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Evidence of Interaction Between H2AFX and SUPT16H

The interaction score between H2AFX and SUPT16H is 256.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between H2AFX and SUPT16H = 0.68

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 7.78E-3
Orthology
OrganismH2AFX OrthologueSUPT16H OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YBL003C 1 YGL207W 1
  • AffinityCaptureMS

Get References From PubMed
bakers yeast YDR225W 1 YGL207W 1
  • Immunoprecipitation
  • AffinityCaptureMS

Get References From PubMed
fly P84051 0.333 Q9W071 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains No domains were used in calculating likelihood of interaction N/A
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation No localisation data was used in calculating likelihood of interaction
Transitive Score

The common interactors between H2AFX and SUPT16H that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between H2AFX andSUPT16H. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , H2AFX has 1184 interactors and SUPT16H has 152 interactors of which there are 62 common interactors.

Common InteractorName of Common InteractorScore for H2AFX-Interactor (?)Score for SUPT16H-Interactor (?)
HIST2H2BE HIST2H2BE, H2BFQ: Histone H2B type 2-E 118.00 0.352
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 72.80 3.05
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 62.90 1.10
HIST1H2BG HIST1H2BC, H2BFL, HIST1H2BE, H2BFH, HIST1H2BF, H2BFG, HIST1H2BG, H2BFA, HIST1H2B 37.10 0.685
HIST1H2BJ HIST1H2BJ, H2BFR: Histone H2B type 1-J 37.10 0.110
HIST1H2BK HIST1H2BK, H2BFT, HIRIP1: Histone H2B type 1-K 37.10 0.138
H2BFS H2BFS: Histone H2B type F-S 37.10 0.138
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 34.20 6.52
HIST1H2BH HIST1H2BH, H2BFJ: Histone H2B type 1-H 32.20 0.593
HIST1H2BB HIST1H2BB, H2BFF: Histone H2B type 1-B 32.20 0.119
HIST3H2BB HIST3H2BB: Histone H2B type 3-B 32.20 0.119
HIST1H2BA HIST1H2BA, TSH2B: Histone H2B type 1-A 32.20 0.119
HIST1H2BN N/A 32.20 0.119
HIST1H2BM HIST1H2BM, H2BFE: Histone H2B type 1-M 32.20 0.119
HIST1H4A HIST1H4A, H4/A, HIST1H4B, H4/I, H4/G, HIST1H4D, H4/B, H4/J, HIST1H4F, HIST4H4, H 30.80 0.443
HIST1H2AG HIST1H2AG, H2AFP, HIST1H2AI, H2AFC, HIST1H2AK, H2AFD, HIST1H2AL, H2AFI, HIST1H2A 29.60 0.110
HIST1H2BD HIST1H2BD, H2BFB, HIRIP2: Histone H2B type 1-D 24.00 0.089
HIST1H2BO HIST1H2BO, H2BFH, H2BFN: Histone H2B type 1-O 24.00 0.443
CSNK2A1 CSNK2A1: CSNK2A1 protein 20.60 3.05
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 9.59 0.181
HIST2H2AC HIST2H2AC, H2AFQ: Histone H2A type 2-C 7.88 0.119
HIST3H3 HIST3H3, H3FT: Histone H3.1t 5.88 0.110
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 4.59 0.902
HIST1H2AC HIST1H2AC, H2AFL: Histone H2A type 1-C 4.16 0.443
HIST1H2AB N/A 1.46 0.138
HIST3H2A HIST3H2A: Histone H2A type 3 1.33 0.119
HIST1H2BL HIST1H2BL, H2BFC: Histone H2B type 1-L 1.27 0.119
HIST2H2AA HIST2H2AA3, H2AFO, HIST2H2AA: Histone H2A type 2-A 1.27 0.119
HIST1H2AK HIST1H2AJ, H2AFE: Histone H2A type 1-J 1.27 0.119
TOP2B TOP2B: DNA topoisomerase 2-beta 1.15 0.593
NAP1L2 NAP1L2, BPX: Nucleosome assembly protein 1-like 2 0.754 0.071
RP11-196G18.6 HIST2H2BF: Histone H2B type 2-F 0.593 0.593
CSNK2A2 CSNK2A2, CK2A2: Casein kinase II subunit alpha' 0.326 0.685
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.276 0.614
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.227 1.84
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.160 0.027
MCM3 MCM3: DNA replication licensing factor MCM3 0.129 0.0739
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 0.129 0.0739
LOC644914 H3L-like histone (Fragment) 0.119 0.119
H2AFJ H2A histone family member J. 0.119 0.119
LOC440093 Histone H3-like 0.119 0.119
TOP2A Uncharacterized protein ENSP00000269577 0.119 0.119
NULL N/A 0.119 0.119
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 0.114 0.221
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.087 0.027
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.087 0.027
BRD4 N/A 0.075 0.119
BOP1 BOP1, KIAA0124: Ribosome biogenesis protein BOP1 0.074 3.05
HIST2H2AB HIST2H2AB: Histone H2A type 2-B 0.071 0.119
HIST2H3C HIST2H3A, HIST2H3C, H3F2, H3FM: Histone H3.2 0.071 0.119
HIST1H2AG HIST1H2AH, HIST1H2AI: Histone H2A type 1-H 0.071 0.119
HIST1H2AA HIST1H2AA: Histone H2A type 1-A 0.071 0.119
HPRT1 HPRT1, HPRT: Hypoxanthine-guanine phosphoribosyltransferase 0.0446 0.027
MTHFD1 MTHFD1, MTHFC, MTHFD: C-1-tetrahydrofolate synthase, cytoplasmic 0.040 0.614
POLR2A POLR2A: Uncharacterized protein POLR2A 0.038 0.902
RAD23A RAD23A: UV excision repair protein RAD23 homolog A 0.038 0.138
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.036 0.027
GTPBP4 GTPBP4, CRFG, NOG1: Nucleolar GTP-binding protein 1 0.036 0.027
C18orf56 N/A 0.027 0.027
SMC4L1 N/A 0.027 0.027
GMNN GMNN: Geminin 0.025 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.025 0.027
0.347
Total Score 256.00