PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between PDCD6IP and CHMP4B

The interaction score between PDCD6IP and CHMP4B is 32.80.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

N/A

Orthology

Organism	PDCD6IP Orthologue		CHMP4B Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
human	IPI00735201	0.166	IPI00023068	0.349
bakers yeast	YOR275C	1	YLR025W	0.349	Y2H Other Get References From PubMed
worm	P34552	1	Q18886	1
worm	P34552	1	Q22916	0.392
fly	Q9VB05	1	Q8T0Q4	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.119

Domains

No domains were used in calculating likelihood of interaction

3.00E-3

Post-translational Modifications

No PTMs were used in calculating likelihood of interaction

Localisation

Protein: PDCD6IP

Localisation	Reference
Cytosol	HPRD
Cytoplasm	HPRD
Cytoskeleton	HPRD

Protein: CHMP4B

Localisation	Reference
Cytosol	HPRD
Cytoplasm	HPRD

Transitive Score

The common interactors between PDCD6IP and CHMP4B that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PDCD6IP andCHMP4B. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PDCD6IP has 52 interactors and CHMP4B has 23 interactors of which there are 5 common interactors.

Common Interactor	Name of Common Interactor	Score for PDCD6IP-Interactor (?)	Score for CHMP4B-Interactor (?)
CHMP4A	N/A	3.68	319.00
VPS4B	VPS4B, SKD1, VPS42: Vacuolar protein sorting-associating protein 4B	1.84	169.00
VPS4A	VPS4A, VPS4: Vacuolar protein sorting-associating protein 4A	0.221	3.58
CHMP4C	CHMP4C, SHAX3: Charged multivesicular body protein 4c	0.143	319.00
LOC283683	N/A	0.119	0.064

0.572

Total Score

32.80