PIPs: Human Protein-Protein Interaction Prediction

Evidence of Interaction Between TBP and TAF9

The interaction score between TBP and TAF9 is 2.29E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

Feature

Evidence

Score (?)

Gene Expression

Pearson's Correlation between TBP and TAF9 = 0.66

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

7.78E-3

Orthology

Organism	TBP Orthologue		TAF9 Orthologue		Experiment
Organism	Accession	Inparalog Score	Accession	Inparalog Score	Experiment
human	IPI00395431	0.192	IPI00642105	0.704
bakers yeast	YER148W	1	YMR236W	1	AffinityCaptureMS AffinityCaptureWestern Get References From PubMed
worm	P32085	1	O45784	0.744
fly	P20227	1	Q27272	0.681	Immunoprecipitation Get References From PubMed

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

3.01

Domains

No domains were used in calculating likelihood of interaction

0.027

Post-translational Modifications

No PTMs were used in calculating likelihood of interaction

Localisation

Protein: TBP

Localisation	Reference
Nucleus	HPRD

Protein: TAF9

Localisation	Reference
Nucleus	HPRD

Transitive Score

The common interactors between TBP and TAF9 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between TBP andTAF9. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , TBP has 180 interactors and TAF9 has 234 interactors of which there are 46 common interactors.

Common Interactor	Name of Common Interactor	Score for TBP-Interactor (?)	Score for TAF9-Interactor (?)
TAF6	TAF6, TAF2E, TAFII70: Transcription initiation factor TFIID subunit 6	80.90	80.90
TAF12	TAF12, TAF15, TAF2J, TAFII20: Transcription initiation factor TFIID subunit 12	48.90	80.90
H2AFZ	H2AFZ, H2AZ: Histone H2A.Z	15.90	0.074
H2AFX	H2AFX, H2AX: Histone H2A.x	9.63	0.044
HIST1H2BG	HIST1H2BC, H2BFL, HIST1H2BE, H2BFH, HIST1H2BF, H2BFG, HIST1H2BG, H2BFA, HIST1H2B	5.83	0.028
TAF13	TAF13, TAF2K, TAFII18: Transcription initiation factor TFIID subunit 13	4.72	5.83
TADA2L	TADA2L, KL04P: Transcriptional adapter 2-like	2.95	0.408
TAF1L	TAF1L: Transcription initiation factor TFIID 210 kDa subunit	1.79	0.390
TAF1	N/A	1.79	0.354
HIST1H2AB	N/A	1.46	0.036
HIST1H2AG	HIST1H2AG, H2AFP, HIST1H2AI, H2AFC, HIST1H2AK, H2AFD, HIST1H2AL, H2AFI, HIST1H2A	1.46	0.028
HIST1H2BK	HIST1H2BK, H2BFT, HIRIP1: Histone H2B type 1-K	1.46	0.036
H2BFS	H2BFS: Histone H2B type F-S	1.46	0.036
TAF5	TAF5, TAF2D: Transcription initiation factor TFIID subunit 5	1.10	32.60
BRD7	BRD7, BP75, CELTIX1: Bromodomain-containing protein 7	1.10	1.82
HIST1H2BJ	HIST1H2BJ, H2BFR: Histone H2B type 1-J	0.950	0.028
ELP4	ELP4, C11orf19, PAXNEB: Elongator complex protein 4	0.902	1.49
NAP1L1	NAP1L1, NRP: Nucleosome assembly protein 1-like 1	0.890	0.074
TAF2	TAF2, CIF150, TAF2B: Transcription initiation factor TFIID subunit 2	0.730	0.593
TAF7L	TAF7L, GHc-521F8.1-003: Transcription initiation factor TFIID subunit 7-like pro	0.408	0.408
SUPT3H	N/A	0.354	0.354
NOLA2	NOLA2, NHP2, HSPC286: H/ACA ribonucleoprotein complex subunit 2	0.298	0.035
PCAF	PCAF: Histone acetyltransferase PCAF	0.264	1.79
TAF7	TAF7, TAF2F, TAFII55: Transcription initiation factor TFIID subunit 7	0.179	3.20
TRRAP	TRRAP, PAF400: Transformation/transcription domain-associated protein	0.143	0.593
BP75	N/A	0.119	0.119
NULL	N/A	0.119	0.119
NULL	N/A	0.119	0.119
NULL	N/A	0.119	0.119
NULL	N/A	0.119	0.119
GCN5L2	GCN5L2, GCN5, HGCN5: General control of amino acid synthesis protein 5-like 2	0.082	0.360
BRD9	N/A	0.071	0.071
TBPL2		0.071	0.071
DR1	DR1: TATA-binding protein-associated phosphoprotein	0.060	0.074
POLE3	POLE3, CHRAC17: DNA polymerase epsilon subunit 3	0.060	0.074
TAF11	TAF11, TAF2I, PRO2134: Transcription initiation factor TFIID subunit 11	0.060	0.060
TAF10	TAF2A, TAF10, TAF2H, TAFII30: Transcription initiation factor TFIID subunit 10	0.060	0.060
TAF4	TAF4, TAF2C, TAF2C1, TAF4A, TAFII130, TAFII135: Transcription initiation factor	0.060	0.044
SOS1	SOS1: Son of sevenless homolog 1	0.044	0.036
SOS2	SOS2: Son of sevenless homolog 2	0.044	0.044
H3F3A	H3F3A, H3.3A, PP781, H3.3B, H3F3B, H3F3: Histone H3.3	0.044	0.044
CENPA	CENPA: Histone H3-like centromeric protein A	0.041	0.050
HIST1H3A	HIST1H3A, H3FA, HIST1H3B, H3FL, HIST1H3C, H3FC, HIST1H3D, H3FB, HIST1H3E, H3FD,	0.028	0.028
NFYB	NFYB, HAP3: Nuclear transcription factor Y subunit beta	0.028	0.036
HIST1H2AD	HIST1H2AD, H2AFG: Histone H2A type 1-D	0.027	0.027
H2AFY2	H2AFY2, MACROH2A2: Core histone macro-H2A.2	0.027	0.027

0.572

Total Score

2.29E4