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Evidence of Interaction Between TIMP1 and MMP1

The interaction score between TIMP1 and MMP1 is 3.15.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TIMP1 and MMP1 = 0.70

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 7.78E-3
Orthology
OrganismTIMP1 OrthologueMMP1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00027166 0.237 IPI00385287 0.289
worm Q21265 0.237 O16901 0.289

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 2.23E-3
Domains Domains present in TIMP1 and MMP1:
Domains in TIMP1Domains in MMP1
IPR001820 Tissue inhibitor of metalloproteinase
IPR008993 TIMP-like OB-fold
IPR001134 Netrin, C-terminal
IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site
IPR000585 Hemopexin
IPR001818 Peptidase M10A and M12B, matrixin and adamalysin
IPR006026 Peptidase, metallopeptidases
IPR009070 Peptidoglycan binding-like
IPR002477 PGBD_1.

The Chi square scores for co-occurrence of domains that are present in TIMP1 and MMP1 are listed below.

Domain 1Domain 2Chi Square
IPR001820 Tissue inhibitor of metalloproteinase IPR001818 Peptidase M10A and M12B, matrixin and adamalysin 900.744
IPR001820 Tissue inhibitor of metalloproteinase IPR002477 PGBD_1. 845.463
IPR001820 Tissue inhibitor of metalloproteinase IPR000585 Hemopexin 767.901
IPR001820 Tissue inhibitor of metalloproteinase IPR006026 Peptidase, metallopeptidases 723.58
IPR001820 Tissue inhibitor of metalloproteinase IPR009070 Peptidoglycan binding-like 711.44
IPR001820 Tissue inhibitor of metalloproteinase IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site 647.351
IPR001134 Netrin, C-terminal IPR001818 Peptidase M10A and M12B, matrixin and adamalysin 201.161
IPR001134 Netrin, C-terminal IPR002477 PGBD_1. 189.631
IPR008993 TIMP-like OB-fold IPR001818 Peptidase M10A and M12B, matrixin and adamalysin 177.258
IPR001134 Netrin, C-terminal IPR000585 Hemopexin 171.346
IPR001134 Netrin, C-terminal IPR006026 Peptidase, metallopeptidases 160.899
IPR001134 Netrin, C-terminal IPR009070 Peptidoglycan binding-like 159.533
IPR008993 TIMP-like OB-fold IPR002477 PGBD_1. 159.012
IPR008993 TIMP-like OB-fold IPR000585 Hemopexin 143.671
IPR001134 Netrin, C-terminal IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site 141.442
IPR008993 TIMP-like OB-fold IPR006026 Peptidase, metallopeptidases 134.907
IPR008993 TIMP-like OB-fold IPR009070 Peptidoglycan binding-like 124.785
IPR008993 TIMP-like OB-fold IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site 124.693

The background colour of the table refers to:

  • Blue Domain is only present in TIMP1
  • Yellow Domain is only present in MMP1
  • Green Domain is present in both TIMP1 and MMP1

 1.30
Post-translational Modifications

Protein: TIMP1

PTMResidueReference
N-linked 53 PubMed, HPRD
N-linked 101 PubMed, HPRD

Protein: MMP1

PTMResidueReference
N-linked 120 PubMed, HPRD
Proteolytic Cleavage 102 PubMed, HPRD
Localisation

Protein: TIMP1

LocalisationReference
Secreted HPRD

Protein: MMP1

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Secreted HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between TIMP1 and MMP1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TIMP1 andMMP1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TIMP1 has 574 interactors and MMP1 has 680 interactors of which there are 417 common interactors.

Common InteractorName of Common InteractorScore for TIMP1-Interactor (?)Score for MMP1-Interactor (?)
MMP2 MMP2, CLG4A: 72 kDa type IV collagenase precursor 12.80 0.461
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 3.28 0.251
COL5A1 N/A 1.67 0.898
MME MME, EPN: Neprilysin 1.48 0.081
MMP14 MMP14: Matrix metalloproteinase-14 precursor 1.36 0.083
MMP7 MMP7, MPSL1, PUMP1: Matrilysin precursor 1.35 0.111
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 1.30 0.165
BMP1 N/A 1.17 0.148
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 1.13 0.166
PRG4 PRG4, MSF, SZP: Proteoglycan-4 precursor 1.07 0.097
VTN VTN: Vitronectin precursor 0.975 0.109
HPX HPX: Hemopexin precursor 0.975 0.109
ACE ACE, DCP, DCP1: Angiotensin-converting enzyme, somatic isoform precursor 0.878 0.098
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.878 0.098
MMP11 MMP11, STMY3: Stromelysin-3 precursor 0.874 0.097
MMP13 MMP13: Collagenase 3 precursor 0.859 0.109
MMP9 MMP9, CLG4B: Matrix metalloproteinase-9 precursor 0.859 0.109
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.822 0.763
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.822 0.763
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.808 0.090
MMP8 CLG1, MMP8: Neutrophil collagenase precursor 0.770 0.097
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.763 0.372
ANPEP ANPEP, APN, CD13, PEPN: Aminopeptidase N 0.735 0.057
ACE ACE, DCP, DCP1: Angiotensin-converting enzyme, testis-specific isoform precursor 0.731 0.081
MBTPS2 MBTPS2, S2P: Membrane-bound transcription factor site-2 protease 0.655 0.073
KEL KEL: Kell blood group glycoprotein 0.644 0.081
ADAMDEC1 ADAMDEC1: ADAM DEC1 precursor 0.644 0.072
PAPPA PAPPA: Pappalysin-1 precursor 0.617 0.051
MMP3 MMP3, STMY1: Stromelysin-1 precursor 0.596 0.074
MEP1A MEP1A: Meprin A subunit alpha precursor 0.577 0.064
MEP1B MEP1B: Meprin A subunit beta precursor 0.577 0.064
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.543 0.044
ECE1 ECE1: Endothelin-converting enzyme 1 0.490 0.035
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.483 0.062
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.483 0.062
C1R C1R: Complement C1r subcomponent precursor 0.416 0.152
C1S C1S: Complement C1s subcomponent precursor 0.416 0.152
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.388 0.161
THBS1 THBS1, TSP, TSP1: Thrombospondin-1 precursor 0.385 0.461
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.355 0.045
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.323 0.037
THOP1 THOP1: Thimet oligopeptidase 0.318 0.041
ENPEP ENPEP: Glutamyl aminopeptidase 0.318 0.041
COL1A1 COL1A1: Collagen alpha-1(I) chain precursor 0.307 0.852
FSTL1 FSTL1, FRP: Follistatin-related protein 1 precursor 0.307 0.852
COL3A1 COL3A1: Collagen alpha-1(III) chain precursor 0.307 1.81
LOX LOX: Protein-lysine 6-oxidase precursor 0.307 0.307
COL5A2 N/A 0.307 1.81
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.304 0.148
SRPX SRPX, ETX1: Sushi repeat-containing protein SRPX precursor 0.293 0.137
MMP16 MMP16, MMPX2: Matrix metalloproteinase-16 precursor 0.274 0.028
ADAMTS19 ADAMTS19: ADAMTS-19 precursor 0.265 0.027
ADAMTS18 ADAMTS18, ADAMTS21: ADAMTS-18 precursor 0.265 0.027
ADAMTS10 ADAMTS10: ADAMTS-10 precursor 0.265 0.027
ADAMTS17 ADAMTS17: ADAMTS-17 precursor 0.265 0.027
PAPPA2 PAPPA2, PLAC3: Pappalysin-2 precursor 0.265 0.027
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.260 0.416
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.253 0.561
ITGAV ITGAV, MSK8, VNRA: Integrin alpha-V precursor 0.245 0.304
IL15RA IL15RA: Interleukin-15 receptor alpha chain precursor 0.191 0.123
CFH CFH, HF, HF1, HF2: Complement factor H precursor 0.191 0.152
CFHR2 CFHR2, CFHL2, FHR2, HFL3: Complement factor H-related protein 2 precursor 0.191 0.152
CSPG2 N/A 0.191 1.20
LAMA2 LAMA2: Uncharacterized protein LAMA2 0.188 0.136
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.181 0.073
CFHR1 CFHR1, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2: Complement factor H-relate 0.165 0.165
F11 F11: Coagulation factor XI precursor 0.165 0.165
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.165 0.165
FN1 N/A 0.165 0.083
CD46 N/A 0.165 0.165
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.165
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.165
PROZ PROZ: Vitamin K-dependent protein Z precursor 0.161 0.130
F7 F7: Coagulation factor VII precursor 0.156 0.174
BGLAP BGLAP: Osteocalcin precursor 0.152 0.152
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.152 0.123
CFB CFB, BF, BFD: Complement factor B precursor 0.152 0.123
PRSS22 PRSS22, BSSP4, SP001LA, PRSS26, UNQ302/PRO343: Brain-specific serine protease 4 0.152 0.123
C4BPA C4BPA, C4BP: C4b-binding protein alpha chain precursor 0.152 0.109
CMA1 CMA1, CYH, CYM: Chymase precursor 0.152 0.123
HP HP: Haptoglobin precursor [Contains: Haptoglobin alpha chain; Haptoglobin beta c 0.152 0.109
ITGA3 ITGA3, MSK18: Integrin alpha-3 precursor 0.148 0.113
COL12A1 COL12A1, COL12A1L: Collagen alpha-1(XII) chain precursor 0.148 0.148
PLAT PLAT: Tissue-type plasminogen activator precursor 0.148 0.165
KLK3 KLK3, APS: Prostate-specific antigen precursor 0.148 0.148
HGF HGF, HPTA: Hepatocyte growth factor precursor 0.148 0.148
CNTN1 CNTN1: Contactin-1 precursor 0.148 0.148
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.148 1.17
CNTN4 CNTN4: Contactin-4 precursor 0.148 0.148
MFAP2 MFAP2, MAGP1: Microfibrillar-associated protein 2 precursor 0.144 0.087
STC2 STC2: Stanniocalcin-2 precursor 0.144 0.144
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.144 0.416
F9 F9: Coagulation factor IX precursor 0.144 0.117
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.139 1.78
FCN3 FCN3, FCNH, HAKA1: Ficolin-3 precursor 0.137 0.156
C7 C7: Complement component C7 precursor 0.136 0.097
C6 C6: Complement component C6 precursor 0.136 0.109
SERPINE1 SERPINE1, PAI1, PLANH1: Plasminogen activator inhibitor 1 precursor 0.129 4.88
CTGF CTGF, CCN2, HCS24: Connective tissue growth factor precursor 0.129 1.62
THBS2 N/A 0.129 0.827
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.124 0.202
ITIH1 ITIH1, IGHEP1: Inter-alpha-trypsin inhibitor heavy chain H1 precursor 0.123 0.055
APOH APOH, B2G1: Beta-2-glycoprotein 1 precursor 0.123 0.109
CEACAM6 CEACAM6, NCA: Carcinoembryonic antigen-related cell adhesion molecule 6 precurso 0.123 0.109
CFI CFI, IF: Complement factor I precursor 0.123 0.109
HGFAC HGFAC: Hepatocyte growth factor activator precursor 0.123 0.109
ITIH4 ITIH4, IHRP, PRO1851, ITIHL1, PK120: Inter-alpha-trypsin inhibitor heavy chain H 0.123 0.055
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.123 0.123
C4BPB C4BPB: C4b-binding protein beta chain precursor 0.123 0.109
C2 C2: Complement C2 precursor 0.123 0.109
PRSS1 PRSS1, TRP1, TRY1, TRYP1: Trypsin-1 precursor 0.123 0.109
F12 F12: Coagulation factor XII precursor 0.123 0.109
F2 F2: Prothrombin precursor 0.117 0.103
F10 F10: Coagulation factor X precursor 0.117 0.103
PROC PROC: Vitamin K-dependent protein C precursor 0.117 0.115
TNC TNC, HXB: Tenascin precursor 0.114 0.136
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.113 0.073
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 0.113 0.090
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.111 0.113
VWF VWF, F8VWF: von Willebrand factor precursor 0.111 0.097
LPA LPA: Apolipoprotein(a) precursor 0.111 0.097
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 0.111 0.056
PLG PLG: Plasminogen precursor 0.111 0.097
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.109 0.109
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.109 0.109
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.109 0.109
GZMB Endogenous granzyme B 0.109 0.109
CTSG CTSG: Cathepsin G precursor 0.109 0.109
ELA3B ELA3B: Elastase-3B precursor 0.109 0.109
AZU1 AZU1: Azurocidin precursor 0.109 0.109
ELA2 ELA2: Leukocyte elastase precursor 0.109 0.109
PRTN3 PRTN3, MBN: Myeloblastin precursor 0.109 0.109
IL12B IL12B, NKSF2: Interleukin-12 subunit beta precursor 0.109 0.109
IL2RA IL2RA: Interleukin-2 receptor alpha chain precursor 0.109 0.109
MBL2 MBL2, MBL: Mannose-binding protein C precursor 0.102 0.117
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.099 0.097
F13B F13B: Coagulation factor XIII B chain precursor 0.098 0.109
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.098 0.098
TMPRSS9 N/A 0.098 0.098
BSG N/A 0.098 0.098
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.098 0.098
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.097 0.097
KLK1 KLK1: Kallikrein-1 precursor 0.097 0.109
THBD THBD, THRM: Thrombomodulin precursor 0.096 0.123
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.091 0.202
F2RL1 F2RL1, GPR11, PAR2: Proteinase-activated receptor 2 precursor 0.091 0.036
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.090 0.064
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 0.090 0.033
KLK6 KLK6, PRSS18, PRSS9: Kallikrein-6 precursor 0.088 0.097
CXCL5 CXCL5, ENA78, SCYB5: Small-inducible cytokine B5 precursor 0.087 5.45
CCL2 CCL2, MCP1, SCYA2: Small-inducible cytokine A2 precursor 0.087 5.45
IL6 IL6, IFNB2: Interleukin-6 precursor 0.087 0.923
CXCL1 CXCL1, GRO, GRO1, GROA, MGSA, SCYB1: Growth-regulated protein alpha precursor 0.087 5.45
PCOLCE PCOLCE, PCPE1: Procollagen C-endopeptidase enhancer 1 precursor 0.087 0.416
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.086 0.069
SLIT2 SLIT2, SLIL3: Slit homolog 2 protein precursor 0.086 0.171
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.083 0.028
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.083 0.165
SRPX2 SRPX2, SRPUL: Sushi repeat-containing protein SRPX2 precursor 0.083 0.067
SELE SELE, ELAM1: E-selectin precursor 0.081 0.072
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.081 0.072
COL4A1 N/A 0.078 0.275
SPARC SPARC, ON: SPARC precursor 0.078 0.372
TNXB TNXB, HXBL, TNX, TNXB1, TNXB2, XB: Tenascin-X precursor 0.077 0.109
PVR PVR, PVS: Poliovirus receptor precursor 0.075 0.166
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.075 0.100
HPN HPN, TMPRSS1: Serine protease hepsin 0.073 0.072
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.073 0.032
ST14 ST14, PRSS14, SNC19, TADG15: Suppressor of tumorigenicity protein 14 0.073 0.064
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.073 0.064
DCC DCC: Netrin receptor DCC precursor 0.073 0.090
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.073 0.064
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.073 0.064
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.073 0.073
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.0727 0.072
ITGAE ITGAE: Integrin alpha-E precursor 0.072 0.081
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.072 0.065
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.072 0.065
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.072 0.072
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.072 0.072
SELL SELL, LNHR, LYAM1: L-selectin precursor 0.072 0.072
ITGB4 N/A 0.072 0.072
IGF2R IGF2R, MPRI: Cation-independent mannose-6-phosphate receptor precursor 0.071 0.063
BGN BGN: Biglycan precursor 0.070 0.0425
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.070 0.515
CCL11 CCL11, SCYA11: Eotaxin precursor 0.070 1.81
MGP MGP, MGLAP, GIG36: Matrix Gla protein precursor 0.070 0.026
IL1B IL1B, IL1F2: Interleukin-1 beta precursor 0.070 0.307
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.070 0.251
NOTCH3 NOTCH3: Neurogenic locus notch homolog protein 3 precursor 0.069 0.111
PRSS23 PRSS23, ZSIG13, UNQ270/PRO307: Serine protease 23 precursor 0.067 0.050
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.067 0.033
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.065 0.064
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.065 0.072
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.065 0.072
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.065 0.072
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.065 0.072
ITGA4 ITGA4, CD49D: Integrin alpha-4 precursor 0.065 0.072
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 0.064 0.064
ITGB7 ITGB7: Integrin beta-7 precursor 0.064 0.064
ITGA2B ITGA2B, GP2B, ITGAB: Integrin alpha-IIb precursor 0.064 0.064
NEO1 NEO1, NGN: Neogenin precursor 0.064 0.064
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.062 0.109
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.062 0.123
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.062 0.109
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.062 0.109
C8A C8A: Complement component C8 alpha chain precursor 0.062 0.109
MUC2 MUC2, SMUC: Mucin-2 precursor 0.062 0.123
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.062 0.109
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 0.060 0.036
ITGA5 ITGA5, FNRA: Integrin alpha-5 precursor 0.059 0.059
KIT KIT: Mast/stem cell growth factor receptor precursor 0.058 0.064
IL1R1 IL1R1, IL1R, IL1RA, IL1RT1: Interleukin-1 receptor type I precursor 0.057 0.053
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.057 0.081
HBEGF HBEGF, DTR, DTS, HEGFL: Proheparin-binding EGF-like growth factor precursor [Con 0.057 0.100
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.056 0.056
C9 C9: Complement component C9 precursor [Contains: Complement component C9a; Compl 0.056 0.097
THBS3 THBS3, TSP3: Thrombospondin-3 precursor 0.056 0.097
C8B C8B: Complement component C8 beta chain precursor 0.056 0.097
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.055 0.109
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.055 0.109
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.055 0.109
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.055 0.109
UMOD UMOD: Uromodulin precursor 0.055 0.109
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.055 0.109
SEL1L SEL1L, TSA305, UNQ128/PRO1063: Protein sel-1 homolog 1 precursor 0.053 0.053
CCL8 CCL8, MCP2, SCYA10, SCYA8: Small-inducible cytokine A8 precursor 0.052 0.852
LIF LIF, HILDA: Leukemia inhibitory factor precursor 0.052 0.144
BDNF BDNF: Brain-derived neurotrophic factor precursor 0.052 0.144
EDN1 EDN1: Endothelin-1 precursor 0.052 0.191
LGALS3BP LGALS3BP, M2BP: Galectin-3-binding protein precursor 0.052 0.191
IL8 IL8: Interleukin-8 precursor 0.052 0.416
PLAU PLAU: Urokinase-type plasminogen activator precursor 0.051 0.051
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
KLKB1 N/A 0.051 0.051
GPLD1 GPLD1, PIGPLD1: Phosphatidylinositol-glycan-specific phospholipase D precursor 0.051 0.051
MST1 MST1, D3F15S2, DNF15S2, HGFL: Hepatocyte growth factor-like protein precursor 0.051 0.051
FN1 FN1, FN: Fibronectin precursor 0.051 0.051
PELO ITGA1: Integrin alpha-1 precursor 0.051 0.051
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 0.051 0.051
NCAM1 N/A 0.051 0.051
NRCAM NRCAM, KIAA0343: Neuronal cell adhesion molecule precursor 0.051 0.051
CD55 CD55, CR, DAF: Complement decay-accelerating factor precursor 0.051 0.0416
LDLR LDLR: Low-density lipoprotein receptor precursor 0.051 0.090
NOTCH2 NOTCH2: Neurogenic locus notch homolog protein 2 precursor 0.051 0.113
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.050 0.050
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.049 0.109
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.049 0.109
KIR3DL1 N/A 0.049 0.109
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.049 0.109
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.049 0.109
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.049 0.109
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.049 0.109
DLK1 DLK1, DLK: Delta-like protein precursor 0.049 0.109
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.049 0.109
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.049 0.109
FAT2 FAT2, CDHF8, KIAA0811, MEGF1: Protocadherin Fat 2 precursor 0.049 0.111
NOTCH4 N/A 0.049 0.088
GPR116 GPR116, KIAA0758: Probable G-protein coupled receptor 116 precursor 0.047 0.0338
CPD CPD: Carboxypeptidase D precursor 0.046 0.038
CNTN3 CNTN3, KIAA1496, PANG: Contactin-3 precursor 0.046 0.046
AGC1 AGC1, CSPG1, MSK16: Aggrecan core protein precursor 0.046 0.617
FLT4 VEGFR3 long form 0.046 0.046
CD59 CD59, MIC11, MIN1, MIN2, MIN3, MSK21: CD59 glycoprotein precursor 0.0446 0.0446
CDH2 CDH2, CDHN, NCAD: Cadherin-2 precursor 0.0446 0.157
MRC2 MRC2, ENDO180, KIAA0709, UPARAP: Macrophage mannose receptor 2 precursor 0.044 0.060
KAL1 KAL1, ADMLX, KAL, KALIG1: Anosmin-1 precursor 0.044 0.049
ATRN N/A 0.044 0.098
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.044 0.098
JAG2 JAG2: Jagged-2 precursor 0.044 0.098
LIPG LIPG, UNQ387/PRO719: Endothelial lipase precursor 0.0425 0.052
ADIPOQ ADIPOQ, ACDC, ACRP30, APM1, GBP28: Adiponectin precursor 0.0425 0.109
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.0425 0.416
SERPINF1 SERPINF1, PEDF: Pigment epithelium-derived factor precursor 0.0425 0.109
EFEMP1 EFEMP1, FBLN3, FBNL: EGF-containing fibulin-like extracellular matrix protein 1 0.042 0.293
CEACAM5 CEACAM5, CEA: Carcinoembryonic antigen-related cell adhesion molecule 5 precurso 0.0416 0.037
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.041 0.064
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.041 0.073
ITGB3 ITGB3, GP3A: Integrin beta-3 precursor 0.041 0.073
ISLR ISLR, UNQ189: ISLR precursor 0.041 0.0308
TTN N/A 0.041 0.041
HSP90B1 HSP90B1, TRA1: Endoplasmin precursor 0.038 0.038
FBN1 FBN1, FBN: Fibrillin-1 precursor 0.038 0.263
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.037 0.072
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.037 0.072
BTC BTC: Probetacellulin precursor [Contains: Betacellulin 0.037 0.081
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.037 0.032
AREG AREG, SDGF: Amphiregulin precursor 0.037 0.081
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.037 0.100
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.037 0.032
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.037 0.037
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.037 0.081
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.037 0.072
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.037 0.072
IL9R IL9R: Interleukin-9 receptor precursor 0.037 0.037
ANXA2 ANXA2, ANX2, ANX2L4, CAL1H, LPC2D: Annexin A2 0.036 0.027
PTGS1 PTGS1, COX1: Prostaglandin G/H synthase 1 precursor 0.034 0.0688
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.033 0.029
IGF1R IGF1R: Insulin-like growth factor 1 receptor precursor 0.033 0.029
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.033 0.072
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.032 0.072
CD7 CD7: T-cell antigen CD7 precursor 0.032 0.072
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.032 0.032
EGF EGF: Pro-epidermal growth factor precursor 0.032 0.072
TGFA TGFA: Protransforming growth factor alpha precursor [Contains: Transforming grow 0.032 0.072
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.032 0.072
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.032 0.065
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.032 0.072
NAGPA NAGPA: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase precur 0.032 0.081
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.032 0.072
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.032 0.072
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.032 0.072
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.032 0.109
SERPING1 SERPING1, C1IN, C1NH: Plasma protease C1 inhibitor precursor 0.032 0.109
CCL24 CCL24, MPIF2, SCYA24: Small-inducible cytokine A24 precursor 0.032 0.191
LGALS3 LGALS3, MAC2: Galectin-3 0.032 0.062
C3 0.032 0.152
COL15A1 COL15A1: Collagen alpha-1(XV) chain precursor [Contains: Endostatin 0.032 0.109
PAPPA PAPPA, RP11-45A16.1-001: Pregnancy-associated plasma protein A, pappalysin 1 (Fr 0.032 0.032
FADD FADD, MORT1: Protein FADD 0.032 0.032
TPBG TPBG, 5T4: Trophoblast glycoprotein precursor 0.032 0.040
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.030 0.030
PTPRZ1 N/A 0.029 0.032
GPA33 GPA33: Cell surface A33 antigen precursor 0.029 0.072
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.029 0.072
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.029 0.072
SORL1 SORL1: Sortilin-related receptor precursor 0.029 0.065
FLT3 FLT3, STK1: FL cytokine receptor precursor 0.029 0.064
COL1A2 COL1A2: Collagen alpha-2(I) chain precursor 0.029 0.027
COL5A2 COL5A2: Collagen alpha-2(V) chain precursor 0.029 0.027
PCGF6 N/A 0.028 0.028
GHRL GHRL, MTLRP, UNQ524/PRO1066: Appetite-regulating hormone precursor 0.028 0.028
C1QC C1QC, C1QG: Complement C1q subcomponent subunit C precursor 0.028 0.165
IL4 IL4: Interleukin-4 precursor 0.028 0.028
CCL14 N/A 0.028 0.028
PCSK6 N/A 0.028 0.028
IRF2BP2 IRF2BP2, RP4-781K5.1-002: Interferon regulatory factor 2-binding protein 2. 0.028 0.028
DCN DCN: Decorin precursor 0.028 0.028
NOG NOG: Noggin precursor 0.028 0.028
CSF1 CSF1: Macrophage colony-stimulating factor 1 precursor 0.028 0.028
CCL15 CCL15, MIP5, NCC3, SCYA15: Small-inducible cytokine A15 precursor 0.028 0.165
ACCN3 ACCN3, ASIC3, SLNAC1, TNAC1: Amiloride-sensitive cation channel 3 0.028 0.028
TUBGCP6 TUBGCP6, GCP6, KIAA1669: Gamma-tubulin complex component 6 0.028 0.028
RTN4R RTN4R, NOGOR, UNQ330/PRO526: Reticulon-4 receptor precursor 0.028 0.028
KITLG KITLG, MGF, SCF: Kit ligand precursor 0.028 0.028
MMRN2 MMRN2, EMILIN3: Multimerin-2 precursor 0.028 0.028
IFNG IFNG: Interferon gamma precursor 0.028 0.028
LRG1 LRG1, LRG: Leucine-rich alpha-2-glycoprotein precursor 0.028 0.028
GRP Gastrin-releasing peptide 0.028 0.028
GUCA2A GUCA2A, GUCA2: Guanylin precursor 0.028 0.028
TFPI TFPI, LACI, TFPI1: Tissue factor pathway inhibitor precursor 0.028 0.165
LOC643930 CCL3L1, D17S1718, G0S19-2, SCYA3L1: Small-inducible cytokine A3-like 1 precursor 0.028 0.165
THPO THPO, MGDF: Thrombopoietin precursor 0.028 0.028
PLAU Plasminogen activator, urokinase 0.028 0.028
CGN N/A 0.028 0.028
CSF3 CSF3, GCSF: Granulocyte colony-stimulating factor precursor 0.028 0.028
LNX1 N/A 0.028 0.028
C1QTNF4 C1QTNF4, CTRP4: Complement C1q tumor necrosis factor-related protein 4 precursor 0.028 0.028
CCL26 CCL26, SCYA26, UNQ216/PRO242: Small-inducible cytokine A26 precursor 0.028 0.165
C4A C4A: Complement C4-A precursor 0.028 0.165
ECM1 ECM1: Extracellular matrix protein 1 precursor 0.028 0.028
DSP DSP: Desmoplakin 0.028 0.028
ZP3 ZP3, ZP3A, ZP3B, ZPC: Zona pellucida sperm-binding protein 3 precursor 0.028 0.028
RAD18 RAD18, RNF73: E3 ubiquitin-protein ligase RAD18 0.028 0.028
OPTC OPTC, OPT: Opticin precursor 0.028 0.028
CST4 CST4: Cystatin-S precursor 0.028 0.028
LECT1 LECT1, CHMI: Chondromodulin-1 precursor 0.028 0.028
PTHLH N/A 0.028 0.028
KLK15 KLK15: Kallikrein-15 precursor 0.028 0.028
CR1L complement component (3b/4b) receptor 1-like 0.027 0.027
NEGR1 NEGR1, UNQ2433/PRO4993: Neuronal growth regulator 1 precursor 0.027 0.027
PTPRT PTPRT, KIAA0283: Receptor-type tyrosine-protein phosphatase T precursor 0.027 0.027
TPSAB1 N/A 0.027 0.027
FSTL5 FSTL5, KIAA1263: Follistatin-related protein 5 precursor 0.027 0.027
MASP2 MASP2: Mannan-binding lectin serine protease 2 precursor 0.027 0.027
ELA2A ELA2A: Elastase-2A precursor 0.027 0.027
CILP2 CILP2: Cartilage intermediate layer protein 2 precursor 0.027 0.027
PRSS27 PRSS27, MPN, UNQ1884/PRO4327: Serine protease 27 precursor 0.027 0.027
KLK9 KLK9: Kallikrein-9 precursor 0.027 0.027
PRSS21 PRSS21, ESP1, UNQ266/PRO303, TEST1: Testisin precursor 0.027 0.027
PRSS36 PRSS36: Polyserase-2 precursor 0.027 0.027
KLK12 KLK12, KLKL5, UNQ669/PRO1303: Kallikrein-12 precursor 0.027 0.027
ROBO1 N/A 0.027 0.027
PSG6 PSG6, CGM3, PSGGB: Pregnancy-specific beta-1-glycoprotein 6 precursor 0.027 0.027
PSG11 PSG11, PSG13, PSG14: Pregnancy-specific beta-1-glycoprotein 11 precursor 0.027 0.027
CFHR3 CFHR3, CFHL3, FHR3: Complement factor H-related protein 3 precursor 0.027 0.027
PSG7 PSG7: Pregnancy-specific beta-1-glycoprotein 7 precursor 0.027 0.027
COL6A2 COL6A2: Collagen alpha-2(VI) chain precursor 0.027 0.027
CSPG3 CSPG3, NCAN, NEUR: Neurocan core protein precursor 0.027 0.265
PSG6 PSG5: Pregnancy-specific beta-1-glycoprotein 5 precursor 0.027 0.027
CSF2 CSF2, GMCSF: Granulocyte-macrophage colony-stimulating factor precursor 0.026 0.026
CLEC3B CLEC3B, TNA: Tetranectin precursor 0.026 0.109
SHBG SHBG: Sex hormone-binding globulin precursor 0.026 0.062
SERPINA1 SERPINA1, AAT, PRO0684, PI, PRO2209: Alpha-1-antitrypsin precursor 0.026 0.109
EDN2 EDN2: Endothelin-2 precursor 0.026 0.152
A2M A2M, FWP007: Alpha-2-macroglobulin precursor 0.026 0.098
CCL13 CCL13, MCP4, NCC1, SCYA13: Small-inducible cytokine A13 precursor 0.026 0.191
C1QA C1QA: Complement C1q subcomponent subunit A precursor 0.026 0.109
SERPINA3 N/A 0.026 0.109
CCL14 CCL14, NCC2, SCYA14: Small-inducible cytokine A14 precursor 0.026 0.109
EFEMP2 EFEMP2, FBLN4, UNQ200/PRO226: EGF-containing fibulin-like extracellular matrix p 0.0255 0.067
LGALS1 LGALS1: Galectin-1 0.025 0.051
PLTP PLTP: Phospholipid transfer protein precursor 0.025 0.025
ATRX ATRX, RAD54L, XH2: Transcriptional regulator ATRX 0.025 0.025
COL18A1 N/A 0.025 0.165
SCRIB N/A 0.025 0.025
CA11 CA11, CARP2, UNQ211/PRO237: Carbonic anhydrase-related protein 11 precursor 0.025 0.025
ANGPTL6 AGF, UNQ152/PRO178, ANGPTL6, ARP5: Angiopoietin-related protein 6 precursor 0.025 0.025
ITM2C ITM2C, BRI3, hucep-14, NPD018, PSEC0047: Integral membrane protein 2C 0.025 0.025
LOC641705 AMY2A: Pancreatic alpha-amylase precursor 0.025 0.025
LOC653509 SFTPA1, PSAP, SFTP1, SFTPA: Pulmonary surfactant-associated protein A1 precursor 0.025 0.148
CPB2 CPB2: Carboxypeptidase B2 precursor 0.025 0.025
FGG FGG, PRO2061: Fibrinogen gamma chain precursor 0.025 0.025
GRN GRN: Granulins precursor 0.025 0.025
SPOCK1 SPOCK1, SPOCK, TIC1, TICN1: Testican-1 precursor 0.025 0.148
VNN1 VNN1: Pantetheinase precursor 0.025 0.025
UNC5D N/A 0.025 0.025
2.15E-3
Total Score 3.15