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Evidence of Interaction Between CCNB2 and MCM3

The interaction score between CCNB2 and MCM3 is 1.59E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between CCNB2 and MCM3 = 0.80

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

0.027
Orthology
OrganismCCNB2 OrthologueMCM3 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YGR108W 0.396 YEL032W 1
bakers yeast YPR119W 1 YEL032W 1
  • BiochemicalActivity

Get References From PubMed

worm Q10653 0.333 Q9XVR7 1
fly P20439 0.246 P91675 1

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

0.593
Domains Domains present in CCNB2 and MCM3:
Domains in CCNB2Domains in MCM3
IPR011028 Cyclin-like
IPR006670 Cyclin
IPR006671 Cyclin, N-terminal
IPR004367 Cyclin, C-terminal
IPR013763 Cyclin-related
IPR003593 AAA ATPase
IPR008994 Nucleic acid-binding OB-fold
IPR001208 MCM
IPR008046 MCM protein 3

The Chi square scores for co-occurrence of domains that are present in CCNB2 and MCM3 are listed below.

Domain 1Domain 2Chi Square
IPR006670 Cyclin IPR001208 MCM 15.4071
IPR011028 Cyclin-like IPR001208 MCM 11.617
IPR013763 Cyclin-related IPR001208 MCM 11.2935
IPR006670 Cyclin IPR003593 AAA ATPase 0.931553
IPR011028 Cyclin-like IPR003593 AAA ATPase 0.663281
IPR013763 Cyclin-related IPR003593 AAA ATPase 0.604607

The background colour of the table refers to:

  • Blue Domain is only present in CCNB2
  • Yellow Domain is only present in MCM3
  • Green Domain is present in both CCNB2 and MCM3

0.027
Post-translational Modifications

Protein: CCNB2

PTMResidueReference

Protein: MCM3

PTMResidueReference
Phosphorylation 713 PubMed, HPRD
Phosphorylation 722 PubMed, HPRD
Phosphoserine 535 PubMed, HPRD
Phosphothreonine 713 HPRD
Phosphothreonine 722 HPRD
Localisation

Protein: CCNB2

LocalisationReference
Golgi HPRD
Secreted HPRD
Cytoplasm HPRD

Protein: MCM3

LocalisationReference
Nucleus HPRD
Nucleoplasm HPRD
Transitive Score

The common interactors between CCNB2 and MCM3 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CCNB2 andMCM3. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CCNB2 has 332 interactors and MCM3 has 1106 interactors of which there are 161 common interactors.

Common InteractorName of Common InteractorScore for CCNB2-Interactor (?)Score for MCM3-Interactor (?)
CDC6 CDC6, CDC18L: Cell division control protein 6 homolog 69.60 1.62
AURKA AURKA, AIK, ARK1, AURA, BTAK, STK15, STK6: Serine/threonine-protein kinase 6 69.60 0.146
CDC25A CDC25A: M-phase inducer phosphatase 1 32.20 0.025
AURKB AURKB, AIK2, AIM1, ARK2, STK12: Serine/threonine-protein kinase 12 13.90 0.053
FOXO3A FOXO3A, FKHRL1: Forkhead box protein O3A 11.70 0.171
CDK2 CDK2: Cell division protein kinase 2 6.55 27.40
CDC25C CDC25C: M-phase inducer phosphatase 3 6.33 0.025
PDPK1 PDPK1, PDK1: 3-phosphoinositide-dependent protein kinase 1 6.33 0.047
ATAD2 ATAD2, L16, PRO2000: ATPase family AAA domain-containing protein 2 6.32 0.503
CDK3 CDK3: Cell division protein kinase 3 4.16 0.956
PRKCE PRKCE, PKCE: Protein kinase C epsilon type 3.75 0.031
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 3.08 0.503
MSH6 MSH6, GTBP: DNA mismatch repair protein MSH6 1.82 0.827
ORC2L ORC2L, ORC2: Origin recognition complex subunit 2 1.10 0.123
FOXO1A FOXO1A, FKHR: Forkhead box protein O1A 0.837 0.111
PRKCG PRKCG, PKCG: Protein kinase C gamma type 0.837 0.0308
CCNB1 Cyclin B1 0.789 40.60
TTK TTK, MPS1L1: Dual specificity protein kinase TTK 0.789 0.053
CCNA2 CCNA2, CCN1, CCNA: Cyclin-A2 0.789 0.263
PRKCA PRKCA, PKCA, PRKACA: Protein kinase C alpha type 0.754 0.035
RUNX1 N/A 0.741 0.046
PRKCQ PRKCQ, PRKCT: Protein kinase C theta type 0.658 0.033
NAP1L1 NAP1L1, NRP: Nucleosome assembly protein 1-like 1 0.657 0.129
CDC23 CDC23: Cell division cycle protein 23 homolog 0.612 0.141
FZR1 N/A 0.538 0.038
DIAPH1 Diaphanous 1 0.408 0.046
USP10 USP10, KIAA0190: Ubiquitin carboxyl-terminal hydrolase 10 0.364 0.040
CAMKK1 N/A 0.354 0.025
SMC4L1 SMC4, CAPC, SMC4L1: Structural maintenance of chromosomes protein 4 0.354 0.075
FKBP1A FKBP1A, FKBP1, FKBP12: FK506-binding protein 1A 0.326 0.029
DDX3Y DDX3Y, DBY: ATP-dependent RNA helicase DDX3Y 0.326 0.114
CCNF CCNF: G2/mitotic-specific cyclin-F 0.293 0.137
MCM2 MCM2, BM28, CCNL1, CDCL1, KIAA0030: DNA replication licensing factor MCM2 0.263 1.29E3
MCM6 MCM6: DNA replication licensing factor MCM6 0.263 209.00
MELK MELK, KIAA0175: Maternal embryonic leucine zipper kinase 0.263 0.053
MCM4 MCM4, CDC21: DNA replication licensing factor MCM4 0.263 1.29E3
MCM7 MCM7, CDC47, MCM2: DNA replication licensing factor MCM7 0.263 209.00
PBK PBK, TOPK: Lymphokine-activated killer T-cell-originated protein kinase 0.263 0.146
PCNA PCNA: Proliferating cell nuclear antigen 0.242 1.62
PLK4 PLK4, SAK, STK18: Serine/threonine-protein kinase PLK4 0.207 0.207
E2F1 E2F1, RBBP3: Transcription factor E2F1 0.137 0.852
CHEK1 CHEK1, CHK1: Serine/threonine-protein kinase Chk1 0.123 0.515
MCM5 MCM5, CDC46: DNA replication licensing factor MCM5 0.123 209.00
BRCA1 BRCA1, RNF53: Breast cancer type 1 susceptibility protein 0.123 0.276
ORC1L ORC1L, ORC1, PARC1: Origin recognition complex subunit 1 0.123 0.763
TFDP1 TFDP1, DP1: Transcription factor Dp-1 0.123 0.060
SNF1LK2 SNF1LK2, KIAA0781, QIK: Serine/threonine-protein kinase SNF1-like kinase 2 0.123 0.118
CDK4 CDK4: Cell division protein kinase 4 0.123 0.515
DDX3X DDX3X, DBX, DDX3: ATP-dependent RNA helicase DDX3X 0.108 0.188
DLG7 DLG7, KIAA0008: Disks large-associated protein DLG7 0.082 0.025
ZWINT N/A 0.082 0.027
HMMR HMMR: Hyaluronan-mediated motility receptor 0.082 0.027
TPX2 TPX2, C20orf1, C20orf2, DIL2, HCA519: Targeting protein for Xklp2 0.082 0.053
MYBL2 MYBL2, BMYB: Myb-related protein B 0.081 0.129
BUB1 0.081 0.053
BUB1B BUB1B, BUBR1, MAD3L: Mitotic checkpoint serine/threonine-protein kinase BUB1 bet 0.081 0.053
HMGB2 HMGB2, HMG2: High mobility group protein B2 0.081 0.276
CSNK2A1 CSNK2A1: CSNK2A1 protein 0.074 0.515
PRKCB1 N/A 0.071 0.025
RB1 RB1: Retinoblastoma-associated protein 0.067 0.515
H1F0 H1F0, H1FV: Histone H1.0 0.060 0.046
CDK7 CDK7, MO15: Cell division protein kinase 7 0.060 0.118
SKIIP SNW1, SKIIP, SKIP: SNW domain-containing protein 1 0.060 0.129
OXSR1 OXSR1, KIAA1101, OSR1: Serine/threonine-protein kinase OSR1 0.060 0.241
STK11 STK11, LKB1, PJS: Serine/threonine-protein kinase 11 0.060 0.071
GTF2F1 GTF2F1, RAP74: Transcription initiation factor IIF subunit alpha 0.060 0.461
CCNG1 CCNG1, CCNG, CYCG1: Cyclin-G1 0.060 0.123
GTF2B GTF2B, TF2B, TFIIB: Transcription initiation factor IIB 0.060 0.372
PHB2 PHB2, BAP, REA: Prohibitin-2 0.053 0.0446
TRIP13 TRIP13: Thyroid receptor-interacting protein 13 0.051 0.503
RFC3 RFC3: Replication factor C subunit 3 0.051 0.207
RFC4 RFC4: Replication factor C subunit 4 0.051 0.207
MAPK6 MAPK6, ERK3, PRKM6: Mitogen-activated protein kinase 6 0.050 0.163
E2F2 E2F2: Transcription factor E2F2 0.050 0.0308
RFX5 RFX5: DNA-binding protein RFX5 0.050 0.137
TOP2A TOP2A, TOP2: DNA topoisomerase 2-alpha 0.049 0.307
MAP2K2 MAP2K2, MEK2, MKK2, PRKMK2: Dual specificity mitogen-activated protein kinase ki 0.047 0.090
HSF1 HSF1, HSTF1: Heat shock factor protein 1 0.044 0.225
GTF2E2 GTF2E2, TF2E2: Transcription initiation factor IIE subunit beta 0.044 0.074
NEK9 NEK9, KIAA1995, NEK8, NERCC: Serine/threonine-protein kinase Nek9 0.044 0.146
AKAP8L AKAP8L, NAKAP95, HRIHFB2018: A-kinase anchor protein 8-like 0.044 0.038
DYRK3 N/A 0.044 0.043
CDC20 CDC20: Cell division cycle protein 20 homolog 0.044 0.276
CCT2 CCT2, 99D8.1, CCTB: T-complex protein 1 subunit beta 0.042 0.141
GTF2F2 N/A 0.041 0.251
STK16 N/A 0.041 0.080
MAP4K1 MAP4K1, HPK1: Mitogen-activated protein kinase kinase kinase kinase 1 0.041 0.163
IRF4 IRF4, MUM1: Interferon regulatory factor 4 0.041 0.067
CBX3 CBX3: Chromobox protein homolog 3 0.038 0.276
RPA1 RPA1, REPA1, RPA70: Replication protein A 70 kDa DNA-binding subunit 0.038 0.263
VRK1 VRK1: Serine/threonine-protein kinase VRK1 0.038 0.515
YBX1 YBX1, NSEP1, YB1: Nuclease sensitive element-binding protein 1 0.038 0.763
SSRP1 SSRP1, FACT80: FACT complex subunit SSRP1 0.038 0.827
WEE1 WEE1: Wee1-like protein kinase 0.038 0.146
PKMYT1 PKMYT1, MYT1: Membrane-associated tyrosine- and threonine-specific cdc2-inhibito 0.038 0.146
EIF2S1 EIF2S1, EIF2A: Eukaryotic translation initiation factor 2 subunit 1 0.038 1.62
BARD1 BARD1: BRCA1-associated RING domain protein 1 0.038 0.515
CUL2 CUL2: Cullin-2 0.036 0.156
RPA2 RPA2, REPA2, RPA32, RPA34: Replication protein A 32 kDa subunit 0.036 0.372
CCNC CCNC: Cyclin-C 0.036 0.060
CCND2 CCND2: G1/S-specific cyclin-D2 0.036 0.060
PIP5K3 PIP5K3, KIAA0981, PIKFYVE: FYVE finger-containing phosphoinositide kinase 0.036 0.461
AKAP8 AKAP8, AKAP95: A-kinase anchor protein 8 0.036 0.078
PRPF4B PRPF4B, KIAA0536, PRP4, PRP4H, PRP4K: Serine/threonine-protein kinase PRP4 homol 0.036 0.146
PKN2 PKN2, PRK2, PRKCL2: Serine/threonine-protein kinase N2 0.036 0.087
RPS6KB1 N/A 0.036 0.118
DVL2 DVL2: Segment polarity protein dishevelled homolog DVL-2 0.035 0.059
ELF1 ELF1: ETS-related transcription factor Elf-1 0.0308 0.416
IRF5 IRF5: Interferon regulatory factor 5 0.0308 0.050
ZAK MLTK, ZAK, HCCS4: Mitogen-activated protein kinase kinase kinase MLT 0.0308 0.048
NEK1 NEK1, KIAA1901: Serine/threonine-protein kinase Nek1 0.0308 0.060
TLK1 TLK1, KIAA0137: Serine/threonine-protein kinase tousled-like 1 0.0308 0.132
PASK PASK, KIAA0135: PAS domain-containing serine/threonine-protein kinase 0.0308 0.080
FOXJ2 FOXJ2, FHX: Forkhead box protein J2 0.0308 0.191
ADAR ADAR, ADAR1, DSRAD, G1P1, IFI4: Double-stranded RNA-specific adenosine deaminase 0.0308 0.067
ROCK1 ROCK1: Rho-associated protein kinase 1 0.0308 0.0971
PRKAA1 N/A 0.0308 0.048
CDK6 CDK6: Cell division protein kinase 6 0.028 0.071
E2F5 E2F5: Transcription factor E2F5 0.028 0.036
GABPA GABPA, E4TF1A: GA-binding protein alpha chain 0.028 0.044
STK3 STK3, MST2: Serine/threonine-protein kinase 3 0.028 0.071
RPS6KA1 RPS6KA1, RSK1: Ribosomal protein S6 kinase alpha-1 0.028 0.087
MAPK12 MAPK12, ERK6, SAPK3: Mitogen-activated protein kinase 12 0.028 0.054
CCND3 CCND3: G1/S-specific cyclin-D3 0.028 0.044
CCNH CCNH: Cyclin-H 0.028 0.225
STK25 STK25, SOK1, YSK1: Serine/threonine-protein kinase 25 0.028 0.071
ADRBK1 ADRBK1, BARK, BARK1, GRK2: Beta-adrenergic receptor kinase 1 0.028 0.087
RPS6KB2 RPS6KB2, STK14B: Ribosomal protein S6 kinase beta-2 0.028 0.087
PSKH1 PSKH1: Serine/threonine-protein kinase H1 0.028 0.054
E2F3 E2F3, KIAA0075: Transcription factor E2F3 0.028 0.060
HSF2 HSF2, HSTF2: Heat shock factor protein 2 0.028 0.275
TCEB3 TCEB3, MSTP059: Transcription elongation factor B polypeptide 3 0.028 0.038
TACC3 TACC3, ERIC1: Transforming acidic coiled-coil-containing protein 3 0.027 0.025
GTSE1 GTSE1: G2 and S phase-expressed protein 1 0.027 0.025
CDCA8 CDCA8, PESCRG3: Borealin 0.027 0.027
GMNN GMNN: Geminin 0.027 0.053
KIAA0101 PAF, KIAA0101, L5, NS5ATP9: PCNA-associated factor 0.027 0.027
C18orf56 N/A 0.027 0.082
SMC4L1 N/A 0.027 0.027
DBF4 DBF4, ASK: Protein DBF4 homolog 0.027 0.025
ZWILCH Protein zwilch homolog. 0.027 0.027
TMPO N/A 0.027 0.027
BIRC5 BIRC5, API4, IAP4: Baculoviral IAP repeat-containing protein 5 0.027 0.074
HILS1 HILS1: Spermatid-specific linker histone H1-like protein 0.027 0.027
SPIC SPIC: Transcription factor Spi-C 0.027 0.027
PAX3 PAX3, HUP2: Paired box protein Pax-3 0.027 0.027
MAPK15 N/A 0.027 0.052
FOXM1 FOXM1, FKHL16, HFH11, MPP2, WIN: Forkhead box protein M1 0.027 0.165
ELF2 ELF2, NERF: ETS-related transcription factor Elf-2 0.027 0.165
FBXO4 FBXO4, FBX4: F-box only protein 4 0.027 0.028
C20orf116 C20orf116: Uncharacterized protein C20orf116 precursor 0.027 0.027
FOXQ1 FOXQ1, HFH1: Forkhead box protein Q1 0.027 0.027
MAPK9 MAPK9, JNK2, PRKM9: Mitogen-activated protein kinase 9 0.027 0.052
PKN1 PKN1, PKN, PRK1, PRKCL1: Serine/threonine-protein kinase N1 0.027 0.052
IRF7 IRF7: Interferon regulatory factor 7 0.027 0.027
HSFY1 HSFY1, HSF2L, HSFY: Heat shock transcription factor, Y-linked 0.027 0.027
MINK1 MAP4K6, MINK1, MINK: Misshapen-like kinase 1 0.027 0.052
HTATIP HTATIP, TIP60: Histone acetyltransferase HTATIP 0.027 0.165
TRIM28 TRIM28, KAP1, RNF96, TIF1B: Transcription intermediary factor 1-beta 0.0255 0.307
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.0255 0.293
BAZ1B BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF: Bromodomain adjacent to zinc finger domain 0.0255 0.144
0.572
Total Score 1.59E4