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Evidence of Interaction Between MCM2 and ORC2L

The interaction score between MCM2 and ORC2L is 28.2.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between MCM2 and ORC2L = 0.73

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.013
Orthology
OrganismMCM2 OrthologueORC2L OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YBL023C 1 YBR060C 1
worm Q9XXI9 1 Q21037 1
fly P49735 1 Q24168 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3
Domains No domains were used in calculating likelihood of interaction 0.027
Post-translational Modifications

Protein: MCM2

PTMResidueReference
Phosphorylation 26 PubMed, HPRD
Phosphorylation 27 PubMed, HPRD
Phosphorylation 41 PubMed, HPRD
Phosphorylation 106 PubMed, HPRD
Phosphorylation 139 PubMed, HPRD
Phosphoserine 27 HPRD
Phosphoserine 41 HPRD
Phosphoserine 108 PubMed, HPRD
Phosphothreonine 106 HPRD

Protein: ORC2L

PTMResidueReference
Localisation

Protein: MCM2

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD

Protein: ORC2L

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between MCM2 and ORC2L that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between MCM2 andORC2L. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , MCM2 has 983 interactors and ORC2L has 98 interactors of which there are 62 common interactors.

Common InteractorName of Common InteractorScore for MCM2-Interactor (?)Score for ORC2L-Interactor (?)
MCM3 MCM3: DNA replication licensing factor MCM3 1.29E3 0.123
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 1.29E3 0.123
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 431.00 19.70
MCM5 MCM5, CDC46: DNA replication licensing factor MCM5 209.00 0.123
MCM7 MCM7, CDC47, MCM2: DNA replication licensing factor MCM7 209.00 0.123
MCM6 MCM6: DNA replication licensing factor MCM6 69.60 0.074
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 69.60 0.123
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 63.90 1.10
HAT1 HAT1: Histone acetyltransferase type B catalytic subunit 6.52 3.05
CCNB1 Cyclin B1 1.62 0.221
ORC5L ORC5L: Origin recognition complex subunit 5 1.49 1.49
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.763 0.044
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.763 0.123
MCM10 MCM10, PRO2249: Protein MCM10 homolog 0.593 0.593
CDK2 CDK2: Cell division protein kinase 2 0.515 0.221
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.515 0.050
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.503 0.047
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.461 0.074
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.372 0.044
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.372 0.044
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.307 0.050
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.304 0.059
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.304 0.047
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.304 0.059
H2AFX H2AFX, H2AX: Histone H2A.x 0.276 0.890
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.275 0.036
MDN1 MDN1, KIAA0301: Midasin 0.275 0.060
CCNB2 CCNB2: G2/mitotic-specific cyclin-B2 0.263 1.10
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.245 0.0968
VCP VCP: Transitional endoplasmic reticulum ATPase 0.245 0.047
RFC4 RFC4: Replication factor C subunit 4 0.207 0.059
RFC5 RFC5: Replication factor C subunit 5 0.207 0.059
RFC3 RFC3: Replication factor C subunit 3 0.207 0.059
SRPR SRPR: Uncharacterized protein SRPR 0.166 0.039
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.156 0.060
PABPC4 PABPC4, APP1, PABP4: Polyadenylate-binding protein 4 0.146 0.221
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.137 0.137
ABCE1 ABCE1, RLI, OK/SW-cl.40, RNASEL1, RNASELI, RNS4I: ATP-binding cassette sub-famil 0.123 0.123
PSMC3 PSMC3, TBP1: 26S protease regulatory subunit 6A 0.0968 0.0968
ATAD3A ATAD3A: ATPase family AAA domain-containing protein 3A 0.0968 0.059
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.087 0.657
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.074 0.060
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.065 0.065
EIF1AX EIF1AX, EIF1A, EIF4C: Eukaryotic translation initiation factor 1A, X-chromosomal 0.060 0.060
EIF1AY EIF1AY: Eukaryotic translation initiation factor 1A, Y-chromosomal 0.060 0.044
GCLC GCLC, GLCL, GLCLC: Glutamate--cysteine ligase catalytic subunit 0.060 0.044
SCYE1 SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe 0.060 0.074
DARS DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic 0.059 0.059
SRP54 SRP54: Signal recognition particle 54 kDa protein 0.059 0.0968
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.059 0.059
RUVBL1 RUVBL1, NMP238, TIP49, TIP49A: RuvB-like 1 0.047 0.047
POLR2G POLR2G: DNA-directed RNA polymerase II subunit RPB7 0.044 0.044
NARS NARS, ASNS: Asparaginyl-tRNA synthetase, cytoplasmic 0.035 0.035
RUVBL2 RUVBL2, TIP48, CGI-46, TIP49B: RuvB-like 2 0.035 0.047
SSBP1 SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor 0.0331 0.0331
VPS4A VPS4A, VPS4: Vacuolar protein sorting-associating protein 4A 0.029 0.029
ABCC4 ABCC4, MRP4: Multidrug resistance-associated protein 4 0.027 0.027
RPA3 RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit 0.027 0.027
ABCF2 ABCF2, HUSSY-18: ATP-binding cassette sub-family F member 2 0.027 0.027
DNAH11 N/A 0.027 0.027
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 0.025 0.071
HIST3H2A HIST3H2A: Histone H2A type 3 0.025 0.071
0.572
Total Score 28.2