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Evidence of Interaction Between EIF3S4 and EIF3S10

The interaction score between EIF3S4 and EIF3S10 is 725.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between EIF3S4 and EIF3S10 = 0.64

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

7.78E-3
Orthology
OrganismEIF3S4 OrthologueEIF3S10 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YDR429C 1 YBR079C 1
  • Immunoprecipitation
  • AffinityCaptureMS
  • AffinityCaptureWestern
  • CoPurification

Get References From PubMed

worm Q19706 1 P34339 1
fly Q9VDM6 1 Q9VN25 1
fly Q9W4X7 0.455 Q9VN25 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593
Domains Domains present in EIF3S4 and EIF3S10:
Domains in EIF3S4Domains in EIF3S10
IPR000504 RNA-binding region RNP-1 (RNA recognition motif)
IPR012677 a_b_plait_nuc_bd.
IPR002017 Spectrin repeat
IPR000717 Proteasome component region PCI

The Chi square scores for co-occurrence of domains that are present in EIF3S4 and EIF3S10 are listed below.

Domain 1Domain 2Chi Square
IPR000504 RNA-binding region RNP-1 (RNA recognition motif) IPR000717 Proteasome component region PCI 10.865
IPR012677 a_b_plait_nuc_bd. IPR000717 Proteasome component region PCI 10.3587
IPR000504 RNA-binding region RNP-1 (RNA recognition motif) IPR002017 Spectrin repeat 0.129962
IPR012677 a_b_plait_nuc_bd. IPR002017 Spectrin repeat 0.0867506

The background colour of the table refers to:

  • Blue Domain is only present in EIF3S4
  • Yellow Domain is only present in EIF3S10
  • Green Domain is present in both EIF3S4 and EIF3S10

4.28E-3
Post-translational Modifications

Protein: EIF3S4

PTMResidueReference
Phosphorylation 41 PubMed, HPRD
Phosphorylation 42 PubMed, HPRD
Phosphoserine 42 HPRD

Protein: EIF3S10

PTMResidueReference
Localisation

Protein: EIF3S4

LocalisationReference
Cytoplasm HPRD

Protein: EIF3S10

LocalisationReference
Cytoplasm HPRD
Transitive Score

The common interactors between EIF3S4 and EIF3S10 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EIF3S4 andEIF3S10. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EIF3S4 has 1095 interactors and EIF3S10 has 291 interactors of which there are 93 common interactors.

Common InteractorName of Common InteractorScore for EIF3S4-Interactor (?)Score for EIF3S10-Interactor (?)
EIF3S9 EIF3S9: Eukaryotic translation initiation factor 3 subunit 9 122.00 11.10
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 49.80 0.612
EIF3S8 EIF3S8: Eukaryotic translation initiation factor 3 subunit 8 48.90 323.00
EIF2S3 EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3 36.30 1.82
EIF5 EIF5: Eukaryotic translation initiation factor 5 30.70 3.05
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 16.60 0.612
CSNK2B CSNK2B, CK2N, G5A: Casein kinase II subunit beta 3.59 1.84
RPS7 RPS7: 40S ribosomal protein S7 3.05 6.52
EIF1 EIF1, SUI1: Eukaryotic translation initiation factor 1 2.54 0.371
EIF1B EIF1B: Eukaryotic translation initiation factor 1b 0.902 1.10
RBM3 RBM3, RNPL: Putative RNA-binding protein 3 0.852 0.0471
RBM15 RBM15, OTT: Putative RNA-binding protein 15 0.763 0.042
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.763 0.042
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.763 0.042
ABCE1 ABCE1, RLI, OK/SW-cl.40, RNASEL1, RNASELI, RNS4I: ATP-binding cassette sub-famil 0.657 3.89
WDR48 WDR48, KIAA1449: WD repeat-containing protein 48 0.657 0.298
RPS8 RPS8, OK/SW-cl.83: 40S ribosomal protein S8 0.593 0.593
FUBP1 N/A 0.561 0.090
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.515 0.0471
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.461 0.127
TIAL1 TIAL1: Nucleolysin TIAR 0.461 0.042
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.461 0.127
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.461 0.042
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.461 0.042
SFRS6 SFRS6, SRP55: Splicing factor, arginine/serine-rich 6 0.372 0.042
SSB SSB: Lupus La protein 0.372 0.127
XPO1 XPO1, CRM1: Exportin-1 0.245 0.044
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.233 0.123
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.188 2.15
EIF3S6 EIF3S6, INT6: Eukaryotic translation initiation factor 3 subunit 6 0.185 2.60
U2AF1 U2AF1, U2AF35, U2AFBP: Splicing factor U2AF 35 kDa subunit 0.156 0.042
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.146 0.081
KIAA1012 KIAA1012: Protein TRS85 homolog 0.129 0.123
COPE COPE: Coatomer subunit epsilon 0.129 0.060
AIP AIP, XAP2: AH receptor-interacting protein 0.129 0.036
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.127 0.083
HD HD, IT15: Huntingtin 0.124 0.0255
KPNB1 KPNB1, NTF97: Importin subunit beta-1 0.123 0.053
NONO NONO, NRB54: Non-POU domain-containing octamer-binding protein 0.123 0.042
NULL Uncharacterized protein ENSP00000352132 0.119 0.119
LOC388076 similar to ribosomal protein S8 isoform 2 0.119 0.119
LOC646119 similar to ribosomal protein S8 0.119 0.119
NULL N/A 0.119 0.119
LOC647058 similar to suppressor of initiator codon mutations, related sequence 1 0.119 0.119
LOC149224 similar to 40S ribosomal protein S7 0.119 0.119
NULL N/A 0.119 0.119
NULL N/A 0.119 0.119
EPRS EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes: 0.111 0.038
STIP1 STIP1: Stress-induced-phosphoprotein 1 0.091 0.083
PSMD11 PSMD11: 26S proteasome non-ATPase regulatory subunit 11 0.090 1.22
ZC3H7A ZC3H7A, ZC3H7, HSPC055, ZC3HDC7: Zinc finger CCCH domain-containing protein 7A 0.083 0.137
CPSF6 CPSF6, CFIM68: Cleavage and polyadenylation specificity factor subunit 6 0.083 0.141
ANAPC5 ANAPC5, APC5: Anaphase-promoting complex subunit 5 0.078 0.263
TMEM1 TMEM1, EHOC1: Transmembrane protein 1 0.078 0.060
SFRS3 SFRS3, SRP20: Splicing factor, arginine/serine-rich 3 0.074 0.042
TARDBP TARDBP, TDP43: TAR DNA-binding protein 43 0.074 0.127
HNRPA3 HNRPA3: Heterogeneous nuclear ribonucleoprotein A3 0.074 0.127
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.074 0.0255
COPS3 COPS3, CSN3: COP9 signalosome complex subunit 3 0.067 1.22
ACTR3 ACTR3, ARP3: Actin-related protein 3 0.066 0.123
LAMR1 RPSA, LAMBR, LAMR1: 40S ribosomal protein SA 0.066 1.82
LPXN LPXN, LDLP: Leupaxin 0.066 0.074
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.066 0.081
STAT6 STAT6: Signal transducer and activator of transcription 6 0.066 0.074
ACTG1 ACTB: Actin, cytoplasmic 1 0.066 0.074
TP53 TP53, P53: Cellular tumor antigen p53 0.063 0.059
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.063 0.047
C20orf4 C20orf4, CGI-23, PRO0225: Uncharacterized protein C20orf4 0.063 0.036
CUL5 CUL5, VACM1: Cullin-5 0.063 0.0968
SFPQ SFPQ, PSF: Splicing factor, proline- and glutamine-rich 0.060 0.127
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.051 0.044
EIF3S5 N/A 0.0479 0.133
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.046 0.494
EIF2S2 EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2 0.046 0.612
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.046 0.0968
SGTA SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A 0.046 0.036
UTX UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein 0.046 0.060
FKBP5 FKBP5, AIG6, FKBP51: FK506-binding protein 5 0.046 0.060
CREBBP CREBBP, CBP: CREB-binding protein 0.046 0.029
VIM VIM: Vimentin 0.0425 0.032
NOLC1 NOLC1, KIAA0035: Nucleolar phosphoprotein p130 0.0407 0.027
PPID PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase 0.040 0.123
PRPF6 PRPF6, C20orf14: Pre-mRNA-processing factor 6 0.038 0.074
LIMS1 N/A 0.036 0.137
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.032 0.060
CDC23 CDC23: Cell division cycle protein 23 homolog 0.032 0.263
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.032 0.044
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.032 0.890
FKBP4 FKBP4: FK506-binding protein 4 0.029 0.036
DNAJC7 DNAJC7, TPR2, TTC2: DnaJ homolog subfamily C member 7 0.029 0.036
NULL Putative uncharacterized protein (Fragment) 0.029 0.119
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.025 0.039
C11orf58 SMAP, C11orf58: Small acidic protein 0.025 0.027
0.572
Total Score 725.00