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Evidence of Interaction Between RPA1 and MCM5

The interaction score between RPA1 and MCM5 is 1.59E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between RPA1 and MCM5 = 0.86

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismRPA1 OrthologueMCM5 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YAR007C 1 YLR274W 1
  • CoLocalization

Get References From PubMed
worm Q19537 1 Q21902 1
fly Q24492 1 Q9VGW6 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in RPA1 and MCM5:
Domains in RPA1Domains in MCM5
IPR008994 Nucleic acid-binding OB-fold
IPR004365 OB-fold nucleic acid binding
IPR004591 Replication factor-a protein 1 Rpa1
IPR007199 Replication factor-A protein 1, N-terminal
IPR012340 OB_NA_bd_sub.
IPR008994 Nucleic acid-binding OB-fold
IPR001208 MCM
IPR008048 MCM protein 5

The Chi square scores for co-occurrence of domains that are present in RPA1 and MCM5 are listed below.

Domain 1Domain 2Chi Square
IPR008994 Nucleic acid-binding OB-fold IPR001208 MCM 301.459
IPR008994 Nucleic acid-binding OB-fold IPR008994 Nucleic acid-binding OB-fold 191.222
IPR012340 OB_NA_bd_sub. IPR008994 Nucleic acid-binding OB-fold 168.682
IPR004365 OB-fold nucleic acid binding IPR001208 MCM 56.6924
IPR012340 OB_NA_bd_sub. IPR001208 MCM 49.9995
IPR004365 OB-fold nucleic acid binding IPR008994 Nucleic acid-binding OB-fold 29.2304

The background colour of the table refers to:

  • Blue Domain is only present in RPA1
  • Yellow Domain is only present in MCM5
  • Green Domain is present in both RPA1 and MCM5

 0.027
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: RPA1

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Cytoskeleton HPRD

Protein: MCM5

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD
Transitive Score

The common interactors between RPA1 and MCM5 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between RPA1 andMCM5. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , RPA1 has 291 interactors and MCM5 has 251 interactors of which there are 137 common interactors.

Common InteractorName of Common InteractorScore for RPA1-Interactor (?)Score for MCM5-Interactor (?)
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 80.90 0.044
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 69.60 209.00
PSMC1 PSMC1: 26S protease regulatory subunit 4 25.60 0.059
RUVBL1 RUVBL1, NMP238, TIP49, TIP49A: RuvB-like 1 12.50 0.047
DDX58 DDX58: Probable ATP-dependent RNA helicase DDX58 11.70 0.028
CORO1C CORO1C, CRNN4: Coronin-1C 0.890 0.890
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.293 0.293
DDX18 DDX18: ATP-dependent RNA helicase DDX18 0.263 0.038
KIAA0788 ASCC3L1, HELIC2, KIAA0788: U5 small nuclear ribonucleoprotein 200 kDa helicase 0.263 0.038
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.263 0.263
MCM3 MCM3: DNA replication licensing factor MCM3 0.263 209.00
SFRS1 SFRS1, ASF, OK/SW-cl.3, SF2, SF2P33: Splicing factor, arginine/serine-rich 1 0.242 0.053
EXOSC8 EXOSC8, OIP2, RRP43: Exosome complex exonuclease RRP43 0.231 0.231
KARS KARS, KIAA0070: Lysyl-tRNA synthetase 0.231 0.108
CORO1A CORO1A, CORO1: Coronin-1A 0.221 0.132
PSMC3 PSMC3, TBP1: 26S protease regulatory subunit 6A 0.207 0.207
SRP54 SRP54: Signal recognition particle 54 kDa protein 0.207 0.0968
CDC45L CDC45L, CDC45L2, UNQ374/PRO710: CDC45-related protein 0.196 0.196
CHD4 CHD4: Chromodomain-helicase-DNA-binding protein 4 0.137 0.042
DDX21 DDX21: Nucleolar RNA helicase 2 0.137 0.042
SMARCAL1 SMARCAL1, HARP: SWI/SNF-related matrix-associated actin-dependent regulator of c 0.137 0.042
DDX46 DDX46, KIAA0801: Probable ATP-dependent RNA helicase DDX46 0.137 0.042
DDX50 DDX50: ATP-dependent RNA helicase DDX50 0.137 0.042
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.123 0.263
MCM6 MCM6: DNA replication licensing factor MCM6 0.123 69.60
DDX23 DDX23: Probable ATP-dependent RNA helicase DDX23 0.123 0.038
SCYE1 SCYE1, EMAP2: Multisynthetase complex auxiliary component p43 [Contains: Endothe 0.123 0.123
POLR2H POLR2H: DNA-directed RNA polymerases I, II, and III subunit RPABC3 0.123 0.074
RPS23 RPS23: 40S ribosomal protein S23 0.123 0.074
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.123 0.123
MRPS28 MRPS28, MRPS35, HSPC007: Mitochondrial 28S ribosomal protein S28 0.123 0.123
MCM7 MCM7, CDC47, MCM2: DNA replication licensing factor MCM7 0.123 69.60
BAT1 N/A 0.123 0.038
DDX47 E4-DBP: DEAD box protein 0.123 0.038
RECQL RECQL, RECQL1: ATP-dependent DNA helicase Q1 0.123 0.060
EIF4A1 EIF4A1, DDX2A, EIF4A: Eukaryotic initiation factor 4A-I 0.123 0.038
SMARCA5 SMARCA5, SNF2H, WCRF135: SWI/SNF-related matrix-associated actin-dependent regul 0.123 0.038
KHDRBS1 KHDRBS1, SAM68: KH domain-containing, RNA-binding, signal transduction-associate 0.123 0.038
DDX1 DDX1: ATP-dependent RNA helicase DDX1 0.123 0.038
EIF2S2 EIF2S2, EIF2B: Eukaryotic translation initiation factor 2 subunit 2 0.123 0.074
ORC2L ORC2L, ORC2: Origin recognition complex subunit 2 0.123 0.123
ABCE1 ABCE1, RLI, OK/SW-cl.40, RNASEL1, RNASELI, RNS4I: ATP-binding cassette sub-famil 0.123 0.123
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.123 0.074
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.0968 0.0968
RFC4 RFC4: Replication factor C subunit 4 0.0968 0.207
RFC5 RFC5: Replication factor C subunit 5 0.0968 0.207
RFC3 RFC3: Replication factor C subunit 3 0.0968 0.0968
EXOSC7 EXOSC7, KIAA0116, RRP42: Exosome complex exonuclease RRP42 0.0968 0.059
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.0968 0.0968
DARS DARS, PIG40: Aspartyl-tRNA synthetase, cytoplasmic 0.0968 0.0968
RBMX RBMX, HNRPG, RBMXP1: Heterogeneous nuclear ribonucleoprotein G 0.090 0.059
POT1 POT1: Protection of telomeres protein 1 0.083 0.083
MUTYH N/A 0.083 0.083
TARDBP TARDBP, TDP43: TAR DNA-binding protein 43 0.081 0.053
SFRS2 SFRS2: Splicing factor, arginine/serine-rich 2 0.081 0.053
SFPQ SFPQ, PSF: Splicing factor, proline- and glutamine-rich 0.081 0.053
SFRS3 SFRS3, SRP20: Splicing factor, arginine/serine-rich 3 0.081 0.053
SFRS10 SFRS10, TRA2B: Splicing factor, arginine/serine-rich 10 0.081 0.053
SART3 SART3, KIAA0156, TIP110: Squamous cell carcinoma antigen recognized by T-cells 3 0.081 0.053
HNRPF HNRPF: Heterogeneous nuclear ribonucleoprotein F 0.081 0.053
SYNCRIP SYNCRIP, HNRPQ, NSAP1: Heterogeneous nuclear ribonucleoprotein Q 0.081 0.053
HNRPA3 HNRPA3: Heterogeneous nuclear ribonucleoprotein A3 0.081 0.053
HELLS HELLS, PASG, Nbla10143, SMARCA6: Lymphoid-specific helicase 0.074 0.038
GCLC GCLC, GLCL, GLCLC: Glutamate--cysteine ligase catalytic subunit 0.074 0.044
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 0.074 32.60
POLR2G POLR2G: DNA-directed RNA polymerase II subunit RPB7 0.074 0.074
YARS YARS: Tyrosyl-tRNA synthetase, cytoplasmic 0.074 0.060
ORC6L ORC6L: Origin recognition complex subunit 6 0.074 0.123
EIF1AX EIF1AX, EIF1A, EIF4C: Eukaryotic translation initiation factor 1A, X-chromosomal 0.074 0.074
EIF2B5 EIF2B5, EIF2BE: Translation initiation factor eIF-2B subunit epsilon 0.074 0.060
RAD54L RAD54L, RAD54A: DNA repair and recombination protein RAD54-like 0.074 0.038
OBFC1 OBFC1: Oligonucleotide/oligosaccharide-binding fold-containing protein 1 0.067 0.041
EIF5AP1 EIF5A: Eukaryotic translation initiation factor 5A-1 0.067 0.050
RAD54B RAD54B: DNA repair and recombination protein RAD54B 0.067 0.0255
SRPR SRPR: Uncharacterized protein SRPR 0.065 0.053
EIF1AY EIF1AY: Eukaryotic translation initiation factor 1A, Y-chromosomal 0.060 0.044
BLM BLM, RECQ2, RECQL3: Bloom syndrome protein 0.060 0.074
RECQL4 RECQL4, RECQ4: ATP-dependent DNA helicase Q4 0.060 0.123
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.060 0.074
WRN WRN, RECQ3, RECQL2: Werner syndrome ATP-dependent helicase 0.060 0.074
MDN1 MDN1, KIAA0301: Midasin 0.060 0.044
ATAD3A ATAD3A: ATPase family AAA domain-containing protein 3A 0.059 0.0968
NARS NARS, ASNS: Asparaginyl-tRNA synthetase, cytoplasmic 0.059 0.047
FXR1 FXR1: Fragile X mental retardation syndrome-related protein 1 0.059 0.059
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 0.059 0.059
VCP VCP: Transitional endoplasmic reticulum ATPase 0.059 0.059
SSBP1 SSBP1, SSBP: Single-stranded DNA-binding protein, mitochondrial precursor 0.055 0.055
XAB1 XAB1, MBDIN, HUSSY-23: XPA-binding protein 1 0.055 0.0331
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.053 0.074
CORO1B CORO1B: Coronin-1B 0.053 0.053
G3BP G3BP1, G3BP: Ras GTPase-activating protein-binding protein 1 0.051 0.042
BRCA2 BRCA2, FACD, FANCD1: Breast cancer type 2 susceptibility protein 0.050 0.067
CORO2B CORO2B, KIAA0925: Coronin-2B 0.047 0.047
VPS4B VPS4B, SKD1, VPS42: Vacuolar protein sorting-associating protein 4B 0.047 0.035
VPS4A VPS4A, VPS4: Vacuolar protein sorting-associating protein 4A 0.047 0.035
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.047 0.047
XRCC3 XRCC3: DNA-repair protein XRCC3 0.044 0.074
EXOSC2 EXOSC2, RRP4: Exosome complex exonuclease RRP4 0.044 0.044
CCNF CCNF: G2/mitotic-specific cyclin-F 0.042 0.137
RFX5 RFX5: DNA-binding protein RFX5 0.042 0.137
ADAR ADAR, ADAR1, DSRAD, G1P1, IFI4: Double-stranded RNA-specific adenosine deaminase 0.042 0.067
RBM14 RBM14, SIP: RNA-binding protein 14 0.042 0.0278
ELAVL1 ELAVL1, HUR: ELAV-like protein 1 0.038 0.053
PABPN1 PABPN1, PAB2, PABP2: Polyadenylate-binding protein 2 0.038 0.053
CCNB1 Cyclin B1 0.038 0.123
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.038 0.123
U2AF1 U2AF1, U2AF35, U2AFBP: Splicing factor U2AF 35 kDa subunit 0.038 0.053
CCNB2 CCNB2: G2/mitotic-specific cyclin-B2 0.038 0.123
CCNA2 CCNA2, CCN1, CCNA: Cyclin-A2 0.038 0.263
NTHL1 NTHL1, NTH1, OCTS3: Endonuclease III-like protein 1 0.036 0.044
CSDA CSDA, DBPA: DNA-binding protein A 0.036 0.036
EXOSC5 EXOSC5, CML28, RRP46: Exosome complex exonuclease RRP46 0.035 0.035
NUBP1 NUBP1, NBP, NBP1: Nucleotide-binding protein 1 0.035 0.029
RUVBL2 RUVBL2, TIP48, CGI-46, TIP49B: RuvB-like 2 0.035 0.035
CLPX CLPX: ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial pr 0.0331 0.027
ERCC1 ERCC1: DNA excision repair protein ERCC-1 0.0308 0.0308
EXOSC4 EXOSC4, RRP41, SKI6: Exosome complex exonuclease RRP41 0.029 0.035
PEX1 PEX1: Peroxisome biogenesis factor 1 0.029 0.029
PTGES3 PTGES3, P23, TEBP: Prostaglandin E synthase 3 0.027 0.027
SERBP1 N/A 0.027 0.027
NUSAP1 NUSAP1, ANKT, BM-037, PRO0310: Nucleolar and spindle-associated protein 1 0.027 0.027
HNRPD N/A 0.027 0.027
SMC4L1 N/A 0.027 0.027
ZWILCH Protein zwilch homolog. 0.027 0.027
TMPO N/A 0.027 0.027
ZWINT N/A 0.027 0.082
CEP57 CEP57, KIAA0092, TSP57: Centrosomal protein of 57 kDa 0.027 0.027
PRSS15 LONP1, PRSS15: Lon protease homolog, mitochondrial precursor 0.027 0.027
ABCC4 ABCC4, MRP4: Multidrug resistance-associated protein 4 0.027 0.027
DNAH11 N/A 0.027 0.027
RPA3 RPA3, REPA3, RPA14: Replication protein A 14 kDa subunit 0.027 0.027
ABCF2 ABCF2, HUSSY-18: ATP-binding cassette sub-family F member 2 0.027 0.027
OGG1 N/A 0.027 0.027
ZCCHC17 ZCCHC17, PS1D, HSPC243, HSPC251, LDC4: Nucleolar protein of 40 kDa 0.027 0.027
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.0255 0.083
HNRPA0 HNRPA0: Heterogeneous nuclear ribonucleoprotein A0 0.0255 0.0278
ELF1 ELF1: ETS-related transcription factor Elf-1 0.0255 0.067
0.572
Total Score 1.59E4