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Evidence of Interaction Between PSMA4 and PSMB2

The interaction score between PSMA4 and PSMB2 is 597.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between PSMA4 and PSMB2 = 0.82

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismPSMA4 OrthologuePSMB2 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YGR135W 1 YER012W 1
  • Immunoprecipitation
  • Other
  • AffinityCaptureMS

Get References From PubMed
worm Q9N599 1 P91477 1
fly P18053 1 Q9VQE5 0.109
fly P18053 1 Q9VJJ0 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in PSMA4 and PSMB2:
Domains in PSMA4Domains in PSMB2
IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 20S proteasome, A and B subunits
IPR000426 Proteasome alpha-subunit
IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 20S proteasome, A and B subunits

The Chi square scores for co-occurrence of domains that are present in PSMA4 and PSMB2 are listed below.

Domain 1Domain 2Chi Square
IPR000426 Proteasome alpha-subunit IPR001353 20S proteasome, A and B subunits 1084.67
IPR000426 Proteasome alpha-subunit IPR000243 Peptidase T1A, proteasome beta-subunit 998.751
IPR001353 20S proteasome, A and B subunits IPR001353 20S proteasome, A and B subunits 972.655
IPR000243 Peptidase T1A, proteasome beta-subunit IPR001353 20S proteasome, A and B subunits 960.483

The background colour of the table refers to:

  • Blue Domain is only present in PSMA4
  • Yellow Domain is only present in PSMB2
  • Green Domain is present in both PSMA4 and PSMB2

 0.265
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: PSMA4

LocalisationReference
ER HPRD
Nucleus HPRD
Cytoplasm HPRD

Protein: PSMB2

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between PSMA4 and PSMB2 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between PSMA4 andPSMB2. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , PSMA4 has 196 interactors and PSMB2 has 257 interactors of which there are 155 common interactors.

Common InteractorName of Common InteractorScore for PSMA4-Interactor (?)Score for PSMB2-Interactor (?)
PSMA2 PSMA2, PSC3: Proteasome subunit alpha type-2 2.07E3 691.00
PSMA5 PSMA5: Proteasome subunit alpha type-5 2.07E3 691.00
PSMA3 PSMA3, PSC8: Proteasome subunit alpha type-3 691.00 691.00
PSMB1 PSMB1, PSC5: Proteasome subunit beta type-1 precursor 691.00 691.00
PSMB7 PSMB7: Proteasome subunit beta type-7 precursor 691.00 691.00
PSMB6 PSMB6, LMPY: Proteasome subunit beta type-6 precursor 323.00 323.00
PSMA6 PSMA6, PROS27: Proteasome subunit alpha type-6 323.00 195.00
PSMB3 PSMB3: Proteasome subunit beta type-3 323.00 323.00
PSMA7 PSMA7: Proteasome subunit alpha type-7 323.00 323.00
PSMB9 PSMB9, LMP2, RING12: Proteasome subunit beta type-9 precursor 31.70 31.70
PSMA8 PSMA8, PSMA7L: Proteasome subunit alpha type-7-like 12.60 12.60
PSMD7 PSMD7, MOV34L: 26S proteasome non-ATPase regulatory subunit 7 6.52 3.05
PSMA1 PSMA1, PROS30, PSC2: Proteasome subunit alpha type-1 2.91 2.91
PSMB4 N/A 1.82 1.82
NULL RcPSMB3 (Fragment) 1.37 1.37
PSMD4 PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4 1.01 0.612
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.739 0.596
CTRL PSMB10, MECL1: Proteasome subunit beta type-10 precursor 0.666 0.491
PSMB5 DKFZp686I0180: Putative uncharacterized protein DKFZp686I0180 (Fragment) 0.593 0.593
PSMA1 N/A 0.354 0.354
PSMB5 PSMB5, LMPX: Proteasome subunit beta type-5 precursor 0.265 0.265
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.263 0.263
PPP2CB PPP2CB: Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0.233 0.233
PLK3 PLK3, CNK, FNK, PRK: Serine/threonine-protein kinase PLK3 0.225 0.179
PSMB8 PSMB8, DAQB-69D7.6-002, DASS-67H14.1-002, XXbac-BCX32M13.6-002, XXbac-BPG246D15. 0.221 0.179
PLK1 PLK1, PLK: Serine/threonine-protein kinase PLK1 0.195 0.195
KIF3A KIF3A, KIF3: Kinesin-like protein KIF3A 0.181 0.146
PPP2CA PPP2CA: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 0.179 0.108
PLK2 PLK2, SNK: Serine/threonine-protein kinase PLK2 0.145 0.179
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.137 0.137
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.123 0.074
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.123 0.074
AURKB AURKB, AIK2, AIM1, ARK2, STK12: Serine/threonine-protein kinase 12 0.123 0.123
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.123 0.123
BUB1B BUB1B, BUBR1, MAD3L: Mitotic checkpoint serine/threonine-protein kinase BUB1 bet 0.123 0.123
CDK4 CDK4: Cell division protein kinase 4 0.123 0.263
CDK7 CDK7, MO15: Cell division protein kinase 7 0.123 0.074
C20orf23 N/A 0.119 0.119
KIF17 N/A 0.119 0.119
NULL N/A 0.119 0.119
VRK2 VRK2: Serine/threonine-protein kinase VRK2 0.0968 0.059
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.0968 0.059
CSNK1G3 CSNK1G3: Casein kinase I isoform gamma-3 0.083 0.050
RIPK2 RIPK2, CARDIAK, UNQ277/PRO314/PRO34092, RICK, RIP2: Receptor-interacting serine/ 0.083 0.067
ROCK1 ROCK1: Rho-associated protein kinase 1 0.083 0.050
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.083 0.067
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.081 0.038
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.074 0.074
CSNK1A1 CSNK1A1: Casein kinase I isoform alpha 0.074 0.060
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.074 0.060
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.074 0.060
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.074 0.123
BUB1 0.074 0.123
RP6-213H19.1 MST4, MASK: Serine/threonine-protein kinase MST4 0.074 0.060
CDK2 CDK2: Cell division protein kinase 2 0.074 6.55
WEE1 WEE1: Wee1-like protein kinase 0.074 0.074
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.074 0.044
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.074 0.060
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.067 0.041
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.060 0.044
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.060 0.036
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.060 0.044
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.060 0.074
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.060 0.036
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.060 0.044
CSNK1G2 CSNK1G2: Casein kinase I isoform gamma-2 0.060 0.044
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.060 0.036
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.060 0.074
STK38L STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like 0.060 0.036
RPS6KB1 N/A 0.060 0.044
DYRK4 DYRK4: Dual specificity tyrosine-phosphorylation-regulated kinase 4 0.060 0.044
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.060 0.044
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.060 0.060
TTK TTK, MPS1L1: Dual specificity protein kinase TTK 0.059 0.059
CAMK2G Calcium/calmodulin-dependent protein kinase isoform A (Fragment) 0.050 0.041
STK16 N/A 0.050 0.067
KIF3C KIF3C: Kinesin-like protein KIF3C 0.047 0.047
CDK9 CDK9, CDC2L4: Cell division protein kinase 9 0.047 0.035
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.044 0.044
STK17A STK17A, DRAK1: Serine/threonine-protein kinase 17A 0.044 0.036
CLK3 CLK3: Dual specificity protein kinase CLK3 0.044 0.044
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.044 0.044
CSNK1D CSNK1D: Casein kinase I isoform delta 0.044 0.036
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.044 0.036
STK10 STK10: Uncharacterized protein STK10 0.044 0.028
SCYL3 SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin 0.044 0.028
NEK2 NEK2, NLK1: Serine/threonine-protein kinase Nek2 0.044 0.044
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.044 0.036
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.044 0.036
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.044 0.036
MAP4K2 MAP4K2, GCK, RAB8IP: Mitogen-activated protein kinase kinase kinase kinase 2 0.044 0.044
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.044 0.044
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.044 0.044
STK38 STK38, NDR1: Serine/threonine-protein kinase 38 0.044 0.028
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.044 0.044
MAP4K5 MAP4K5: Mitogen-activated protein kinase kinase kinase kinase 5 0.044 0.028
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.044 0.036
VRK3 N/A 0.041 0.041
MAP3K5 MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5 0.041 0.0308
MAP3K8 MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8 0.041 0.0308
MAPKAPK2 MAPKAPK2: MAP kinase-activated protein kinase 2 0.041 0.041
EIF2AK1 N/A 0.041 0.041
DYRK2 DYRK2: Dual specificity tyrosine-phosphorylation-regulated kinase 2 0.041 0.0308
LIMK2 LIMK2: LIM domain kinase 2 0.041 0.0308
CSNK2A2 CSNK2A2, CK2A2: Casein kinase II subunit alpha' 0.036 0.036
IRAK4 IRAK4: Interleukin-1 receptor-associated kinase 4 0.036 0.036
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.036 0.036
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.036 0.036
PRKX PRKX, PKX1: Serine/threonine-protein kinase PRKX 0.036 0.028
WNK1 WNK1, KDP, KIAA0344, PRKWNK1: Serine/threonine-protein kinase WNK1 0.036 0.028
PIM1 N/A 0.036 0.028
CSNK1E CSNK1E: Casein kinase I isoform epsilon 0.036 0.028
NEK7 NEK7: Serine/threonine-protein kinase Nek7 0.036 0.028
ILK ILK, ILK1, ILK2: Integrin-linked protein kinase 0.036 0.044
MAPKAPK3 MAPKAPK3: MAP kinase-activated protein kinase 3 0.036 0.036
ARAF ARAF, ARAF1, PKS, PKS2: A-Raf proto-oncogene serine/threonine-protein kinase 0.036 0.044
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.036 0.044
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.036 0.036
KIF3B KIF3B, KIAA0359: Kinesin-like protein KIF3B 0.0363 0.0294
GAK GAK: Cyclin G-associated kinase 0.035 0.029
ACVR2A ACVR2A, ACVR2: Activin receptor type-2A precursor 0.035 0.035
PSMB4 PSMB4: Proteasome subunit beta type-4 precursor 0.0288 0.0288
PSMB8 PSMB8, LMP7, RING10, Y2: Proteasome subunit beta type-8 precursor 0.0288 0.0288
MAPK13 MAPK13, PRKM13, SAPK4: Mitogen-activated protein kinase 13 0.028 0.036
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.028 0.036
CDK6 CDK6: Cell division protein kinase 6 0.028 0.028
PTD004 N/A 0.027 0.027
MRPL22 MRPL22, HSPC158: 39S ribosomal protein L22, mitochondrial precursor 0.027 0.027
PSME3 PSME3: Proteasome activator complex subunit 3 0.027 0.027
HSPC185 CGI-117, HSPC111: UPF0384 protein CGI-117 0.027 0.027
SERBP1 N/A 0.027 0.027
ERN2 ERN2, IRE2: Serine/threonine-protein kinase/endoribonuclease IRE2 precursor 0.027 0.0331
NEK11 NEK11: Serine/threonine-protein kinase Nek11 0.027 0.027
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.027 0.027
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.027 0.027
ALS2CR7 ALS2CR7: Serine/threonine-protein kinase ALS2CR7 0.027 0.027
MAPKAPK5 N/A 0.027 0.027
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.027 0.027
PRKACB PRKACB: cAMP-dependent protein kinase, beta-catalytic subunit 0.027 0.027
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.027 0.027
MAP2K5 N/A 0.027 0.027
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.027
PDIK1L PDIK1L, CLIK1L: Serine/threonine-protein kinase PDIK1L 0.027 0.027
STK35 STK35, CLIK1, PDIK1: Serine/threonine-protein kinase 35 0.027 0.027
CDC2L2 N/A 0.027 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.027
RIPK5 RIPK5, KIAA0472, HDCMD38P, RIP5, SGK496: Receptor-interacting serine/threonine-p 0.027 0.027
NEK4 NEK4, STK2: Serine/threonine-protein kinase Nek4 0.027 0.027
CAMKK1 CAMKK1, CAMKKA: Calcium/calmodulin-dependent protein kinase kinase 1 0.027 0.027
GRK7 GRK7, GPRK7: G protein-coupled receptor kinase 7 precursor 0.027 0.027
MAPK15 N/A 0.027 0.027
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.027 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.027 0.027
ANKK1 ANKK1, PKK2, SGK288: Ankyrin repeat and protein kinase domain-containing protein 0.027 0.027
BMP2K BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase 0.027 0.027
2.15E-3
Total Score 597.00