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Evidence of Interaction Between SOCS3 and IGF1R

The interaction score between SOCS3 and IGF1R is 52.80.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between SOCS3 and IGF1R = -0.16

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 1.48E-3
Orthology N/A N/A
Domains Domains present in SOCS3 and IGF1R:
Domains in SOCS3Domains in IGF1R
IPR000980 SH2 motif
IPR001496 SOCS protein, C-terminal
IPR000494 Epidermal growth-factor receptor (EGFR), L domain
IPR000719 Protein kinase
IPR001245 Tyrosine protein kinase
IPR006211 Furin-like cysteine rich region
IPR006212 Furin-like repeat
IPR008266 Tyrosine protein kinase, active site
IPR009030 Growth factor, receptor
IPR011009 Protein kinase-like
IPR003961 Fibronectin, type III
IPR008957 Fibronectin, type III-like fold
IPR000463 Cytosolic fatty-acid binding protein
IPR002011 Receptor tyrosine kinase, class II

The Chi square scores for co-occurrence of domains that are present in SOCS3 and IGF1R are listed below.

Domain 1Domain 2Chi Square
IPR000980 SH2 motif IPR008266 Tyrosine protein kinase, active site 383.26
IPR000980 SH2 motif IPR001245 Tyrosine protein kinase 238.73
IPR000980 SH2 motif IPR003961 Fibronectin, type III 184.508
IPR000980 SH2 motif IPR000719 Protein kinase 82.1364
IPR001496 SOCS protein, C-terminal IPR003961 Fibronectin, type III 73.3816
IPR000980 SH2 motif IPR011009 Protein kinase-like 59.6059
IPR000980 SH2 motif IPR000494 Epidermal growth-factor receptor (EGFR), L domain 46.2087
IPR000980 SH2 motif IPR006211 Furin-like cysteine rich region 46.2087
IPR000980 SH2 motif IPR006212 Furin-like repeat 43.075
IPR000980 SH2 motif IPR008957 Fibronectin, type III-like fold 27.8744
IPR000980 SH2 motif IPR002011 Receptor tyrosine kinase, class II 24.6768
IPR001496 SOCS protein, C-terminal IPR008266 Tyrosine protein kinase, active site 19.5756
IPR001496 SOCS protein, C-terminal IPR001245 Tyrosine protein kinase 12.3822
IPR000980 SH2 motif IPR009030 Growth factor, receptor 10.8957
IPR001496 SOCS protein, C-terminal IPR000494 Epidermal growth-factor receptor (EGFR), L domain 7.71735
IPR001496 SOCS protein, C-terminal IPR006211 Furin-like cysteine rich region 7.71735
IPR001496 SOCS protein, C-terminal IPR006212 Furin-like repeat 7.35881
IPR001496 SOCS protein, C-terminal IPR009030 Growth factor, receptor 4.02952
IPR001496 SOCS protein, C-terminal IPR011009 Protein kinase-like 3.49909
IPR001496 SOCS protein, C-terminal IPR000719 Protein kinase 2.92744
IPR000980 SH2 motif IPR000463 Cytosolic fatty-acid binding protein 0.0471124

The background colour of the table refers to:

  • Blue Domain is only present in SOCS3
  • Yellow Domain is only present in IGF1R
  • Green Domain is present in both SOCS3 and IGF1R

 0.980
Post-translational Modifications

Protein: SOCS3

PTMResidueReference
Ubiquitination 6 PubMed, HPRD

Protein: IGF1R

PTMResidueReference
Phosphorylation 973 PubMed, HPRD
Phosphorylation 980 PubMed, HPRD
Phosphorylation 1161 PubMed, HPRD
Phosphorylation 1165 PubMed, HPRD
Phosphorylation 1166 PubMed, HPRD
Phosphorylation 1280 PubMed, HPRD
Phosphorylation 1281 PubMed, HPRD
Phosphorylation 1346 PubMed, HPRD
Phosphotyrosine 980 PubMed, HPRD
Localisation

Protein: SOCS3

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD

Protein: IGF1R

LocalisationReference
Plasma membrane HPRD
Transitive Score

The common interactors between SOCS3 and IGF1R that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between SOCS3 andIGF1R. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , SOCS3 has 1169 interactors and IGF1R has 1365 interactors of which there are 622 common interactors.

Common InteractorName of Common InteractorScore for SOCS3-Interactor (?)Score for IGF1R-Interactor (?)
INSL3 JAK3: Tyrosine-protein kinase JAK3 1.98 0.581
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 1.98 0.731
NTRK2 NTRK2, TRKB: BDNF/NT-3 growth factors receptor precursor 1.53 0.051
FLT4 VEGFR3 long form 1.53 0.046
PTK7 PTK7, CCK4: Tyrosine-protein kinase-like 7 precursor 1.53 0.051
FRK FRK, PTK5, RAK: Tyrosine-protein kinase FRK 1.50 0.520
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 1.50 0.577
BMX N/A 1.50 0.581
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 1.50 0.520
TEC TEC, PSCTK4: Tyrosine-protein kinase Tec 1.50 0.520
JAK2 JAK2: Tyrosine-protein kinase JAK2 1.50 0.520
EPHB4 EPHB4, HTK, TYRO11: Ephrin type-B receptor 4 precursor 1.48 0.136
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 1.30 0.878
MATK MATK, CTK, HYL: Megakaryocyte-associated tyrosine-protein kinase 1.30 0.980
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 1.30 0.098
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 1.30 0.980
FYN FYN: Proto-oncogene tyrosine-protein kinase Fyn 1.30 0.878
CSK CSK: Tyrosine-protein kinase CSK 1.20 0.577
LYN LYN: Tyrosine-protein kinase Lyn 1.20 0.577
HCK N/A 1.20 0.655
FGR FGR, SRC2: Proto-oncogene tyrosine-protein kinase FGR 1.20 0.577
SYK SYK: Tyrosine-protein kinase SYK 1.20 0.577
EPHB1 EPHT2, EPHB1, NET: Ephrin type-B receptor 1 precursor 1.13 0.097
FLT3 FLT3, STK1: FL cytokine receptor precursor 1.13 0.088
EPHB3 EPHB3, ETK2, HEK2, TYRO6: Ephrin type-B receptor 3 precursor 1.13 0.171
EPHB2 EPHB2, DRT, EPHT3, EPTH3, ERK, HEK5, TYRO5: Ephrin type-B receptor 2 precursor 1.13 0.097
AXL AXL, UFO: Tyrosine-protein kinase receptor UFO precursor 0.980 0.165
ERBB3 ERBB3, HER3: Receptor tyrosine-protein kinase erbB-3 precursor 0.980 0.148
RET RET: Proto-oncogene tyrosine-protein kinase receptor ret precursor 0.980 0.148
FGFR1 FGFR1, FGFBR, FLG, FLT2: Basic fibroblast growth factor receptor 1 precursor 0.980 0.165
EPHA8 EPHA8, EEK, KIAA1459: Ephrin type-A receptor 8 precursor 0.980 0.148
FGFR3 FGFR3, JTK4: Fibroblast growth factor receptor 3 precursor 0.980 0.165
EGFR EGFR, ERBB1: Epidermal growth factor receptor precursor 0.980 0.148
PTK2 PTK2, FAK, FAK1: Focal adhesion kinase 1 0.975 0.073
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.975 0.577
JAK1 0.975 0.577
TXK TXK, PTK4: Tyrosine-protein kinase TXK 0.975 0.577
CSF1R CSF1R, FMS: Macrophage colony-stimulating factor 1 receptor precursor 0.902 0.111
FLT1 FLT1, FLT, FRT: Vascular endothelial growth factor receptor 1 precursor 0.902 0.136
MST1R MST1R, PTK8, RON: Macrophage-stimulating protein receptor precursor 0.902 0.111
MERTK MERTK, MER: Proto-oncogene tyrosine-protein kinase MER precursor 0.902 0.123
FGFR4 FGFR4, JTK2, TKF: Fibroblast growth factor receptor 4 precursor 0.902 0.111
EPHA7 EPHA7, EHK3, HEK11: Ephrin type-A receptor 7 precursor 0.902 0.111
TEK TEK, TIE2: Angiopoietin-1 receptor precursor 0.902 0.152
LCK LCK: Proto-oncogene tyrosine-protein kinase LCK 0.859 0.731
TESK1 TESK1: Dual specificity testis-specific protein kinase 1 0.859 0.126
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.859 1.13
ZAP70 ZAP70: Uncharacterized protein ZAP70 0.859 0.655
YES1 YES1, YES: Proto-oncogene tyrosine-protein kinase Yes 0.859 0.655
PTK6 PTK6, BRK: Tyrosine-protein kinase 6 0.859 0.731
KDR KDR, FLK1: Vascular endothelial growth factor receptor 2 precursor 0.731 0.136
MET MET: Hepatocyte growth factor receptor precursor 0.731 0.123
KIT KIT: Mast/stem cell growth factor receptor precursor 0.731 0.111
INSR INSR: Insulin receptor precursor 0.731 0.111
EPHA1 EPHA1, EPH, EPHT, EPHT1: Ephrin type-A receptor 1 precursor 0.644 0.111
EPHA4 EPHA4, HEK8, SEK, TYRO1: Ephrin type-A receptor 4 precursor 0.644 0.111
ERBB4 ERBB4, HER4: Receptor tyrosine-protein kinase erbB-4 precursor 0.644 0.097
PDGFRA PDGFRA: Alpha-type platelet-derived growth factor receptor precursor 0.644 0.111
PDGFRB PDGFRB: Beta-type platelet-derived growth factor receptor precursor 0.644 0.136
EPHA2 EPHA2, ECK: Ephrin type-A receptor 2 precursor 0.644 0.111
ALK ALK: ALK tyrosine kinase receptor precursor 0.623 0.058
NTRK1 NTRK1, TRK: High affinity nerve growth factor receptor precursor 0.617 0.051
EPHA3 EPHA3, ETK, ETK1, HEK, TYRO4: Ephrin type-A receptor 3 precursor 0.617 0.051
TNK2 TNK2, ACK1: Activated CDC42 kinase 1 0.617 0.046
ERBB2 ERBB2, HER2, NEU, NGL: Receptor tyrosine-protein kinase erbB-2 precursor 0.581 0.225
EPHA5 EPHA5, EHK1, HEK7: Ephrin type-A receptor 5 precursor 0.540 0.098
FRS3 FRS3: Fibroblast growth factor receptor substrate 3 0.307 0.073
PLD2 PLD2: Phospholipase D2 0.307 0.090
SRMS SRMS, C20orf148: Tyrosine-protein kinase Srms 0.265 0.265
MAP3K10 MAP3K10, MLK2, MST: Mitogen-activated protein kinase kinase kinase 10 0.251 0.064
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 0.251 0.029
GAB1 GAB1: GRB2-associated-binding protein 1 0.251 0.072
TLN1 TLN1: Uncharacterized protein TLN1 0.251 0.073
PLCB3 PLCB3: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 0.251 0.073
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.251 0.058
DOK1 DOK1: Docking protein 1 0.251 0.064
FGFR2 N/A 0.217 0.027
IL9R IL9R: Interleukin-9 receptor precursor 0.202 0.098
STAT2 STAT2: Signal transducer and activator of transcription 2 0.202 0.320
MIP MIP, AQP0: Lens fiber major intrinsic protein 0.202 0.0308
IRS4 IRS4, RP6-24A23.4-001, hCG_20762: Insulin receptor substrate 4 0.191 0.072
PLD1 PLD1: Phospholipase D1 0.191 0.058
ROCK1 ROCK1: Rho-associated protein kinase 1 0.191 0.0727
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.191 0.037
ARHGEF6 ARHGEF6, COOL2, KIAA0006, PIXA: Rho guanine nucleotide exchange factor 6 0.191 0.064
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.191 0.029
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.191 0.026
RIN1 RIN1: Ras and Rab interactor 1 0.191 0.577
NCF1 Neutrophil cytosolic factor 1 variant (Fragment) 0.191 0.072
PSCD4 PSCD4, CYT4: Cytohesin-4 0.191 0.064
PIK3R2 PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta 0.191 0.586
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.191 0.058
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.191 0.033
PIK3CD PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i 0.191 0.072
APS SH2B2, APS: SH2B adapter protein 2 0.191 0.655
FYN N/A 0.174 0.162
MATK DKFZp434N1212, MATK, hCG_23522: Putative uncharacterized protein DKFZp434N1212 0.174 0.162
MPL MPL, TPOR: Thrombopoietin receptor precursor 0.166 0.109
DCC DCC: Netrin receptor DCC precursor 0.166 0.097
IFNAR1 IFNAR1, IFNAR: Interferon-alpha/beta receptor alpha chain precursor 0.166 0.123
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.165 0.098
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.165 0.098
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.165 0.109
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.165 0.098
EEF2K EEF2K: Elongation factor 2 kinase 0.165 0.098
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.165 0.980
LATS1 LATS1, WARTS: Serine/threonine-protein kinase LATS1 0.165 0.098
EPB41L1 EPB41L1, KIAA0338: Band 4.1-like protein 1 0.165 0.098
SPTBN1 SPTBN1, SPTB2: Spectrin beta chain, brain 1 0.165 0.098
ELMO1 N/A 0.165 0.098
CDC2L5 CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5 0.165 0.098
DUSP6 DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6 0.165 0.098
DNM3 DNM3: Uncharacterized protein DNM3 0.165 0.109
LNK SH2B3, LNK: SH2B adapter protein 3 0.165 0.980
PTP4A3 PTP4A3, PRL3: Protein tyrosine phosphatase type IVA protein 3 0.165 0.040
NF2 NF2, SCH: Merlin 0.165 0.109
DUSP16 DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16 0.165 0.098
PSCD1 PSCD1, D17S811E: Cytohesin-1 0.165 0.109
KIAA1804 MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase 0.165 0.098
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 0.165 0.098
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.165 0.098
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.165 0.878
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.165 0.098
BIN1 BIN1, AMPHL: Myc box-dependent-interacting protein 1 0.165 0.098
MAP2K5 N/A 0.165 0.049
PSCD2 N/A 0.165 0.109
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.165 0.098
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.165 0.109
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.165 0.049
CNN2 CNN2: Calponin-2 0.165 0.109
ARHGEF7 N/A 0.165 0.098
AMPH AMPH, AMPH1: Amphiphysin 0.165 0.109
BAIAP2 BAIAP2: Brain-specific angiogenesis inhibitor 1-associated protein 2 0.165 0.098
CAMK4 CAMK4: Calcium/calmodulin-dependent protein kinase type IV 0.165 0.025
DGKD DGKD, KIAA0145: Diacylglycerol kinase delta 0.165 0.098
GRB2 GRB2, ASH: Growth factor receptor-bound protein 2 0.165 0.878
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.165 0.049
SH3KBP1 SH3KBP1, CIN85: SH3 domain-containing kinase-binding protein 1 0.165 0.098
MAPK15 N/A 0.165 0.109
STAT3 0.165 0.878
PIK3CG PIK3CG: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma i 0.152 0.064
MCF2 MCF2, DBL: Proto-oncogene DBL 0.152 0.065
MAP3K11 MAP3K11, MLK3, PTK1, SPRK: Mitogen-activated protein kinase kinase kinase 11 0.152 0.113
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.152 0.064
HUWE1 HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1 0.152 0.072
SH3BP2 SH3BP2: Uncharacterized protein SH3BP2 0.152 0.731
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.152 0.073
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.152 0.581
IQSEC1 IQSEC1, ARFGEP100, BRAG2, KIAA0763: IQ motif and Sec7 domain-containing protein 0.152 0.073
RASA3 RASA3: Ras GTPase-activating protein 3 0.152 0.064
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.152 0.064
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.152 0.064
STAM2 STAM2: Signal transducing adapter molecule 2 0.152 0.064
CENTB2 CENTB2, KIAA0041: Centaurin-beta 2 0.152 0.073
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.152 0.064
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.152 0.029
CXorf9 N/A 0.152 0.058
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.152 0.041
FABP3 FABP3, FABP11, MDGI: Fatty acid-binding protein, heart 0.152 0.029
WAS WAS, IMD2: Wiskott-Aldrich syndrome protein 0.152 0.064
OSBP OSBP, OSBP1: Oxysterol-binding protein 1 0.152 0.113
WASPIP N/A 0.152 0.029
TTN N/A 0.152 0.064
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.152 0.051
CRKL CRKL: Crk-like protein 0.152 0.577
IKBKB IKBKB, IKKB: Inhibitor of nuclear factor kappa-B kinase subunit beta 0.152 0.081
RPS6KB1 N/A 0.152 0.064
IRS2 IRS2: Insulin receptor substrate 2 0.152 0.100
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.152 0.049
PTEN PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du 0.152 0.058
DAB1 DAB1: Disabled homolog 1 0.152 0.064
STAT6 STAT6: Signal transducer and activator of transcription 6 0.152 0.655
LASP1 LASP1, MLN50: LIM and SH3 domain protein 1 0.152 0.033
PSTPIP1 PSTPIP1, CD2BP1: Proline-serine-threonine phosphatase-interacting protein 1 0.152 0.072
ROCK2 ROCK2, KIAA0619: Rho-associated protein kinase 2 0.152 0.064
PTP4A1 PTP4A1, PRL1, PTPCAAX1: Protein tyrosine phosphatase type IVA protein 1 0.152 0.026
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.152 0.577
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.152 0.064
LIMK1 LIMK1, LIMK: LIM domain kinase 1 0.152 0.064
VAV1 VAV1, VAV: Proto-oncogene vav 0.152 0.577
APPL APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha 0.152 0.081
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.152 0.064
RIPK1 RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1 0.152 0.072
PIK3CB PIK3CB, PIK3C1: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 0.152 0.073
OSBPL11 OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11 0.152 0.072
TIE1 TIE1, TIE: Tyrosine-protein kinase receptor Tie-1 precursor 0.143 0.0308
EEF2 EEF2, EF2: Elongation factor 2 0.140 0.073
FURIN FURIN, FUR, PACE, PCSK3: Furin precursor 0.126 0.069
MPZL1 MPZL1, PZR, UNQ849/PRO1787: Myelin protein zero-like protein 1 precursor 0.126 0.123
MAG MAG, GMA: Myelin-associated glycoprotein precursor 0.126 0.098
LILRB1 N/A 0.126 0.098
TP73 TP73, P73: Tumor protein p73 0.126 0.041
IL12RB2 IL12RB2: Interleukin-12 receptor beta-2 chain precursor 0.126 0.109
NACA NACA, HSD48: Nascent polypeptide-associated complex subunit alpha 0.126 0.037
PTPN1 PTP1B, PTPN1: Tyrosine-protein phosphatase non-receptor type 1 0.126 0.111
CD33 CD33, SIGLEC3: Myeloid cell surface antigen CD33 precursor 0.126 0.098
VASP VASP: Vasodilator-stimulated phosphoprotein 0.123 0.100
ARHGAP12 ARHGAP12: Rho GTPase-activating protein 12 0.123 0.064
SGK3 SGK3, SGK2, SGKL: Serine/threonine-protein kinase Sgk3 0.123 0.064
DAPK1 DAPK1, DAPK: Death-associated protein kinase 1 0.123 0.041
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.123 0.073
DAB2 DAB2, DOC2: Disabled homolog 2 0.123 0.090
CD2AP CD2AP: CD2-associated protein 0.123 0.064
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.123 0.072
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.123 0.090
RANBP2 RANBP2, NUP358: E3 SUMO-protein ligase RanBP2 0.123 0.058
PLEKHA5 PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member 0.123 0.081
SH2D2A SH2D2A, SCAP, TSAD, VRAP: SH2 domain-containing protein 2A 0.123 0.731
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.123 0.041
MSN MSN: Moesin 0.123 0.073
CTTN CTTN, EMS1: Src substrate cortactin 0.123 0.100
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.123 0.098
SNTA1 SNTA1, SNT1: Alpha-1-syntrophin 0.123 0.073
SQSTM1 SQSTM1: Uncharacterized protein SQSTM1 0.123 0.126
NCF4 NCF4, SH3PXD4: Neutrophil cytosol factor 4 0.123 0.081
FNBP1 N/A 0.123 0.064
FABP5 FABP5: Fatty acid-binding protein, epidermal 0.123 0.026
ATM ATM: Serine-protein kinase ATM 0.123 0.029
SPTA1 SPTA1, SPTA: Spectrin alpha chain, erythrocyte 0.123 0.072
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.123 0.577
SORBS3 SORBS3, SCAM1: Vinexin 0.123 0.090
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.123 0.148
NEK3 NEK3: Serine/threonine-protein kinase Nek3 0.123 0.072
VIL2 N/A 0.123 0.073
PLCG1 PLCG1, PLC1: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 0.123 0.731
PTPN12 PTPN12: Tyrosine-protein phosphatase non-receptor type 12 0.123 0.073
TAGLN2 TAGLN2, RP11-48O20.1-003, hCG_39730: TAGLN2 protein 0.123 0.073
TLN2 TLN2: Uncharacterized protein TLN2 0.123 0.073
PRKD1 PRKD1, PKD, PKD1, PRKCM: Serine/threonine-protein kinase D1 0.123 0.171
PAK7 PAK7, KIAA1264, PAK5: Serine/threonine-protein kinase PAK 7 0.123 0.033
GAB2 N/A 0.123 0.081
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.123 0.073
RPS6KA5 RPS6KA5, MSK1: Ribosomal protein S6 kinase alpha-5 0.123 0.051
GRAP2 GRAP2, GADS, GRB2L, GRID: GRB2-related adapter protein 2 0.123 0.577
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.123 0.064
RAB32 RAB32: Ras-related protein Rab-32 0.123 0.030
PTPRE PTPRE: Receptor-type tyrosine-protein phosphatase epsilon precursor 0.109 0.165
PTPN2 PTPN2, PTPT: Tyrosine-protein phosphatase non-receptor type 2 0.109 0.148
PHC2 PHC2, EDR2, PH2: Polyhomeotic-like protein 2 0.109 0.030
FCGR2B FCGR2B, CD32, FCG2, IGFR2: Low affinity immunoglobulin gamma Fc region receptor 0.109 0.165
IL6ST IL6ST: Interleukin-6 receptor subunit beta precursor 0.109 0.165
PTPRR PTPRR, ECPTP, PTPRQ: Receptor-type tyrosine-protein phosphatase R precursor 0.109 0.165
SSH2 SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2 0.109 0.062
NEK8 NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8 0.109 0.062
KIR3DL1 N/A 0.109 0.165
TRPV1 TRPV1: Vanilloid receptor variant TRPV1b 0.109 0.165
L1CAM L1CAM, CAML1, MIC5: Neural cell adhesion molecule L1 precursor 0.109 0.148
CCR2 CCR2, CMKBR2: C-C chemokine receptor type 2 0.109 0.083
PTPRF PTPRF, LAR: Receptor-type tyrosine-protein phosphatase F precursor 0.109 0.148
ACVR1B ACVR1B, ACVRLK4: Activin receptor type-1B precursor 0.109 0.025
H2-ALPHA TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain 0.109 0.062
LEPR LEPR, DB, OBR: Leptin receptor precursor 0.109 0.165
PTPRC PTPRC, RP11-553K8.4-001, hCG_1811178: Protein tyrosine phosphatase, receptor typ 0.109 0.165
CD79B CD79B, B29, IGB: B-cell antigen receptor complex-associated protein beta-chain p 0.109 0.165
STAT1 STAT1: Signal transducer and activator of transcription 1-alpha/beta 0.109 0.483
TRPV4 TRPV4, VRL2, VROAC: Transient receptor potential cation channel subfamily V memb 0.109 0.165
CD247 CD247, CD3Z, T3Z, TCRZ: T-cell surface glycoprotein CD3 zeta chain precursor 0.109 0.165
LAT LAT: Linker for activation of T-cells family member 1 0.109 0.083
SIGLEC10 SIGLEC10, SLG2, UNQ477/PRO940: Sialic acid-binding Ig-like lectin 10 precursor 0.109 0.165
ADAM15 ADAM15, MDC15: ADAM 15 precursor 0.109 0.165
IL4R IL4R, 582J2.1, IL4RA: Interleukin-4 receptor alpha chain precursor 0.109 0.165
MAPK8IP1 MAPK8IP1, IB1, JIP1, PRKM8IP: C-jun-amino-terminal kinase-interacting protein 1 0.109 0.064
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.109 0.029
TAGLN TAGLN, SM22, WS3-10: Transgelin 0.109 0.113
CNKSR2 CNKSR2, CNK2, KIAA0902, KSR2: Connector enhancer of kinase suppressor of ras 2 0.109 0.073
FABP4 FABP4: Fatty acid-binding protein, adipocyte 0.109 0.029
HSPB8 HSPB8, CRYAC, PP1629, E2IG1, HSP22: Heat shock protein beta-8 0.109 0.051
SRPK2 SRPK2: Serine/threonine-protein kinase SRPK2 0.109 0.072
EPB41L2 EPB41L2: Band 4.1-like protein 2 0.109 0.064
EPB41L3 EPB41L3, DAL1, KIAA0987: Band 4.1-like protein 3 0.109 0.064
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.109 0.090
ELMO2 ELMO2, CED12A, KIAA1834: Engulfment and cell motility protein 2 0.109 0.090
IRS1 IRS1: Insulin receptor substrate 1 0.109 0.126
PAK4 PAK4, KIAA1142: Serine/threonine-protein kinase PAK 4 0.109 0.0818
PLCB1 PLCB1, KIAA0581: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta- 0.109 0.073
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.109 0.058
PSD TYL: TYL protein 0.109 0.073
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.109 0.073
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.109 0.073
RDX RDX: Radixin 0.109 0.064
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.109 0.113
WASL WASL: Neural Wiskott-Aldrich syndrome protein 0.109 0.090
NCK2 NCK2: Cytoplasmic protein NCK2 0.109 1.01
CASKIN2 CASKIN2, KIAA1139: Caskin-2 0.109 0.113
HAPLN1 HAPLN1, CRTL1: Hyaluronan and proteoglycan link protein 1 precursor 0.105 0.064
ETS2 ETS2: Protein C-ets-2 0.100 0.0513
NPR1 NPR1, ANPRA: Atrial natriuretic peptide receptor A precursor 0.100 0.136
PRLR PRLR: Prolactin receptor precursor 0.100 0.098
CCR5 CCR5: CCR5 receptor (Fragment) 0.100 0.049
IL10RA IL10RA, IL10R: Interleukin-10 receptor alpha chain precursor 0.100 0.109
DUSP1 DUSP1, CL100, MKP1, PTPN10, VH1: Dual specificity protein phosphatase 1 0.100 0.046
PLEK PLEK, P47: Pleckstrin 0.100 0.041
STAT5B STAT5B: Signal transducer and activator of transcription 5B 0.100 0.361
SOS1 SOS1: Son of sevenless homolog 1 0.100 0.046
CSF2RB CSF2RB, IL3RB, IL5RB: Cytokine receptor common beta chain precursor 0.100 0.123
HLA-A HLA-A, HLAA: HLA class I histocompatibility antigen, A-3 alpha chain precursor 0.100 0.123
ICAM5 ICAM5, TLCN, TLN: Intercellular adhesion molecule 5 precursor 0.100 0.109
CD79A CD79A, IGA, MB1: B-cell antigen receptor complex-associated protein alpha-chain 0.100 0.098
CEACAM1 CEACAM1, BGP, BGP1: Carcinoembryonic antigen-related cell adhesion molecule 1 pr 0.100 0.109
ICAM3 ICAM3: Intercellular adhesion molecule 3 precursor 0.100 0.123
IFNGR1 IFNGR1: Interferon-gamma receptor alpha chain precursor 0.100 0.109
K-ALPHA-1 TUBA1B: Tubulin alpha-1B chain 0.100 0.041
ADAM23 ADAM23, MDC3: ADAM 23 precursor 0.100 0.109
CRLF3 N/A 0.100 0.109
PIGR PIGR: Polymeric-immunoglobulin receptor precursor 0.100 0.123
CD5 CD5, LEU1: T-cell surface glycoprotein CD5 precursor 0.100 0.062
PTPRB PTPRB, PTPB: Receptor-type tyrosine-protein phosphatase beta precursor 0.100 0.111
CD22 CD22, SIGLEC2: B-cell receptor CD22 precursor 0.100 0.098
F11R F11R, JAM1, UNQ264/PRO301, JCAM: Junctional adhesion molecule A precursor 0.100 0.152
HLA-B HLA-B, HLAB: HLA class I histocompatibility antigen, B-7 alpha chain precursor 0.100 0.123
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.100 0.123
SSH1 SSH1, KIAA1298, SSH1L: Protein phosphatase Slingshot homolog 1 0.100 0.057
ITGB2 ITGB2, CD18, MFI7: Integrin beta-2 precursor 0.100 0.111
CNN3 CNN3: Calponin-3 0.098 0.166
PIK3C2A PIK3C2A: Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha po 0.098 0.073
PRKCZ PRKCZ, PKC2: Protein kinase C zeta type 0.098 0.090
COBL N/A 0.098 0.0453
ANKS1A ANKS1A, ANKS1, KIAA0229: Ankyrin repeat and SAM domain-containing protein 1A 0.098 0.181
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.098 0.090
SPTAN1 N/A 0.098 0.100
PAK6 PAK6, PAK5: Serine/threonine-protein kinase PAK 6 0.098 0.033
HNRPK HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K 0.083 0.04
RASGRP3 RASGRP3, GRP3, KIAA0846: RAS guanyl-releasing protein 3 0.083 0.098
SF1 SF1, ZFM1, ZNF162: Splicing factor 1 0.083 0.04
SNCA SNCA, NACP, PARK1: Alpha-synuclein 0.083 0.109
ROBO4 ROBO4, UNQ421/PRO3674: Roundabout homolog 4 precursor 0.082 0.109
CBL CBL, CBL2, RNF55: E3 ubiquitin-protein ligase CBL 0.081 0.318
CEBPA CEBPA: CCAAT/enhancer-binding protein alpha 0.081 0.045
LCP2 LCP2: Lymphocyte cytosolic protein 2 0.081 0.403
SLAMF1 SLAMF1, SLAM: Signaling lymphocytic activation molecule precursor 0.081 0.098
LIFR LIFR: Leukemia inhibitory factor receptor precursor 0.081 0.123
TUBB TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain 0.081 0.041
STAT4 STAT4: Signal transducer and activator of transcription 4 0.081 0.318
MS4A1 MS4A1, CD20: B-lymphocyte antigen CD20 0.081 0.049
TUBA6 TUBA1C, TUBA6: Tubulin alpha-1C chain 0.081 0.041
SORL1 SORL1: Sortilin-related receptor precursor 0.081 0.152
CD28 CD28: T-cell-specific surface glycoprotein CD28 precursor 0.081 0.109
CBLB CBLB, RNF56, Nbla00127: E3 ubiquitin-protein ligase CBL-B 0.081 0.361
DUSP3 DUSP3, VHR: Dual specificity protein phosphatase 3 0.081 0.063
EPOR EPOR: Erythropoietin receptor precursor 0.081 0.123
CSPG2 N/A 0.0794 0.072
FRS2 FRS2: Fibroblast growth factor receptor substrate 2 0.0782 0.030
IQGAP1 IQGAP1, KIAA0051: Ras GTPase-activating-like protein IQGAP1 0.077 0.064
NMT1 NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1 0.077 0.029
GRLF1 N/A 0.077 0.081
FUBP1 N/A 0.077 0.072
PCBP1 PCBP1: Poly(rC)-binding protein 1 0.077 0.027
GMIP GMIP: GEM-interacting protein 0.077 0.064
ATP4A ATP4A: Potassium-transporting ATPase alpha chain 1 0.075 0.055
ADAM17 ADAM17, CSVP, TACE: ADAM 17 precursor 0.075 0.088
ADAM19 ADAM19, MLTNB, FKSG34: ADAM 19 precursor 0.075 0.109
APBA2 APBA2, MINT2, X11L: Amyloid beta A4 precursor protein-binding family A member 2 0.072 0.046
GHR GHR: Growth hormone receptor precursor 0.072 0.109
ROBO1 ROBO1, DUTT1: Roundabout homolog 1 precursor 0.072 0.097
EGF EGF: Pro-epidermal growth factor precursor 0.072 0.152
CD3E CD3E, T3E: T-cell surface glycoprotein CD3 epsilon chain precursor 0.072 0.109
CD3G CD3G, T3G: T-cell surface glycoprotein CD3 gamma chain precursor 0.072 0.123
IL1RL1 IL1RL1, DER4, ST2, T1: Interleukin-1 receptor-like 1 precursor 0.072 0.152
IL2RB IL2RB: Interleukin-2 receptor subunit beta precursor 0.072 0.123
CD3D CD3D, T3D: T-cell surface glycoprotein CD3 delta chain precursor 0.072 0.109
CBLC CBLC, CBL3, RNF57: Signal transduction protein CBL-C 0.072 0.497
TUBA1 TUBA4A, TUBA1: Tubulin alpha-4A chain 0.071 0.041
BCAN BCAN, BEHAB, UNQ2525/PRO6018, CSPG7: Brevican core protein precursor 0.0688 0.098
HAVCR1 HAVCR1, TIM1, TIMD1: Hepatitis A virus cellular receptor 1 precursor 0.067 0.098
SIRPB1 SIRPB1: Signal regulatory protein beta-1 precursor 0.067 0.109
PVR PVR, PVS: Poliovirus receptor precursor 0.067 0.123
TUBB2A TUBB2A, TUBB2: Tubulin beta-2A chain 0.065 0.046
ARHGEF12 ARHGEF12, KIAA0382, LARG: Rho guanine nucleotide exchange factor 12 0.065 0.0794
ITGB4 N/A 0.065 0.191
JAM2 JAM2, C21orf43, UNQ219/PRO245, VEJAM: Junctional adhesion molecule B precursor 0.065 0.191
TUBB3 TUBB3, TUBB4: Tubulin beta-3 chain 0.065 0.051
F3 F3: Tissue factor precursor 0.065 0.152
CXADR CXADR, CAR: Coxsackievirus and adenovirus receptor precursor 0.065 0.251
HSPG2 HSPG2: Basement membrane-specific heparan sulfate proteoglycan core protein prec 0.063 0.073
RPS6KA3 RPS6KA3, ISPK1, RSK2: Ribosomal protein S6 kinase alpha-3 0.063 0.064
RAPGEF6 RAPGEF6, PDZGEF2: Rap guanine nucleotide exchange factor 6 0.062 0.064
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.062 1.02
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.062 0.026
ACP1 ACP1: Low molecular weight phosphotyrosine protein phosphatase 0.062 0.064
FXR2 FXR2, FMR1L2: Fragile X mental retardation syndrome-related protein 2 0.062 0.027
PCBP2 PCBP2: Poly(rC)-binding protein 2 0.062 0.033
EPS15L1 EPS15L1, EPS15R: Epidermal growth factor receptor substrate 15-like 1 0.060 0.073
KIAA1967 KIAA1967, DBC1: Protein KIAA1967 0.060 0.064
TRPC3 N-terminally extended type 3 canonical transient receptor potential channel 0.057 0.049
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.056 0.980
HDLBP HDLBP, HBP, VGL: Vigilin 0.055 0.041
ACTN4 ACTN4: Alpha-actinin-4 0.052 0.098
EHD4 EHD4, HCA10, FKSG7, HCA11, PAST4: EH domain-containing protein 4 0.052 0.098
CAPN3 CAPN3, CANP3, CANPL3, NCL1: Calpain-3 0.052 0.109
S100A16 S100A16, AAG13: Protein S100-A16 0.052 0.109
PPEF1 N/A 0.052 0.109
AP1GBP1 AP1GBP1, SYNG: AP1 subunit gamma-binding protein 1 0.052 0.098
KCNIP3 KCNIP3, CSEN, DREAM, KCHIP3: Calsenilin 0.052 0.098
BCAR1 BCAR1, CAS, CRKAS: Breast cancer anti-estrogen resistance protein 1 0.051 0.046
KIAA1914 AFAP1L2, KIAA1914: Actin filament-associated protein 1-like 2 0.051 0.051
VAV2 VAV2: Uncharacterized protein VAV2 0.051 0.553
MAPK14 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2: Mitogen-activated protein kinase 14 0.051 0.046
DNM2 DNM2, DYN2: Dynamin-2 0.051 0.051
KIF1B KIF1B, KIAA0591, KIAA1448: Kinesin-like protein KIF1B 0.051 0.046
RAPH1 N/A 0.051 0.051
SHC1 SHC1, SHC, SHCA: SHC-transforming protein 1 0.051 0.617
PTPNS1 SIRPA, BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP: Tyrosine-protein phosphatase non-rec 0.051 0.051
DLG1 DLG1: Disks large homolog 1 0.051 0.051
PTPRA N/A 0.051 0.051
EVL EVL, RNB6: Ena/VASP-like protein 0.051 0.051
LRIG2 LRIG2, KIAA0806, LIG2: Leucine-rich repeats and immunoglobulin-like domains prot 0.051 0.046
TBC1D4 TBC1D4: TBC1D4 protein 0.051 0.046
MYLK MYLK, MLCK: Myosin light chain kinase, smooth muscle 0.051 0.051
MARK2 N/A 0.051 0.051
PHLDB2 PHLDB2, LL5B: Pleckstrin homology-like domain family B member 2 0.051 0.046
PTPN11 PTPN11, PTP2C, SHPTP2: Tyrosine-protein phosphatase non-receptor type 11 0.051 0.617
C9orf88 N/A 0.051 0.051
CRK CRK: Proto-oncogene C-crk 0.051 0.617
EPB41 EPB41, E41P: Protein 4.1 0.051 0.046
MARK1 MARK1, KIAA1477, MARK: Serine/threonine-protein kinase MARK1 0.051 0.051
TJP2 TJP2, X104, ZO2: Tight junction protein ZO-2 0.051 0.051
CDC42BPA CDC42BPA: Serine/threonine-protein kinase MRCK alpha 0.051 0.051
UNC5D UNC5D, KIAA1777, UNQ6012/PRO34692, UNC5H4: Netrin receptor UNC5D precursor 0.051 0.051
PLCG2 PLCG2: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 0.051 0.553
PHC3 PHC3, EDR3, PH3: Polyhomeotic-like protein 3 0.051 0.046
DOK2 DOK2: Docking protein 2 0.051 0.051
BCR BCR, BCR1, D22S11: Breakpoint cluster region protein 0.051 0.051
LMO7 N/A 0.051 0.046
DNM1 DNM1, DNM: Dynamin-1 0.051 0.051
GRB10 N/A 0.051 0.617
UBAP2L N/A 0.051 0.051
DBNL DBNL, CMAP, PP5423, SH3P7: Drebrin-like protein 0.051 0.051
MAP3K9 MAP3K9, MLK1, PRKE1: Mitogen-activated protein kinase kinase kinase 9 0.051 0.051
COL6A3 COL6A3: Collagen alpha-3(VI) chain precursor 0.051 0.051
SYNGAP1 SYNGAP1, KIAA1938: Ras GTPase-activating protein SynGAP 0.051 0.046
C6orf21 LY6G6F, C6orf21, G6F, LY6G6D, NG32: Lymphocyte antigen 6 complex locus protein G 0.051 0.051
KIRREL KIRREL, KIRREL1, NEPH1: Kin of IRRE-like protein 1 precursor 0.051 0.051
STK16 N/A 0.051 0.072
IGFBP3 IGFBP3, IBP3: Insulin-like growth factor-binding protein 3 precursor 0.051 0.081
CENTA1 CENTA1: Centaurin-alpha 1 0.051 0.051
COL7A1 COL7A1: Collagen alpha-1(VII) chain precursor 0.051 0.100
GAD2 GAD2, GAD65: Glutamate decarboxylase 2 0.051 0.058
FASLG FASLG, APT1LG1, FASL, TNFSF6: Tumor necrosis factor ligand superfamily member 6 0.051 0.055
PTPRJ PTPRJ, DEP1: Receptor-type tyrosine-protein phosphatase eta precursor 0.051 0.098
ICOSLG ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653: ICOS ligand precursor 0.051 0.123
CD80 CD80, CD28LG, CD28LG1, LAB7: T-lymphocyte activation antigen CD80 precursor 0.051 0.098
HLA-DMA DMA, HLA-DMA, DAQB-96B10.1-001, DASS-67H14.8-001, XXbac-BCX136A3.1-001, XXbac-BP 0.051 0.109
TRPV6 TRPV6, ECAC2: Transient receptor potential cation channel subfamily V member 6 0.049 0.075
ADAMTS4 ADAMTS4, KIAA0688, UNQ769/PRO1563: ADAMTS-4 precursor 0.049 0.083
ATRN N/A 0.049 0.148
TRPM7 TRPM7, CHAK1, LTRPC7: Transient receptor potential cation channel subfamily M me 0.049 0.148
ATP2A2 ATP2A2, ATP2B: Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0.049 0.075
PLAUR PLAUR, MO3, UPAR: Urokinase plasminogen activator surface receptor precursor 0.049 0.083
ATP1A1 ATP1A1: Sodium/potassium-transporting ATPase subunit alpha-1 precursor 0.049 0.075
S100A9 S100A9, CAGB, CFAG, MRP14: Protein S100-A9 0.048 0.072
EHD1 EHD1, PAST, CDABP0131, PAST1: EH domain-containing protein 1 0.048 0.073
LCP1 LCP1, PLS2: Plastin-2 0.048 0.064
PECAM1 PECAM1: Platelet endothelial cell adhesion molecule precursor 0.047 0.038
TBC1D2 TBC1D2, PARIS1: TBC1 domain family member 2 0.047 0.034
CTLA4 CTLA4, CD152: Cytotoxic T-lymphocyte protein 4 precursor 0.047 0.038
CD36 CD36, GP3B, GP4: Platelet glycoprotein 4 0.0453 0.049
ADAMTS1 ADAMTS1, KIAA1346, METH1: ADAMTS-1 precursor 0.045 0.0453
IGFBP4 IGFBP4, IBP4: Insulin-like growth factor-binding protein 4 precursor 0.045 0.081
IGFBP5 IGFBP5, IBP5: Insulin-like growth factor-binding protein 5 precursor 0.045 0.126
IGFBP7 IGFBP7, MAC25, PSF: Insulin-like growth factor-binding protein 7 precursor 0.045 0.126
IGFBP1 IGFBP1, IBP1: Insulin-like growth factor-binding protein 1 precursor 0.045 0.081
NULL A1BG: Alpha-1B-glycoprotein precursor 0.044 0.165
FN1 N/A 0.044 0.165
PVRL1 PVRL1, HVEC, PRR1: Poliovirus receptor-related protein 1 precursor 0.044 0.165
VCAM1 VCAM1, L1CAM: Vascular cell adhesion protein 1 precursor 0.044 0.165
MDGA1 MDGA1, MAMDC3: MAM domain-containing glycosylphosphatidylinositol anchor protein 0.044 0.165
CNTN1 CNTN1: Contactin-1 precursor 0.044 0.148
BSG N/A 0.044 0.148
SIGLEC12 SIGLEC12, SIGLECL1, UNQ9215/PRO34042, SLG: Sialic acid-binding Ig-like lectin 12 0.044 0.165
ADAM33 ADAM33, UNQ873/PRO1891: ADAM 33 precursor 0.044 0.148
PTPRS PTPRS: Receptor-type tyrosine-protein phosphatase S precursor 0.044 0.165
CNTN4 CNTN4: Contactin-4 precursor 0.044 0.148
KIAA0690 N/A 0.0425 0.027
SLA SLA, SLAP, SLAP1: SRC-like-adapter 0.0416 0.902
VWF VWF, F8VWF: von Willebrand factor precursor 0.041 0.148
HLA-G HLA-G, HLA-6.0, HLAG: HLA class I histocompatibility antigen, alpha chain G prec 0.0407 0.123
CD58 CD58, LFA3: Lymphocyte function-associated antigen 3 precursor 0.0407 0.109
NCAM2 NCAM2, NCAM21: Neural cell adhesion molecule 2 precursor 0.0407 0.088
GPA33 GPA33: Cell surface A33 antigen precursor 0.0407 0.123
CXCR4 CXCR4: C-X-C chemokine receptor type 4 0.0407 0.055
ICAM1 ICAM1: Intercellular adhesion molecule 1 precursor 0.0407 0.098
HLA-C HLA-C, HLAC: HLA class I histocompatibility antigen, Cw-7 alpha chain precursor 0.0407 0.123
HLA-DPB1 HLA-DPB1: MHC class II lymphocyte antigen beta chain precursor 0.0407 0.109
CD4 CD4: T-cell surface glycoprotein CD4 precursor 0.0407 0.109
TIAM1 TIAM1: T-lymphoma invasion and metastasis-inducing protein 1 0.0407 0.046
HLA-DMB HLA-DMB, DMB, RING7: HLA class II histocompatibility antigen, DM beta chain prec 0.0407 0.109
GGA3 GGA3, KIAA0154: ADP-ribosylation factor-binding protein GGA3 0.04 0.030
CETN1 CETN1, CEN1, CETN: Centrin-1 0.04 0.062
STOM STOM, BND7, EPB72: Erythrocyte band 7 integral membrane protein 0.04 0.025
LETM1 LETM1: Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial 0.04 0.062
EPS15 EPS15, AF1P: Epidermal growth factor receptor substrate 15 0.039 0.058
CAPNS1 CAPNS1, CAPN4, CAPNS: Calpain small subunit 1 0.039 0.051
TNNC1 TNNC1, TNNC: Troponin C, slow skeletal and cardiac muscles 0.039 0.033
EHD2 EHD2, PAST2: EH domain-containing protein 2 0.039 0.090
MYL3 MYL3: Myosin light polypeptide 3 0.039 0.073
MYL4 MYL4, MLC1, PRO1957: Myosin light polypeptide 4 0.039 0.064
CAPN2 CAPN2, CANPL2: Calpain-2 catalytic subunit precursor 0.039 0.073
S100A3 S100A3, S100E: Protein S100-A3 0.039 0.081
TBC1D1 TBC1D1, KIAA1108: TBC1 domain family member 1 0.038 0.042
CD44 N/A 0.037 0.062
ANXA1 ANXA1, ANX1, LPC1: Annexin A1 0.037 0.034
IQGAP2 IQGAP2: Ras GTPase-activating-like protein IQGAP2 0.037 0.046
AGTR1 AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B: Type-1 angiotensin II receptor 0.037 0.077
SEMA5A SEMA5A, SEMAF: Semaphorin-5A precursor 0.037 0.069
ADRB2 ADRB2, ADRB2R, B2AR: Beta-2 adrenergic receptor 0.037 0.069
HPN HPN, TMPRSS1: Serine protease hepsin 0.037 0.049
PMP2 PMP2: Myelin P2 protein 0.037 0.029
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.034 0.073
S100A11 MLN70, S100A11, S100C: Protein S100-A11 0.034 0.100
SNCB SNCB: Beta-synuclein 0.034 0.081
ACTN1 ACTN1: Alpha-actinin-1 0.034 0.148
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.034 0.041
SNCG SNCG, BCSG1, PERSYN, PRSN: Gamma-synuclein 0.034 0.072
S100B S100B: Protein S100-B 0.034 0.072
CNN1 CNN1: Calponin-1 0.034 0.0955
TAOK1 TAOK1, KIAA1361, MAP3K16: Serine/threonine-protein kinase TAO1 0.0338 0.053
ICAM2 ICAM2: Intercellular adhesion molecule 2 precursor 0.033 0.109
ALCAM ALCAM, MEMD: CD166 antigen precursor 0.033 0.109
LILRB5 LILRB5, LIR8: Leukocyte immunoglobulin-like receptor subfamily B member 5 precur 0.033 0.123
CD47 CD47, MER6: Leukocyte surface antigen CD47 precursor 0.033 0.123
ATP2B1 N/A 0.032 0.062
IL8RB IL8RB, CXCR2: High affinity interleukin-8 receptor B 0.032 0.026
TMPRSS2 TMPRSS2, PRSS10: Transmembrane protease, serine 2 precursor 0.032 0.233
LYPD3 LYPD3, C4.4A, UNQ491/PRO1007: Ly6/PLAUR domain-containing protein 3 precursor 0.032 0.062
CFLAR CFLAR, CASH, CASP8AP1, CLARP, MRIT: CASP8 and FADD-like apoptosis regulator prec 0.032 0.0453
ARVCF ARVCF: Armadillo repeat protein deleted in velo-cardio-facial syndrome 0.032 0.029
DRIM UTP20, DRIM: Small subunit processome component 20 homolog 0.032 0.0263
MYL9 MYL9, MLC2, MRLC1, MYRL2: Myosin regulatory light chain 2, smooth muscle isoform 0.031 0.148
GRAP GRAP: GRB2-related adapter protein 0.0308 0.115
SOCS1 SOCS1, SSI1, TIP3: Suppressor of cytokine signaling 1 0.0308 0.128
VAV3 VAV3: Protein vav-3 0.0308 0.145
ANXA2 ANXA2, ANX2, ANX2L4, CAL1H, LPC2D: Annexin A2 0.030 0.039
ANXA9 ANXA9, ANX31: Annexin A9 0.030 0.034
HGS HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate 0.030 0.028
NCAM1 NCAM1, NCAM: Neural cell adhesion molecule 1, 140 kDa isoform precursor 0.029 0.123
PTPRZ1 N/A 0.029 0.097
TNC TNC, HXB: Tenascin precursor 0.029 0.136
CD7 CD7: T-cell antigen CD7 precursor 0.029 0.123
CNTN2 CNTN2, AXT, TAG1, TAX1: Contactin-2 precursor 0.029 0.097
CD2 CD2, SRBC: T-cell surface antigen CD2 precursor 0.029 0.123
CD1A CD1A: T-cell surface glycoprotein CD1a precursor 0.029 0.123
PTPRG PTPRG, PTPG: Receptor-type tyrosine-protein phosphatase gamma precursor 0.029 0.111
NEO1 NEO1, NGN: Neogenin precursor 0.029 0.171
FES Proto-oncogene c-fes variant 4 0.0288 0.0288
FES Proto-oncogene c-fes variant 3 0.0288 0.0288
FES N/A 0.0288 0.0258
BLK BLK: Tyrosine-protein kinase BLK 0.0288 0.0288
BTK BTK kinase deficient isoform 6: Dominant-negative kinase-deficient Brutons tyros 0.0288 0.0288
FES FES, FPS: Proto-oncogene tyrosine-protein kinase Fes/Fps 0.0288 0.0288
KIAA0031 EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component 0.028 0.098
RSU1 RSU1, RSP1: Ras suppressor protein 1 0.028 0.044
RAB5B RAB5B: Ras-related protein Rab-5B 0.028 0.098
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.028 0.049
PKP4 PKP4: Plakophilin-4 0.028 0.049
UACA UACA, KIAA1561: Uveal autoantigen with coiled-coil domains and ankyrin repeats 0.028 0.028
FBXL10 FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio 0.028 0.036
LTA4H LTA4H, LTA4: Leukotriene A-4 hydrolase 0.028 0.044
LRRC7 LRRC7, KIAA1365, LAP1: Leucine-rich repeat-containing protein 7 0.028 0.044
GSN GSN: Gelsolin precursor 0.028 0.036
AKAP12 AKAP12, AKAP250: A-kinase anchor protein 12 0.028 0.049
KCNAB2 KCNAB2, KCNA2B, KCNK2: Voltage-gated potassium channel subunit beta-2 0.028 0.044
PARD6A PARD6A, PAR6A: Partitioning defective 6 homolog alpha 0.028 0.044
SNX3 N/A 0.028 0.098
NLN NLN, AGTBP, KIAA1226: Neurolysin, mitochondrial precursor 0.028 0.044
COTL1 COTL1, CLP: Coactosin-like protein 0.028 0.036
CASP8 CASP8, MCH5: Caspase-8 precursor 0.028 0.049
CDC25C CDC25C: M-phase inducer phosphatase 3 0.028 0.098
TSC2 TSC2, TSC4: Tuberin 0.028 0.044
RAB21 RAB21, KIAA0118: Ras-related protein Rab-21 0.028 0.040
GART GART, PGFT, PRGS: Trifunctional purine biosynthetic protein adenosine-3 [Include 0.028 0.044
SVIL SVIL: Supervillin 0.028 0.036
DPP8 DPP8, DPRP1, MSTP097, MSTP135, MSTP141: Dipeptidyl peptidase 8 0.028 0.044
CFL2 CFL2: Cofilin-2 0.028 0.036
NIPBL N/A 0.028 0.036
KRT6E KRT6C, KRT6E: Keratin, type II cytoskeletal 6C 0.028 0.049
YWHAG YWHAG: 14-3-3 protein gamma 0.028 0.049
DNAJC13 DNAJC13, KIAA0678, RME8: DnaJ homolog subfamily C member 13 0.028 0.049
CDC25A CDC25A: M-phase inducer phosphatase 1 0.028 0.098
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.217
SOCS4 SOCS4, SOCS7: Suppressor of cytokine signaling 4 0.027 0.217
MPP4 MPP4, ALS2CR5, DLG6: MAGUK p55 subfamily member 4 0.027 0.027
SH2D1B SH2D1B, EAT2: SH2 domain-containing protein 1B 0.027 0.217
PTPRN2 PTPRN2: Receptor-type tyrosine-protein phosphatase N2 precursor 0.027 0.027
CISH CISH, G18: Cytokine-inducible SH2-containing protein 0.027 0.217
TOM1L1 TOM1L1, SRCASM: TOM1-like protein 1 0.0263 0.031
PTPRM PTPRM, PTPRL1: Receptor-type tyrosine-protein phosphatase mu precursor 0.026 0.171
BCAM BCAM, LU, MSK19: Lutheran blood group glycoprotein precursor 0.026 0.251
THY1 THY1: Thy-1 membrane glycoprotein precursor 0.026 0.123
HSP90AB1 HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta 0.026 0.065
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.026 0.029
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 0.026 0.029
TRAF1 TRAF1, EBI6: TNF receptor-associated factor 1 0.026 0.026
MDN1 MDN1, KIAA0301: Midasin 0.026 0.026
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.026 0.058
NRAS NRAS, HRAS1: GTPase NRas precursor 0.026 0.058
MAPRE1 MAPRE1: Microtubule-associated protein RP/EB family member 1 0.026 0.029
PARVA PARVA, MXRA2: Alpha-parvin 0.026 0.033
RRAD RRAD, RAD: GTP-binding protein RAD 0.026 0.073
CTPS CTPS: CTP synthase 1 0.026 0.026
SEC24C SEC24C, KIAA0079: Protein transport protein Sec24C 0.026 0.027
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.026 0.081
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.026 0.073
THOC1 THOC1, HPR1: THO complex subunit 1 0.026 0.026
CCT8 CCT8: Uncharacterized protein CCT8 0.026 0.026
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.026 0.029
KIAA0528 KIAA0528: Uncharacterized protein KIAA0528 0.026 0.032
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.026 0.033
MAPRE2 MAPRE2, RP1: Microtubule-associated protein RP/EB family member 2 0.026 0.029
IMPDH2 IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2 0.026 0.029
TBCE TBCE: Tubulin-specific chaperone E 0.026 0.027
COPA COPA: Coatomer subunit alpha 0.026 0.033
PSMA5 PSMA5: Proteasome subunit alpha type-5 0.026 0.026
PITPNM1 PITPNM1: Uncharacterized protein PITPNM1 0.026 0.029
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.026 0.026
GTPBP4 GTPBP4, CRFG, NOG1: Nucleolar GTP-binding protein 1 0.026 0.026
RIMS1 RIMS1, KIAA0340, Nbla00761, RAB3IP2, RIM1: Regulating synaptic membrane exocytos 0.026 0.029
RAB5A RAB5A, RAB5: Ras-related protein Rab-5A 0.026 0.030
TRAFD1 TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1 0.026 0.029
TRAP1 TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor 0.026 0.026
FLII FLII, FLIL: Protein flightless-1 homolog 0.026 0.033
CD6 CD6: T-cell differentiation antigen CD6 precursor 0.025 0.029
MCOLN1 MCOLN1, ML4, MSTP080: Mucolipin-1 0.025 0.035
0.228
Total Score 52.80