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Evidence of Interaction Between TIMP1 and MMP3

The interaction score between TIMP1 and MMP3 is 54.30.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TIMP1 and MMP3 = 0.58

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

6.27E-3
Orthology
OrganismTIMP1 OrthologueMMP3 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00027166 0.237 IPI00385287 0.329
worm Q21265 0.237 O16901 0.329

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3
Domains Domains present in TIMP1 and MMP3:
Domains in TIMP1Domains in MMP3
IPR001820 Tissue inhibitor of metalloproteinase
IPR008993 TIMP-like OB-fold
IPR001134 Netrin, C-terminal
IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site
IPR000585 Hemopexin
IPR001818 Peptidase M10A and M12B, matrixin and adamalysin
IPR006026 Peptidase, metallopeptidases
IPR009070 Peptidoglycan binding-like
IPR002477 PGBD_1.

The Chi square scores for co-occurrence of domains that are present in TIMP1 and MMP3 are listed below.

Domain 1Domain 2Chi Square
IPR001820 Tissue inhibitor of metalloproteinase IPR001818 Peptidase M10A and M12B, matrixin and adamalysin 900.744
IPR001820 Tissue inhibitor of metalloproteinase IPR002477 PGBD_1. 845.463
IPR001820 Tissue inhibitor of metalloproteinase IPR000585 Hemopexin 767.901
IPR001820 Tissue inhibitor of metalloproteinase IPR006026 Peptidase, metallopeptidases 723.58
IPR001820 Tissue inhibitor of metalloproteinase IPR009070 Peptidoglycan binding-like 711.44
IPR001820 Tissue inhibitor of metalloproteinase IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site 647.351
IPR001134 Netrin, C-terminal IPR001818 Peptidase M10A and M12B, matrixin and adamalysin 201.161
IPR001134 Netrin, C-terminal IPR002477 PGBD_1. 189.631
IPR008993 TIMP-like OB-fold IPR001818 Peptidase M10A and M12B, matrixin and adamalysin 177.258
IPR001134 Netrin, C-terminal IPR000585 Hemopexin 171.346
IPR001134 Netrin, C-terminal IPR006026 Peptidase, metallopeptidases 160.899
IPR001134 Netrin, C-terminal IPR009070 Peptidoglycan binding-like 159.533
IPR008993 TIMP-like OB-fold IPR002477 PGBD_1. 159.012
IPR008993 TIMP-like OB-fold IPR000585 Hemopexin 143.671
IPR001134 Netrin, C-terminal IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site 141.442
IPR008993 TIMP-like OB-fold IPR006026 Peptidase, metallopeptidases 134.907
IPR008993 TIMP-like OB-fold IPR009070 Peptidoglycan binding-like 124.785
IPR008993 TIMP-like OB-fold IPR006025 Peptidase M, neutral zinc metallopeptidases, zinc-binding site 124.693

The background colour of the table refers to:

  • Blue Domain is only present in TIMP1
  • Yellow Domain is only present in MMP3
  • Green Domain is present in both TIMP1 and MMP3

0.265
Post-translational Modifications

Protein: TIMP1

PTMResidueReference
N-linked 53 PubMed, HPRD
N-linked 101 PubMed, HPRD

Protein: MMP3

PTMResidueReference
Localisation

Protein: TIMP1

LocalisationReference
Secreted HPRD

Protein: MMP3

LocalisationReference
Secreted HPRD
Transitive Score

The common interactors between TIMP1 and MMP3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TIMP1 andMMP3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TIMP1 has 574 interactors and MMP3 has 221 interactors of which there are 110 common interactors.

Common InteractorName of Common InteractorScore for TIMP1-Interactor (?)Score for MMP3-Interactor (?)
MMP2 MMP2, CLG4A: 72 kDa type IV collagenase precursor 12.80 0.074
MMP1 MMP1, CLG: Interstitial collagenase precursor 3.64 0.074
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 3.28 0.0308
COL5A1 N/A 1.67 0.067
MME MME, EPN: Neprilysin 1.48 0.032
MMP14 MMP14: Matrix metalloproteinase-14 precursor 1.36 0.067
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 1.30 0.027
PRG4 PRG4, MSF, SZP: Proteoglycan-4 precursor 1.07 0.028
LAMC1 LAMC1, LAMB2: Laminin subunit gamma-1 precursor 0.822 0.074
LAMB1 LAMB1: Laminin subunit beta-1 precursor 0.822 0.074
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.763 0.044
C1R C1R: Complement C1r subcomponent precursor 0.416 0.0308
C1S C1S: Complement C1s subcomponent precursor 0.416 0.050
ADAMTS2 ADAMTS2, PCINP, PCPNI: ADAMTS-2 precursor 0.402 0.050
PROS1 PROS1, PROS: Vitamin K-dependent protein S precursor 0.388 0.0308
THBS1 THBS1, TSP, TSP1: Thrombospondin-1 precursor 0.385 0.036
COL1A1 COL1A1: Collagen alpha-1(I) chain precursor 0.307 0.067
FSTL1 FSTL1, FRP: Follistatin-related protein 1 precursor 0.307 0.083
COL3A1 COL3A1: Collagen alpha-1(III) chain precursor 0.307 0.083
COL5A2 N/A 0.307 0.083
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.304 0.035
SRPX SRPX, ETX1: Sushi repeat-containing protein SRPX precursor 0.293 0.083
MMP19 MMP19, MMP18, RASI: Matrix metalloproteinase-19 precursor 0.274 0.028
MMP16 MMP16, MMPX2: Matrix metalloproteinase-16 precursor 0.274 0.028
ADAMTS19 ADAMTS19: ADAMTS-19 precursor 0.265 0.027
ADAMTS18 ADAMTS18, ADAMTS21: ADAMTS-18 precursor 0.265 0.027
ADAMTS10 ADAMTS10: ADAMTS-10 precursor 0.265 0.027
ADAMTS17 ADAMTS17: ADAMTS-17 precursor 0.265 0.027
PAPPA2 PAPPA2, PLAC3: Pappalysin-2 precursor 0.265 0.027
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.260 0.041
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.253 0.053
ITGAV ITGAV, MSK8, VNRA: Integrin alpha-V precursor 0.245 0.029
CFH CFH, HF, HF1, HF2: Complement factor H precursor 0.191 0.0308
CSPG2 N/A 0.191 0.197
LAMA2 LAMA2: Uncharacterized protein LAMA2 0.188 0.044
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.181 0.029
F11 F11: Coagulation factor XI precursor 0.165 0.027
IL6R IL6R: Interleukin-6 receptor alpha chain precursor 0.165 0.027
CD46 N/A 0.165 0.027
NULL A1BG: Alpha-1B-glycoprotein precursor 0.165 0.027
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.165 0.027
CFHR1 CFHR1, CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, HFL1, HFL2: Complement factor H-relate 0.165 0.027
F7 F7: Coagulation factor VII precursor 0.156 0.027
PLAT PLAT: Tissue-type plasminogen activator precursor 0.148 0.027
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.148 0.237
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.144 0.050
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.139 0.218
SERPINE1 SERPINE1, PAI1, PLANH1: Plasminogen activator inhibitor 1 precursor 0.129 0.060
CTGF CTGF, CCN2, HCS24: Connective tissue growth factor precursor 0.129 0.060
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.124 0.032
TNC TNC, HXB: Tenascin precursor 0.114 0.028
LRP1 LRP1, A2MR, APR: Prolow-density lipoprotein receptor-related protein 1 precursor 0.111 0.035
CXCL5 CXCL5, ENA78, SCYB5: Small-inducible cytokine B5 precursor 0.087 0.083
CCL2 CCL2, MCP1, SCYA2: Small-inducible cytokine A2 precursor 0.087 0.083
CXCL1 CXCL1, GRO, GRO1, GROA, MGSA, SCYB1: Growth-regulated protein alpha precursor 0.087 0.083
PCOLCE PCOLCE, PCPE1: Procollagen C-endopeptidase enhancer 1 precursor 0.087 0.067
AZGP1 AZGP1, tcag7.638: Alpha-2-glycoprotein 1, zinc-binding 0.083 0.027
SRPX2 SRPX2, SRPUL: Sushi repeat-containing protein SRPX2 precursor 0.083 0.067
COL4A1 N/A 0.078 0.036
SPARC SPARC, ON: SPARC precursor 0.078 0.044
PVR PVR, PVS: Poliovirus receptor precursor 0.075 0.032
IGFBP6 IGFBP6, IBP6: Insulin-like growth factor-binding protein 6 precursor 0.070 0.067
CCL11 CCL11, SCYA11: Eotaxin precursor 0.070 0.083
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.070 0.0308
PRSS23 PRSS23, ZSIG13, UNQ270/PRO307: Serine protease 23 precursor 0.067 0.0308
ITGA5 ITGA5, FNRA: Integrin alpha-5 precursor 0.059 0.035
IL1R1 IL1R1, IL1R, IL1RA, IL1RT1: Interleukin-1 receptor type I precursor 0.057 0.053
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.056 0.027
CCL8 CCL8, MCP2, SCYA10, SCYA8: Small-inducible cytokine A8 precursor 0.052 0.067
IL8 IL8: Interleukin-8 precursor 0.052 0.041
AGC1 AGC1, CSPG1, MSK16: Aggrecan core protein precursor 0.046 0.0288
MRC2 MRC2, ENDO180, KIAA0709, UPARAP: Macrophage mannose receptor 2 precursor 0.044 0.044
ADIPOQ ADIPOQ, ACDC, ACRP30, APM1, GBP28: Adiponectin precursor 0.0425 0.041
IL1A IL1A, IL1F1: Interleukin-1 alpha precursor 0.0425 0.041
SERPINF1 SERPINF1, PEDF: Pigment epithelium-derived factor precursor 0.0425 0.0308
EFEMP1 EFEMP1, FBLN3, FBNL: EGF-containing fibulin-like extracellular matrix protein 1 0.042 0.067
ISLR ISLR, UNQ189: ISLR precursor 0.041 0.041
FBN1 FBN1, FBN: Fibrillin-1 precursor 0.038 0.074
CILP CILP, UNQ602/PRO1188: Cartilage intermediate layer protein 1 precursor 0.0308 0.041
CCL15 CCL15, MIP5, NCC3, SCYA15: Small-inducible cytokine A15 precursor 0.028 0.027
LOC643930 CCL3L1, D17S1718, G0S19-2, SCYA3L1: Small-inducible cytokine A3-like 1 precursor 0.028 0.027
TFPI TFPI, LACI, TFPI1: Tissue factor pathway inhibitor precursor 0.028 0.027
CCL26 CCL26, SCYA26, UNQ216/PRO242: Small-inducible cytokine A26 precursor 0.028 0.027
C4A C4A: Complement C4-A precursor 0.028 0.027
C1QC C1QC, C1QG: Complement C1q subcomponent subunit C precursor 0.028 0.027
KLK15 KLK15: Kallikrein-15 precursor 0.028 0.028
PTPRT PTPRT, KIAA0283: Receptor-type tyrosine-protein phosphatase T precursor 0.027 0.027
TPSAB1 N/A 0.027 0.027
FSTL5 FSTL5, KIAA1263: Follistatin-related protein 5 precursor 0.027 0.027
MASP2 MASP2: Mannan-binding lectin serine protease 2 precursor 0.027 0.027
ELA2A ELA2A: Elastase-2A precursor 0.027 0.027
CILP2 CILP2: Cartilage intermediate layer protein 2 precursor 0.027 0.027
PRSS27 PRSS27, MPN, UNQ1884/PRO4327: Serine protease 27 precursor 0.027 0.027
KLK9 KLK9: Kallikrein-9 precursor 0.027 0.027
PRSS21 PRSS21, ESP1, UNQ266/PRO303, TEST1: Testisin precursor 0.027 0.027
PRSS36 PRSS36: Polyserase-2 precursor 0.027 0.027
KLK12 KLK12, KLKL5, UNQ669/PRO1303: Kallikrein-12 precursor 0.027 0.027
ROBO1 N/A 0.027 0.027
PSG6 PSG6, CGM3, PSGGB: Pregnancy-specific beta-1-glycoprotein 6 precursor 0.027 0.027
PSG11 PSG11, PSG13, PSG14: Pregnancy-specific beta-1-glycoprotein 11 precursor 0.027 0.027
CFHR3 CFHR3, CFHL3, FHR3: Complement factor H-related protein 3 precursor 0.027 0.027
PSG7 PSG7: Pregnancy-specific beta-1-glycoprotein 7 precursor 0.027 0.027
COL6A2 COL6A2: Collagen alpha-2(VI) chain precursor 0.027 0.027
CSPG3 CSPG3, NCAN, NEUR: Neurocan core protein precursor 0.027 0.265
PSG6 PSG5: Pregnancy-specific beta-1-glycoprotein 5 precursor 0.027 0.027
CR1L complement component (3b/4b) receptor 1-like 0.027 0.027
NEGR1 NEGR1, UNQ2433/PRO4993: Neuronal growth regulator 1 precursor 0.027 0.027
CCL13 CCL13, MCP4, NCC1, SCYA13: Small-inducible cytokine A13 precursor 0.026 0.0308
EFEMP2 EFEMP2, FBLN4, UNQ200/PRO226: EGF-containing fibulin-like extracellular matrix p 0.0255 0.050
COL18A1 N/A 0.025 0.027
0.228
Total Score 54.30