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Evidence of Interaction Between EIF2S3 and EXOSC3

The interaction score between EIF2S3 and EXOSC3 is 1.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

 N/A
Orthology
OrganismEIF2S3 OrthologueEXOSC3 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YER025W 1 YOL142W 1
  • Y2H
  • Other

Get References From PubMed
worm Q95XR0 1 Q93830 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains No domains were used in calculating likelihood of interaction 4.88E-3
Post-translational Modifications

Protein: EIF2S3

PTMResidueReference
Acetylation 2 PubMed, HPRD

Protein: EXOSC3

PTMResidueReference
N-acetylalanine 1 HPRD
Localisation

Protein: EIF2S3

LocalisationReference
Cytosol HPRD
Nucleolus HPRD
Cytoplasm HPRD

Protein: EXOSC3

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between EIF2S3 and EXOSC3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between EIF2S3 andEXOSC3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , EIF2S3 has 913 interactors and EXOSC3 has 59 interactors of which there are 32 common interactors.

Common InteractorName of Common InteractorScore for EIF2S3-Interactor (?)Score for EXOSC3-Interactor (?)
PABPC1 PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1 0.484 0.025
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.276 0.137
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.227 0.025
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.227 0.025
TRAF2 TRAF2, TRAP3: TNF receptor-associated factor 2 0.210 0.028
TP53 TP53, P53: Cellular tumor antigen p53 0.141 0.025
PPIA PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A 0.129 0.025
NULL Putative uncharacterized protein (Fragment) 0.119 0.119
SNRPD1 SNRPD1: Small nuclear ribonucleoprotein Sm D1 0.066 0.025
SNRPD3 SNRPD3: Small nuclear ribonucleoprotein Sm D3 0.066 0.025
LMNB1 LMNB1, LMN2, LMNB: Lamin-B1 0.066 0.025
NRAS NRAS, HRAS1: GTPase NRas precursor 0.063 0.025
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.063 1.16
ACTG1 ACTB: Actin, cytoplasmic 1 0.063 0.025
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.063 0.025
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.046 0.025
NR3C1 NR3C1, GRL: Glucocorticoid receptor 0.0446 0.028
HNRPA2B1 HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1 0.044 0.025
HNRPH3 HNRPH3: Heterogeneous nuclear ribonucleoprotein H3 0.044 0.137
EWSR1 EWSR1, EWS: RNA-binding protein EWS 0.044 0.137
NFKBIA NFKBIA, IKBA, MAD3, NFKBI: NF-kappa-B inhibitor alpha 0.0425 0.025
CTDP1 CTDP1, FCP1: RNA polymerase II subunit A C-terminal domain phosphatase 0.0425 0.025
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.040 0.025
SAT SAT1, SAT: Diamine acetyltransferase 1 0.032 0.028
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.032 0.025
H2AFX H2AFX, H2AX: Histone H2A.x 0.032 0.025
PCNA PCNA: Proliferating cell nuclear antigen 0.032 0.025
CDC42 N/A 0.028 0.028
YWHAG YWHAG: 14-3-3 protein gamma 0.028 0.028
SOCS3 SOCS3, CIS3, SSI3: Suppressor of cytokine signaling 3 0.026 0.028
CDC25C CDC25C: M-phase inducer phosphatase 3 0.025 0.025
RAC1 N/A 0.025 0.025
2.15E-3
Total Score 1.00