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Evidence of Interaction Between CHMP4C and CHMP6

The interaction score between CHMP4C and CHMP6 is 7.31E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

N/A

N/A
Orthology
OrganismCHMP4C OrthologueCHMP6 OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YLR025W 0.279 YMR077C 1
  • Y2H
  • AffinityCaptureWestern

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worm Q18886 0.157 Q9BL60 1
fly Q8T0Q4 0.246 Q9W236 1
  • Y2H
  • Other

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The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

3.01
Domains No domains were used in calculating likelihood of interaction 0.265
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: CHMP4C

LocalisationReference
Cytosol HPRD
Cytoplasm HPRD

Protein: CHMP6

LocalisationReference
Endosome HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between CHMP4C and CHMP6 that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between CHMP4C andCHMP6. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , CHMP4C has 25 interactors and CHMP6 has 23 interactors of which there are 15 common interactors.

Common InteractorName of Common InteractorScore for CHMP4C-Interactor (?)Score for CHMP6-Interactor (?)
CHMP4A N/A 319.00 803.00
CHMP4B CHMP4B, C20orf178, SHAX1: Charged multivesicular body protein 4b 319.00 319.00
VPS4B VPS4B, SKD1, VPS42: Vacuolar protein sorting-associating protein 4B 169.00 83.90
VPS24 VPS24, CHMP3, CGI-149, NEDF: Charged multivesicular body protein 3 169.00 61.90
CHMP2A CHMP2A, BC2, CHMP2: Charged multivesicular body protein 2a 12.60 0.596
VPS4A VPS4A, VPS4: Vacuolar protein sorting-associating protein 4A 3.58 12.40
CHMP1B CHMP1B, C18orf2: Charged multivesicular body protein 1b 0.265 0.491
CHMP7 CHMP7: Charged multivesicular body protein 7 0.265 0.491
CHMP5 CHMP5, C9orf83, CGI-34, SNF7DC2, HSPC177, PNAS-2, PNAS-114: Charged multivesicul 0.237 0.274
CHMP2B CHMP2B, CGI-84: Charged multivesicular body protein 2b 0.237 0.440
SNX15 SNX15: Sorting nexin-15 0.141 0.0924
CAPN7 CAPN7, PALBH: Calpain-7 0.126 0.191
FBXO34 CGI-301: Protein CGI-301 0.0288 0.0288
PCOLN3 CHMP1A, CHMP1, KIAA0047, PCOLN3, PRSM1: Charged multivesicular body protein 1a 0.0288 0.0288
SRPR SRPR: Uncharacterized protein SRPR 0.027 0.067
0.572
Total Score 7.31E4