PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between LSM8 and LSM7

The interaction score between LSM8 and LSM7 is 597.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between LSM8 and LSM7 = 0.86

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.027

Orthology

Organism	LSM8 Orthologue		LSM7 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
worm	Q95XD4	1	Q23543	1
fly	Q9W087	1	Q9VJI7	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

2.23E-3

Domains

Domains present in LSM8 and LSM7:

Domains in LSM8

Domains in LSM7

IPR001163	Small nuclear ribonucleoprotein (Sm protein)
IPR010920	Small nuclear-like ribonucleoprotein
IPR006649	snRNP domain

IPR001163	Small nuclear ribonucleoprotein (Sm protein)
IPR010920	Small nuclear-like ribonucleoprotein
IPR006649	snRNP domain

The Chi square scores for co-occurrence of domains that are present in LSM8 and LSM7 are listed below.

Domain 1		Domain 2		Chi Square
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR006649	snRNP domain	1325.87
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR001163	Small nuclear ribonucleoprotein (Sm protein)	1297.61
IPR006649	snRNP domain	IPR006649	snRNP domain	1206.57
IPR010920	Small nuclear-like ribonucleoprotein	IPR006649	snRNP domain	1168.89
IPR001163	Small nuclear ribonucleoprotein (Sm protein)	IPR010920	Small nuclear-like ribonucleoprotein	1143.95
IPR010920	Small nuclear-like ribonucleoprotein	IPR010920	Small nuclear-like ribonucleoprotein	355.236

The background colour of the table refers to:

Blue Domain is only present in LSM8
Yellow Domain is only present in LSM7
Green Domain is present in both LSM8 and LSM7

0.265

Post-translational Modifications

Protein: LSM8

PTM	Residue	Reference
N-acetylthreonine	1	HPRD

Protein: LSM7

PTM	Residue	Reference

Localisation

Protein: LSM8

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Protein: LSM7

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between LSM8 and LSM7 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between LSM8 andLSM7. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , LSM8 has 288 interactors and LSM7 has 270 interactors of which there are 200 common interactors.

Common Interactor	Name of Common Interactor	Score for LSM8-Interactor (?)	Score for LSM7-Interactor (?)
LSM2	LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2	383.00	3.51E3
SNRPF	SNRPF, PBSCF: Small nuclear ribonucleoprotein F	205.00	205.00
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	10.30	205.00
LSM3	LSM3, MDS017: U6 snRNA-associated Sm-like protein LSm3	10.30	691.00
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	10.30	2.60
LSM5	LSM5: U6 snRNA-associated Sm-like protein LSm5	4.86	3.51E3
SNRPE	SNRPE: Small nuclear ribonucleoprotein E	2.91	8.73
SNRPB	SNRPB, COD, SNRPB1: Small nuclear ribonucleoprotein-associated proteins B and B'	2.91	2.91
SNRPD2	SNRPD2, SNRPD1: Small nuclear ribonucleoprotein Sm D2	2.60	691.00
SNRPG	SNRPG, PBSCG: Small nuclear ribonucleoprotein G	2.60	2.60
LSM6	LSM6: U6 snRNA-associated Sm-like protein LSm6	2.60	323.00
LSM4	LSM4: U6 snRNA-associated Sm-like protein LSm4	1.22	1.64E3
LSM1	LSM1, CASM: U6 snRNA-associated Sm-like protein LSm1	0.739	195.00
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.613	0.137
GNB2L1	Lung cancer oncogene 7	0.613	0.293
DDX21	DDX21: Nucleolar RNA helicase 2	0.613	0.293
DHX15	DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase	0.293	0.293
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.287	0.137
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.287	0.293
CNOT7	CNOT7, CAF1: CCR4-NOT transcription complex subunit 7	0.263	0.263
BAT1	N/A	0.263	0.263
RBBP4	RBBP4, RBAP48: Histone-binding protein RBBP4	0.257	0.123
EIF3S2	EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2	0.257	0.123
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.257	0.123
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.257	0.263
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.257	0.123
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.257	0.263
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.257	69.60
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.257	0.123
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.257	0.123
LSM10	LSM10: U7 snRNA-associated Sm-like protein LSm10	0.237	0.237
LSM11	LSM11: U7 snRNA-associated Sm-like protein LSm11	0.237	0.237
SNRPN	HCERN3, SNRPN, SMN: Small nuclear ribonucleoprotein-associated protein N	0.158	0.156
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.156	0.074
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.156	0.074
CDC20	CDC20: Cell division cycle protein 20 homolog	0.156	0.060
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.156	0.123
CHAF1B	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B	0.156	0.060
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.156	0.074
BLM	BLM, RECQ2, RECQL3: Bloom syndrome protein	0.156	0.074
WDR1	N/A	0.140	0.067
GTF3C2	GTF3C2, KIAA0011: General transcription factor 3C polypeptide 2	0.137	0.293
DDX50	DDX50: ATP-dependent RNA helicase DDX50	0.137	0.293
FBXW2	FBXW2, FBW2, FWD2: F-box/WD repeat-containing protein 2	0.137	0.137
WRN	WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase	0.126	0.044
Nle	NLE1, HUSSY-07: Notchless protein homolog 1	0.126	0.074
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.126	0.074
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.126	0.074
COPA	COPA: Coatomer subunit alpha	0.126	0.060
SEC31L1	N/A	0.126	0.074
COPB2	COPB2: Coatomer subunit beta'	0.126	0.060
ARPC1B	ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B	0.126	0.060
NUP43	N/A	0.123	0.263
DDX48	EIF4A3, DDX48, KIAA0111: Eukaryotic initiation factor 4A-III	0.123	0.123
PPP2R2A	PPP2R2A: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alp	0.123	0.123
DDX47	E4-DBP: DEAD box protein	0.123	0.263
DDX19A	DDX19A, DDX19L: ATP-dependent RNA helicase DDX19A	0.123	0.123
DDX18	DDX18: ATP-dependent RNA helicase DDX18	0.123	0.263
POLD1	POLD1, POLD: DNA polymerase delta catalytic subunit	0.123	0.123
DDX39	DDX39: ATP-dependent RNA helicase DDX39	0.123	0.123
PRPF4	PRPF4, PRP4: U4/U6 small nuclear ribonucleoprotein Prp4	0.123	69.60
WDR3	WDR3: WD repeat-containing protein 3	0.123	0.123
WDR77	WDR77, HKMT1069, hCG_39991: Androgen receptor cofactor p44	0.123	0.123
NUP37	NUP37: Nucleoporin Nup37	0.123	0.123
DDX23	DDX23: Probable ATP-dependent RNA helicase DDX23	0.123	0.123
EIF4A1	EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I	0.123	0.263
RBBP7	RBBP7, RBAP46: Histone-binding protein RBBP7	0.123	0.123
DDX27	DDX27, RHLP, HSPC259, PP3241: Probable ATP-dependent RNA helicase DDX27	0.123	0.263
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.103	0.044
PRP19	PRPF19, NMP200, PRP19, SNEV: Pre-mRNA-processing factor 19	0.0968	25.60
CORO1C	CORO1C, CRNN4: Coronin-1C	0.093	0.044
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.093	0.060
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.093	0.060
REXO2	REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor	0.093	0.044
ERCC3	ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit	0.093	0.044
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.093	0.060
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.093	0.074
GNB2	GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2	0.093	0.060
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.093	0.044
WDR41	N/A	0.083	0.293
SEC13L1	SEC13, D3S1231E, SEC13L1, SEC13R: Protein SEC13 homolog	0.083	0.137
DDB2	DDB2: DNA damage-binding protein 2	0.083	0.067
ISG20	ISG20, HEM45: Interferon-stimulated gene 20 kDa protein	0.083	0.067
SMARCAL1	SMARCAL1, HARP: SWI/SNF-related matrix-associated actin-dependent regulator of c	0.083	0.083
WDR8	WDR8: WD repeat-containing protein 8	0.083	0.083
BRIP1	BRIP1, BACH1, FANCJ: Fanconi anemia group J protein	0.076	0.028
EML4	EML4, C2orf2, EMAPL4: Echinoderm microtubule-associated protein-like 4	0.076	0.028
DDX24	DDX24: ATP-dependent RNA helicase DDX24	0.076	0.044
CNOT8	CNOT8, CALIF, POP2: CCR4-NOT transcription complex subunit 8	0.074	0.074
WDR68	WDR68, HAN11: WD repeat-containing protein 68	0.074	0.123
WDR39	CIAO1, WDR39: Protein CIAO1	0.074	0.123
ASCC3	ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3	0.074	0.074
DDX17	DDX17: Probable ATP-dependent RNA helicase DDX17	0.074	0.074
DDX49	DDX49: Probable ATP-dependent RNA helicase DDX49	0.074	0.263
DDX54	DDX54: ATP-dependent RNA helicase DDX54	0.074	0.123
CDC40	CDC40, EHB3, PRP17, PRPF17: Pre-mRNA-processing factor 17	0.074	0.123
BOP1	BOP1, KIAA0124: Ribosome biogenesis protein BOP1	0.074	0.123
STRAP	STRAP, MAWD, UNRIP: Serine-threonine kinase receptor-associated protein	0.074	0.123
LRBA	LRBA, BGL, CDC4L, LBA: Lipopolysaccharide-responsive and beige-like anchor prote	0.074	0.074
EML3	EML3: Echinoderm microtubule-associated protein-like 3	0.074	0.074
PWP2H	PWP2, PWP2H: Periodic tryptophan protein 2 homolog	0.074	0.123
TSSC1	TSSC1: Protein TSSC1	0.074	0.123
DDX1	DDX1: ATP-dependent RNA helicase DDX1	0.074	0.123
IFIH1	IFIH1, MDA5, RH116: Interferon-induced helicase C domain-containing protein 1	0.074	0.074
POLE	POLE, POLE1: DNA polymerase epsilon catalytic subunit A	0.074	0.074
CORO1A	CORO1A, CORO1: Coronin-1A	0.074	0.060
KIAA0052	SKIV2L2, KIAA0052: Superkiller viralicidic activity 2-like 2	0.074	0.060
CORO7	CORO7: Coronin-7	0.074	0.074
TAF5	TAF5, TAF2D: Transcription initiation factor TFIID subunit 5	0.074	0.074
DHX38	DHX38, DDX38, KIAA0224, PRP16: Pre-mRNA-splicing factor ATP-dependent RNA helica	0.074	0.074
WDR57	WDR57, PRP8BP, SFP38: WD repeat-containing protein 57	0.074	0.074
RECQL	RECQL, RECQL1: ATP-dependent DNA helicase Q1	0.074	0.074
RNU3IP2	RRP9, RNU3IP2, U355K: U3 small nucleolar RNA-interacting protein 2	0.074	0.074
WDR12	WDR12: WD repeat-containing protein 12	0.074	0.074
DDX10	DDX10: Probable ATP-dependent RNA helicase DDX10	0.074	0.074
FLJ10439	WDR74, NSA1: WD repeat-containing protein 74	0.074	0.123
RAD54L	RAD54L, RAD54A: DNA repair and recombination protein RAD54-like	0.074	0.060
WDR18	N/A	0.074	0.123
XPMC2H	REXO4, PMC2, XPMC2H: RNA exonuclease 4	0.074	0.123
HELLS	HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase	0.067	0.060
DDX28	DDX28, MDDX28: Probable ATP-dependent RNA helicase DDX28	0.060	0.074
GRWD1	GRWD1, GRWD, WDR28: Glutamate-rich WD repeat-containing protein 1	0.060	0.074
JMJD2C	JMJD2C, GASC1, JHDM3C, KIAA0780: JmjC domain-containing histone demethylation pr	0.060	0.074
WIPI2	WIPI2, CGI-50: WD repeat domain phosphoinositide-interacting protein 2	0.060	0.060
POLA	POLA1, POLA: DNA polymerase alpha catalytic subunit	0.060	0.060
DHX35	C20orf15, DHX35, DDX35: Probable ATP-dependent RNA helicase DHX35	0.060	0.060
TTF2	TTF2: Transcription termination factor 2	0.060	0.044
RAE1	RAE1, MRNP41: mRNA export factor	0.060	0.044
WDR26	WDR26, CDW2, PRO0852, MIP2: WD repeat-containing protein 26	0.060	0.044
AAMP	AAMP: Angio-associated migratory cell protein	0.060	0.074
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.056	0.027
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.056	0.027
WDR54	N/A	0.056	0.027
RNASEH1	RNASEH1, RNH1: Ribonuclease H1	0.055	0.055
POLG	POLG, MDP1, POLG1, POLGA: DNA polymerase subunit gamma-1	0.055	0.055
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.054	0.049
PHF20	PHF20, C20orf104, GLEA2, HCA58, NZF, TZP: PHD finger protein 20	0.053	0.065
LGP2	DHX58, D11LGP2E, LGP2: Probable ATP-dependent RNA helicase DHX58	0.050	0.044
RAD54B	RAD54B: DNA repair and recombination protein RAD54B	0.050	0.050
NUTF2	NUTF2, NTF2: Nuclear transport factor 2	0.047	0.059
BCDO2	PTS: 6-pyruvoyl tetrahydrobiopterin synthase	0.046	0.028
NBEAL2	N/A	0.044	0.060
PIK3R4	PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4	0.044	0.074
PARN	PARN, DAN: Poly(A)-specific ribonuclease PARN	0.044	0.044
DDX58	DDX58: Probable ATP-dependent RNA helicase DDX58	0.044	0.044
WDR42A	N/A	0.044	0.044
DDX56	DDX56, DDX21, NOH61: Probable ATP-dependent RNA helicase DDX56	0.044	0.044
WDR67	WDR67: WD repeat-containing protein 67	0.044	0.044
AAAS	AAAS, ADRACALA, GL003: Aladin	0.044	0.044
DDX52	DDX52, ROK1, HUSSY-19: Probable ATP-dependent RNA helicase DDX52	0.044	0.036
THRAP5	MED16, DRIP92, THRAP5: Mediator of RNA polymerase II transcription subunit 16	0.044	0.060
WDR13	WDR13: WD repeat-containing protein 13	0.041	0.050
REV3L	REV3L, POLZ, REV3: DNA polymerase zeta catalytic subunit	0.041	0.041
GNB1L	GNB1L, GY2, FKSG1, KIAA1645, WDR14: Guanine nucleotide-binding protein subunit b	0.041	0.050
DYNC1I2	N/A	0.037	0.028
RECQL4	RECQL4, RECQ4: ATP-dependent DNA helicase Q4	0.036	0.044
SETDB1	SETDB1, KIAA0067: Histone-lysine N-methyltransferase SETDB1	0.036	0.036
EIF4A2	EIF4A2, DDX2B, EIF4F: Eukaryotic initiation factor 4A-II	0.036	0.044
WDR37	N/A	0.036	0.044
WDR45L	N/A	0.036	0.044
WDR48	WDR48, KIAA1449: WD repeat-containing protein 48	0.036	0.044
ARPC1A	ARPC1A, SOP2L: Actin-related protein 2/3 complex subunit 1A	0.036	0.044
LBR	LBR: Lamin-B receptor	0.0331	0.027
TLE4	TLE4: TLE4 protein	0.028	0.036
CORO1B	CORO1B: Coronin-1B	0.028	0.028
XTP3TPA	XTP3TPA, CDA03: XTP3-transactivated gene A protein	0.027	0.027
HNRPD	N/A	0.027	0.027
E2IG3	N/A	0.027	0.027
RPL17	RPL17: 60S ribosomal protein L17	0.027	0.027
MGC9850	N/A	0.027	0.027
NOL7	NOL7, C6orf90, NOP27: Nucleolar protein 7	0.027	0.027
RPS24	40S ribosomal protein S24. Isoform 2	0.027	0.027
RPS21	RPS21: 40S ribosomal protein S21	0.027	0.027
DGUOK	N/A	0.027	0.027
RPL14	RPL14: RPL14 protein	0.027	0.027
BUB3	N/A	0.027	0.027
DKFZP586L0724	NOL11, L14: Nucleolar protein 11	0.027	0.027
RPL15	RPL15, EC45, TCBAP0781: 60S ribosomal protein L15	0.027	0.027
BRWD2	BRWD2, WDR11, WDR15: Bromodomain and WD repeat-containing protein 2	0.027	0.0331
WSB1	WSB1, SWIP1: WD repeat and SOCS box-containing protein 1	0.027	0.027
FLJ12671	ISG20L2, HSD38, HSD-38: Interferon-stimulated 20 kDa exonuclease-like 2	0.027	0.027
KIF21A	N/A	0.027	0.027
FBXW8	FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6: F-box/WD repeat-containing protein 8	0.027	0.027
WDR53	N/A	0.027	0.027
PHF1	N/A	0.027	0.027
DDX53	DDX53, CAGE: Probable ATP-dependent RNA helicase DDX53	0.027	0.027
WDR72	N/A	0.027	0.027
TAF5L	TAF5L, PAF65B: TAF5-like RNA polymerase II p300/CBP-associated factor-associated	0.027	0.027
REXO1L1	REXO1L1, GOR: Exonuclease GOR	0.027	0.027
NEDD1	N/A	0.027	0.027
TLE6	TLE6: Transducin-like enhancer protein 6	0.027	0.027
WDR17	N/A	0.027	0.027
RFWD2	RFWD2, COP1, RNF200: E3 ubiquitin-protein ligase RFWD2	0.027	0.027
WDR34	N/A	0.027	0.027
BRWD1	N/A	0.027	0.027
TDRD4	TDRD4: Tudor domain-containing protein 4	0.027	0.027
ERCC8	ERCC8, CKN1, CSA: DNA excision repair protein ERCC-8	0.027	0.027
TREX1	TREX1: Three prime repair exonuclease 1	0.027	0.027
EXOSC8	EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43	0.027	0.057
SNRPB	N/A	0.0258	0.0258

0.572

Total Score

597.00