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Evidence of Interaction Between HIST1H4A and ASF1A

The interaction score between HIST1H4A and ASF1A is 379.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between HIST1H4A and ASF1A = 0.17

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

2.30E-3
Orthology
OrganismHIST1H4A OrthologueASF1A OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00453473 1 IPI00041127 0.213
  • InVitro
  • InVivo

Get References From PubMed

bakers yeast YBR009C 1 YJL115W 0.213
  • pullDown
  • AffinityCaptureMS

Get References From PubMed

bakers yeast YNL030W 1 YJL115W 0.213
  • AffinityCaptureMS

Get References From PubMed

worm P62784 1 Q17603 0.298

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

3.01
Domains No domains were used in calculating likelihood of interaction 1.48E-3
Post-translational Modifications

Protein: HIST1H4A

PTMResidueReference
"N6,N6-dimethyllysine " 20 PubMed, HPRD
Acetylation 6 PubMed, HPRD
Acetylation 9 PubMed, HPRD
Acetylation 13 PubMed, HPRD
Acetylation 17 PubMed, HPRD
N-acetylserine 1 HPRD
N6-acetyllysine 5 HPRD
N6-acetyllysine 8 HPRD
N6-acetyllysine 12 HPRD
N6-acetyllysine 16 HPRD
N6-methyllysine 20 PubMed, HPRD

Protein: ASF1A

PTMResidueReference
Localisation

Protein: HIST1H4A

LocalisationReference
Nucleus HPRD
Nucleolus HPRD
Nucleoplasm HPRD

Protein: ASF1A

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between HIST1H4A and ASF1A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between HIST1H4A andASF1A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , HIST1H4A has 774 interactors and ASF1A has 33 interactors of which there are 21 common interactors.

Common InteractorName of Common InteractorScore for HIST1H4A-Interactor (?)Score for ASF1A-Interactor (?)
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 156.00 2.07
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 38.10 2.73
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 29.20 0.179
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 14.70 0.082
HIST3H3 HIST3H3, H3FT: Histone H3.1t 9.09 0.035
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 6.64 0.071
TBP TBP, GTF2D1, TF2D, TFIID: TATA-box-binding protein 4.72 0.132
CSNK2A1 CSNK2A1: CSNK2A1 protein 4.36 0.179
BRD4 N/A 3.97 0.038
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 2.96 0.044
RFC1 N/A 1.45 0.221
TAF1L TAF1L: Transcription initiation factor TFIID 210 kDa subunit 0.390 0.038
TAF1 N/A 0.354 0.071
POLR1D POLR1D: DNA-directed RNA polymerases I and III subunit RPAC2 0.354 0.071
CSNK2A2 CSNK2A2, CK2A2: Casein kinase II subunit alpha' 0.233 0.065
LOC644914 H3L-like histone (Fragment) 0.119 0.064
LOC440093 Histone H3-like 0.119 0.064
TBPL2 0.071 0.038
HIST2H3C HIST2H3A, HIST2H3C, H3F2, H3FM: Histone H3.2 0.071 0.038
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.049 0.179
BRDT N/A 0.029 0.064
0.572
Total Score 379.00