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Evidence of Interaction Between EIF2S1 and EIF2B1

The interaction score between EIF2S1 and EIF2B1 is 842.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EIF2S1 and EIF2B1 = 0.76

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.013
Orthology
OrganismEIF2S1 OrthologueEIF2B1 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YJR007W 1 YKR026C 1
  • Immunoprecipitation
  • AffinityCaptureMS
  • SyntheticGrowthDefect
  • AffinityCaptureWestern
  • CoFractionation

Get References From PubMed

worm Q9BKU3 1 P34604 1
fly P41374 1 Q9GQ89 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593
Domains No domains were used in calculating likelihood of interaction 3.00E-3
Post-translational Modifications

Protein: EIF2S1

PTMResidueReference
Dephosphorylation 52 PubMed, HPRD
Phosphorylation 49 PubMed, HPRD
Phosphorylation 52 PubMed, HPRD
Phosphoserine 51 PubMed, HPRD
Proteolytic Cleavage 52 PubMed, HPRD
Proteolytic Cleavage 301 PubMed, HPRD

Protein: EIF2B1

PTMResidueReference
Localisation

Protein: EIF2S1

LocalisationReference
Nucleolus HPRD
Cytoplasm HPRD
Ribosome HPRD

Protein: EIF2B1

LocalisationReference
Plasma membrane HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between EIF2S1 and EIF2B1 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EIF2S1 andEIF2B1. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EIF2S1 has 1064 interactors and EIF2B1 has 107 interactors of which there are 40 common interactors.

Common InteractorName of Common InteractorScore for EIF2S1-Interactor (?)Score for EIF2B1-Interactor (?)
EIF2S2 EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2 431.00 1.84
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 122.00 3.68
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 80.50 6.52
EIF2B2 EIF2B2, EIF2BB: Translation initiation factor eIF-2B subunit beta 1.79 1.10
EIF2B4 N/A 1.10 1.49
EIF2B3 EIF2B3: Translation initiation factor eIF-2B subunit gamma 1.10 0.902
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.917 0.027
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.881 0.027
FOXK2 N/A 0.593 0.593
FUBP1 N/A 0.561 0.027
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.430 0.027
PTMA N/A 0.307 0.027
SCYE1 SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe 0.263 0.030
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.231 0.0331
SET SET: Protein SET 0.144 0.027
ABCF1 N/A 0.144 0.027
HMGN1 HMGN1, HMG14: Non-histone chromosomal protein HMG-14 0.144 0.027
NULL Putative uncharacterized protein (Fragment) 0.143 0.119
NULL N/A 0.119 0.119
FLJ14977 N/A 0.119 0.119
NULL hCG_2006325: Uncharacterized protein ENSP00000249480 0.119 0.119
SSBP1 SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor 0.117 0.030
CPSF6 CPSF6, CFIM68: Cleavage and polyadenylation specificity factor subunit 6 0.090 0.027
CLTC CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1 0.078 1.10
FARSLA FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain 0.075 0.593
CCT4 CCT4, CCTD, SRB: T-complex protein 1 subunit delta 0.066 3.05
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.066 1.84
XAB1 XAB1, MBDIN, HUSSY-23: XPA-binding protein 1 0.055 3.05
C11orf58 SMAP, C11orf58: Small acidic protein 0.053 0.027
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.053 0.027
LSM5 LSM5: U6 snRNA-associated Sm-like protein LSm5 0.048 3.05
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.038 0.902
CLPX CLPX: ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial pr 0.0331 1.84
HNRPD N/A 0.027 0.027
RNF138 N/A 0.027 0.027
NOL7 NOL7, C6orf90, NOP27: Nucleolar protein 7 0.027 0.027
BUB3 N/A 0.027 0.027
DKFZP586L0724 NOL11, L14: Nucleolar protein 11 0.027 0.027
ADAR ADAR, ADAR1, DSRAD, G1P1, IFI4: Double-stranded RNA-specific adenosine deaminase 0.0255 0.027
MAP2K3 N/A 0.025 0.191
0.572
Total Score 842.00