Home
Advanced Search
Help
Update History
Statistics
Downloads
The Barton Group
<<< Back to VPS4B

Evidence of Interaction Between VPS4B and CHMP4A

The interaction score between VPS4B and CHMP4A is 2.38E4.

This page provides the details about the evidence that was used to calculate the interaction Score between the two proteins

The Scores that are listed with each module are based on the interaction score where that module provides the only source of evidence. The final Score is the integration of all the sources of evidence.

FeatureEvidenceScore (?)
Gene Expression

Pearson's Correlation between VPS4B and CHMP4A = 0.75

The original expression data was collated from the NCBI GEO database. For further information about this dataset please refer to the NCBI GEO dataset GDS596.

 0.013
Orthology
OrganismVPS4B OrthologueCHMP4A OrthologueExperiment
AccessionInparalog ScoreAccessionInparalog Score
bakers yeast YPR173C 1 YLR025W 1
  • Y2H
  • Other
  • AffinityCaptureMS

Get References From PubMed
worm Q9BL83 1 Q18886 0.056
fly Q9Y162 1 Q8T0Q4 0.156

The Inparalog Score is calculated by InParanoid

The experiment type Other refers to techniques other than Y2H, MS, Immunoprecipitation, SurfacePlasmonResonance, XrayDiffraction, Xlinking, CompetitionBinding, Immunofluorescence, GelRetardationAssay, AffinityChromatography, InVitroBinding, InVitro, InVivo, FarWestern, pullDown, AffinityCaptureMS, EpistaticMiniArrayProfile, AffinityCaptureWestern, BiochemicalActivity, CoCrystalStructure, FRET, ReconstitutedComplex, CoLocalization, CoPurification or CoFractionation.

 0.593
Domains No domains were used in calculating likelihood of interaction 0.141
Post-translational Modifications No PTMs were used in calculating likelihood of interaction
Localisation

Protein: VPS4B

LocalisationReference
Endosome HPRD
Vacuole HPRD
Cytoplasm HPRD

Protein: CHMP4A

LocalisationReference
Lysosome HPRD
Endosome HPRD
Cytoplasm HPRD
Transitive Score

The common interactors between VPS4B and CHMP4A that are considered by the Transitive module are listed below.

The Scores listed are the values used by the transitive module to calculate the final interaction Score between VPS4B andCHMP4A. The values listed are therefore not the final Score value for the listed interactions.

With a Score value ≥0.025 , VPS4B has 94 interactors and CHMP4A has 62 interactors of which there are 31 common interactors.

Common InteractorName of Common InteractorScore for VPS4B-Interactor (?)Score for CHMP4A-Interactor (?)
CHMP4C CHMP4C, SHAX3: Charged multivesicular body protein 4c 169.00 319.00
CHMP4B CHMP4B, C20orf178, SHAX1: Charged multivesicular body protein 4b 169.00 319.00
CHMP6 CHMP6, VPS20: Charged multivesicular body protein 6 83.90 803.00
PDCD6IP PDCD6IP, AIP1, ALIX, KIAA1375: Programmed cell death 6-interacting protein 1.84 3.68
CHMP1B CHMP1B, C18orf2: Charged multivesicular body protein 1b 0.724 0.824
VPS24 VPS24, CHMP3, CGI-149, NEDF: Charged multivesicular body protein 3 0.606 528.00
CHMP7 CHMP7: Charged multivesicular body protein 7 0.438 0.824
CHMP2B CHMP2B, CGI-84: Charged multivesicular body protein 2b 0.392 0.596
CHMP2A CHMP2A, BC2, CHMP2: Charged multivesicular body protein 2a 0.392 323.00
CHMP5 CHMP5, C9orf83, CGI-34, SNF7DC2, HSPC177, PNAS-2, PNAS-114: Charged multivesicul 0.317 0.440
LOC283683 N/A 0.119 0.119
SRP54 SRP54: Signal recognition particle 54 kDa protein 0.074 0.055
PSMC6 PSMC6, SUG2: 26S protease regulatory subunit S10B 0.074 0.117
SRPR SRPR: Uncharacterized protein SRPR 0.067 0.083
PSMC1 PSMC1: 26S protease regulatory subunit 4 0.060 0.0331
DDX58 DDX58: Probable ATP-dependent RNA helicase DDX58 0.059 0.0331
DHX15 DHX15, DBP1, DDX15: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase 0.053 0.061
ASCC3 ASCC3, HELIC1: Activating signal cointegrator 1 complex subunit 3 0.047 0.027
VCP VCP: Transitional endoplasmic reticulum ATPase 0.044 0.027
ABCE1 ABCE1, RLI, OK/SW-cl.40, RNASEL1, RNASELI, RNS4I: ATP-binding cassette sub-famil 0.044 0.027
PSMC2 PSMC2, MSS1: 26S protease regulatory subunit 7 0.044 0.0331
VPS4A VPS4A, VPS4: Vacuolar protein sorting-associating protein 4A 0.044 20.80
TAF9 AK6, AD-004, CGI-137: Adenylate kinase isoenzyme 6 0.041 0.030
PSMC3 PSMC3, TBP1: 26S protease regulatory subunit 6A 0.036 0.0331
PCOLN3 CHMP1A, CHMP1, KIAA0047, PCOLN3, PRSM1: Charged multivesicular body protein 1a 0.0288 0.0288
FBXO34 CGI-301: Protein CGI-301 0.0288 0.0288
MCM3 MCM3: DNA replication licensing factor MCM3 0.029 0.027
SYF2 N/A 0.027 0.027
CLPX CLPX: ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial pr 0.027 0.027
ABCD3 ABCD3, PMP70, PXMP1: ATP-binding cassette sub-family D member 3 0.027 0.027
XAB1 XAB1, MBDIN, HUSSY-23: XPA-binding protein 1 0.027 0.0331
0.347
Total Score 2.38E4