 0.097
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.037 0.045
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.037 0.041
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.037 0.045
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.037 0.051
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.037 0.033
HDLBP HDLBP, HBP, VGL: Vigilin 0.037 0.033
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.037 0.045
YWHAZ YWHAZ: 14-3-3 protein zeta/delta 0.037 2.47
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.037 0.097
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.037 0.136
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.037 0.026
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.037 0.097
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.037 0.152
SALL1 SALL1, SAL1: Sal-like protein 1 0.037 0.056
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.037 0.088
YWHAQ YWHAQ: 14-3-3 protein theta 0.037 0.032
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.036 0.136
LIMA1 LIMA1, EPLIN, PP624, SREBP3: LIM domain and actin-binding protein 1 0.036 0.029
TNN TNN: Tenascin-N precursor 0.0338 0.034
CNN1 CNN1: Calponin-1 0.0338 0.0338
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.034 0.028
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.034 0.025
CREB1 CREB1: cAMP response element-binding protein 0.034 0.025
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.034 0.148
CCNT2 CCNT2: Cyclin-T2 0.034 0.025
MAL2 MAL2: Protein MAL2 0.034 0.034
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.034 0.028
ZFP91 ZFP91, FKSG11: Zinc finger protein 91 homolog 0.034 0.083
TRERF1 TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1 0.034 0.075
ZFPM1 ZFPM1, FOG1: Zinc finger protein ZFPM1 0.034 0.075
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.034 0.028
RBM10 RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10 0.034 0.075
GGA3 GGA3, KIAA0154: ADP-ribosylation factor-binding protein GGA3 0.034 0.030
ZHX1 ZHX1: Zinc fingers and homeoboxes protein 1 0.034 0.083
POGZ POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain 0.034 0.083
ZNF579 ZNF579: Zinc finger protein 579 0.034 0.083
OSR1 OSR1, ODD: Protein odd-skipped-related 1 0.034 0.075
CCNE1 CCNE1, CCNE: G1/S-specific cyclin-E1 0.034 0.025
PRDM2 PRDM2, RIZ: PR domain zinc finger protein 2 0.034 0.075
ZNF295 ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295 0.034 0.083
HIST1H1C HIST1H1C, H1F2: Histone H1.2 0.034 0.025
BRD4 N/A 0.034 0.025
BID BID: BH3-interacting domain death agonist 0.034 0.028
C10orf9 CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y 0.034 0.047
HDAC8 N/A 0.034 0.028
ZNF174 ZNF174, ZSCAN8: Zinc finger protein 174 0.034 0.075
HDAC7A N/A 0.034 0.025
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.034 0.025
ZNF644 ZNF644, KIAA1221, ZEP2: Zinc finger protein 644 0.034 0.083
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.033 0.123
ATM ATM: Serine-protein kinase ATM 0.033 0.111
THOC1 THOC1, HPR1: THO complex subunit 1 0.033 0.073
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.033 0.073
WASPIP N/A 0.033 0.073
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.033 0.041
YWHAB YWHAB: 14-3-3 protein beta/alpha 0.033 4.41
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.032 0.064
SCRIB SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL: Protein LAP4 0.032 0.032
PPP1CB PPP1CB: Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0.032 0.029
PEA15 PEA15: Astrocytic phosphoprotein PEA-15 0.032 0.065
COBL N/A 0.032 0.065
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.032 0.029
YWHAH YWHAH, YWHA1: 14-3-3 protein eta 0.032 0.029
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.032 0.064
SLC9A3R1 SLC9A3R1, NHERF: Ezrin-radixin-moesin-binding phosphoprotein 50 0.032 0.037
RIMS1 RIMS1, KIAA0340, Nbla00761, RAB3IP2, RIM1: Regulating synaptic membrane exocytos 0.032 0.033
EEA1 EEA1, ZFYVE2: Early endosome antigen 1 0.032 0.056
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.032 0.088
GIT1 GIT1: ARF GTPase-activating protein GIT1 0.032 0.043
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.032 0.064
MYST4 MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4 0.031 0.069
MUSK MUSK: Muscle, skeletal receptor tyrosine protein kinase precursor 0.0308 0.094
PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 0.030 0.038
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.030 0.029
SIPA1L1 SIPA1L1, E6TP1, KIAA0440: Signal-induced proliferation-associated 1-like protein 0.029 0.049
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.029 0.097
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.029 0.109
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.029 1.20
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.029 0.064
TRADD TRADD: Tumor necrosis factor receptor type 1-associated DEATH domain protein 0.029 0.081
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.029 0.081
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.029 0.041
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.029 0.111
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
FES N/A 0.0288 0.0258
SHC2 N/A 0.0288 1.29
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
ADCY6 ADCY6, KIAA0422: Adenylate cyclase type 6 0.028 0.062
OPTC OPTC, OPT: Opticin precursor 0.028 0.034
EMR2 EMR2: EGF-like module-containing mucin-like hormone receptor-like 2 precursor 0.028 0.034
JAG2 JAG2: Jagged-2 precursor 0.028 0.030
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.028 0.034
DRD2 DRD2: D(2) dopamine receptor 0.028 0.034
KLRD1 KLRD1, CD94: Natural killer cells antigen CD94 0.028 0.034
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.028 0.034
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.028 0.062
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.028 0.098
SNAP23 SNAP23: Synaptosomal-associated protein 23 0.028 0.030
TNFSF14 TNFSF14, HVEML, UNQ391/PRO726, LIGHT: Tumor necrosis factor ligand superfamily m 0.028 0.034
FUBP1 N/A 0.027 0.037
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.027 0.033
DDR1 DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE: Epithelial discoidin domain-con 0.027 0.126
FGFR2 N/A 0.027 0.141
FER1L3 FER1L3, KIAA1207, MYOF: Myoferlin 0.027 0.027
MICAL-L1 MICALL1, KIAA1668, MIRAB13: MICAL-like protein 1 0.027 0.073
FXR2 FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2 0.0263 0.029
PMP2 PMP2: Myelin P2 protein 0.0263 0.026
STK4 STK4, MST1: Serine/threonine-protein kinase 4 0.0263 0.111
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.0263 0.071
BRPF1 BRPF1, BR140: Peregrin 0.026 0.069
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.026 0.049
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.026 0.033
SELE SELE, ELAM1: E-selectin precursor 0.026 0.025
TSHR N/A 0.026 0.035
GP1BA N/A 0.026 0.025
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.026 0.041
CCNB1 Cyclin B1 0.025 0.035
LIG4 LIG4: DNA ligase 4 0.025 0.069
ETS2 ETS2: Protein C-ets-2 0.025 0.109
EGR1 EGR1, ZNF225: Early growth response protein 1 0.025 0.049
ZBTB16 ZBTB16, PLZF, ZNF145: Zinc finger and BTB domain-containing protein 16 0.025 0.049
RAP1GA1 N/A 0.025 0.025
HIVEP1 N/A 0.025 0.062
SCML2 SCML2: Sex comb on midleg-like protein 2 0.025 0.152
ZBTB33 KAISO, ZBTB33, ZNF348: Transcriptional regulator Kaiso 0.025 0.062
CCNH CCNH: Cyclin-H 0.025 0.035
ZBTB7A ZBTB7A, FBI1, LRF, ZBTB7: Zinc finger and BTB domain-containing protein 7A 0.025 0.069
CCND1 CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1 0.025 0.035
ZFX ZFX: Zinc finger X-chromosomal protein 0.025 0.077
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.025 0.026
0.228
Total Score 36.60