PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between EXOSC4 and EXOSC5

The interaction score between EXOSC4 and EXOSC5 is 2.69E3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between EXOSC4 and EXOSC5 = 0.48

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

4.62E-3

Orthology

Organism	EXOSC4 Orthologue		EXOSC5 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YGR195W	1	YGR095C	1	Other AffinityCaptureMS Get References From PubMed
worm	Q17533	1	Q17952	1
fly	Q8SYC8	1	Q9VGZ2	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593

Domains

No domains were used in calculating likelihood of interaction

0.027

Post-translational Modifications

Protein: EXOSC4

PTM	Residue	Reference
N-acetylalanine	1	HPRD

Protein: EXOSC5

PTM	Residue	Reference

Localisation

Protein: EXOSC4

Localisation	Reference
Nucleus	HPRD
Nucleolus	HPRD
Cytoplasm	HPRD

Protein: EXOSC5

Localisation	Reference
Nucleus	HPRD
Nucleolus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between EXOSC4 and EXOSC5 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EXOSC4 andEXOSC5. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EXOSC4 has 140 interactors and EXOSC5 has 101 interactors of which there are 84 common interactors.

Common Interactor	Name of Common Interactor	Score for EXOSC4-Interactor (?)	Score for EXOSC5-Interactor (?)
EXOSC2	EXOSC2, RRP4: Exosome complex exonuclease RRP4	12.10	15.90
EXOSC3	EXOSC3, RRP40, CGI-102: Exosome complex exonuclease RRP40	1.16	0.354
EXOSC9	N/A	0.715	0.715
EXOSC10	EXOSC10, PMSCL, PMSCL2: Exosome component 10	0.715	0.715
MYO5B	MYO5B, KIAA1119: Myosin-Vb	0.593	0.593
KPNA5	KPNA5: Importin subunit alpha-6	0.408	0.264
KPNA6	N/A	0.326	0.408
KIAA1008	N/A	0.210	0.326
FXR1	FXR1: Fragile X mental retardation syndrome-related protein 1	0.126	0.044
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.126	0.060
MYO5A	N/A	0.119	0.119
MPP6	MPP6, VAM1: MAGUK p55 subfamily member 6	0.103	0.050
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	0.103	0.083
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.093	0.044
MYO5C	MYO5C: Myosin-Vc	0.089	0.089
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.082	0.065
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.082	0.065
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.0735	0.035
MCM4	MCM4, CDC21: DNA replication licensing factor MCM4	0.0735	0.047
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.0735	0.059
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.0735	0.035
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.0735	0.029
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.0735	0.059
MCM3	MCM3: DNA replication licensing factor MCM3	0.0735	0.047
POLR2H	POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3	0.0735	0.0968
DDX21	DDX21: Nucleolar RNA helicase 2	0.067	0.053
KARS	KARS, KIAA0070: Lysyl-tRNA synthetase	0.067	0.067
KPNA1	KPNA1, RCH2: Importin subunit alpha-1	0.065	0.132
MCM2	MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2	0.060	0.035
YARS	YARS: Tyrosyl-tRNA synthetase, cytoplasmic	0.060	0.059
ERCC3	ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit	0.060	0.029
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.060	0.059
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.060	0.035
MRPS28	MRPS28, MRPS35, HSPC007: Mitochondrial 28S ribosomal protein S28	0.060	0.060
DDX39	DDX39: ATP-dependent RNA helicase DDX39	0.059	0.047
FXR2	FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2	0.058	0.028
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.051	0.041
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.051	0.032
OBFC1	OBFC1: Oligonucleotide/oligosaccharide-binding fold-containing protein 1	0.050	0.050
EXOSC8	EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43	0.050	0.050
DDX19A	DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A	0.047	0.047
BLM	BLM, RECQ2, RECQL3: Bloom syndrome protein	0.046	0.035
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.046	0.035
WRN	WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase	0.046	0.029
EXOSC7	EXOSC7, KIAA0116, RRP42: Exosome complex exonuclease RRP42	0.044	0.074
DARS	DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic	0.036	0.060
POLD1	POLD1, POLD: DNA polymerase delta catalytic subunit	0.035	0.059
DDX28	DDX28, MDDX28: Probable ATP-dependent RNA helicase DDX28	0.035	0.047
EIF4A1	EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I	0.035	0.047
MCM5	MCM5, CDC46: DNA replication licensing factor MCM5	0.035	0.035
DDX49	DDX49: Probable ATP-dependent RNA helicase DDX49	0.035	0.047
DDX48	EIF4A3, DDX48, KIAA0111: Eukaryotic initiation factor 4A-III	0.035	0.059
DHX15	DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase	0.032	0.053
DDX50	DDX50: ATP-dependent RNA helicase DDX50	0.032	0.032
POT1	POT1: Protection of telomeres protein 1	0.0308	0.041
RPA1	RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit	0.029	0.035
BAT1	N/A	0.029	0.047
DDX1	DDX1: ATP-dependent RNA helicase DDX1	0.029	0.035
POLE	POLE, POLE1: DNA polymerase epsilon catalytic subunit A	0.029	0.035
DHX38	DHX38, DDX38, KIAA0224, PRP16: Pre-mRNA-splicing factor ATP-dependent RNA helica	0.029	0.029
DDX54	DDX54: ATP-dependent RNA helicase DDX54	0.029	0.047
POLR2G	POLR2G: DNA-directed RNA polymerase II subunit RPB7	0.029	0.035
RAD54L	RAD54L, RAD54A: DNA repair and recombination protein RAD54-like	0.029	0.035
XPMC2H	REXO4, PMC2, XPMC2H: RNA exonuclease 4	0.029	0.029
DDX27	DDX27, RHLP, HSPC259, PP3241: Probable ATP-dependent RNA helicase DDX27	0.029	0.035
DDX47	E4-DBP: DEAD box protein	0.029	0.035
CNOT7	CNOT7, CAF1: CCR4-NOT transcription complex subunit 7	0.029	0.035
DDX10	DDX10: Probable ATP-dependent RNA helicase DDX10	0.029	0.059
MCM6	MCM6: DNA replication licensing factor MCM6	0.029	0.047
DDX18	DDX18: ATP-dependent RNA helicase DDX18	0.029	0.035
DDX23	DDX23: Probable ATP-dependent RNA helicase DDX23	0.029	0.029
DDX56	DDX56, DDX21, NOH61: Probable ATP-dependent RNA helicase DDX56	0.029	0.047
HELLS	HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase	0.029	0.035
EIF1AX	EIF1AX, EIF1A, EIF4C: Eukaryotic translation initiation factor 1A, X-chromosomal	0.028	0.044
PSMC6	PSMC6, SUG2: 26S protease regulatory subunit S10B	0.028	0.036
LIN7C	LIN7C, MALS3, VELI3: Lin-7 homolog C	0.028	0.036
NARS	NARS, ASNS: Asparaginyl-tRNA synthetase, cytoplasmic	0.028	0.060
SCYE1	SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe	0.028	0.060
MRPS12	MRPS12, RPMS12, RPSM12: 28S ribosomal protein S12, mitochondrial precursor	0.027	0.055
CARD11	CARD11, CARMA1: Caspase recruitment domain-containing protein 11	0.027	0.027
CARD14	CARD14, CARMA2: Caspase recruitment domain-containing protein 14	0.027	0.027
BFSP1	BFSP1: Filensin	0.027	0.027
MPP4	MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4	0.027	0.027
RPA3	RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit	0.027	0.027

0.572

Total Score

2.69E3