Home
Advanced Search
Help
Update History
Statistics
Downloads
The Barton Group
<<< Back to RANBP1

Evidence of Interaction Between RANBP1 and RAN

The interaction score between RANBP1 and RAN is 6.34E3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RANBP1 and RAN = 0.88

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismRANBP1 OrthologueRAN OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YDR002W 1 YLR293C 1
  • Y2H
  • Immunoprecipitation
  • AffinityChromatography
  • AffinityCaptureWestern

Get References From PubMed
bakers yeast YDR002W 1 YOR185C 0.86

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in RANBP1 and RAN:
Domains in RANBP1Domains in RAN
IPR000156 RanBP1 domain
IPR003975 Shal voltage-gated K+ channel
IPR011993 PH_type.
IPR001806 Ras GTPase superfamily
IPR002041 GTP-binding nuclear protein Ran
IPR005225 Small GTP-binding protein domain
IPR013753 Ras

The Chi square scores for co-occurrence of domains that are present in RANBP1 and RAN are listed below.

Domain 1Domain 2Chi Square
IPR011993 PH_type. IPR001806 Ras GTPase superfamily 16.5399
IPR011993 PH_type. IPR005225 Small GTP-binding protein domain 15.9939
IPR011993 PH_type. IPR013753 Ras 4.76414

The background colour of the table refers to:

  • Blue Domain is only present in RANBP1
  • Yellow Domain is only present in RAN
  • Green Domain is present in both RANBP1 and RAN

 0.027
Post-translational Modifications

Protein: RANBP1

PTMResidueReference

Protein: RAN

PTMResidueReference
Phosphotyrosine 147 HPRD
Localisation

Protein: RANBP1

LocalisationReference
Nucleus HPRD
Centrosome HPRD
Cytoplasm HPRD

Protein: RAN

LocalisationReference
Nucleus HPRD
Mitochondrion HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between RANBP1 and RAN that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RANBP1 andRAN. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RANBP1 has 336 interactors and RAN has 1090 interactors of which there are 174 common interactors.

Common InteractorName of Common InteractorScore for RANBP1-Interactor (?)Score for RAN-Interactor (?)
XPO1 XPO1, CRM1: Exportin-1 19.70 202.00
TNPO1 11.70 19.70
CHC1 RCC1: RCC1-I (Fragment) 5.33 4.67
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.612 0.066
RANGAP1 KIAA1835: KIAA1835 protein (Fragment) 0.593 0.593
PRKDC PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit 0.293 0.917
BUB1B BUB1B, BUBR1, MAD3L: Mitotic checkpoint serine/threonine-protein kinase BUB1 bet 0.263 0.053
CDK4 CDK4: Cell division protein kinase 4 0.263 0.515
AURKB AURKB, AIK2, AIM1, ARK2, STK12: Serine/threonine-protein kinase 12 0.263 0.053
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.263 0.048
CNAP1 NCAPD2, CAPD2, CNAP1, KIAA0159: Condensin complex subunit 1 0.263 0.081
GTPBP4 GTPBP4, CRFG, NOG1: Nucleolar GTP-binding protein 1 0.137 0.054
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.137 0.053
CAND1 CAND1, KIAA0829, TIP120, TIP120A: Cullin-associated NEDD8-dissociated protein 1 0.137 0.081
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.137 0.241
CDK2 CDK2: Cell division protein kinase 2 0.123 0.241
KPNB1 KPNB1, NTF97: Importin subunit beta-1 0.123 145.00
RANBP5 0.123 69.60
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.123 0.241
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.123 0.515
CSE1L CSE1L, CAS, XPO2: Exportin-2 0.123 145.00
TNPO2 N/A 0.119 0.119
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.083 0.146
WEE1 WEE1: Wee1-like protein kinase 0.083 0.146
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.083 0.269
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.083 0.241
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 0.074 0.146
KPNA2 KPNA2, RCH1, SRP1: Importin subunit alpha-2 0.074 0.045
CDC7 CDC7, CDC7L1: Cell division cycle 7-related protein kinase 0.074 0.146
SCC-112 N/A 0.074 0.038
CDK7 CDK7, MO15: Cell division protein kinase 7 0.074 0.241
CRKL CRKL: Crk-like protein 0.074 0.146
PSMD1 PSMD1: 26S proteasome non-ATPase regulatory subunit 1 0.074 0.385
CKS1B CKS1B, CKS1, PNAS-16, PNAS-143: Cyclin-dependent kinases regulatory subunit 1 0.0739 0.0739
IPO7 IPO7: Uncharacterized protein IPO7 0.067 0.416
CTNNBL1 N/A 0.067 0.0255
ATXN10 ATXN10, SCA10: Ataxin-10 0.067 0.038
MNAR PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1 0.067 0.210
IPO4 N/A 0.067 0.050
BTK BTK, AGMX1, ATK, BPK: Tyrosine-protein kinase BTK 0.067 0.372
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.067 0.210
MPP6 MPP6, VAM1: MAGUK p55 subfamily member 6 0.067 0.210
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.067 0.032
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.060 0.146
KPNA3 KPNA3: Importin subunit alpha-3 0.060 0.038
CD2AP CD2AP: CD2-associated protein 0.060 0.078
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.060 0.146
EIF5B EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B 0.060 0.129
EEF2 EEF2, EF2: Elongation factor 2 0.060 0.063
STK24 STK24, MST3, STK3: Serine/threonine-protein kinase 24 0.060 0.241
CAD CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase 0.053 0.276
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.053 0.112
PSMD5 PSMD5, KIAA0072: 26S proteasome non-ATPase regulatory subunit 5 0.050 0.037
HD HD, IT15: Huntingtin 0.050 0.210
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.050 0.118
FHOD1 FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1 0.050 0.139
BLNK BLNK, BASH, SLP65: B-cell linker protein 0.050 0.052
IPO9 IPO9, IMP9, HSPC273, KIAA1192, RANBP9: Importin-9 0.050 0.140
CSK CSK: Tyrosine-protein kinase CSK 0.044 0.063
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.044 0.372
ATR ATR, FRP1: Serine/threonine-protein kinase ATR 0.044 0.188
KPNA1 KPNA1, RCH2: Importin subunit alpha-1 0.044 0.982
NRAS NRAS, HRAS1: GTPase NRas precursor 0.044 0.078
TYK2 TYK2: Non-receptor tyrosine-protein kinase TYK2 0.041 0.046
TSC1 TSC1, KIAA0243, TSC: Hamartin 0.041 0.038
DOCK2 DOCK2, KIAA0209: Dedicator of cytokinesis protein 2 0.041 0.275
TBK1 TBK1, NAK: Serine/threonine-protein kinase TBK1 0.041 0.046
ABL1 ABL1, ABL, JTK7: Proto-oncogene tyrosine-protein kinase ABL1 0.041 0.0425
CTNNB1 CTNNB1, CTNNB, OK/SW-cl.35, PRO2286: Catenin beta-1 0.041 0.188
SYMPK SYMPK, SPK: Symplekin 0.041 0.139
STK16 N/A 0.041 0.0971
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.041 0.026
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.041 0.060
ARHGEF7 ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB: Rho guanine nucleotide exchange 0.041 0.050
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.041 0.071
ROCK1 ROCK1: Rho-associated protein kinase 1 0.041 0.307
VDP DKFZp451D234: Putative uncharacterized protein DKFZp451D234 0.039 0.233
DNMBP DNMBP, KIAA1010: Dynamin-binding protein 0.036 0.225
AP3B1 AP3B1, ADTB3A: AP-3 complex subunit beta-1 0.036 0.036
SF3B1 SF3B1, SAP155: Splicing factor 3B subunit 1 0.036 0.139
RPS6KB1 N/A 0.036 0.139
RAP1A RAP1A, KREV1: Ras-related protein Rap-1A precursor 0.036 0.046
MAP2K1 MAP2K1, MEK1, PRKMK1: Dual specificity mitogen-activated protein kinase kinase 1 0.036 0.118
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.036 0.225
CRKRS CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7 0.036 0.071
KPNA6 N/A 0.036 4.88
FER FER, TYK3: Proto-oncogene tyrosine-protein kinase FER 0.036 0.114
STAT5A STAT5A, STAT5: Signal transducer and activator of transcription 5A 0.036 0.038
COPG 0.036 0.060
FNBP1 N/A 0.036 0.139
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.036 0.071
CXorf9 N/A 0.036 0.071
RAF1 RAF1, RAF: RAF proto-oncogene serine/threonine-protein kinase 0.036 0.275
IRAK1 IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1 0.036 0.118
BTAF1 BTAF1, TAF172: TATA-binding protein-associated factor 172 0.035 0.111
AP1G1 AP1G1, ADTG, CLAPG1: AP-1 complex subunit gamma-1 0.032 0.050
CDK6 CDK6: Cell division protein kinase 6 0.0308 0.043
SYK SYK: Tyrosine-protein kinase SYK 0.0308 0.029
TAOK3 TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3 0.0308 0.071
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.0308 0.114
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.0308 0.080
PRKD2 PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2 0.0308 0.225
PCTK1 PCTK1: Serine/threonine-protein kinase PCTAIRE-1 0.0308 0.054
FRAP1 FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein 0.0308 0.096
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.0308 0.114
ADRBK2 ADRBK2, BARK2, GRK3: Beta-adrenergic receptor kinase 2 0.0308 0.028
SRC SRC, SRC1: Proto-oncogene tyrosine-protein kinase Src 0.0308 0.032
RHOA RHOA, ARH12, ARHA, RHO12: Transforming protein RhoA precursor 0.0308 0.052
ACVR2A ACVR2A, ACVR2: Activin receptor type-2A precursor 0.029 0.035
ARFGEF2 ARFGEF2, ARFGEP2, BIG2: Brefeldin A-inhibited guanine nucleotide-exchange protei 0.029 0.275
BRAF BRAF, BRAF1, RAFB1: B-Raf proto-oncogene serine/threonine-protein kinase 0.028 0.225
RASA4 RASA4, CAPRI, GAPL, KIAA0538: Ras GTPase-activating protein 4 0.028 0.028
CLASP1 CLASP1, KIAA0622, MAST1: CLIP-associating protein 1 0.028 0.086
STAM STAM, STAM1: Signal transducing adapter molecule 1 0.028 0.114
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.028 0.275
VAV1 VAV1, VAV: Proto-oncogene vav 0.028 0.171
PRKCI PRKCI, DXS1179E: Protein kinase C iota type 0.028 0.275
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.028 0.046
AKT1 AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase 0.028 0.225
STAT6 STAT6: Signal transducer and activator of transcription 6 0.028 0.038
APS SH2B2, APS: SH2B adapter protein 2 0.028 0.171
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.028 0.114
RAP1B RAP1B, OK/SW-cl.11: Ras-related protein Rap-1b precursor 0.028 0.038
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.028 0.038
MAPK1 MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1 0.028 0.071
JUP JUP, CTNNG, DP3: Junction plakoglobin 0.028 0.114
PRKD3 PRKD3, EPK2, PRKCN: Serine/threonine-protein kinase D3 0.028 0.036
RABEP1 RABEP1, RABPT5, RABPT5A: Rab GTPase-binding effector protein 1 0.027 0.035
HSPC185 CGI-117, HSPC111: UPF0384 protein CGI-117 0.027 0.027
PTD004 N/A 0.027 0.027
GMNN GMNN: Geminin 0.027 0.025
MAPKAPK5 N/A 0.027 0.052
PHKG1 PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo 0.027 0.047
NEDD9 NEDD9, CASL: Enhancer of filamentation 1 0.027 0.025
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.165
BRDG1 STAP1, BRDG1: Signal-transducing adaptor protein 1 0.027 0.027
STAT3 0.027 0.025
AMPH AMPH, AMPH1: Amphiphysin 0.027 0.028
SPAG6 SPAG6, PF16: Sperm-associated antigen 6 0.027 0.083
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.083
CDC2L2 CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2 0.027 0.052
NEK6 NEK6: Serine/threonine-protein kinase Nek6 0.027 0.047
MAPK8 MAPK8, JNK1, PRKM8: Mitogen-activated protein kinase 8 0.027 0.052
ABI1 ABI1, SSH3BP1: Abl interactor 1 0.027 0.028
TSC2 TSC2, TSC4: Tuberin 0.027 0.075
DYRK1A DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin 0.027 0.052
RPS6KA4 RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4 0.027 0.075
LATS2 LATS2, KPM: Serine/threonine-protein kinase LATS2 0.027 0.075
ARL5A ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A 0.027 0.025
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.027 0.052
ITK ITK, EMT, LYK: Tyrosine-protein kinase ITK/TSK 0.027 0.148
IPO11 IPO11, RANBP11: Importin-11 0.027 0.027
LNK SH2B3, LNK: SH2B adapter protein 3 0.027 0.165
MAPK15 N/A 0.027 0.028
AKT3 AKT3: RAC-gamma serine/threonine-protein kinase 0.027 0.148
DYRK1B DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B 0.027 0.047
AP4B1 AP4B1: AP-4 complex subunit beta-1 0.027 0.027
SLA2 SLA2, C20orf156, SLAP2: Src-like-adapter 2 0.027 0.028
MAPK10 MAPK10, JNK3, JNK3A, PRKM10: Mitogen-activated protein kinase 10 0.027 0.052
EEF2K EEF2K: Elongation factor 2 kinase 0.027 0.025
KIAA0031 EFTUD2, KIAA0031, SNRP116: 116 kDa U5 small nuclear ribonucleoprotein component 0.027 0.025
ITSN1 ITSN1, ITSN, SH3D1A: Intersectin-1 0.027 0.165
RASA1 RASA1, RASA: Ras GTPase-activating protein 1 0.027 0.148
STAC STAC: SH3 and cysteine-rich domain-containing protein 0.027 0.027
CDC2 CDC2: Cell division control protein 2 homolog 0.027 0.047
ITSN2 ITSN2, KIAA1256, SH3D1B, SWAP: Intersectin-2 0.027 0.148
MAP3K7 MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7 0.027 0.047
PKN3 PKN3, PKNBETA: Serine/threonine-protein kinase N3 0.027 0.050
CDC2L1 CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1 0.027 0.052
PTPN6 PTPN6, HCP, PTP1C: Tyrosine-protein phosphatase non-receptor type 6 0.027 0.028
ABL2 ABL2, ABLL, ARG: Tyrosine-protein kinase ABL2 0.027 0.028
PKP4 PKP4: Plakophilin-4 0.027 0.083
MKNK2 MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2 0.027 0.047
PTK2B PTK2B, FAK2, PYK2, RAFTK: Protein tyrosine kinase 2 beta 0.027 0.025
0.228
Total Score 6.34E3