Home
Advanced Search
Help
Update History
Statistics
Downloads
The Barton Group
<<< Back to CCNB2

Evidence of Interaction Between CCNB2 and CDC6

The interaction score between CCNB2 and CDC6 is 1.59E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between CCNB2 and CDC6 = 0.82

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.027
Orthology
OrganismCCNB2 OrthologueCDC6 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YGR108W 0.396 YJL194W 1
bakers yeast YPR119W 1 YJL194W 1
  • AffinityCaptureWestern
  • ReconstitutedComplex
  • DosageLethality

Get References From PubMed
worm Q10653 0.333 P91155 1
fly P20439 0.246 Q9VSM9 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains Domains present in CCNB2 and CDC6:
Domains in CCNB2Domains in CDC6
IPR011028 Cyclin-like
IPR006670 Cyclin
IPR006671 Cyclin, N-terminal
IPR004367 Cyclin, C-terminal
IPR013763 Cyclin-related
IPR003593 AAA ATPase
IPR003959 AAA ATPase, central region
IPR011991 Wing_hlx_DNA_bd.

The Chi square scores for co-occurrence of domains that are present in CCNB2 and CDC6 are listed below.

Domain 1Domain 2Chi Square
IPR011028 Cyclin-like IPR011991 Wing_hlx_DNA_bd. 1.5847
IPR013763 Cyclin-related IPR011991 Wing_hlx_DNA_bd. 1.45942
IPR006670 Cyclin IPR011991 Wing_hlx_DNA_bd. 1.20156
IPR006670 Cyclin IPR003593 AAA ATPase 0.931553
IPR011028 Cyclin-like IPR003593 AAA ATPase 0.663281
IPR013763 Cyclin-related IPR003593 AAA ATPase 0.604607
IPR006671 Cyclin, N-terminal IPR011991 Wing_hlx_DNA_bd. 0.0618816

The background colour of the table refers to:

  • Blue Domain is only present in CCNB2
  • Yellow Domain is only present in CDC6
  • Green Domain is present in both CCNB2 and CDC6

 0.027
Post-translational Modifications

Protein: CCNB2

PTMResidueReference

Protein: CDC6

PTMResidueReference
Phosphorylation 54 PubMed, HPRD
Phosphorylation 74 PubMed, HPRD
Phosphorylation 106 PubMed, HPRD
Localisation

Protein: CCNB2

LocalisationReference
Golgi HPRD
Secreted HPRD
Cytoplasm HPRD

Protein: CDC6

LocalisationReference
Nucleus HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between CCNB2 and CDC6 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CCNB2 andCDC6. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CCNB2 has 332 interactors and CDC6 has 931 interactors of which there are 131 common interactors.

Common InteractorName of Common InteractorScore for CCNB2-Interactor (?)Score for CDC6-Interactor (?)
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 69.60 0.276
MCM3 MCM3: DNA replication licensing factor MCM3 69.60 1.62
CDC25A CDC25A: M-phase inducer phosphatase 1 32.20 0.025
CKS2 CKS2: Cyclin-dependent kinases regulatory subunit 2 19.50 3.05
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 11.70 0.086
CDK2 CDK2: Cell division protein kinase 2 6.55 6.86
CDC25C CDC25C: M-phase inducer phosphatase 3 6.33 0.025
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 6.33 0.025
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 6.32 0.503
CDK3 CDK3: Cell division protein kinase 3 4.16 0.264
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 3.08 65.00
CKAP5 CKAP5, KIAA0097: Cytoskeleton-associated protein 5 3.05 0.061
MSH6 MSH6, GTBP: DNA mismatch repair protein MSH6 1.82 0.129
CKS1B CKS1B, CKS1, PNAS-16, PNAS-143: Cyclin-dependent kinases regulatory subunit 1 1.31 1.31
ORC2L ORC2L, ORC2: Origin recognition complex subunit 2 1.10 19.70
FOXO1A FOXO1A, FKHR: Forkhead box protein O1A 0.837 0.044
CCNB1 Cyclin B1 0.789 86.60
CCNA2 CCNA2, CCN1, CCNA: Cyclin-A2 0.789 0.263
RUNX1 N/A 0.741 0.046
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.657 0.063
CDC23 CDC23: Cell division cycle protein 23 homolog 0.612 0.040
FZR1 N/A 0.538 0.038
DIAPH1 Diaphanous 1 0.408 0.029
CAMKK1 N/A 0.354 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.354 0.075
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.326 0.029
CCNF CCNF: G2/mitotic-specific cyclin-F 0.293 0.137
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.263 431.00
MCM6 MCM6: DNA replication licensing factor MCM6 0.263 0.263
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.263 1.62
MCM7 MCM7, CDC47, MCM2: DNA replication licensing factor MCM7 0.263 69.60
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.263 0.129
PCNA PCNA: Proliferating cell nuclear antigen 0.242 1.62
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.137 0.917
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.123 0.276
MCM5 MCM5, CDC46: DNA replication licensing factor MCM5 0.123 32.60
BRCA1 BRCA1, RNF53: Breast cancer type 1 susceptibility protein 0.123 0.385
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.123 0.763
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.123 0.063
CDK4 CDK4: Cell division protein kinase 4 0.123 0.129
LOC646469 Uncharacterized protein ENSP00000368241 0.119 0.119
NULL N/A 0.119 0.119
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.108 0.029
DLG7 DLG7, KIAA0008: Disks large-associated protein DLG7 0.082 0.025
ZWINT N/A 0.082 0.027
HMMR HMMR: Hyaluronan-mediated motility receptor 0.082 0.027
PTTG1 PTTG1, EAP1, PTTG, TUTR1: Securin 0.082 0.025
TPX2 TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2 0.082 0.053
MYBL2 MYBL2, BMYB: Myb-related protein B 0.081 0.385
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.081 0.385
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.074 0.078
PRKCB1 N/A 0.071 0.025
RB1 RB1: Retinoblastoma-associated protein 0.067 0.416
CDK7 CDK7, MO15: Cell division protein kinase 7 0.060 0.046
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.060 0.063
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.060 0.063
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.060 0.029
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.060 0.139
CCNG1 CCNG1, CCNG, CYCG1: Cyclin-G1 0.060 0.060
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.060 0.225
MLLT7 N/A 0.053 0.056
PHB2 PHB2, BAP, REA: Prohibitin-2 0.053 0.036
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.051 0.503
RFC3 RFC3: Replication factor C subunit 3 0.051 0.207
RFC4 RFC4: Replication factor C subunit 4 0.051 0.207
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.050 0.052
RFX5 RFX5: DNA-binding protein RFX5 0.050 0.050
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.049 0.307
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.044 0.086
GTF2E2 GTF2E2, TF2E2: Transcription initiation factor IIE subunit beta 0.044 0.036
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.044 0.046
AKAP8L AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like 0.044 0.114
CDC20 CDC20: Cell division cycle protein 20 homolog 0.044 0.276
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.042 0.066
GTF2F2 N/A 0.041 0.155
STK16 N/A 0.041 0.0425
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.041 0.0425
CBX3 CBX3: Chromobox protein homolog 3 0.038 0.078
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 0.038 0.074
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.038 0.129
KNTC1 KNTC1, KIAA0166: Kinetochore-associated protein 1 0.038 0.123
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.038 0.461
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.038 0.385
WEE1 WEE1: Wee1-like protein kinase 0.038 0.078
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.038 0.078
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.038 0.461
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.038 0.385
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.036 0.086
CCNC CCNC: Cyclin-C 0.036 0.044
CCND2 CCND2: G1/S-specific cyclin-D2 0.036 0.028
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.036 0.114
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.036 0.114
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.036 0.038
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.036 0.038
RPS6KB1 N/A 0.036 0.038
ELF1 ELF1: ETS-related transcription factor Elf-1 0.0308 0.077
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.0308 0.032
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.0308 0.0425
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.0308 0.032
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.0308 0.032
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.0308 0.077
ROCK1 ROCK1: Rho-associated protein kinase 1 0.0308 0.032
CDK6 CDK6: Cell division protein kinase 6 0.028 0.038
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.028 0.029
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.028 0.114
CCND3 CCND3: G1/S-specific cyclin-D3 0.028 0.028
CCNH CCNH: Cyclin-H 0.028 0.136
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.028 0.029
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.028 0.086
TCEB3 TCEB3, MSTP059: Transcription elongation factor B polypeptide 3 0.028 0.029
TACC3 TACC3, ERIC1: Transforming acidic coiled-coil-containing protein 3 0.027 0.068
GTSE1 GTSE1: G2 and S phase-expressed protein 1 0.027 0.025
CDCA8 CDCA8, PESCRG3: Borealin 0.027 0.027
DKFZp762E1312 FAKTS, FLEG1: 14-3-3-associated AKT substrate 0.027 0.027
GMNN GMNN: Geminin 0.027 0.053
KIAA0101 PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor 0.027 0.027
C18orf56 N/A 0.027 0.027
SMC4L1 N/A 0.027 0.027
DBF4 DBF4, ASK: Protein DBF4 homolog 0.027 0.025
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.027 0.157
MAPK15 N/A 0.027 0.052
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.027 0.083
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.027 0.083
FBXO4 FBXO4, FBX4: F-box only protein 4 0.027 0.028
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.027 0.083
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.028
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.028
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.027 0.083
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.0255 0.515
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.0255 0.083
BAZ1B BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain 0.0255 0.515
0.572
Total Score 1.59E4