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Evidence of Interaction Between CHMP4B and CHMP4A

The interaction score between CHMP4B and CHMP4A is 7.31E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

N/A
Orthology
OrganismCHMP4B OrthologueCHMP4A OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YLR025W 0.349 YLR025W 1
  • Y2H
  • Other

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worm Q18886 1 Q18886 0.056
worm Q22916 0.392 Q18886 0.056
fly Q8T0Q4 1 Q8T0Q4 0.156
  • Y2H
  • Other

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The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

3.01
Domains No domains were used in calculating likelihood of interaction 0.265
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: CHMP4B

LocalisationReference
Cytosol HPRD
Cytoplasm HPRD

Protein: CHMP4A

LocalisationReference
Lysosome HPRD
Endosome HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between CHMP4B and CHMP4A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CHMP4B andCHMP4A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CHMP4B has 23 interactors and CHMP4A has 62 interactors of which there are 20 common interactors.

Common InteractorName of Common InteractorScore for CHMP4B-Interactor (?)Score for CHMP4A-Interactor (?)
CHMP4C CHMP4C, SHAX3: Charged multivesicular body protein 4c 319.00 319.00
CHMP6 CHMP6, VPS20: Charged multivesicular body protein 6 319.00 803.00
VPS4B VPS4B, SKD1, VPS42: Vacuolar protein sorting-associating protein 4B 169.00 171.00
VPS24 VPS24, CHMP3, CGI-149, NEDF: Charged multivesicular body protein 3 169.00 528.00
CHMP2A CHMP2A, BC2, CHMP2: Charged multivesicular body protein 2a 12.60 323.00
VPS4A VPS4A, VPS4: Vacuolar protein sorting-associating protein 4A 3.58 20.80
CHMP7 CHMP7: Charged multivesicular body protein 7 0.265 0.824
CHMP1B CHMP1B, C18orf2: Charged multivesicular body protein 1b 0.265 0.824
CHMP5 CHMP5, C9orf83, CGI-34, SNF7DC2, HSPC177, PNAS-2, PNAS-114: Charged multivesicul 0.237 0.440
CHMP2B CHMP2B, CGI-84: Charged multivesicular body protein 2b 0.237 0.596
STAMBP STAMBP, AMSH: STAM-binding protein 0.177 0.601
PDCD6IP PDCD6IP, AIP1, ALIX, KIAA1375: Programmed cell death 6-interacting protein 0.143 3.68
SNX15 SNX15: Sorting nexin-15 0.141 0.129
CAPN7 CAPN7, PALBH: Calpain-7 0.126 0.317
STAMBPL1 N/A 0.117 0.0718
ATP6V0D2 ATP6V0D2: Vacuolar ATP synthase subunit d 2 0.064 0.119
LOC283683 N/A 0.064 0.119
FBXO34 CGI-301: Protein CGI-301 0.0288 0.0288
PCOLN3 CHMP1A, CHMP1, KIAA0047, PCOLN3, PRSM1: Charged multivesicular body protein 1a 0.0288 0.0288
SRPR SRPR: Uncharacterized protein SRPR 0.027 0.083
0.572
Total Score 7.31E4