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Evidence of Interaction Between H3F3A and ASF1A

The interaction score between H3F3A and ASF1A is 379.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between H3F3A and ASF1A = 0.40

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

3.80E-3
Orthology
OrganismH3F3A OrthologueASF1A OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00219038 1 IPI00041127 0.213
  • Immunoprecipitation
  • InVivo

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human IPI00216402 0.417 IPI00041127 0.213
human IPI00419884 0.292 IPI00041127 0.213
human IPI00413826 0.792 IPI00041127 0.213
human IPI00171611 0.708 IPI00041127 0.213
bakers yeast YBR010W 1 YJL115W 0.213
  • Immunoprecipitation
  • pullDown
  • AffinityCaptureMS
  • CoPurification

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bakers yeast YNL031C 1 YJL115W 0.213
  • Immunoprecipitation
  • pullDown
  • AffinityCaptureMS

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worm Q10453 0.5 Q17603 0.298

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

3.01
Domains No domains were used in calculating likelihood of interaction 1.48E-3
Post-translational Modifications

Protein: H3F3A

PTMResidueReference
Acetylation 15 PubMed, HPRD
Methylation 27 PubMed, HPRD
N6-acetyllysine 14 PubMed, HPRD
N6-acetyllysine 23 PubMed, HPRD
N6-methyllysine 9 PubMed, HPRD
N6-methyllysine 27 HPRD
N6-methyllysine 36 PubMed, HPRD
Phosphorylation 11 PubMed, HPRD
Phosphorylation 29 PubMed, HPRD

Protein: ASF1A

PTMResidueReference
Localisation

Protein: H3F3A

LocalisationReference
Nucleus HPRD

Protein: ASF1A

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between H3F3A and ASF1A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between H3F3A andASF1A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , H3F3A has 1286 interactors and ASF1A has 33 interactors of which there are 20 common interactors.

Common InteractorName of Common InteractorScore for H3F3A-Interactor (?)Score for ASF1A-Interactor (?)
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 390.00 2.07
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 98.70 0.179
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 49.80 0.082
HIST1H4A HIST1H4A, H4/A, HIST1H4B, H4/I, H4/G, HIST1H4D, H4/B, H4/J, HIST1H4F, HIST4H4, H 38.10 1.65
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 20.40 0.044
HIST3H3 HIST3H3, H3FT: Histone H3.1t 19.80 0.035
CSNK2A1 CSNK2A1: CSNK2A1 protein 16.60 0.179
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 7.28 0.0294
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 6.64 0.071
BRD4 N/A 3.97 0.038
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 1.10 0.366
CSNK2A2 CSNK2A2, CK2A2: Casein kinase II subunit alpha' 0.326 0.065
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.171 0.179
TAF7 TAF7, TAF2F, TAFII55: Transcription initiation factor TFIID subunit 7 0.123 0.071
LOC440093 Histone H3-like 0.119 0.064
NULL N/A 0.119 0.064
LOC644914 H3L-like histone (Fragment) 0.119 0.064
HIST2H3C HIST2H3A, HIST2H3C, H3F2, H3FM: Histone H3.2 0.071 0.038
TBP TBP, GTF2D1, TF2D, TFIID: TATA-box-binding protein 0.044 0.132
BRDT N/A 0.029 0.064
0.347
Total Score 379.00