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Evidence of Interaction Between TAF12 and TAF9

The interaction score between TAF12 and TAF9 is 1.85E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between TAF12 and TAF9 = 0.50

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 6.27E-3
Orthology
OrganismTAF12 OrthologueTAF9 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YDR145W 1 YMR236W 1
  • SyntheticLethal
  • AffinityCaptureMS

Get References From PubMed
worm Q9U226 1 O45784 0.744
  • Y2H
  • Other

Get References From PubMed
fly P49905 1 Q27272 0.681

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 3.01
Domains Domains present in TAF12 and TAF9:
Domains in TAF12Domains in TAF9
IPR009072 Histone-fold
IPR003228 Transcription initiation factor TFIID
IPR007124 Histone-fold/TFIID-TAF/NF-Y
IPR009072 Histone-fold
IPR003162 Transcription factor TAFII-31
IPR007124 Histone-fold/TFIID-TAF/NF-Y

The Chi square scores for co-occurrence of domains that are present in TAF12 and TAF9 are listed below.

Domain 1Domain 2Chi Square
IPR007124 Histone-fold/TFIID-TAF/NF-Y IPR007124 Histone-fold/TFIID-TAF/NF-Y 33.1556
IPR009072 Histone-fold IPR007124 Histone-fold/TFIID-TAF/NF-Y 19.0387

The background colour of the table refers to:

  • Blue Domain is only present in TAF12
  • Yellow Domain is only present in TAF9
  • Green Domain is present in both TAF12 and TAF9

 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: TAF12

LocalisationReference
Nucleus HPRD
Plasma membrane HPRD
Cytoplasm HPRD

Protein: TAF9

LocalisationReference
Nucleus HPRD
Transitive Score

The common interactors between TAF12 and TAF9 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TAF12 andTAF9. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TAF12 has 254 interactors and TAF9 has 234 interactors of which there are 195 common interactors.

Common InteractorName of Common InteractorScore for TAF12-Interactor (?)Score for TAF9-Interactor (?)
TBP TBP, GTF2D1, TF2D, TFIID: TATA-box-binding protein 48.90 100.00
TAF5 TAF5, TAF2D: Transcription initiation factor TFIID subunit 5 15.90 32.60
TAF6 TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6 7.31 80.90
TAF13 TAF13, TAF2K, TAFII18: Transcription initiation factor TFIID subunit 13 5.83 5.83
TAF7 TAF7, TAF2F, TAFII55: Transcription initiation factor TFIID subunit 7 3.20 3.20
TAF4 TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135: Transcription initiation factor 1.89 0.044
PCAF PCAF: Histone acetyltransferase PCAF 1.79 1.79
BRD7 BRD7, BP75, CELTIX1: Bromodomain-containing protein 7 0.890 1.82
TRRAP TRRAP, PAF400: Transformation/transcription domain-associated protein 0.593 0.593
TAF2 TAF2, CIF150, TAF2B: Transcription initiation factor TFIID subunit 2 0.593 0.593
USP22 0.593 0.593
ENY2 ENY2, DC6: Enhancer of yellow 2 transcription factor homolog 0.593 0.593
TAF1L TAF1L: Transcription initiation factor TFIID 210 kDa subunit 0.390 0.390
SUPT3H N/A 0.354 0.354
TAF1 N/A 0.354 0.354
TADA2L TADA2L, KL04P: Transcriptional adapter 2-like 0.326 0.408
GCN5L2 GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2 0.291 0.360
CHD2 N/A 0.261 0.261
TAF7L TAF7L, GHc-521F8.1-003: Transcription initiation factor TFIID subunit 7-like pro 0.233 0.408
CHD1 CHD1: Chromodomain-helicase-DNA-binding protein 1 0.143 0.143
NULL N/A 0.119 0.119
NULL N/A 0.119 0.119
NULL N/A 0.119 0.119
BP75 N/A 0.119 0.119
H3F3A H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3 0.074 0.044
BRD9 N/A 0.071 0.071
TBPL2 0.071 0.071
USP51 USP51: Ubiquitin carboxyl-terminal hydrolase 51 0.071 0.071
GTF3C2 GTF3C2, KIAA0011: General transcription factor 3C polypeptide 2 0.067 0.067
WDR41 N/A 0.067 0.083
SP110 SP110: Sp110 nuclear body protein 0.067 0.041
FBXW2 FBXW2, FBW2, FWD2: F-box/WD repeat-containing protein 2 0.067 0.067
PTMA N/A 0.067 0.083
GNB2L1 Lung cancer oncogene 7 0.067 0.067
PHF11 RP11-185C18.3, PHF11, RP11-185C18.3-001, hCG_28346: OTTHUMP00000018414 0.067 0.050
WDR1 N/A 0.067 0.050
OSTF1 N/A 0.065 0.032
MTF2 MTF2: Metal-response element-binding transcription factor 2 0.060 0.074
JARID1A JARID1A, RBBP2, RBP2: Histone demethylase JARID1A 0.060 0.044
CPSF1 CPSF1, CPSF160: Cleavage and polyadenylation specificity factor subunit 1 0.060 0.074
WDR3 WDR3: WD repeat-containing protein 3 0.060 0.074
PRPF4 PRPF4, PRP4: U4/U6 small nuclear ribonucleoprotein Prp4 0.060 0.074
CORO1A CORO1A, CORO1: Coronin-1A 0.060 0.036
IEF-SSP-9502 PWP1: Periodic tryptophan protein 1 homolog 0.060 0.074
TRIM33 TRIM33, KIAA1113, RFG7, TIF1G: E3 ubiquitin-protein ligase TRIM33 0.060 0.060
CORO7 CORO7: Coronin-7 0.060 0.044
DR1 DR1: TATA-binding protein-associated phosphoprotein 0.060 0.074
TAF10 TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10 0.060 0.060
WDR68 WDR68, HAN11: WD repeat-containing protein 68 0.060 0.060
PPP2R2A PPP2R2A: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alp 0.060 0.074
JMJD2C JMJD2C, GASC1, JHDM3C, KIAA0780: JmjC domain-containing histone demethylation pr 0.060 0.044
POLE3 POLE3, CHRAC17: DNA polymerase epsilon subunit 3 0.060 0.074
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.060 0.074
INTS12 INTS12, PHF22, SBBI22: Integrator complex subunit 12 0.060 0.074
WDR26 WDR26, CDW2, PRO0852, MIP2: WD repeat-containing protein 26 0.060 0.044
CDC40 CDC40, EHB3, PRP17, PRPF17: Pre-mRNA-processing factor 17 0.060 0.060
ARPC1B ARC41, ARPC1B: Actin-related protein 2/3 complex subunit 1B 0.060 0.036
RBBP4 RBBP4, RBAP48: Histone-binding protein RBBP4 0.060 0.123
RPL7A RPL7A, SURF-3, SURF3: 60S ribosomal protein L7a 0.059 0.059
PHF20 PHF20, C20orf104, GLEA2, HCA58, NZF, TZP: PHD finger protein 20 0.053 0.039
OFD1 OFD1, CXorf5: Oral-facial-digital syndrome 1 protein 0.053 0.053
BRD1 BRD1, BRL, BRPF2: Bromodomain-containing protein 1 0.050 0.067
TCOF1 N/A 0.050 0.067
BAZ1B BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain 0.050 0.067
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.050 0.067
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.050 0.083
PHF3 PHF3, KIAA0244: PHD finger protein 3 0.050 0.067
WDR8 WDR8: WD repeat-containing protein 8 0.050 0.050
SEC13L1 SEC13, D3S1231E, SEC13L1, SEC13R: Protein SEC13 homolog 0.050 0.067
PRP19 PRPF19, NMP200, PRP19, SNEV: Pre-mRNA-processing factor 19 0.047 0.047
NCK1 NCK1, NCK: Cytoplasmic protein NCK1 0.047 0.035
NHP2L1 NHP2L1: NHP2-like protein 1 0.047 0.059
RPL30 RPL30: 60S ribosomal protein L30 0.047 0.047
HCLS1 HCLS1, HS1: Hematopoietic lineage cell-specific protein 0.047 0.029
ETF1 ETF1, ERF1, RF1, SUP45L1: Eukaryotic peptide chain release factor subunit 1 0.047 0.059
DPF2 DPF2, REQ, UBID4: Zinc finger protein ubi-d4 0.047 0.035
SEC31L1 N/A 0.044 0.060
GNB1 GNB1: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0.044 0.036
RBBP7 RBBP7, RBAP46: Histone-binding protein RBBP7 0.044 0.074
PWP2H PWP2, PWP2H: Periodic tryptophan protein 2 homolog 0.044 0.044
MYST3 MYST3, MOZ, RUNXBP2, ZNF220: Histone acetyltransferase MYST3 0.044 0.044
BAZ2A BAZ2A, KIAA0314, TIP5: Bromodomain adjacent to zinc finger domain protein 2A 0.044 0.044
GNB2 GNB2: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0.044 0.036
SF3B3 N/A 0.044 0.060
WDR77 WDR77, HKMT1069, hCG_39991: Androgen receptor cofactor p44 0.044 0.060
C20orf11 C20orf11: Protein C20orf11 0.044 0.044
WIPI2 WIPI2, CGI-50: WD repeat domain phosphoinositide-interacting protein 2 0.044 0.060
TLE4 TLE4: TLE4 protein 0.044 0.028
H2AFZ H2AFZ, H2AZ: Histone H2A.Z 0.044 0.074
COPA COPA: Coatomer subunit alpha 0.044 0.036
CGI-48 UTP18, WDR50, CDABP0061, CGI-48: U3 small nucleolar RNA-associated protein 18 ho 0.044 0.123
NUP43 N/A 0.044 0.074
TSSC1 TSSC1: Protein TSSC1 0.044 0.060
BOP1 BOP1, KIAA0124: Ribosome biogenesis protein BOP1 0.044 0.060
BRPF1 BRPF1, BR140: Peregrin 0.044 0.044
CSTF1 CSTF1: Cleavage stimulation factor 50 kDa subunit 0.044 0.123
PHF10 N/A 0.044 0.060
FBXL11 FBXL11, FBL7, JHDM1A, KIAA1004: JmjC domain-containing histone demethylation pro 0.044 0.036
COPB2 COPB2: Coatomer subunit beta' 0.044 0.044
FLJ10439 WDR74, NSA1: WD repeat-containing protein 74 0.044 0.060
PIK3R4 PIK3R4: Phosphoinositide 3-kinase regulatory subunit 4 0.044 0.044
CXXC1 CXXC1, CGBP, PCCX1, PHF18: CpG-binding protein 0.044 0.044
SOS2 SOS2: Son of sevenless homolog 2 0.044 0.044
WDR57 WDR57, PRP8BP, SFP38: WD repeat-containing protein 57 0.044 0.074
CORO1C CORO1C, CRNN4: Coronin-1C 0.044 0.044
STRAP STRAP, MAWD, UNRIP: Serine-threonine kinase receptor-associated protein 0.044 0.074
WDR39 CIAO1, WDR39: Protein CIAO1 0.044 0.044
EIF3S2 EIF3S2, TRIP1: Eukaryotic translation initiation factor 3 subunit 2 0.044 0.074
NUP37 NUP37: Nucleoporin Nup37 0.044 0.123
WDR67 WDR67: WD repeat-containing protein 67 0.044 0.044
NAP1L4 NAP1L4, NAP2: Nucleosome assembly protein 1-like 4 0.041 0.067
DDB2 DDB2: DNA damage-binding protein 2 0.041 0.050
CBFA2T3 MTGR2: MTG8-related protein (Fragment) 0.041 0.0308
SP140 SP140, LYSP100: Nuclear body protein SP140 0.041 0.041
NUP214 N/A 0.041 0.041
WDR12 WDR12: WD repeat-containing protein 12 0.036 0.074
GRWD1 GRWD1, GRWD, WDR28: Glutamate-rich WD repeat-containing protein 1 0.036 0.044
PAK1IP1 PAK1IP1, PIP1, WDR84: p21-activated protein kinase-interacting protein 1 0.036 0.044
LRBA LRBA, BGL, CDC4L, LBA: Lipopolysaccharide-responsive and beige-like anchor prote 0.036 0.060
AAMP AAMP: Angio-associated migratory cell protein 0.036 0.036
WDR48 WDR48, KIAA1449: WD repeat-containing protein 48 0.036 0.060
HIRA HIRA, DGCR1, HIR, TUPLE1: Protein HIRA 0.036 0.036
CHAF1B CHAF1B, CAF1A, CAF1P60, MPHOSPH7, MPP7: Chromatin assembly factor 1 subunit B 0.036 0.060
WDR18 N/A 0.036 0.060
WDR37 N/A 0.036 0.028
NBEAL2 N/A 0.036 0.028
TAF11 TAF11, TAF2I, PRO2134: Transcription initiation factor TFIID subunit 11 0.036 0.060
EML3 EML3: Echinoderm microtubule-associated protein-like 3 0.036 0.036
RNU3IP2 RRP9, RNU3IP2, U355K: U3 small nucleolar RNA-interacting protein 2 0.036 0.060
HIST1H3A HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD, 0.036 0.028
SOS1 SOS1: Son of sevenless homolog 1 0.036 0.036
SMCY JARID1D, HY, HYA, KIAA0234, SMCY: Histone demethylase JARID1D 0.036 0.028
AAAS AAAS, ADRACALA, GL003: Aladin 0.036 0.044
THRAP5 MED16, DRIP92, THRAP5: Mediator of RNA polymerase II transcription subunit 16 0.036 0.028
RAE1 RAE1, MRNP41: mRNA export factor 0.036 0.074
SMYD2 SMYD2: SET and MYND domain-containing protein 2 0.036 0.044
HIST1H2BK HIST1H2BK, H2BFT, HIRIP1: Histone H2B type 1-K 0.036 0.036
H2AFX H2AFX, H2AX: Histone H2A.x 0.036 0.044
SSBP2 SSBP2, SSDP2: Single-stranded DNA-binding protein 2 0.036 0.036
CD2AP CD2AP: CD2-associated protein 0.035 0.047
PRDM4 PRDM4, PFM1: PR domain zinc finger protein 4 0.0308 0.041
NPAT Similar to nuclear protein, ataxia-telangiectasia locus (Fragment) 0.0308 0.041
GNB1L GNB1L, GY2, FKSG1, KIAA1645, WDR14: Guanine nucleotide-binding protein subunit b 0.0308 0.041
CENPA CENPA: Histone H3-like centromeric protein A 0.0308 0.050
NOLA2 NOLA2, NHP2, HSPC286: H/ACA ribonucleoprotein complex subunit 2 0.029 0.035
SECISBP2 SECISBP2, SBP2: SECIS-binding protein 2 0.029 0.047
Nle NLE1, HUSSY-07: Notchless protein homolog 1 0.028 0.036
WDR45L N/A 0.028 0.028
H2BFS H2BFS: Histone H2B type F-S 0.028 0.036
CDC20 CDC20: Cell division cycle protein 20 homolog 0.028 0.074
ING2 ING2, ING1L: Inhibitor of growth protein 2 0.028 0.060
WDR42A N/A 0.028 0.028
RANBP9 RANBP9, RANBPM: Ran-binding protein 9 0.028 0.123
SUV39H1 SUV39H1, SUV39H: Histone-lysine N-methyltransferase SUV39H1 0.028 0.036
TBPL1 TBPL1, TLP, TLP21, TRF2: TATA box-binding protein-like protein 1 0.028 0.074
SMYD3 SMYD3, ZMYND1, ZNFN3A1: SET and MYND domain-containing protein 3 0.028 0.036
NFYB NFYB, HAP3: Nuclear transcription factor Y subunit beta 0.028 0.036
SETDB1 SETDB1, KIAA0067: Histone-lysine N-methyltransferase SETDB1 0.028 0.036
MKLN1 MKLN1: Muskelin 0.028 0.044
HIST1H2AB N/A 0.028 0.036
HIST1H2BG HIST1H2BC, H2BFL, HIST1H2BE, H2BFH, HIST1H2BF, H2BFG, HIST1H2BG, H2BFA, HIST1H2B 0.028 0.028
WDR54 N/A 0.027 0.027
TCF20 TCF20, KIAA0292, SPBP: Transcription factor 20 0.027 0.027
OGG1 N/A 0.027 0.027
WDR53 N/A 0.027 0.027
NEDD1 N/A 0.027 0.027
PRDM14 PRDM14: PR domain zinc finger protein 14 0.027 0.027
RFWD2 RFWD2, COP1, RNF200: E3 ubiquitin-protein ligase RFWD2 0.027 0.027
WDR34 N/A 0.027 0.027
UHRF2 UHRF2, NIRF, RNF107: E3 ubiquitin-protein ligase UHRF2 0.027 0.027
WHSC1 WHSC1, KIAA1090, MMSET, NSD2, TRX5: Probable histone-lysine N-methyltransferase 0.027 0.027
PHF1 N/A 0.027 0.027
PHF13 PHF13: PHD finger protein 13 0.027 0.027
PHF12 PHF12, KIAA1523: PHD finger protein 12 0.027 0.027
PYGO2 PYGO2, PP7910: Pygopus homolog 2 0.027 0.027
TCF19 TCF19, SC1: Transcription factor 19 0.027 0.027
PRDM13 PRDM13, PFM10: PR domain zinc finger protein 13 0.027 0.027
CBFA2T2 CBFA2T2, EHT, MTGR1: Protein CBFA2T2 0.027 0.027
HIST1H2AD HIST1H2AD, H2AFG: Histone H2A type 1-D 0.027 0.027
TLE3 TLE3, KIAA1547: Transducin-like enhancer protein 3 0.027 0.027
PHF6 PHF6, KIAA1823: PHD finger protein 6 0.027 0.027
SETD7 SETD7, KIAA1717, SET7: Histone-lysine N-methyltransferase, H3 lysine-4 specific 0.027 0.027
ERCC8 ERCC8, CKN1, CSA: DNA excision repair protein ERCC-8 0.027 0.027
WDR17 N/A 0.027 0.027
H2AFY2 H2AFY2, MACROH2A2: Core histone macro-H2A.2 0.027 0.027
MLL5 MLL5: Myeloid/lymphoid or mixed-lineage leukemia 5 0.027 0.027
UHRF1 0.027 0.027
MLL2 MLL2, ALR: Myeloid/lymphoid or mixed-lineage leukemia protein 2 0.027 0.027
TAF5L TAF5L, PAF65B: TAF5-like RNA polymerase II p300/CBP-associated factor-associated 0.027 0.027
WDR72 N/A 0.027 0.027
FBXW8 FBXW8, FBW6, FBW8, FBX29, FBXO29, FBXW6: F-box/WD repeat-containing protein 8 0.027 0.027
TLE6 TLE6: Transducin-like enhancer protein 6 0.027 0.027
BRWD1 N/A 0.027 0.027
WSB1 WSB1, SWIP1: WD repeat and SOCS box-containing protein 1 0.027 0.027
KIF21A N/A 0.027 0.027
0.572
Total Score 1.85E4