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Evidence of Interaction Between CHMP1B and VPS4A

The interaction score between CHMP1B and VPS4A is 32.2.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between CHMP1B and VPS4A = 0.51

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

6.27E-3
Orthology N/A N/A
Domains No domains were used in calculating likelihood of interaction 0.141
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: CHMP1B

LocalisationReference
Cytosol HPRD
Endosome HPRD
Cytoplasm HPRD

Protein: VPS4A

LocalisationReference
Nucleus HPRD
Endosome HPRD
Vacuole HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between CHMP1B and VPS4A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CHMP1B andVPS4A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CHMP1B has 18 interactors and VPS4A has 89 interactors of which there are 15 common interactors.

Common InteractorName of Common InteractorScore for CHMP1B-Interactor (?)Score for VPS4A-Interactor (?)
CHMP2B CHMP2B, CGI-84: Charged multivesicular body protein 2b 0.824 0.234
CHMP4A N/A 0.824 20.80
VPS4B VPS4B, SKD1, VPS42: Vacuolar protein sorting-associating protein 4B 0.724 0.044
CHMP2A CHMP2A, BC2, CHMP2: Charged multivesicular body protein 2a 0.666 0.317
CHMP7 CHMP7: Charged multivesicular body protein 7 0.666 0.261
CHMP5 CHMP5, C9orf83, CGI-34, SNF7DC2, HSPC177, PNAS-2, PNAS-114: Charged multivesicul 0.491 0.191
CHMP6 CHMP6, VPS20: Charged multivesicular body protein 6 0.491 12.40
VPS24 VPS24, CHMP3, CGI-149, NEDF: Charged multivesicular body protein 3 0.438 0.490
CHMP4C CHMP4C, SHAX3: Charged multivesicular body protein 4c 0.265 3.58
CHMP4B CHMP4B, C20orf178, SHAX1: Charged multivesicular body protein 4b 0.265 3.58
SRPR SRPR: Uncharacterized protein SRPR 0.067 0.050
DDX58 DDX58: Probable ATP-dependent RNA helicase DDX58 0.030 0.029
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.030 0.060
PCOLN3 CHMP1A, CHMP1, KIAA0047, PCOLN3, PRSM1: Charged multivesicular body protein 1a 0.0288 0.0288
FBXO34 CGI-301: Protein CGI-301 0.0288 0.0288
0.228
Total Score 32.2