PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between CDC7 and MCM4

The interaction score between CDC7 and MCM4 is 7.83E3.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between CDC7 and MCM4 = 0.73

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.013

Orthology

Organism	CDC7 Orthologue		MCM4 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
bakers yeast	YDL017W	1	YPR019W	1	BiochemicalActivity Get References From PubMed
fly	Q9VJ90	0.181	Q26454	1
fly	Q9W3Y1	1	Q26454	1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593

Domains

Domains present in CDC7 and MCM4:

Domains in CDC7

Domains in MCM4

IPR000719	Protein kinase
IPR011009	Protein kinase-like
IPR008271	Serine/threonine protein kinase, active site

IPR008994	Nucleic acid-binding OB-fold
IPR001208	MCM
IPR008047	MCM protein 4

The Chi square scores for co-occurrence of domains that are present in CDC7 and MCM4 are listed below.

Domain 1		Domain 2		Chi Square
IPR000719	Protein kinase	IPR008994	Nucleic acid-binding OB-fold	8.03577
IPR011009	Protein kinase-like	IPR008994	Nucleic acid-binding OB-fold	3.26757
IPR000719	Protein kinase	IPR001208	MCM	1.68697
IPR008271	Serine/threonine protein kinase, active site	IPR008994	Nucleic acid-binding OB-fold	1.487
IPR011009	Protein kinase-like	IPR001208	MCM	0.165645
IPR008271	Serine/threonine protein kinase, active site	IPR001208	MCM	0.0171402

The background colour of the table refers to:

Blue Domain is only present in CDC7
Yellow Domain is only present in MCM4
Green Domain is present in both CDC7 and MCM4

0.028

Post-translational Modifications

Protein: CDC7

PTM	Residue	Reference
Phosphorylation	376	PubMed, HPRD

Protein: MCM4

PTM	Residue	Reference
Phosphorylation	7	PubMed, HPRD
Phosphorylation	19	PubMed, HPRD
Phosphorylation	32	PubMed, HPRD
Phosphorylation	54	PubMed, HPRD
Phosphorylation	110	PubMed, HPRD
Phosphorylation	326	PubMed, HPRD
Phosphoserine	326	HPRD

Localisation

Protein: CDC7

Localisation	Reference
Nucleus	HPRD
Cytoplasm	HPRD

Protein: MCM4

Localisation	Reference
Nucleus	HPRD
Nucleolus	HPRD

Transitive Score

The common interactors between CDC7 and MCM4 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CDC7 andMCM4. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CDC7 has 1406 interactors and MCM4 has 882 interactors of which there are 720 common interactors.

Common Interactor	Name of Common Interactor	Score for CDC7-Interactor (?)	Score for MCM4-Interactor (?)
MCM2	MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2	63.90	1.29E3
MCM3	MCM3: DNA replication licensing factor MCM3	63.90	1.29E3
COPB2	COPB2: Coatomer subunit beta'	10.00	0.046
CORO1C	CORO1C, CRNN4: Coronin-1C	7.66	0.046
CDK2	CDK2: Cell division protein kinase 2	4.15	0.276
MCM7	MCM7, CDC47, MCM2: DNA replication licensing factor MCM7	1.82	69.60
MCM6	MCM6: DNA replication licensing factor MCM6	1.82	69.60
MCM5	MCM5, CDC46: DNA replication licensing factor MCM5	1.10	0.263
ORC2L	ORC2L, ORC2: Origin recognition complex subunit 2	1.10	0.123
HMGN1	HMGN1, HMG14: Non-histone chromosomal protein HMG-14	0.515	0.087
HMGN2	HMGN2, HMG17: Non-histone chromosomal protein HMG-17	0.515	0.087
PSMA5	PSMA5: Proteasome subunit alpha type-5	0.461	0.066
CUL2	CUL2: Cullin-2	0.433	0.093
TOP2A	TOP2A, TOP2: DNA topoisomerase 2-alpha	0.430	0.923
ADPRT	PARP1, ADPRT, PPOL: Poly [ADP-ribose] polymerase 1	0.425	0.425
IMPDH2	IMPDH2, IMPD2: Inosine-5'-monophosphate dehydrogenase 2	0.385	0.066
THOC1	THOC1, HPR1: THO complex subunit 1	0.385	0.032
CTPS	CTPS: CTP synthase 1	0.385	0.141
MLH1	MLH1, COCA2: DNA mismatch repair protein Mlh1	0.385	0.141
PSMB7	PSMB7: Proteasome subunit beta type-7 precursor	0.372	0.040
PSMA2	PSMA2, PSC3: Proteasome subunit alpha type-2	0.372	0.040
PSMA3	PSMA3, PSC8: Proteasome subunit alpha type-3	0.372	0.066
ACP1	ACP1: Low molecular weight phosphotyrosine protein phosphatase	0.372	0.040
ATF1	ATF1: Cyclic AMP-dependent transcription factor ATF-1	0.307	0.063
STAT5A	STAT5A, STAT5: Signal transducer and activator of transcription 5A	0.275	0.067
CRKL	CRKL: Crk-like protein	0.275	0.032
PRKDC	PRKDC, HYRC, HYRC1: DNA-dependent protein kinase catalytic subunit	0.269	0.307
HSP90AB1	HSP90AB1, HSP90B, HSPC2, HSPCB: Heat shock protein HSP 90-beta	0.260	0.074
MYB	MYB: Myb proto-oncogene protein	0.260	0.052
ROCK1	ROCK1: Rho-associated protein kinase 1	0.251	0.0425
APPL	APPL1, APPL, DIP13A, KIAA1428: DCC-interacting protein 13-alpha	0.251	0.026
CAD	CAD: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	0.233	0.141
HSP90AA1	Hsp89-alpha-delta-N	0.233	0.040
CCNB1	Cyclin B1	0.233	1.62
CDC20	CDC20: Cell division cycle protein 20 homolog	0.233	0.276
NPM1	NPM1, NPM: Nucleophosmin	0.233	0.276
STAT5B	STAT5B: Signal transducer and activator of transcription 5B	0.225	0.054
PTEN	PTEN, MMAC1, TEP1: Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and du	0.225	0.046
ADRBK1	ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1	0.225	0.029
RB1	RB1: Retinoblastoma-associated protein	0.210	0.416
BRCA2	BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein	0.210	0.515
STAT2	STAT2: Signal transducer and activator of transcription 2	0.191	0.048
PLEKHA5	PLEKHA5, KIAA1686, PEPP2: Pleckstrin homology domain-containing family A member	0.191	0.026
PLEK	PLEK, P47: Pleckstrin	0.191	0.0425
BLNK	BLNK, BASH, SLP65: B-cell linker protein	0.191	0.027
SNF1LK2	SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2	0.188	0.078
PIP5K3	PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase	0.188	0.275
NAP1L1	NAP1L1, NRP: Nucleosome assembly protein 1-like 1	0.188	0.063
EIF2B5	EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon	0.188	0.275
NEK9	NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9	0.188	0.063
ATR	ATR, FRP1: Serine/threonine-protein kinase ATR	0.188	0.046
STAT1	STAT1: Signal transducer and activator of transcription 1-alpha/beta	0.165	0.047
STAT3		0.165	0.036
NF2	NF2, SCH: Merlin	0.165	0.028
EEF2K	EEF2K: Elongation factor 2 kinase	0.165	0.025
CREB1	CREB1: cAMP response element-binding protein	0.165	0.025
NSBP1	NSBP1: Nucleosome-binding protein 1	0.165	0.028
BIRC5	BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5	0.163	0.157
TRAF2	TRAF2, TRAP3: TNF receptor-associated factor 2	0.155	0.027
MPP6	MPP6, VAM1: MAGUK p55 subfamily member 6	0.155	0.036
CDC25A	CDC25A: M-phase inducer phosphatase 1	0.148	0.025
ELMO1	N/A	0.148	0.025
DUSP16	DUSP16, KIAA1700, MKP7: Dual specificity protein phosphatase 16	0.148	0.025
AKT3	AKT3: RAC-gamma serine/threonine-protein kinase	0.148	0.025
DUSP6	DUSP6, MKP3, PYST1: Dual specificity protein phosphatase 6	0.148	0.025
SSH2	SSH2, KIAA1725, SSH2L: Protein phosphatase Slingshot homolog 2	0.148	0.025
PDPK1	PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1	0.148	0.025
CDC25C	CDC25C: M-phase inducer phosphatase 3	0.148	0.025
RAN	RAN, ARA24, OK/SW-cl.81: GTP-binding nuclear protein Ran	0.146	0.141
DNMT1	DNMT1, AIM, DNMT: DNA	0.144	0.515
RBMX	RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G	0.144	0.269
BRCA1	BRCA1, RNF53: Breast cancer type 1 susceptibility protein	0.144	0.129
E2F1	E2F1, RBBP3: Transcription factor E2F1	0.144	0.852
BAZ1B	BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain	0.144	0.087
NACA	NACA, HSD48: Nascent polypeptide-associated complex subunit alpha	0.139	0.038
TRAP1	TRAP1, HSP75: Heat shock protein 75 kDa, mitochondrial precursor	0.139	0.032
CD2AP	CD2AP: CD2-associated protein	0.139	0.032
NMT1	NMT1, NMT: Glycylpeptide N-tetradecanoyltransferase 1	0.139	0.040
DOK1	DOK1: Docking protein 1	0.136	0.029
PRKD2	PRKD2, PKD2, HSPC187: Serine/threonine-protein kinase D2	0.136	0.029
STAT6	STAT6: Signal transducer and activator of transcription 6	0.136	0.033
AKT1	AKT1, PKB, RAC: RAC-alpha serine/threonine-protein kinase	0.136	0.029
SSB	SSB: Lupus La protein	0.129	0.241
TOPBP1	TOPBP1, KIAA0259: DNA topoisomerase 2-binding protein 1	0.129	0.129
SNRPD1	SNRPD1: Small nuclear ribonucleoprotein Sm D1	0.129	0.276
APEX1	APEX1, APE, APEX, APX, HAP1, REF1: DNA-(apurinic or apyrimidinic site) lyase	0.129	0.129
ANP32B	ANP32B, APRIL, PHAPI2: Acidic leucine-rich nuclear phosphoprotein 32 family memb	0.129	0.129
CCT6A	CCT6A, CCT6, CCTZ: T-complex protein 1 subunit zeta	0.129	0.066
MSH6	MSH6, GTBP: DNA mismatch repair protein MSH6	0.129	0.276
CDC6	CDC6, CDC18L: Cell division control protein 6 homolog	0.129	1.62
KIF11	N/A	0.129	0.276
UNG	N/A	0.129	0.129
MAD2L1	MAD2L1, MAD2: Mitotic spindle assembly checkpoint protein MAD2A	0.129	0.276
HMGB2	HMGB2, HMG2: High mobility group protein B2	0.129	0.276
CHEK1	CHEK1, CHK1: Serine/threonine-protein kinase Chk1	0.129	0.276
BLM	BLM, RECQ2, RECQL3: Bloom syndrome protein	0.129	0.461
CCT2	CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta	0.129	0.141
UBA2	SAE2, UBA2, HRIHFB2115, UBLE1B: SUMO-activating enzyme subunit 2	0.129	0.078
NUP153	N/A	0.129	0.129
TIMELESS	TIMELESS, TIM, TIM1, TIMELESS1: Protein timeless homolog	0.129	0.129
CBX3	CBX3: Chromobox protein homolog 3	0.129	0.129
LIG1	LIG1: DNA ligase 1	0.129	0.129
VRK1	VRK1: Serine/threonine-protein kinase VRK1	0.129	0.129
COPS3	COPS3, CSN3: COP9 signalosome complex subunit 3	0.129	0.066
CSPG6	SMC3, BAM, BMH, CSPG6, SMC3L1: Structural maintenance of chromosomes protein 3	0.129	0.129
PCNA	PCNA: Proliferating cell nuclear antigen	0.129	0.827
XPO1	XPO1, CRM1: Exportin-1	0.129	0.066
SFRS1	SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1	0.129	0.241
RACGAP1	RACGAP1, KIAA1478, MGCRACGAP: Rac GTPase-activating protein 1	0.129	0.141
ATAD2	ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2	0.129	0.503
SMARCA3	HLTF, HIP116A, RNF80, SMARCA3, SNF2L3, ZBU1: Helicase-like transcription factor	0.129	0.188
OSBPL11	OSBPL11, ORP11, OSBP12: Oxysterol-binding protein-related protein 11	0.123	0.026
STAT4	STAT4: Signal transducer and activator of transcription 4	0.123	0.028
TUBB	TUBB, TUBB5, OK/SW-cl.56: Tubulin beta chain	0.118	0.129
K-ALPHA-1	TUBA1B: Tubulin alpha-1B chain	0.118	0.078
IQGAP2	IQGAP2: Ras GTPase-activating-like protein IQGAP2	0.114	0.038
EIF4G2	EIF4G2, DAP5, OK/SW-cl.75: Eukaryotic translation initiation factor 4 gamma 2	0.114	0.038
GTF2B	GTF2B, TF2B, TFIIB: Transcription initiation factor IIB	0.114	0.275
FNBP1	N/A	0.114	0.046
IRAK1	IRAK1, IRAK: Interleukin-1 receptor-associated kinase 1	0.114	0.038
PA2G4	PA2G4, EBP1: Proliferation-associated protein 2G4	0.101	0.0479
HSF2	HSF2, HSTF2: Heat shock factor protein 2	0.0971	0.225
ARFGAP1	N/A	0.0971	0.0425
EIF4G1	EIF4G1, EIF4F, EIF4G, EIF4GI: Eukaryotic translation initiation factor 4 gamma 1	0.096	0.070
PIK3CD	PIK3CD: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta i	0.096	0.032
FRAP1	FRAP1, FRAP, FRAP2: FKBP12-rapamycin complex-associated protein	0.096	0.026
H1FX	H1FX: Histone H1x	0.096	0.152
KIF23	N/A	0.087	0.144
MKI67	MKI67: Antigen KI-67	0.087	0.307
RBM14	RBM14, SIP: RNA-binding protein 14	0.087	0.163
BARD1	BARD1: BRCA1-associated RING domain protein 1	0.087	0.276
IPO7	IPO7: Uncharacterized protein IPO7	0.087	0.027
TK1	TK1: Thymidine kinase, cytosolic	0.087	0.066
UBAP2	N/A	0.087	0.087
MATR3	MATR3, KIAA0723: Matrin-3	0.087	0.132
CENPA	CENPA: Histone H3-like centromeric protein A	0.087	0.307
SET	SET: Protein SET	0.087	0.087
TRIM28	TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta	0.087	0.144
PTMA	N/A	0.087	0.087
SMARCA4	SMARCA4, BRG1, SNF2B, SNF2L4: Probable global transcription activator SNF2L4	0.087	0.260
ESPL1	N/A	0.087	0.307
TOP2B	N/A	0.087	0.052
FANCA	FANCA, FAA, FACA, FANCH: Fanconi anemia group A protein	0.087	0.087
TCOF1	N/A	0.087	0.087
TUBA6	TUBA1C, TUBA6: Tubulin alpha-1C chain	0.087	0.063
CXorf9	N/A	0.086	0.029
DAXX	DAXX, BING2, DAP6: Death domain-associated protein 6	0.086	0.038
MAPK1	MAPK1, ERK2, PRKM1, PRKM2: Mitogen-activated protein kinase 1	0.086	0.029
MAPK12	MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12	0.086	0.038
HIST1H1E	HIST1H1E, H1F4: Histone H1.4	0.086	0.136
CCNH	CCNH: Cyclin-H	0.086	0.225
CCNL1	CCNL1, BM-001, UNQ530/PRO1073: Cyclin-L1	0.086	0.136
BID	BID: BH3-interacting domain death agonist	0.083	0.028
MAPK15	N/A	0.083	0.028
NFATC2	NFATC2, NFAT1, NFATP: Nuclear factor of activated T-cells, cytoplasmic 2	0.083	0.028
HMGA1	HMGA1, HMGIY: High mobility group protein HMG-I/HMG-Y	0.083	0.028
NFATC3	NFATC3, NFAT4: Nuclear factor of activated T-cells, cytoplasmic 3	0.083	0.028
MAPK9	MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9	0.083	0.028
MAP4K1	MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1	0.080	0.070
SFRS10	SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10	0.078	0.146
SSRP1	SSRP1, FACT80: FACT complex subunit SSRP1	0.078	0.276
MYBL2	MYBL2, BMYB: Myb-related protein B	0.078	0.276
PABPC4	PABPC4, APP1, PABP4: Polyadenylate-binding protein 4	0.078	0.146
SKIIP	SNW1, SKIIP, SKIP: SNW domain-containing protein 1	0.078	0.078
WRN	WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase	0.078	0.461
EIF5B	EIF5B, IF2, KIAA0741: Eukaryotic translation initiation factor 5B	0.078	0.040
MDN1	MDN1, KIAA0301: Midasin	0.078	0.275
CDC23	CDC23: Cell division cycle protein 23 homolog	0.078	0.066
CDK4	CDK4: Cell division protein kinase 4	0.078	0.276
EPRS	EPRS, GLNS, PARS, QARS, QPRS: Bifunctional aminoacyl-tRNA synthetase [Includes:	0.078	0.066
CGI-48	UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho	0.078	0.078
CCT4	CCT4, CCTD, SRB: T-complex protein 1 subunit delta	0.078	0.066
SNRPD3	SNRPD3: Small nuclear ribonucleoprotein Sm D3	0.078	0.129
TIAL1	TIAL1: Nucleolysin TIAR	0.078	0.146
LDHB	LDHB: L-lactate dehydrogenase B chain	0.078	0.040
ANAPC5	ANAPC5, APC5: Anaphase-promoting complex subunit 5	0.078	0.078
SNRPC	SNRPC: U1 small nuclear ribonucleoprotein C	0.078	0.129
NOL1	N/A	0.078	0.078
ZNF330	ZNF330, NOA36: Zinc finger protein 330	0.078	0.078
HDAC2	HDAC2: Histone deacetylase 2	0.078	0.078
ORC1L	ORC1L, ORC1, PARC1: Origin recognition complex subunit 1	0.078	0.763
LMNB1	LMNB1, LMN2, LMNB: Lamin-B1	0.078	0.276
SYNCRIP	SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q	0.078	0.241
ZCCHC8	ZCCHC8: Zinc finger CCHC domain-containing protein 8	0.078	0.078
H2AFX	H2AFX, H2AX: Histone H2A.x	0.078	0.276
WDHD1	WDHD1, AND1: WD repeat and HMG-box DNA-binding protein 1	0.078	0.078
PABPN1	PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2	0.078	0.146
AURKA	AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6	0.078	0.129
PBK	PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase	0.078	0.129
YBX1	YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1	0.078	0.461
EIF2S1	EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1	0.078	0.763
CSTF1	CSTF1: Cleavage stimulation factor 50 kDa subunit	0.078	0.078
G3BP	G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1	0.078	0.185
HSPH1	HSPH1, HSP105, HSP110, KIAA0201: Heat shock protein 105 kDa	0.078	0.040
FRG1	FRG1: Protein FRG1	0.078	0.032
CCT8	CCT8: Uncharacterized protein CCT8	0.078	0.066
TRIP13	TRIP13: Thyroid receptor-interacting protein 13	0.078	0.503
SFRS2	SFRS2: Splicing factor, arginine/serine-rich 2	0.078	0.146
SUZ12	SUZ12, CHET9, JJAZ1, KIAA0160: Polycomb protein SUZ12	0.078	0.078
EIF3S9	EIF3S9: Eukaryotic translation initiation factor 3 subunit 9	0.078	0.241
WEE1	WEE1: Wee1-like protein kinase	0.078	0.129
HSPD1		0.078	0.141
CHAF1B	CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B	0.078	0.276
TCF3	TCF3, E2A, ITF1: Transcription factor E2-alpha	0.078	0.078
RRM2	RRM2, RR2: Ribonucleoside-diphosphate reductase subunit M2	0.078	0.423
TDG	TDG: G/T mismatch-specific thymine DNA glycosylase	0.078	0.078
POLA2	POLA2: DNA polymerase subunit alpha B	0.078	0.276
RIPK1	RIPK1, RIP: Receptor-interacting serine/threonine-protein kinase 1	0.077	0.026
HUWE1	HUWE1, KIAA0312, HSPC272, KIAA1578, UREB1: E3 ubiquitin-protein ligase HUWE1	0.077	0.0425
TRAFD1	TRAFD1, FLN29: TRAF-type zinc finger domain-containing protein 1	0.077	0.032
LATS1	LATS1, WARTS: Serine/threonine-protein kinase LATS1	0.075	0.025
C10orf9	CCNY, C10orf9, CBCP1, CFP1: Cyclin-Y	0.075	0.148
CCNE1	CCNE1, CCNE: G1/S-specific cyclin-E1	0.075	0.148
LATS2	LATS2, KPM: Serine/threonine-protein kinase LATS2	0.075	0.025
RBL1	RBL1: Retinoblastoma-like protein 1	0.075	0.148
HIST1H1C	HIST1H1C, H1F2: Histone H1.2	0.075	0.148
CCNT2	CCNT2: Cyclin-T2	0.075	0.148
KIAA1804	MLK4, KIAA1804: Mitogen-activated protein kinase kinase kinase	0.075	0.025
NEK8	NEK8, JCK, NEK12A: Serine/threonine-protein kinase Nek8	0.075	0.025
PLK1	PLK1, PLK: Serine/threonine-protein kinase PLK1	0.075	0.148
TUBA1	TUBA4A, TUBA1: Tubulin alpha-4A chain	0.071	0.046
NRAS	NRAS, HRAS1: GTPase NRas precursor	0.071	0.032
GIT1	GIT1: ARF GTPase-activating protein GIT1	0.071	0.029
RNPS1	RNPS1, LDC2: RNA-binding protein with serine-rich domain 1	0.070	0.132
ABCF1	N/A	0.070	0.087
RANGAP1	RANGAP1, SD: Ran GTPase-activating protein 1	0.070	0.0446
MNAR	PELP1, HMX3, MNAR: Proline-, glutamic acid- and leucine-rich protein 1	0.070	0.036
KIF22	KIF22, KID, KNSL4: Kinesin-like protein KIF22	0.070	0.087
API5	N/A	0.070	0.070
HNRPA0	HNRPA0: Heterogeneous nuclear ribonucleoprotein A0	0.070	0.132
XRCC6	XRCC6, G22P1: ATP-dependent DNA helicase 2 subunit 1	0.070	0.087
CHD4	CHD4: Chromodomain-helicase-DNA-binding protein 4	0.070	0.260
TERF2	TERF2, TRBF2, TRF2: Telomeric repeat-binding factor 2	0.070	0.0425
FUBP1	N/A	0.070	0.124
KIAA0853	N/A	0.070	0.052
STOML2	STOML2, SLP2, HSPC108: Stomatin-like protein 2	0.070	0.074
CHUK	N/A	0.070	0.052
ZNF638	ZNF638, NP220, ZFML: Zinc finger protein 638	0.070	0.052
NBN	NBN, NBS, NBS1, P95: Nibrin	0.070	0.087
USP24	USP24, KIAA1057: Ubiquitin carboxyl-terminal hydrolase 24	0.070	0.052
NME1	NME1, NDPKA, NM23: Nucleoside diphosphate kinase A	0.070	0.074
DDX46	DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46	0.070	0.210
DDX21	DDX21: Nucleolar RNA helicase 2	0.070	0.260
UBAP2L	UBAP2L, KIAA0144, NICE4: Ubiquitin-associated protein 2-like	0.070	0.087
KIAA0528	KIAA0528: Uncharacterized protein KIAA0528	0.070	0.052
AOF2	AOF2, KIAA0601, LSD1: Lysine-specific histone demethylase 1	0.070	0.087
RBL2	RBL2, RB2: Retinoblastoma-like protein 2	0.069	0.111
HIST1H1B	HIST1H1B, H1F5: Histone H1.5	0.069	0.136
HIST1H1D	HIST1H1D, H1F3: Histone H1.3	0.069	0.136
STK3	STK3, MST2: Serine/threonine-protein kinase 3	0.069	0.038
PSMC1	PSMC1: 26S protease regulatory subunit 4	0.063	0.304
SAFB	SAFB, HAP, HET, SAFB1: Scaffold attachment factor B	0.063	0.118
STAG2	STAG2, SA2: Cohesin subunit SA-2	0.063	0.063
LAMR1	RPSA, LAMBR, LAMR1: 40S ribosomal protein SA	0.063	0.032
MTHFD1	MTHFD1, MTHFC, MTHFD: C-1-tetrahydrofolate synthase, cytoplasmic	0.063	0.141
YARS	YARS: Tyrosyl-tRNA synthetase, cytoplasmic	0.063	0.461
CSTF2T	CSTF2T, KIAA0689: Cleavage stimulation factor 64 kDa subunit, tau variant	0.063	0.087
HNRPF	HNRPF: Heterogeneous nuclear ribonucleoprotein F	0.063	0.241
EIF2S3	EIF2S3, EIF2G: Eukaryotic translation initiation factor 2 subunit 3	0.063	0.040
REXO2	REXO2, SFN, CGI-114, SMFN: Oligoribonuclease, mitochondrial precursor	0.063	0.046
MRE11A	MRE11A, HNGS1, MRE11: Double-strand break repair protein MRE11A	0.063	0.063
AKAP8	AKAP8, AKAP95: A-kinase anchor protein 8	0.063	0.046
CPSF1	CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1	0.063	0.063
SFRS6	SFRS6, SRP55: Splicing factor, arginine/serine-rich 6	0.063	0.087
PRPF4B	PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol	0.063	0.046
FXR1	FXR1: Fragile X mental retardation syndrome-related protein 1	0.063	0.304
TXNL1	TXNL1, TRP32, TXL, TXNL: Thioredoxin-like protein 1	0.063	0.040
RBM15	RBM15, OTT: Putative RNA-binding protein 15	0.063	0.118
ELAVL1	ELAVL1, HUR: ELAV-like protein 1	0.063	0.241
SFRS4	SFRS4, SRP75: Splicing factor, arginine/serine-rich 4	0.063	0.146
MTA1	MTA1: Metastasis-associated protein MTA1	0.063	0.372
HDGF	HDGF, HMG1L2: Hepatoma-derived growth factor	0.063	0.078
SPEN	SPEN, KIAA0929, MINT, SHARP: Msx2-interacting protein	0.063	0.087
PAK1IP1	PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1	0.063	0.078
KHDRBS1	KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate	0.063	0.233
QARS	QARS: Glutaminyl-tRNA synthetase	0.063	0.032
PSMD11	PSMD11: 26S proteasome non-ATPase regulatory subunit 11	0.063	0.066
CSNK2A1	CSNK2A1: CSNK2A1 protein	0.063	0.129
PKN2	PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2	0.063	0.038
PTPN11	N/A	0.063	0.032
SNRPB2	SNRPB2: U2 small nuclear ribonucleoprotein B''	0.063	0.241
KPNA2	KPNA2, RCH1, SRP1: Importin subunit alpha-2	0.063	0.040
PKMYT1	PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito	0.063	0.078
SMC1L1	SMC1A, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1: Structural maintenance of chromos	0.063	0.276
NCOR1	NCOR1, KIAA1047: Nuclear receptor corepressor 1	0.063	0.046
KIAA0788	ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase	0.063	0.233
PPIA	PPIA, CYPA: Peptidyl-prolyl cis-trans isomerase A	0.063	0.032
PPID	PPID, CYP40, CYPD: 40 kDa peptidyl-prolyl cis-trans isomerase	0.063	0.032
PAPOLA	PAPOLA, PAP: Poly(A) polymerase alpha	0.063	0.063
LSM2	LSM2, C6orf28, G7b: U6 snRNA-associated Sm-like protein LSm2	0.063	0.129
HDAC3	HDAC3: Histone deacetylase 3	0.063	0.129
EIF2S2	EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2	0.063	0.461
SMARCA5	SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul	0.063	0.233
ME2	ME2: NAD-dependent malic enzyme, mitochondrial precursor	0.063	0.032
OXSR1	OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1	0.063	0.078
RUNX1	N/A	0.063	0.038
YEATS2	KIAA1197, YEATS2: YEATS domain-containing protein 2	0.063	0.063
CASP3	CASP3, CPP32: Caspase-3 precursor	0.063	0.032
PPP1R8	N/A	0.063	0.063
PHF10	N/A	0.063	0.046
BTAF1	BTAF1, TAF172: TATA-binding protein-associated factor 172	0.063	0.139
TAF6	TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6	0.063	0.063
MDM4	MDM4, MDMX: Mdm4 protein	0.062	0.026
GRLF1	N/A	0.062	0.026
ERF	ERF: ETS domain-containing transcription factor ERF	0.062	0.191
MGMT	MGMT: Methylated-DNA--protein-cysteine methyltransferase	0.062	0.100
BATF	BATF: Basic leucine zipper transcriptional factor ATF-like	0.060	0.052
HIST1H1A	HIST1H1A, H1F1: Histone H1.1	0.056	0.111
CDK5R1	CDK5R1, CDK5R, NCK5A: Cyclin-dependent kinase 5 activator 1 precursor	0.056	0.097
ETV1	ETV1, ER81: ETS translocation variant 1	0.055	0.098
HSF1	HSF1, HSTF1: Heat shock factor protein 1	0.054	0.225
MINK1	MAP4K6, MINK1, MINK: Misshapen-like kinase 1	0.052	0.028
RAB4A	N/A	0.052	0.028
HD	HD, IT15: Huntingtin	0.052	0.036
MYBBP1A	MYBBP1A, P160: Myb-binding protein 1A	0.052	0.052
ZNF318	ZNF318, HRIHFB2436: Zinc finger protein 318	0.052	0.087
FNBP4	FNBP4, FBP30, KIAA1014: Formin-binding protein 4	0.052	0.0425
EIF5AP1	EIF5A: Eukaryotic translation initiation factor 5A-1	0.052	0.416
STIP1	STIP1: Stress-induced-phosphoprotein 1	0.052	0.074
UBTF	UBTF, UBF, UBF1: Nucleolar transcription factor 1	0.052	0.070
RDBP	RDBP, NELFE, RD: Negative elongation factor E	0.052	0.0971
TGIF2	TGIF2: Homeobox protein TGIF2	0.052	0.052
GNB2L1	Lung cancer oncogene 7	0.052	0.052
RBM6	RBM6, DEF3: RNA-binding protein 6	0.052	0.048
SREBF2	N/A	0.052	0.070
PHF3	PHF3, KIAA0244: PHD finger protein 3	0.052	0.0425
SFRS15	SFRS15, KIAA1172: Splicing factor, arginine/serine-rich 15	0.052	0.048
SH2BP1	CTR9, KIAA0155, SH2BP1: RNA polymerase-associated protein CTR9 homolog	0.052	0.052
PASK	PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase	0.052	0.0425
PHB2	PHB2, BAP, REA: Prohibitin-2	0.052	0.036
YWHAQ	YWHAQ: 14-3-3 protein theta	0.052	0.027
MAPK6	MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6	0.052	0.087
SNAPC4	SNAPC4, SNAP190: snRNA-activating protein complex subunit 4	0.052	0.0425
TP53BP1	TP53BP1: Tumor suppressor p53-binding protein 1	0.052	0.0425
TRRAP	N/A	0.052	0.0425
BAZ2A	BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A	0.052	0.046
ERG	ERG: Transcriptional regulator ERG	0.052	0.191
JMJD1A	JMJD1A, JHDM2A, JMJD1, KIAA0742: JmjC domain-containing histone demethylation pr	0.052	0.0425
MYST4	MYST4, KIAA0383, MORF, MOZ2: Histone acetyltransferase MYST4	0.049	0.097
CCND1	CCND1, BCL1, PRAD1: G1/S-specific cyclin-D1	0.049	0.111
GIT2	N/A	0.047	0.025
H2-ALPHA	TUBA3C, TUBA2, TUBA3D: Tubulin alpha-3C/D chain	0.047	0.025
USP34	USP34, KIAA0570, KIAA0729: Ubiquitin carboxyl-terminal hydrolase 34	0.046	0.029
CLTC	CLTC, CLH17, CLTCL2, KIAA0034: Clathrin heavy chain 1	0.046	0.063
TP53	TP53, P53: Cellular tumor antigen p53	0.046	0.241
DDX41	DDX41, ABS: Probable ATP-dependent RNA helicase DDX41	0.046	0.139
STK24	STK24, MST3, STK3: Serine/threonine-protein kinase 24	0.046	0.063
USP7	USP7, HAUSP: Ubiquitin carboxyl-terminal hydrolase 7	0.046	0.032
RPS6KB1	N/A	0.046	0.046
KIAA0664	KIAA0664: Putative eukaryotic translation initiation factor 3 subunit	0.046	0.032
MAPRE1	MAPRE1: Microtubule-associated protein RP/EB family member 1	0.046	0.040
MBD3	MBD3: Methyl-CpG-binding domain protein 3	0.046	0.046
SP3	SP3: Transcription factor Sp3	0.046	0.038
RPA2	RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit	0.046	0.225
CUL5	CUL5, VACM1: Cullin-5	0.046	0.038
DDX3Y	DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y	0.046	0.086
PSMC2	PSMC2, MSS1: 26S protease regulatory subunit 7	0.046	0.304
WBSCR20A	N/A	0.046	0.038
IEF-SSP-9502	PWP1: Periodic tryptophan protein 1 homolog	0.046	0.063
EXOSC2	EXOSC2, RRP4: Exosome complex exonuclease RRP4	0.046	0.275
PSMD1	PSMD1: 26S proteasome non-ATPase regulatory subunit 1	0.046	0.078
PSMD4	PSMD4, MCB1: 26S proteasome non-ATPase regulatory subunit 4	0.046	0.063
ACIN1	ACIN1, ACINUS, KIAA0670: Apoptotic chromatin condensation inducer in the nucleus	0.046	0.087
EP300	N/A	0.046	0.038
TSC1	TSC1, KIAA0243, TSC: Hamartin	0.046	0.029
NOC2L	NOC2L: Nucleolar complex protein 2 homolog	0.046	0.046
GSR	GSR, GLUR, GRD1: Glutathione reductase, mitochondrial precursor	0.046	0.040
FKBP4	FKBP4: FK506-binding protein 4	0.046	0.046
GTF2F1	GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha	0.046	0.461
MAP2K2	MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki	0.046	0.032
ETV6	ETV6, TEL, TEL1: Transcription factor ETV6	0.046	0.275
TOP3A	TOP3A, TOP3: DNA topoisomerase 3-alpha	0.046	0.038
USP10	USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10	0.046	0.032
THOP1	THOP1: Thimet oligopeptidase	0.046	0.040
DHX16	DHX16, DBP2, DDX16, KIAA0577: Putative pre-mRNA-splicing factor ATP-dependent RN	0.046	0.114
EIF3S8	EIF3S8: Eukaryotic translation initiation factor 3 subunit 8	0.046	0.040
HNRPK	N/A	0.046	0.040
RREB1	RREB1, FINB: RAS-responsive element-binding protein 1	0.046	0.038
SAPS3	N/A	0.046	0.038
SND1	SND1, TDRD11: Staphylococcal nuclease domain-containing protein 1	0.046	0.046
PABPC1	PABPC1, PAB1, PABP1, PABPC2: Polyadenylate-binding protein 1	0.046	0.071
EIF3S2	EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2	0.046	0.063
KIAA0683	DKFZp434A073, DKFZp434I062, KIAA0683, TELO2, hCG_42688: Putative uncharacterized	0.046	0.038
ZNF24	ZNF24, KOX17, ZNF191, ZSCAN3: Zinc finger protein 24	0.046	0.029
RARS	RARS: Arginyl-tRNA synthetase, cytoplasmic	0.046	0.040
SNRP70	SNRP70, RNPU1Z, RPU1, U1AP1: U1 small nuclear ribonucleoprotein 70 kDa	0.046	0.054
KLF1	KLF1, EKLF: Krueppel-like factor 1	0.046	0.046
HDAC1	HDAC1, RPD3L1: Histone deacetylase 1	0.046	0.063
YY1	YY1: Transcriptional repressor protein YY1	0.046	0.063
ABCC1	ABCC1, MRP, MRP1: Multidrug resistance-associated protein 1	0.044	0.062
TLK1	TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1	0.0425	0.052
DRIM	UTP20, DRIM: Small subunit processome component 20 homolog	0.0425	0.0425
NEK1	NEK1, KIAA1901: Serine/threonine-protein kinase Nek1	0.0425	0.032
SFRS5	SFRS5, HRS, SRP40: Splicing factor, arginine/serine-rich 5	0.0425	0.043
GTF2F2	N/A	0.0425	0.251
ZNF148	ZNF148, ZBP89: Zinc finger protein 148	0.0425	0.032
ITGB1BP1	ITGB1BP1, ICAP1: Integrin beta-1-binding protein 1	0.0425	0.0425
ELF1	ELF1: ETS-related transcription factor Elf-1	0.0425	0.251
COIL	COIL, CLN80: Coilin	0.0425	0.0425
IKBKG	IKBKG, FIP3, NEMO: NF-kappa-B essential modulator	0.0425	0.052
RBM3	RBM3, RNPL: Putative RNA-binding protein 3	0.0425	0.0971
SMARCC2	N/A	0.0425	0.0425
RFXDC2	RFXDC2: Regulatory factor X domain-containing protein 2.	0.0425	0.0425
HIVEP1	N/A	0.0425	0.032
XRCC1	XRCC1: DNA-repair protein XRCC1	0.0425	0.052
TERF1	TERF1, PIN2, TRBF1, TRF, TRF1: Telomeric repeat-binding factor 1	0.0425	0.032
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	0.038	0.038
PRDX1	PRDX1, PAGA, PAGB, TDPX2: Peroxiredoxin-1	0.038	0.032
TOPORS	TOPORS, LUN, TP53BPL: E3 ubiquitin-protein ligase Topors	0.038	0.038
KLHDC4	N/A	0.038	0.038
WBSCR1	EIF4H, KIAA0038, WBSCR1, WSCR1: Eukaryotic translation initiation factor 4H	0.038	0.118
CDK7	CDK7, MO15: Cell division protein kinase 7	0.038	0.063
AKAP8L	AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like	0.038	0.038
SF3B1	SF3B1, SAP155: Splicing factor 3B subunit 1	0.038	0.038
SF3B4	SF3B4, SAP49: Splicing factor 3B subunit 4	0.038	0.118
STK11	STK11, LKB1, PJS: Serine/threonine-protein kinase 11	0.038	0.038
SOX4	SOX4: Transcription factor SOX-4	0.038	0.029
TAL1	TAL1, SCL, TCL5: T-cell acute lymphocytic leukemia protein 1	0.038	0.038
POLR2A	POLR2A: Uncharacterized protein POLR2A	0.038	0.114
CRKRS	CRKRS, CRK7, KIAA0904: Cell division cycle 2-related protein kinase 7	0.038	0.029
ZNF551	N/A	0.038	0.029
PIK4CB	PIK4CB, RP11-126K1.4-003, hCG_1811976: Phosphatidylinositol 4-kinase, catalytic,	0.038	0.029
GMCL1L	GMCL1L, GCL: Germ cell-less protein-like 1-like	0.038	0.029
DICER1	DICER1, DICER, HERNA, KIAA0928: Endoribonuclease Dicer	0.038	0.114
SRF	SRF: Serum response factor	0.038	0.046
KIAA1012	KIAA1012: Protein TRS85 homolog	0.038	0.029
DUSP22	DUSP22, JSP1, MKPX: Dual specificity protein phosphatase 22	0.038	0.029
STK25	STK25, SOK1, YSK1: Serine/threonine-protein kinase 25	0.038	0.029
RBM8A	RBM8A, RBM8, HSPC114, MDS014: RNA-binding protein 8A	0.038	0.054
HGS	HGS, HRS: Hepatocyte growth factor-regulated tyrosine kinase substrate	0.038	0.029
CSDA	CSDA, DBPA: DNA-binding protein A	0.038	0.275
MAFG	MAFG: Transcription factor MafG	0.038	0.046
ERCC3	ERCC3, XPB, XPBC: TFIIH basal transcription factor complex helicase XPB subunit	0.038	0.086
SEC24C	SEC24C, KIAA0079: Protein transport protein Sec24C	0.038	0.046
MTF1	MTF1: Metal regulatory transcription factor 1	0.038	0.029
CUL4B	N/A	0.038	0.029
DDX3X	DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X	0.038	0.139
DIAPH1	Diaphanous 1	0.038	0.029
VCP	VCP: Transitional endoplasmic reticulum ATPase	0.038	0.245
WDR79	N/A	0.038	0.046
SMAD2	SMAD2, MADH2, MADR2: Mothers against decapentaplegic homolog 2	0.038	0.063
FHOD1	FHOD1, FHOS, FHOS1: FH1/FH2 domain-containing protein 1	0.038	0.038
CARS	CARS: Cysteinyl-tRNA synthetase, cytoplasmic	0.038	0.032
CRSP2	MED14, ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170: Mediator of RNA pol	0.038	0.046
BRD3	BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3	0.038	0.029
BRD2	BRD2, KIAA9001, RING3: Bromodomain-containing protein 2	0.038	0.038
CDK6	CDK6: Cell division protein kinase 6	0.038	0.038
ENO1	ENO1, ENO1L1, MBPB1, MPB1: Alpha-enolase	0.038	0.032
DDX51	DDX51: ATP-dependent RNA helicase DDX51	0.038	0.046
HTATSF1	HTATSF1: HIV Tat-specific factor 1	0.038	0.071
SKIV2L	SKIV2L, XXbac-BCX116I9.5-001, XXbac-BPG116M5.1-001: Superkiller viralicidic acti	0.038	0.114
NR5A1	NR5A1, AD4BP, FTZF1, SF1: Steroidogenic factor 1	0.038	0.029
GCN5L2	GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2	0.038	0.029
UTX	UTX: Ubiquitously transcribed X chromosome tetratricopeptide repeat protein	0.038	0.029
DDX5	DDX5, G17P1, HELR, HLR1: Probable ATP-dependent RNA helicase DDX5	0.038	0.086
HIRA	HIRA, DGCR1, HIR, TUPLE1: Protein HIRA	0.038	0.038
GPI	GPI: Glucose-6-phosphate isomerase	0.038	0.040
STK38L	STK38L, KIAA0965, NDR2: Serine/threonine-protein kinase 38-like	0.038	0.038
RBMX2	RBMX2, CGI-79: RNA-binding motif protein, X-linked 2	0.038	0.071
RANBP9	RANBP9, RANBPM: Ran-binding protein 9	0.038	0.038
PLK4	PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4	0.038	0.207
CCNA2	CCNA2, CCN1, CCNA: Cyclin-A2	0.038	0.789
EIF5	EIF5: Eukaryotic translation initiation factor 5	0.036	0.086
ABCB9	ABCB9, KIAA1520: ATP-binding cassette sub-family B member 9 precursor	0.034	0.062
MAP3K5	MAP3K5, ASK1, MAPKKK5, MEKK5: Mitogen-activated protein kinase kinase kinase 5	0.032	0.032
TERF2IP	TERF2IP, RAP1, PP8000: Telomeric repeat-binding factor 2-interacting protein 1	0.032	0.032
VAV2	VAV2, RP11-153P4.1-003: Vav 2 oncogene	0.032	0.027
PER2	PER2, KIAA0347: Period circadian protein homolog 2	0.032	0.026
NR3C1	NR3C1, GRL: Glucocorticoid receptor	0.032	0.052
ZAK	MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT	0.032	0.026
ZNF267	ZNF267: Zinc finger protein 267	0.032	0.052
STRN3	STRN3, GS2NA, SG2NA: Striatin-3	0.032	0.026
EMD	EMD, EDMD, STA: Emerin	0.032	0.0425
AFF1	N/A	0.032	0.052
SP100	N/A	0.032	0.032
SRPR	SRPR: Uncharacterized protein SRPR	0.032	0.166
IRF3	IRF3: Interferon regulatory factor 3	0.032	0.191
ZNF217	ZNF217, ZABC1: Zinc finger protein 217	0.032	0.029
ZFX	ZFX: Zinc finger X-chromosomal protein	0.032	0.032
PRKR	EIF2AK2, PKR, PRKR: Interferon-induced, double-stranded RNA-activated protein ki	0.032	0.032
XRCC4	N/A	0.032	0.032
NCOA3	N/A	0.032	0.0425
REST	REST, NRSF, XBR: RE1-silencing transcription factor	0.032	0.026
BRIP1	BRIP1, BACH1, FANCJ: Fanconi anemia group J protein	0.032	0.086
CEP170	CEP170, FAM68A, KAB, KIAA0470: Centrosomal protein of 170 kDa	0.032	0.026
IFI16	N/A	0.032	0.0425
PPARA	PPARA, NR1C1, PPAR: Peroxisome proliferator-activated receptor alpha	0.032	0.026
PHF8	PHF8, KIAA1111, ZNF422: PHD finger protein 8	0.032	0.026
MAP2K3	MAP2K3, MEK3, MKK3, PRKMK3: Dual specificity mitogen-activated protein kinase ki	0.032	0.0425
POU2F1	POU2F1, OCT1, OTF1: POU domain, class 2, transcription factor 1	0.032	0.032
PTGES3	PTGES3, P23, TEBP: Prostaglandin E synthase 3	0.030	0.025
ARMET	ARMET, ARP: Protein ARMET precursor	0.029	0.029
JARID1A	JARID1A, RBBP2, RBP2: Histone demethylase JARID1A	0.029	0.029
FOXO3A	FOXO3A, FKHRL1: Forkhead box protein O3A	0.029	0.171
SGTA	SGTA, SGT: Small glutamine-rich tetratricopeptide repeat-containing protein A	0.029	0.029
RBM7		0.029	0.087
HIST1H3A	HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD,	0.029	0.029
HDAC6	HDAC6, JM21: Histone deacetylase 6	0.029	0.029
FKBP5	FKBP5, AIG6, FKBP51: FK506-binding protein 5	0.029	0.046
PCBP1	PCBP1: Poly(rC)-binding protein 1	0.029	0.0818
METTL1	METTL1, C12orf1: tRNA	0.029	0.038
DDX24	DDX24: ATP-dependent RNA helicase DDX24	0.029	0.086
PCBP2	PCBP2: Poly(rC)-binding protein 2	0.029	0.0818
GNB1	GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0.029	0.029
RPS6KB2	RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2	0.029	0.038
GGCX	GGCX, GC: Vitamin K-dependent gamma-carboxylase	0.029	0.038
FZR1	N/A	0.029	0.038
SYMPK	SYMPK, SPK: Symplekin	0.029	0.046
TAOK3	TAOK3, DPK, JIK, KDS, MAP3K18: Serine/threonine-protein kinase TAO3	0.029	0.029
TAF10	TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10	0.029	0.038
PPP1R12A	PPP1R12A, MBS, MYPT1: Protein phosphatase 1 regulatory subunit 12A	0.029	0.029
GATA2	N/A	0.029	0.029
SEC31L1	N/A	0.029	0.029
EIF3S4	EIF3S4: Eukaryotic translation initiation factor 3 subunit 4	0.029	0.054
SCYL3	SCYL3, PACE1: Protein-associating with the carboxyl-terminal domain of ezrin	0.029	0.029
GSK3B	N/A	0.029	0.029
RPS6KA1	RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1	0.029	0.029
PCAF	PCAF: Histone acetyltransferase PCAF	0.029	0.029
ARNT	ARNT: Aryl hydrocarbon receptor nuclear translocator	0.028	0.028
SMARCAD1	SMARCAD1, KIAA1122: SWI/SNF-related matrix-associated actin-dependent regulator	0.028	0.083
WDR54	N/A	0.028	0.028
NEK6	NEK6: Serine/threonine-protein kinase Nek6	0.028	0.025
NIPA1	NIPA1: Non-imprinted in Prader-Willi/Angelman syndrome region protein 1	0.028	0.028
ZNF265	N/A	0.028	0.028
CUTL1	CUTL1: Homeobox protein cut-like 1	0.028	0.028
KIAA1443	HOMEZ, KIAA1443: Homeobox and leucine zipper protein Homez	0.028	0.028
TMPO	TMPO, LAP2: Lamina-associated polypeptide 2 isoform alpha	0.028	0.028
JDP2	jdp2, JDP2: Jun dimerization protein 2	0.028	0.028
SFRS9	SFRS9, SRP30C: Splicing factor, arginine/serine-rich 9	0.028	0.047
DSP	DSP: Desmoplakin	0.028	0.028
HDAC8	N/A	0.028	0.028
TFAP4	TFAP4: Transcription factor AP-4	0.028	0.025
BCOR	N/A	0.028	0.025
ZC3HAV1	ZC3HAV1, ZC3HDC2, PRO1677: Zinc finger CCCH type antiviral protein 1	0.028	0.028
ZNF687	ZNF687, KIAA1441: Zinc finger protein 687	0.028	0.028
TCF20	TCF20, KIAA0292, SPBP: Transcription factor 20	0.028	0.028
PHLDB2	N/A	0.028	0.028
ATXN2L	ATXN2L, A2D, A2LG, A2LP, A2RP: Ataxin-2-like protein	0.028	0.028
MLL2	MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2	0.028	0.028
UHRF1		0.028	0.028
CDC2	CDC2: Cell division control protein 2 homolog	0.028	0.025
CCAR1	CCAR1, CARP1, DIS: Cell division cycle and apoptosis regulator protein 1	0.028	0.028
FOXM1	FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1	0.028	0.165
FBXO4	FBXO4, FBX4: F-box only protein 4	0.028	0.028
ZFP91	ZFP91, FKSG11: Zinc finger protein 91 homolog	0.028	0.028
TRERF1	TRERF1, BCAR2, RAPA, TREP132: Transcriptional-regulating factor 1	0.028	0.025
SYTL4	Endocrine transmitter regulatory protein	0.028	0.028
DKFZp434K1815	DKFZp434K1815, hCG_1736780: Putative uncharacterized protein DKFZp434K1815	0.028	0.028
ZNF644	ZNF644, KIAA1221, ZEP2: Zinc finger protein 644	0.028	0.028
ZCCHC3	ZCCHC3, C20orf99: Zinc finger CCHC domain-containing protein 3	0.028	0.028
KIF1B	N/A	0.028	0.028
POGZ	POGZ, KIAA0461, Nbla00003: Pogo transposable element with ZNF domain	0.028	0.028
RAVER1	RAVER1, KIAA1978: Ribonucleoprotein PTB-binding 1	0.028	0.052
AR	AR, DHTR, NR3C4: Androgen receptor	0.028	0.028
CABLES1	N/A	0.028	0.028
CDC2L2	CDC2L2, CDC2L3, PITSLREB: PITSLRE serine/threonine-protein kinase CDC2L2	0.028	0.028
FLJ21816	PALB2, FANCN: Partner and localizer of BRCA2	0.028	0.028
HNRPK	HNRPK, HNRNPK: Heterogeneous nuclear ribonucleoprotein K	0.028	0.049
ELF2	ELF2, NERF: ETS-related transcription factor Elf-2	0.028	0.165
LOC642558	FUSIP1, FUSIP2, TASR: FUS-interacting serine-arginine-rich protein 1	0.028	0.052
PKN1	PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1	0.028	0.028
C20orf18	N/A	0.028	0.028
PKN3	PKN3, PKNBETA: Serine/threonine-protein kinase N3	0.028	0.025
TLE3	TLE3, KIAA1547: Transducin-like enhancer protein 3	0.028	0.028
C13orf8	N/A	0.028	0.028
GPRASP2	GPRASP2: G-protein coupled receptor-associated sorting protein 2	0.028	0.028
DYRK1B	DYRK1B, MIRK: Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0.028	0.025
DYRK1A	DYRK1A, DYRK, MNB, MNBH: Dual specificity tyrosine-phosphorylation-regulated kin	0.028	0.028
CBFA2T2	CBFA2T2, EHT, MTGR1: Protein CBFA2T2	0.028	0.028
C14orf151	C14orf151: Uncharacterized protein C14orf151 (Fragment)	0.028	0.028
SF1	SF1, ZFM1, ZNF162: Splicing factor 1	0.028	0.083
ZHX1	ZHX1: Zinc fingers and homeoboxes protein 1	0.028	0.028
MLL4	WBP7, HRX2, KIAA0304, MLL2, MLL4, TRX2: WW domain-binding protein 7	0.028	0.025
SNRPB	N/A	0.028	0.028
IRF7	N/A	0.028	0.028
CORO6	N/A	0.028	0.028
HNRPC	HNRPC: Heterogeneous nuclear ribonucleoproteins C1/C2	0.028	0.052
CDC2L1	CDC2L1, PITSLREA, PK58: PITSLRE serine/threonine-protein kinase CDC2L1	0.028	0.028
MITF	MITF: Microphthalmia-associated transcription factor	0.028	0.028
BMP2K	BMP2K, BIKE, HRIHFB2017: BMP-2-inducible protein kinase	0.028	0.028
NFIA	NFIA, RP5-902P15.1-003, hCG_2032260: Nuclear factor I/A	0.028	0.028
MAPKAPK5	N/A	0.028	0.028
ZNF295	ZNF295, KIAA1227, ZBTB21: Zinc finger protein 295	0.028	0.028
PTBP1	PTBP1: Polypyrimidine tract binding protein 1	0.028	0.028
HTATIP	HTATIP, TIP60: Histone acetyltransferase HTATIP	0.028	0.165
HES6	HES6: Transcription cofactor HES-6	0.028	0.028
HDAC7A	N/A	0.028	0.025
PPP1R12C	PPP1R12C, MBS85: Protein phosphatase 1 regulatory subunit 12C	0.028	0.028
ZNF579	ZNF579: Zinc finger protein 579	0.028	0.028
ILF3	ILF3, DRBF, MPHOSPH4, NF90: Interleukin enhancer-binding factor 3	0.028	0.028
DUSP15	N/A	0.028	0.028
PPEF1	N/A	0.028	0.028
WNK4	WNK4, PRKWNK4: Serine/threonine-protein kinase WNK4	0.028	0.025
KIAA0101	PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor	0.027	0.027
WDR1	N/A	0.026	0.032
ETS2	ETS2: Protein C-ets-2	0.026	0.123
VCPIP1	VCPIP1, KIAA1850, VCIP135: Deubiquitinating protein VCIP135	0.026	0.026
ELK1	ELK1: ETS domain-containing protein Elk-1	0.026	0.111
STK16	N/A	0.026	0.0425
AANAT	AANAT, SNAT: Serotonin N-acetyltransferase	0.026	0.026
GTF3C1	N/A	0.026	0.026
RGS14	N/A	0.026	0.026
GAS2	GAS2: Growth arrest-specific protein 2	0.026	0.027
ARID3A	ARID3A, DRIL1, DRIL3, DRX, E2FBP1: AT-rich interactive domain-containing protein	0.026	0.029
CDKN2D	CDKN2D: Cyclin-dependent kinase 4 inhibitor D	0.026	0.026
FOXJ2	FOXJ2, FHX: Forkhead box protein J2	0.026	0.152
MAP3K8	MAP3K8, COT, ESTF: Mitogen-activated protein kinase kinase kinase 8	0.026	0.026
DEF6	DEF6, IBP: Differentially expressed in FDCP 6	0.026	0.026
DLX3	DLX3: Homeobox protein DLX-3	0.025	0.025
TAL2	TAL2: T-cell acute lymphocytic leukemia protein 2	0.025	0.025
CPNE1	RBM12, KIAA0765, HRIHFB2091: RNA-binding protein 12	0.025	0.047
HNRPH3	HNRPH3: Heterogeneous nuclear ribonucleoprotein H3	0.025	0.047
G3BP2	G3BP2, KIAA0660: Ras GTPase-activating protein-binding protein 2	0.025	0.036
CAMK2A	N/A	0.025	0.025
MAP2K3	N/A	0.025	0.025
SAP14	SF3B14, CGI-110, HSPC175, HT006: Pre-mRNA branch site protein p14	0.025	0.047
SYAP1	SYAP1, PRO3113: Synapse-associated protein 1	0.025	0.025
NSUN2	NSUN2, SAKI, TRM4: tRNA	0.025	0.025
MAP3K7	MAP3K7, TAK1: Mitogen-activated protein kinase kinase kinase 7	0.025	0.025
PPP1R9B	PPP1R9B, PPP1R6: Neurabin-2	0.025	0.025
DHX8	DHX8, DDX8: ATP-dependent RNA helicase DHX8	0.025	0.148
SOX8	SOX8: Transcription factor SOX-8	0.025	0.025
GRK6	N/A	0.025	0.025
PHC2	PHC2, EDR2, PH2: Polyhomeotic-like protein 2	0.025	0.025
SMU1	SMU1: Smu-1 suppressor of mec-8 and unc-52 protein homolog	0.025	0.025
RBM10	RBM10, CTD-2522E6.5-001, hCG_1811529: RNA binding motif protein 10	0.025	0.047
PRDM2	PRDM2, RIZ: PR domain zinc finger protein 2	0.025	0.025
REXO1	REXO1, ELOABP1, KIAA1138, TCEB3BP1: RNA exonuclease 1 homolog	0.025	0.025
PRKCB1	N/A	0.025	0.025
IWS1	IWS1, IWS1L: IWS1 homolog	0.025	0.025
EDF1	EDF1: Endothelial differentiation-related factor 1	0.025	0.025
MAX	MAX: Protein max	0.025	0.025
RPS6KA2	RPS6KA2, RSK3: Ribosomal protein S6 kinase alpha-2	0.025	0.025
C14orf4	C14orf4, KIAA1865, My039: RING finger protein C14orf4	0.025	0.025
ZNF174	ZNF174, ZSCAN8: Zinc finger protein 174	0.025	0.025
CHEK2	CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2	0.025	0.025
MLXIPL	MLXIPL, MIO, WBSCR14: Williams-Beuren syndrome chromosome region 14 protein	0.025	0.025
LMNA	LMNA, LMN1: Lamin-A/C	0.025	0.025
NIPBL	N/A	0.025	0.025
SPAST	SPAST, KIAA1083, SPG4: Spastin	0.025	0.098
EXO1	EXO1, EXOI, HEX1: Exonuclease 1	0.025	0.025
ATXN2L	N/A	0.025	0.025
NES	N/A	0.025	0.025
HNRPM	HNRPM, NAGR1: Heterogeneous nuclear ribonucleoprotein M	0.025	0.047
RBBP6	RBBP6, P2PR, My038, PACT, RBQ1: Retinoblastoma-binding protein 6	0.025	0.025
POLR1C	POLR1C, POLR1E: DNA-directed RNA polymerases I and III subunit RPAC1	0.025	0.025
FLJ40432	FLJ40432, hCG_2036624: CDNA FLJ40432 fis, clone TESTI2039227	0.025	0.025
MKNK1	MKNK1, MNK1: MAP kinase-interacting serine/threonine-protein kinase 1	0.025	0.025
MKI67IP	MKI67IP, NIFK, NOPP34: MKI67 FHA domain-interacting nucleolar phosphoprotein	0.025	0.047
EWSR1	EWSR1, EWS: RNA-binding protein EWS	0.025	0.047
DDX20	DDX20, DP103, GEMIN3: Probable ATP-dependent RNA helicase DDX20	0.025	0.075
CAMKK1	N/A	0.025	0.025
FBXL10	FBXL10, CXXC2, FBL10, JHDM1B, PCCX2: JmjC domain-containing histone demethylatio	0.025	0.025
ATRX	ATRX, RAD54L, XH2: Transcriptional regulator ATRX	0.025	0.075
PURB	PURB: Transcriptional activator protein Pur-beta	0.025	0.025
PHKG1	PHKG1, PHKG: Phosphorylase b kinase gamma catalytic chain, skeletal muscle isofo	0.025	0.025
HNRPA2B1	HNRPA2B1: Heterogeneous nuclear ribonucleoproteins A2/B1	0.025	0.047
BRD4	N/A	0.025	0.025
HNRPUL1	HNRPUL1, E1BAP5: Heterogeneous nuclear ribonucleoprotein U-like protein 1	0.025	0.025
NFYA	NFYA: Nuclear transcription factor Y subunit alpha	0.025	0.025
MKNK2	MKNK2, GPRK7, MNK2: MAP kinase-interacting serine/threonine-protein kinase 2	0.025	0.025
HOXA10	HOXA10, HOX1H: Homeobox protein Hox-A10	0.025	0.025
HIST2H2AC	HIST2H2AC, H2AFQ: Histone H2A type 2-C	0.025	0.025
CAMK1D	CAMK1D: Calcium/calmodulin-dependent protein kinase type 1D	0.025	0.025
MSL3L1	MSL3L1: Male-specific lethal 3-like 1	0.025	0.025
CETN1	CETN1, CEN1, CETN: Centrin-1	0.025	0.025
FAF1	FAF1, CGI-03: FAS-associated factor 1	0.025	0.025
GEMIN5	GEMIN5: Gem-associated protein 5	0.025	0.025
CARHSP1	CARHSP1: Calcium-regulated heat stable protein 1	0.025	0.148
SETD3	SETD3, C14orf154: SET domain-containing protein 3	0.025	0.025
FLJ23436	N/A	0.025	0.025
NCOA3	NCOA3, AIB1, RAC3, TRAM1: Nuclear receptor coactivator 3	0.025	0.025
SEC13L1	N/A	0.025	0.025
ADK	ADK: Adenosine kinase	0.025	0.025
DIDO1	N/A	0.025	0.025
WWTR1	WWTR1, TAZ: WW domain-containing transcription regulator protein 1	0.025	0.025
NEDD4	NEDD4: Uncharacterized protein NEDD4	0.025	0.025
SGK2	SGK2: Serine/threonine-protein kinase Sgk2	0.025	0.025
SMN2	SMN1, SMN, SMN2, SMNC, SMNT: Survival motor neuron protein	0.025	0.025
MIER1	MIER1, KIAA1610: Mesoderm induction early response protein 1	0.025	0.025
RNF20		0.025	0.025
PRKACA	PRKACA, PKACA: cAMP-dependent protein kinase, alpha-catalytic subunit	0.025	0.025
ZFPM1	ZFPM1, FOG1: Zinc finger protein ZFPM1	0.025	0.025
RNF113A	RNF113A, RNF113, ZNF183: RING finger protein 113A	0.025	0.025
CDC2L5	CDC2L5, CDC2L, CHED, KIAA1791: Cell division cycle 2-like protein kinase 5	0.025	0.025
TCEA1	N/A	0.025	0.025
SSBP4	SSBP4: Single-stranded DNA-binding protein 4	0.025	0.025
SMAD1	SMAD1, BSP1, MADH1, MADR1: Mothers against decapentaplegic homolog 1	0.025	0.025
C20orf77	N/A	0.025	0.025
TIA1	TIA1: Nucleolysin TIA-1 isoform p40	0.025	0.047
raptor	RAPTOR, KIAA1303: Regulatory-associated protein of mTOR	0.025	0.025
OSR1	OSR1, ODD: Protein odd-skipped-related 1	0.025	0.025
FARSLA	FARSA, FARS, FARSL, FARSLA: Phenylalanyl-tRNA synthetase alpha chain	0.025	0.148
RFFL	RFFL, RNF189, RNF34L: E3 ubiquitin-protein ligase rififylin	0.025	0.025
SON		0.025	0.025
ARID1A	ARID1A, C1orf4, OSA1, SMARCF1: AT-rich interactive domain-containing protein 1A	0.025	0.025
ARL5A	ARL5A, ARFLP5, ARL5: ADP-ribosylation factor-like protein 5A	0.025	0.025
NHN1	NHN1: Conserved nuclear protein NHN1	0.025	0.025
BUB3	BUB3: Mitotic checkpoint protein BUB3	0.025	0.025
NUP98	N/A	0.025	0.025
ZNF598	ZNF598: Zinc finger protein 598	0.025	0.025
HEXIM2	HEXIM2, L3: Protein HEXIM2	0.025	0.025
PSIP1	PSIP1, DFS70, LEDGF, PSIP2: PC4 and SFRS1-interacting protein	0.025	0.025
RPS6KA4	RPS6KA4, MSK2: Ribosomal protein S6 kinase alpha-4	0.025	0.025
PDE8B	PDE8B: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodies	0.025	0.025
ARID4A	ARID4A, RBBP1, RBP1: AT-rich interactive domain-containing protein 4A	0.025	0.025
SMC4L1	SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4	0.025	0.025
HIST3H2A	HIST3H2A: Histone H2A type 3	0.025	0.025
RAD51	RAD51, RAD51A, RECA: DNA repair protein RAD51 homolog 1	0.025	0.148
SMARCA2	SMARCA2, BRM, SNF2A, SNF2L2: Probable global transcription activator SNF2L2	0.025	0.025
GATAD2B	GATAD2B, KIAA1150: Transcriptional repressor p66 beta	0.025	0.025
PHF16	PHF16, JADE3, KIAA0215: Protein Jade-3	0.025	0.025
KCTD1		0.025	0.025
HTATIP	N/A	0.025	0.025
MAPK8IP3	N/A	0.025	0.025
ISL2	ISL2: Insulin gene enhancer protein ISL-2	0.025	0.025
HNRPD	HNRPD, AUF1: Heterogeneous nuclear ribonucleoprotein D0	0.025	0.047
GMNN	GMNN: Geminin	0.025	0.160
NOLC1	NOLC1, KIAA0035: Nucleolar phosphoprotein p130	0.025	0.025
DBF4	DBF4, ASK: Protein DBF4 homolog	0.025	0.025

0.572

Total Score

7.83E3