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Evidence of Interaction Between PSMA2 and PSMB6

The interaction score between PSMA2 and PSMB6 is 280.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PSMA2 and PSMB6 = 0.74

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismPSMA2 OrthologuePSMB6 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YML092C 1 YJL001W 1
  • AffinityCaptureMS

Get References From PubMed
worm Q27488 1 Q966I8 1
fly P40301 1 Q8SYQ2 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in PSMA2 and PSMB6:
Domains in PSMA2Domains in PSMB6
IPR001353 20S proteasome, A and B subunits
IPR000426 Proteasome alpha-subunit
IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 20S proteasome, A and B subunits

The Chi square scores for co-occurrence of domains that are present in PSMA2 and PSMB6 are listed below.

Domain 1Domain 2Chi Square
IPR000426 Proteasome alpha-subunit IPR001353 20S proteasome, A and B subunits 1084.67
IPR000426 Proteasome alpha-subunit IPR000243 Peptidase T1A, proteasome beta-subunit 998.751
IPR001353 20S proteasome, A and B subunits IPR001353 20S proteasome, A and B subunits 972.655
IPR001353 20S proteasome, A and B subunits IPR000243 Peptidase T1A, proteasome beta-subunit 960.483

The background colour of the table refers to:

  • Blue Domain is only present in PSMA2
  • Yellow Domain is only present in PSMB6
  • Green Domain is present in both PSMA2 and PSMB6

 0.265
Post-translational Modifications

Protein: PSMA2

PTMResidueReference
Phosphotyrosine 23 HPRD
Phosphotyrosine 97 HPRD

Protein: PSMB6

PTMResidueReference
Localisation

Protein: PSMA2

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: PSMB6

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PSMA2 and PSMB6 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PSMA2 andPSMB6. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PSMA2 has 927 interactors and PSMB6 has 158 interactors of which there are 151 common interactors.

Common InteractorName of Common InteractorScore for PSMA2-Interactor (?)Score for PSMB6-Interactor (?)
PSMA5 PSMA5: Proteasome subunit alpha type-5 1.02E4 323.00
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 3.41E3 195.00
PSMA4 PSMA4, PSC9: Proteasome subunit alpha type-4 2.07E3 323.00
PSMA7 PSMA7: Proteasome subunit alpha type-7 1.64E3 691.00
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 1.59E3 691.00
PSMB1 PSMB1, PSC5: Proteasome subunit beta type-1 precursor 691.00 323.00
PSMB2 PSMB2: Proteasome subunit beta type-2 691.00 323.00
PSMA8 PSMA8, PSMA7L: Proteasome subunit alpha type-7-like 319.00 12.60
PSMB3 PSMB3: Proteasome subunit beta type-3 195.00 691.00
PSMA6 PSMA6, PROS27: Proteasome subunit alpha type-6 195.00 195.00
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 69.20 0.195
PSMB9 PSMB9, LMP2, RING12: Proteasome subunit beta type-9 precursor 31.70 31.70
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 5.97 1.10
PSMB8 PSMB8, DAQB-69D7.6-002, DASS-67H14.1-002, XXbac-BCX32M13.6-002, XXbac-BPG246D15. 5.60 0.179
PSMB5 DKFZp686I0180: Putative uncharacterized protein DKFZp686I0180 (Fragment) 3.01 0.593
PSMA1 PSMA1, PROS30, PSC2: Proteasome subunit alpha type-1 2.91 1.36
PSMB4 N/A 1.82 3.89
PSMA1 N/A 1.79 0.354
CSNK2A1 CSNK2A1: CSNK2A1 protein 1.62 0.123
NULL RcPSMB3 (Fragment) 1.37 1.37
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.852 0.083
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.763 0.123
CDK7 CDK7, MO15: Cell division protein kinase 7 0.763 0.074
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.763 0.060
CDK4 CDK4: Cell division protein kinase 4 0.763 0.074
CTRL PSMB10, MECL1: Proteasome subunit beta type-10 precursor 0.666 0.666
PSMB4 PSMB4: Proteasome subunit beta type-4 precursor 0.617 0.0288
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.596 0.440
PSME4 PSME4, KIAA0077: Proteasome activator complex subunit 4 0.593 0.593
VAC14 VAC14, TAX1BP2, TRX: Protein VAC14 homolog 0.538 0.408
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.515 0.050
CDK2 CDK2: Cell division protein kinase 2 0.461 0.060
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.461 0.074
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.461 0.074
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.461 0.044
ROCK1 ROCK1: Rho-associated protein kinase 1 0.416 0.041
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.372 0.036
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.372 0.044
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.372 0.036
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.372 0.044
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.372 0.044
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.372 0.036
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.372 0.044
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.372 0.060
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.372 0.036
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.372 0.036
RPS6KB1 N/A 0.372 0.036
WEE1 WEE1: Wee1-like protein kinase 0.372 0.036
STK16 N/A 0.307 0.067
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.304 0.047
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.275 0.036
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.275 0.028
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.275 0.044
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.275 0.028
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.275 0.060
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.275 0.060
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.275 0.044
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.275 0.036
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.275 0.036
PSMB5 PSMB5, LMPX: Proteasome subunit beta type-5 precursor 0.265 0.265
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.251 0.041
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.225 0.060
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.225 0.036
STK10 STK10: Uncharacterized protein STK10 0.225 0.028
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.225 0.036
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.225 0.036
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.225 0.036
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.225 0.028
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.225 0.074
PLK3 PLK3, CNK, FNK, PRK: Serine/threonine-protein kinase PLK3 0.225 0.179
KIAA0368 ECM29, KIAA0368: Proteasome-associated protein ECM29 homolog 0.218 0.593
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.191 0.0308
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.191 0.0308
PLK2 PLK2, SNK: Serine/threonine-protein kinase PLK2 0.179 0.179
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.171 0.036
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.171 0.060
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.171 0.036
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.165 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.165 0.027
MAPK15 N/A 0.165 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.165 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.165 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.165 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.165 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.165 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.165 0.027
MAPKAPK5 N/A 0.165 0.027
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.152 0.0308
CDK5 CDK5: Cell division protein kinase 5 0.136 0.036
GRK5 GRK5, GPRK5: G protein-coupled receptor kinase 5 0.136 0.028
MAP2K4 MAP2K4, JNKK1, MKK4, PRKMK4, SERK1: Dual specificity mitogen-activated protein k 0.136 0.028
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.136 0.028
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.129 1.10
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.126 0.036
AURKB AURKB, AIK2, AIM1, ARK2, STK12: Serine/threonine-protein kinase 12 0.123 0.060
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.123 0.060
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.111 0.028
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.103 0.041
MAPK3 MAPK3, ERK1, PRKM3: Mitogen-activated protein kinase 3 0.097 0.028
VRK2 VRK2: Serine/threonine-protein kinase VRK2 0.0968 0.035
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.093 0.036
LIMK2 LIMK2: LIM domain kinase 2 0.085 0.041
RIPK2 RIPK2, CARDIAK, UNQ277/PRO314/PRO34092, RICK, RIP2: Receptor-interacting serine/ 0.083 0.050
CSNK1G3 CSNK1G3: Casein kinase I isoform gamma-3 0.083 0.067
BUB1 0.074 0.044
BUB1B BUB1B, BUBR1, MAD3L: Mitotic checkpoint serine/threonine-protein kinase BUB1 bet 0.074 0.044
CSNK1A1 CSNK1A1: Casein kinase I isoform alpha 0.074 0.074
MAP2K3 MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki 0.064 0.0308
RP6-213H19.1 MST4, MASK: Serine/threonine-protein kinase MST4 0.060 0.044
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.058 0.028
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.058 0.028
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.058 0.060
MAP2K5 N/A 0.056 0.027
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.056 0.027
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.056 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.056 0.027
CAMK2G Calcium/calmodulin-dependent protein kinase isoform A (Fragment) 0.050 0.050
TTK TTK, MPS1L1: Dual specificity protein kinase TTK 0.047 0.035
CLK3 CLK3: Dual specificity protein kinase CLK3 0.044 0.044
DYRK4 DYRK4: Dual specificity tyrosine-phosphorylation-regulated kinase 4 0.044 0.044
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.044 0.028
STK17A STK17A, DRAK1: Serine/threonine-protein kinase 17A 0.044 0.036
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.044 0.044
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.044 0.036
NEK2 NEK2, NLK1: Serine/threonine-protein kinase Nek2 0.044 0.028
CSNK1G2 CSNK1G2: Casein kinase I isoform gamma-2 0.044 0.044
MAP4K2 MAP4K2, GCK, RAB8IP: Mitogen-activated protein kinase kinase kinase kinase 2 0.044 0.044
EIF2AK1 N/A 0.041 0.041
DYRK2 DYRK2: Dual specificity tyrosine-phosphorylation-regulated kinase 2 0.041 0.0308
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.036 0.044
PRKX PRKX, PKX1: Serine/threonine-protein kinase PRKX 0.036 0.028
CSNK1D CSNK1D: Casein kinase I isoform delta 0.036 0.060
IRAK4 IRAK4: Interleukin-1 receptor-associated kinase 4 0.036 0.028
MAP4K5 MAP4K5: Mitogen-activated protein kinase kinase kinase kinase 5 0.036 0.028
CDK9 CDK9, CDC2L4: Cell division protein kinase 9 0.035 0.047
DAPK3 DAPK3, ZIPK: Death-associated protein kinase 3 0.0308 0.041
VRK3 N/A 0.0308 0.041
PSMB8 PSMB8, LMP7, RING10, Y2: Proteasome subunit beta type-8 precursor 0.0288 0.0288
GAK GAK: Cyclin G-associated kinase 0.029 0.035
PCTK2 PCTK2: Serine/threonine-protein kinase PCTAIRE-2 0.028 0.028
WNK1 WNK1, KDP, KIAA0344, PRKWNK1: Serine/threonine-protein kinase WNK1 0.028 0.028
CSNK2A2 CSNK2A2, CK2A2: Casein kinase II subunit alpha' 0.028 0.028
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
CDC2L2 N/A 0.027 0.027
2.15E-3
Total Score 280.00