<<< Back to HIST1H3A

Evidence of Interaction Between HIST1H3A and ASF1A

The interaction score between HIST1H3A and ASF1A is 475.00.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between HIST1H3A and ASF1A = 0.29

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

2.88E-3
Orthology
OrganismHIST1H3A OrthologueASF1A OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
human IPI00465070 1 IPI00041127 0.213
  • Immunoprecipitation
  • InVitro
  • InVivo

Get References From PubMed

human IPI00219038 0.625 IPI00041127 0.213
  • Immunoprecipitation
  • InVivo

Get References From PubMed

human IPI00216402 0.375 IPI00041127 0.213
human IPI00171611 1 IPI00041127 0.213
bakers yeast YBR010W 0.625 YJL115W 0.213
  • Immunoprecipitation
  • pullDown
  • AffinityCaptureMS
  • CoPurification

Get References From PubMed

bakers yeast YNL031C 0.625 YJL115W 0.213
  • Immunoprecipitation
  • pullDown
  • AffinityCaptureMS

Get References From PubMed

worm P08898 1 Q17603 0.298

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

3.01
Domains No domains were used in calculating likelihood of interaction 1.48E-3
Post-translational Modifications

Protein: HIST1H3A

PTMResidueReference
Methylation 5 PubMed, HPRD
Methylation 10 PubMed, HPRD
N6-acetyllysine 14 HPRD
N6-acetyllysine 23 HPRD
N6-methyllysine 9 HPRD
N6-methyllysine 27 HPRD
N6-methyllysine 36 HPRD

Protein: ASF1A

PTMResidueReference
Localisation

Protein: HIST1H3A

LocalisationReference
Nucleus HPRD

Protein: ASF1A

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between HIST1H3A and ASF1A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between HIST1H3A andASF1A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , HIST1H3A has 1056 interactors and ASF1A has 33 interactors of which there are 19 common interactors.

Common InteractorName of Common InteractorScore for HIST1H3A-Interactor (?)Score for ASF1A-Interactor (?)
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 390.00 2.73
HIST1H4A HIST1H4A, H4/A, HIST1H4B, H4/I, H4/G, HIST1H4D, H4/B, H4/J, HIST1H4F, HIST4H4, H 156.00 1.65
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 9.09 0.179
BRD3 BRD3, KIAA0043, RING3L: Bromodomain-containing protein 3 4.59 0.082
HIST3H3 HIST3H3, H3FT: Histone H3.1t 3.88 0.035
BRD2 BRD2, KIAA9001, RING3: Bromodomain-containing protein 2 3.23 0.044
BRD4 N/A 2.13 0.038
CSNK2A1 CSNK2A1: CSNK2A1 protein 1.53 0.179
CHEK2 CHEK2, CHK2, RAD53: Serine/threonine-protein kinase Chk2 1.33 0.071
CALM2 CALM1, CALM, CALM2, CAM2, CALM3, CALML2, CAM, CAMB, CAM3, CAM1, CAMC, CAMIII: Ca 0.941 0.0294
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.171 0.179
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 0.108 0.366
NULL N/A 0.064 0.064
LOC644914 H3L-like histone (Fragment) 0.064 0.064
LOC440093 Histone H3-like 0.064 0.064
CSNK2A2 CSNK2A2, CK2A2: Casein kinase II subunit alpha' 0.053 0.065
TAF7 TAF7, TAF2F, TAFII55: Transcription initiation factor TFIID subunit 7 0.044 0.071
HIST2H3C HIST2H3A, HIST2H3C, H3F2, H3FM: Histone H3.2 0.038 0.038
TBP TBP, GTF2D1, TF2D, TFIID: TATA-box-binding protein 0.028 0.132
0.572
Total Score 475.00