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Evidence of Interaction Between U2AF2 and U2AF1

The interaction score between U2AF2 and U2AF1 is 27.80.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismU2AF2 OrthologueU2AF1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
worm P90978 1 Q9U2U0 1
  • Y2H
  • Other

Get References From PubMed
fly Q24562 1 Q94535 1
  • Y2H

Get References From PubMed

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 3.01
Domains Domains present in U2AF2 and U2AF1:
Domains in U2AF2Domains in U2AF1
IPR000504 RNA-binding region RNP-1 (RNA recognition motif)
IPR006529 U2 snRNP auxilliary factor, large subunit, splicing factor
IPR012677 a_b_plait_nuc_bd.
IPR000504 RNA-binding region RNP-1 (RNA recognition motif)
IPR000571 Zn-finger, C-x8-C-x5-C-x3-H type
IPR003954 RNA recognition, region 1
IPR009145 U2 auxiliary factor small subunit
IPR012677 a_b_plait_nuc_bd.

The Chi square scores for co-occurrence of domains that are present in U2AF2 and U2AF1 are listed below.

Domain 1Domain 2Chi Square
IPR000504 RNA-binding region RNP-1 (RNA recognition motif) IPR009145 U2 auxiliary factor small subunit 286.992
IPR012677 a_b_plait_nuc_bd. IPR009145 U2 auxiliary factor small subunit 277.003
IPR000504 RNA-binding region RNP-1 (RNA recognition motif) IPR012677 a_b_plait_nuc_bd. 272.752
IPR012677 a_b_plait_nuc_bd. IPR012677 a_b_plait_nuc_bd. 261.323
IPR000504 RNA-binding region RNP-1 (RNA recognition motif) IPR003954 RNA recognition, region 1 259.422
IPR012677 a_b_plait_nuc_bd. IPR003954 RNA recognition, region 1 250.22
IPR000504 RNA-binding region RNP-1 (RNA recognition motif) IPR000504 RNA-binding region RNP-1 (RNA recognition motif) 235.771
IPR000504 RNA-binding region RNP-1 (RNA recognition motif) IPR000571 Zn-finger, C-x8-C-x5-C-x3-H type 148.69
IPR012677 a_b_plait_nuc_bd. IPR000571 Zn-finger, C-x8-C-x5-C-x3-H type 143.31

The background colour of the table refers to:

  • Blue Domain is only present in U2AF2
  • Yellow Domain is only present in U2AF1
  • Green Domain is present in both U2AF2 and U2AF1

 0.027
Post-translational Modifications

Protein: U2AF2

PTMResidueReference

Protein: U2AF1

PTMResidueReference
N-acetylalanine 1 HPRD
Localisation

Protein: U2AF2

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: U2AF1

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between U2AF2 and U2AF1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between U2AF2 andU2AF1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , U2AF2 has 78 interactors and U2AF1 has 347 interactors of which there are 59 common interactors.

Common InteractorName of Common InteractorScore for U2AF2-Interactor (?)Score for U2AF1-Interactor (?)
MATR3 MATR3, KIAA0723: Matrin-3 0.027 0.174
ZCCHC12 ZCCHC12: Zinc finger CCHC domain-containing protein 12 0.027 0.027
ZCCHC5 ZCCHC5: Zinc finger CCHC domain-containing protein 5 0.027 0.027
RBM14 RBM14, SIP: RNA-binding protein 14 0.027 0.287
ZCCHC3 ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3 0.027 0.056
HNRPC HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2 0.027 0.056
ZC3H8 ZC3H8, ZC3HDC8: Zinc finger CCCH domain-containing protein 8 0.027 0.027
MECP2 MECP2: Methyl-CpG-binding protein 2 0.027 0.085
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.027 0.287
ZC3HAV1 ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1 0.027 0.056
BOLL BOLL, BOULE: Protein boule-like 0.027 0.027
POLDIP3 POLDIP3, KIAA1649, PDIP46: Polymerase delta-interacting protein 3 0.027 0.027
RBMY1H RBMY1C, YRRM: Y-chromosome RNA recognition motif protein (Fragment) 0.027 0.027
SFRS15 SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15 0.027 0.085
HMGA2 HMGA2, HMGIC: High mobility group protein HMGI-C 0.027 0.0416
CIRBP CIRBP, A18HNRNP, CIRP: Cold-inducible RNA-binding protein 0.027 0.041
DDX53 DDX53, CAGE: Probable ATP-dependent RNA helicase DDX53 0.027 0.027
UHMK1 UHMK1, KIS, KIST: Serine/threonine-protein kinase Kist 0.027 0.027
PARP12 PARP12, ZC3HDC1: Poly [ADP-ribose] polymerase 12 0.027 0.067
KAT3 RBMXL1, DKFZp547N1117, RP4-531M19.2-001, hCG_23341: RNA-binding motif protein X- 0.027 0.265
RDBP RDBP, NELFE, RD: Negative elongation factor E 0.027 0.174
ZNF638 ZNF638, NP220, ZFML: Zinc finger protein 638 0.027 0.174
ZC3H7A ZC3H7A, ZC3H7, HSPC055, ZC3HDC7: Zinc finger CCCH domain-containing protein 7A 0.027 0.067
ATXN2L ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein 0.027 0.056
ZCCHC4 ZCCHC4: Zinc finger CCHC domain-containing protein 4 0.027 0.027
PPARGC1A PPARGC1A, LEM6, PGC1, PGC1A, PPARGC1: Peroxisome proliferator-activated receptor 0.027 0.033
HMGA1 HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y 0.027 0.174
SETBP1 N/A 0.027 0.027
RBM6 RBM6, DEF3: RNA-binding protein 6 0.027 0.103
RNPS1 RNPS1, LDC2: RNA-binding protein with serine-rich domain 1 0.027 0.287
RAVER1 RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1 0.027 0.056
SFRS12 SFRS12, SRRP86: Splicing factor, arginine/serine-rich 12 0.027 0.083
ZNF278 PATZ1, PATZ, RIAZ, ZBTB19, ZNF278, ZSG: POZ-, AT hook-, and zinc finger-containi 0.027 0.027
LEMD3 LEMD3, MAN1: Inner nuclear membrane protein Man1 0.027 0.060
LOC642558 FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1 0.027 0.056
SRrp35 SRRP35: 35 kDa SR repressor protein 0.027 0.027
ZCCHC2 ZCCHC2, KIAA1744: Zinc finger CCHC domain-containing protein 2 0.027 0.067
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.027 0.287
RBMY1A1 RBMY1A1, RBM1, RBM2, YRRM1: RNA-binding motif protein, Y chromosome, family 1 me 0.027 0.027
DND1 DND1, RBMS4: Dead end protein homolog 1 0.027 0.050
ZCCHC17 ZCCHC17, PS1D, HSPC243, HSPC251, LDC4: Nucleolar protein of 40 kDa 0.027 0.027
U1SNRNPBP U1SNRNPBP: U1-snRNP binding protein homolog 0.027 0.027
HMGN4 HMGN4, HMG17L3, NHC: High mobility group nucleosome-binding domain-containing pr 0.027 0.083
PTBP1 PTBP1, PTB: Polypyrimidine tract-binding protein 1 0.027 0.027
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.027 0.056
ZCCHC9 ZCCHC9: ZCCHC9 protein 0.027 0.027
RBPMS RBPMS: RNA-binding protein with multiple splicing 0.027 0.027
ACF ACF, ASP: APOBEC1 complementation factor 0.027 0.027
DUX4 FSHD, DUX4: Facioscapulohumeral muscular dystrophy 0.027 0.027
ZCCHC7 ZCCHC7, HSPC086: Zinc finger CCHC domain-containing protein 7 0.027 0.027
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.027 0.613
EIF4G1 EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1 0.027 0.140
CPSF6 CPSF6, CFIM68: Cleavage and polyadenylation specificity factor subunit 6 0.027 0.293
ZGPAT N/A 0.027 0.027
PABPC5 PABPC5, PABP5: Polyadenylate-binding protein 5 0.027 0.027
GRLF1 N/A 0.027 0.0416
RALY RALY: RNA binding protein (Fragment) 0.027 0.027
ROD1 ROD1: Regulator of differentiation 1 0.027 0.050
NUPL2 NUPL2, CG1: Nucleoporin-like 2 0.027 0.083
2.15E-3
Total Score 27.80